{"id":"https://openalex.org/W87311561","doi":null,"title":"Sensitivity of the appetite control system in obese subjects to nutritional and serotoninergic challenges.","display_name":"Sensitivity of the appetite control system in obese subjects to nutritional and serotoninergic challenges.","publication_year":1990,"publication_date":"1990-03-01","ids":{"openalex":"https://openalex.org/W87311561","mag":"87311561","pmid":"https://pubmed.ncbi.nlm.nih.gov/2187822"},"language":"en","primary_location":{"id":"pmid:2187822","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2187822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of obesity","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066468157","display_name":"Andrew J. Hill","orcid":"https://orcid.org/0000-0003-3192-0427","observed_orcids":["https://orcid.org/0000-0003-3192-0427"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A J Hill","raw_affiliation_strings":["Psychology Department, University of Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychology Department, University of Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039586613","display_name":"John Edward Blundell","orcid":"https://orcid.org/0000-0002-7085-9596","observed_orcids":["https://orcid.org/0000-0002-7085-9596"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J E Blundell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9513,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.83320669,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"14","issue":"3","first_page":"219","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10263","display_name":"Eating Disorders and Behaviors","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/appetite-regulation","display_name":"appetite regulation","score":0.7070000171661377},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.984000027179718},{"id":"https://openalex.org/keywords/hunger","display_name":"hunger","score":0.4269999861717224},{"id":"https://openalex.org/keywords/satiety","display_name":"satiety","score":0.9369999766349792},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.5820000171661377},{"id":"https://openalex.org/keywords/fenfluramine","display_name":"fenfluramine","score":0.9259999990463257},{"id":"https://openalex.org/keywords/high-protein-diet","display_name":"high-protein diet","score":0.7450000047683716},{"id":"https://openalex.org/keywords/caloric-restriction","display_name":"caloric restriction","score":0.8500000238418579},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.6710000038146973},{"id":"https://openalex.org/keywords/food-preferences","display_name":"food preferences","score":0.6579999923706055},{"id":"https://openalex.org/keywords/anorectic-drugs","display_name":"anorectic drugs","score":0.7279999852180481},{"id":"https://openalex.org/keywords/dietary-intervention","display_name":"dietary intervention","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C75908981","wikidata":"https://www.wikidata.org/wiki/Q28578","display_name":"Appetite","level":2,"score":0.8578973412513733},{"id":"https://openalex.org/C2779638493","wikidata":"https://www.wikidata.org/wiki/Q418928","display_name":"Fenfluramine","level":4,"score":0.7652440071105957},{"id":"https://openalex.org/C190362976","wikidata":"https://www.wikidata.org/wiki/Q845261","display_name":"Caloric theory","level":2,"score":0.6954018473625183},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6792927384376526},{"id":"https://openalex.org/C2778345441","wikidata":"https://www.wikidata.org/wiki/Q6460735","display_name":"Meal","level":2,"score":0.6696292161941528},{"id":"https://openalex.org/C2777369949","wikidata":"https://www.wikidata.org/wiki/Q567709","display_name":"Anorectic","level":3,"score":0.6549283266067505},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.6394329071044922},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5470522046089172},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5435400605201721},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5314568281173706},{"id":"https://openalex.org/C2994137971","wikidata":"https://www.wikidata.org/wiki/Q130964","display_name":"Caloric intake","level":3,"score":0.48129215836524963},{"id":"https://openalex.org/C2780320433","wikidata":"https://www.wikidata.org/wiki/Q3403879","display_name":"Weight