{"id":"https://openalex.org/W875733087","doi":null,"title":"Synthetic biology approach to cellulose degradation","display_name":"Synthetic biology approach to cellulose degradation","publication_year":2012,"publication_date":"2012-06-22","ids":{"openalex":"https://openalex.org/W875733087","mag":"875733087"},"language":"en","primary_location":{"id":"pmh:oai:era.ed.ac.uk:1842/9887","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1842/9887","pdf_url":"http://hdl.handle.net/1842/9887","source":{"id":"https://openalex.org/S7407055182","display_name":"ERA","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1842/9887","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005968068","display_name":"Sahreena Lakhundi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sahreena Lakhundi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5005968068"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellulose-degradation","display_name":"cellulose degradation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cellulase","display_name":"cellulase","score":0.7089999914169312},{"id":"https://openalex.org/keywords/heterologous-expression","display_name":"heterologous expression","score":0.765999972820282},{"id":"https://openalex.org/keywords/biobricks","display_name":"BioBricks","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cellulomonas-fimi","display_name":"Cellulomonas fimi","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cytophaga-hutchinsonii","display_name":"Cytophaga hutchinsonii","score":0.9670000076293945},{"id":"https://openalex.org/keywords/citrobacter-freundii","display_name":"Citrobacter freundii","score":0.8859999775886536},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8579999804496765},{"id":"https://openalex.org/keywords/bacillus-subtilis","display_name":"Bacillus subtilis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/dehydrogenase","display_name":"dehydrogenase","score":0.6940000057220459},{"id":"https://openalex.org/keywords/cellulosic-biomass","display_name":"cellulosic biomass","score":0.5669999718666077},{"id":"https://openalex.org/keywords/bioethanol-production","display_name":"bioethanol production","score":0.578000009059906},{"id":"https://openalex.org/keywords/cellulose-recalcitrance","display_name":"cellulose recalcitrance","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.6369397044181824},{"id":"https://openalex.org/C2779251873","wikidata":"https://www.wikidata.org/wiki/Q80294","display_name":"Cellulose","level":2,"score":0.6181622743606567},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40318769216537476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38378700613975525},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.33286821842193604},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2919699549674988},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.20592644810676575},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17921596765518188},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.05801588296890259}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:era.ed.ac.uk:1842/9887","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1842/9887","pdf_url":"http://hdl.handle.net/1842/9887","source":{"id":"https://openalex.org/S7407055182","display_name":"ERA","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},{"id":"mag:875733087","doi":null,"is_oa":false,"landing_page_url":"https://era.ed.ac.uk/handle/1842/9887","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:era.ed.ac.uk:1842/9887","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1842/9887","pdf_url":"http://hdl.handle.net/1842/9887","source":{"id":"https://openalex.org/S7407055182","display_name":"ERA","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},"sustainable_development_goals":[{"score":0.7811999917030334,"id":"https://metadata.un.org/sdg/12","display_name":"Responsible consumption and production"},{"score":0.5690000057220459,"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W875733087.pdf","grobid_xml":"https://content.openalex.org/works/W875733087.