gain","level":3,"score":0.4746694564819336},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.41597533226013184},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.35575589537620544},{"id":"https://openalex.org/C3018685816","wikidata":"https://www.wikidata.org/wiki/Q213449","display_name":"Food intake","level":2,"score":0.21160641312599182},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.20014545321464539},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001069","descriptor_name":"Appetite Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002149","descriptor_name":"Energy Intake","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004040","descriptor_name":"Dietary Carbohydrates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004044","descriptor_name":"Dietary Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005277","descriptor_name":"Fenfluramine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005518","descriptor_name":"Food Preferences","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006815","descriptor_name":"Hunger","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009767","descriptor_name":"Obesity, Morbid","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012527","descriptor_name":"Satiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2187822","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2187822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of obesity","raw_type":"Clinical Trial"},{"id":"mag:87311561","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2187822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2418912136","https://openalex.org/W163233472","https://openalex.org/W2431989417","https://openalex.org/W2148757228","https://openalex.org/W2142610566","https://openalex.org/W2423010306","https://openalex.org/W2127273420","https://openalex.org/W2410651715","https://openalex.org/W2412880465","https://openalex.org/W1973238805"],"abstract_inverted_index":{"The":[0,29,214],"sensitivity":[1],"of":[2,6,9,34,43,98,126,137,165,193,204,220,237],"the":[3,32,41,65,135,175,181,191,201,218,235],"appetite":[4,202,222],"system":[5,203],"a":[7,35,69,93,141,151],"group":[8],"obese":[10,47],"individuals":[11],"was":[12,207],"assessed":[13],"in":[14,26,117],"response":[15],"to":[16,20,68,209],"two":[17],"challenges":[18,30,114],"known":[19],"reduce":[21],"hunger":[22,127,194,238],"and":[23,40,122,129,139,169],"enhance":[24],"satiety":[25],"lean":[27],"people.":[28],"were":[31,115,132,188],"presentation":[33],"caloric":[36,109,167,241],"(high":[37],"protein)":[38],"load":[39,168],"activation":[42],"serotonin":[44],"systems.":[45],"Eight":[46],"female":[48],"adults":[49],"(BMI":[50],"=":[51],"38)":[52],"received":[53],"2":[54,70,72],"X":[55,71,75],"15":[56],"mg":[57],"d-fenfluramine":[58,178],"or":[59,101],"placebo":[60],"daily":[61],"for":[62,140,150,234],"3":[63,89,143],"days,":[64],"study":[66,197],"conforming":[67],"factor":[73],"(drug":[74],"lunch":[76,138],"type),":[77],"double":[78],"blind,":[79],"repeated":[80],"measures":[81],"design.":[82],"Three":[83],"hours":[84],"after":[85],"dosing":[86],"on":[87,171],"day":[88],"they":[90],"ate":[91],"either":[92],"high":[94,102,176],"carbohydrate":[95],"(63":[96],"percent":[97],"total":[99],"energy)":[100],"protein":[103,177],"(54":[104],"percent)":[105],"lunchtime":[106],"meal":[107,113,160],"(the":[108],"load).":[110],"These":[111,186],"fixed":[112],"equal":[116],"energy":[118,172],"(475":[119],"kcal),":[120],"weight":[121],"fat":[123],"content.":[124],"Ratings":[125],"motivation":[128],"food":[130],"preferences":[131],"tracked":[133],"over":[134],"course":[136],"further":[142],"hours,":[144],"at":[145],"which":[146],"point":[147],"subjects":[148,206],"returned":[149],"self-selection":[152],"test":[153],"meal.":[154],"Intakes":[155],"from":[156,240],"this":[157],"second":[158],"open":[159],"revealed":[161],"significant":[162],"main":[163],"effects":[164],"both":[166],"drug":[170,224],"intake,":[173],"with":[174,225],"combination":[179,219],"being":[180],"most":[182],"potent":[183],"anorectic":[184],"pairing.":[185],"findings":[187],"supported":[189],"by":[190],"profiles":[192],"motivation.":[195],"This":[196],"has":[198],"confirmed":[199],"that":[200,217],"these":[205,210],"responsive":[208],"biologically":[211],"relevant":[212],"challenges.":[213],"results":[215],"suggest":[216],"an":[221,231],"modulating":[223],"specific":[226],"dietary":[227],"intervention":[228],"may":[229],"represent":[230],"effective":[232],"strategy":[233],"management":[236],"arising":[239],"restriction.":[242]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}