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2519460020","https://openalex.org/W402539262","https://openalex.org/W1952805380","https://openalex.org/W1917814533","https://openalex.org/W2766409275","https://openalex.org/W233798420","https://openalex.org/W7164992235","https://openalex.org/W3015636473","https://openalex.org/W7097752950","https://openalex.org/W3204859141"],"abstract_inverted_index":{"Cellulose,":[0],"the":[1,35,45,97,140,181,198,247,282,289,292,316,334,354,412,473],"most":[2,37],"abundant":[3,39],"biopolymer":[4],"on":[5],"earth,":[6],"is":[7,27,34,92,338,491],"composed":[8],"of":[9,47,77,86,99,128,142,183,221,310,363,387,392,482,515],"\u03b2":[10],"\u2013":[11,13,405,424],"1,4":[12],"linked":[14],"glucose":[15],"units,":[16],"which":[17,91,130,216,337],"in":[18,102,158,256,333],"turn":[19],"form":[20],"a":[21,125,361,385,480,513],"highly":[22],"ordered":[23],"crystalline":[24,118],"structure":[25],"that":[26,180,238,368,464],"insoluble":[28],"and":[29,40,58,63,73,95,155,175,188,190,193,224,252,374,382,397],"recalcitrant":[30],"to":[31,107,116,121,124,146,197,210,287,348,356,378,394,411,468,475,492],"degradation.":[32,342],"It":[33,177,235,365],"world\u2019s":[36],"attractive,":[38],"renewable":[41],"energy":[42],"resource,":[43],"representing":[44],"bioconversion":[46],"carbon":[48,89,388],"dioxide":[49,90],"into":[50,81,231],"green":[51],"plants.":[52],"Cellulosic":[53],"biomass,":[54],"such":[55],"as":[56,70,273,304,325,360,384,456,479,512],"agricultural":[57],"forestry":[59],"residues,":[60],"waste":[61,65],"paper":[62,381,419],"industrial":[64],"can":[66],"therefore":[67],"be":[68,122],"used":[69,272,286,303,324,442,455],"an":[71,105,274,305,326,457],"inexpensive":[72],"abundantly":[74],"available":[75],"source":[76,362,386,481,514],"sugar":[78],"for":[79,132,202,340,503],"fermentation":[80],"fuel":[82],"ethanol.":[83],"The":[84,114,484],"combustion":[85],"biofuels":[87],"releases":[88],"thus":[93],"recycled":[94],"hence":[96],"use":[98,211,357,379,476],"these":[100,489],"fuels":[101],"transportation":[103],"provides":[104],"alternative":[106],"fossil":[108],"fuels,":[109],"solving":[110],"many":[111],"environmental":[112],"problems.":[113],"ability":[115,474],"degrade":[117],"cellulose":[119,153,341],"seems":[120],"restricted":[123],"specialized":[126],"group":[127],"microorganisms":[129],"includes":[131],"example":[133],"Clostridium,":[134],"Cellulomonas,":[135],"Cytophaga,":[136],"Trichoderma":[137],"etc.":[138],"Hence":[139,460],"aim":[141],"this":[143,257,311],"project":[144],"was":[145,178,195,208,236,265,271,278,285,294,302,313,323,331,366,376,402,431,435,441,445,454,462],"create":[147],"BioBricks":[148,220],"using":[149,170,488,509],"different":[150,159,172,232],"cellulases":[151,186,212,222,352,466,508],"from":[152,213,226],"degraders":[154],"express":[156],"them":[157],"expression":[160,182,233,260,275,293,306,327,458],"hosts":[161],"like":[162],"Escherichia":[163],"coli,":[164],"Bacillus":[165],"subtilis,":[166],"Citrobacter":[167,243],"freundii":[168,244,321,370,429,470],"etc.,":[169],"two":[171],"promoters,":[173],"spac":[174],"lac.":[176],"observed":[179,237,367,436],"Cytophaga":[184],"hutchinsonii":[185],"(CHU_2103":[187],"CHU_2802)":[189],"dehydrogenases":[191],"(CHU_1944":[192],"CHU_2315)":[194],"toxic":[196],"E.":[199,268,297,438],"coli":[200,269,298,439],"host":[201,355],"some":[203],"unknown":[204],"reason.":[205],"Therefore":[206],"it":[207,461],"decided":[209],"Cellulomonas":[214],"fimi,":[215],"are":[217],"well":[218],"characterized.":[219],"(cenA":[223],"cex)":[225],"C.":[227,320,369,428,469],"fimi":[228],"were":[229,254,346],"introduced":[230],"hosts.":[234],"under":[239],"our":[240,493],"experimental":[241],"conditions":[242],"SBS197":[245,322,371,430,471],"gave":[246],"best":[248],"results.":[249],"Both":[250],"Pspac":[251,264],"Plac":[253],"functional":[255],"organism":[258],"with":[259,389,472],"being":[261],"higher":[262,295,408,495],"when":[263,281,296,319,409,427,437,450],"used.":[266,432],"When":[267],"JM109":[270,299,440],"host,":[276,307,328],"activity":[277,312,330],"only":[279],"detected":[280,332],"lac":[283],"promoter":[284],"control":[288,413],"expression.":[290],"Although":[291],"(containing":[300],"Plac)":[301],"almost":[308],"all":[309],"residing":[314],"within":[315,422],"cells,":[317],"whereas":[318],"considerable":[329],"surrounding":[335],"medium,":[336],"essential":[339],"Growth":[343],"curve":[344],"studies":[345],"done":[347],"see":[349],"if":[350],"heterologous":[351,465,507],"enable":[353],"cellulosic":[358,477,510],"substrates":[359,478,511],"carbon.":[364,483,516],"expressing":[372,506],"cenA":[373],"cex":[375],"able":[377],"filter":[380],"Avicel":[383],"maximum":[390,485],"growth":[391,486],"up":[393],"8.8\u00d7108":[395],"cfu/ml":[396,399],"1.2\u00d7109":[398],"respectively.":[400],"This":[401],"about":[403],"2":[404],"5":[406],"fold":[407],"compared":[410],"(vector":[414],"and/or":[415],"negative)":[416],"strains.":[417],"Filter":[418],"completely":[420],"disappeared":[421],"3":[423],"4":[425],"days":[426],"Slight":[433],"degradation":[434,448],"but":[443],"there":[444],"no":[446],"physical":[447],"seen":[449],"B.":[451],"subtilis":[452],"168":[453],"host.":[459],"concluded":[463],"impart":[467],"obtained":[487],"cultures":[490],"knowledge":[494],"than":[496],"what":[497],"has":[498],"been":[499],"reported":[500],"so":[501],"far":[502],"recombinant":[504],"organisms":[505]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2016-06-24T00:00:00"}
