{"id":"https://openalex.org/W87236722","doi":"https://doi.org/10.4049/jimmunol.186.supp.107.16","title":"Structural requirements for the inhibition of calcium mobilization and mast cell activation by the pyrazole derivative BTP2 (107.16)","display_name":"Structural requirements for the inhibition of calcium mobilization and mast cell activation by the pyrazole derivative BTP2 (107.16)","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W87236722","doi":"https://doi.org/10.4049/jimmunol.186.supp.107.16","mag":"87236722"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.186.supp.107.16","doi":"https://doi.org/10.4049/jimmunol.186.supp.107.16","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.186.supp.107.16","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066442533","display_name":"Mankit Law","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mankit Law","raw_affiliation_strings":["Cornell University , Ithaca, NY","Pennsylvania State University , State College, PA","1Pennsylvania State University, State College, PA","2Cornell University, Ithaca, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornell University , Ithaca, NY","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Pennsylvania State University , State College, PA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"1Pennsylvania State University, State College, PA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"2Cornell University, Ithaca, NY","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034807019","display_name":"Laurie F. Mottram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurie Mottram","raw_affiliation_strings":["Pennsylvania State University , State College, PA","1Pennsylvania State University, State College, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pennsylvania State University , State College, PA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"1Pennsylvania State University, State College, PA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jose Morales","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose Morales","raw_affiliation_strings":["Pennsylvania State University , State College, PA","1Pennsylvania State University, State College, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pennsylvania State University , State College, PA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"1Pennsylvania State University, State College, PA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040465204","display_name":"Blake R. Peterson","orcid":"https://orcid.org/0000-0001-8251-3579","observed_orcids":["https://orcid.org/0000-0001-8251-3579"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blake Peterson","raw_affiliation_strings":["Pennsylvania State University , State College, PA","1Pennsylvania State University, State College, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pennsylvania State University , State College, PA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"1Pennsylvania State University, State College, PA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000896541","display_name":"Avery August","orcid":"https://orcid.org/0000-0003-4968-3415","observed_orcids":["https://orcid.org/0000-0003-4968-3415"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Avery August","raw_affiliation_strings":["Cornell University , Ithaca, NY","Pennsylvania State University , State College, PA","1Pennsylvania State University, State College, PA","2Cornell University, Ithaca, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornell University , Ithaca, NY","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Pennsylvania State University , State College, PA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"1Pennsylvania State University, State College, PA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"2Cornell University, Ithaca, NY","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"186","issue":"1_Supplement","first_page":"107.16","last_page":"107.16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/btp2","display_name":"BTP2","score":0.9879999756813049},{"id":"https://openalex.org/keywords/pyrazoles","display_name":"pyrazole derivatives","score":0.9739999771118164},{"id":"https://openalex.org/keywords/mast-cell-activation","display_name":"mast cell activation","score":0.828000009059906},{"id":"https://openalex.org/keywords/calcium-mobilization","display_name":"calcium mobilization","score":0.9639999866485596},{"id":"https://openalex.org/keywords/fcepsilonri-signaling","display_name":"Fc\u03b5RI signaling","score":0.8550000190734863},{"id":"https://openalex.org/keywords/degranulation","display_name":"degranulation","score":0.7310000061988831},{"id":"https://openalex.org/keywords/nfat-nuclear-translocation","display_name":"NFAT nuclear translocation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6800000071525574},{"id":"https://openalex.org/keywords/trifluoromethyl-substituents","display_name":"trifluoromethyl group","score":0.9240000247955322},{"id":"https://openalex.org/keywords/rbl-2h3-cells","display_name":"RBL-2H3 cells","score":0.8970000147819519},{"id":"https://openalex.org/keywords/bone-marrow-mast-cells","display_name":"bone marrow mast cells","score":0.9089999794960022},{"id":"https://openalex.org/keywords/histamine-release","display_name":"histamine release","score":0.902999997138977},{"id":"https://openalex.org/keywords/allergic-reactions","display_name":"allergic reactions","score":0.8330000042915344},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C49802076","wikidata":"https://www.wikidata.org/wiki/Q5251810","display_name":"Degranulation","level":3,"score":0.7423732280731201},{"id":"https://openalex.org/C189938988","wikidata":"https://www.wikidata.org/wiki/Q24744925","display_name":"NFAT","level":4,"score":0.7304744720458984},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.6713865995407104},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.6032443046569824},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6029801964759827},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5653465390205383},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5191775560379028},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4945478141307831},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.4575341045856476},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.44299861788749695},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4244595170021057},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4186147451400757},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30161046981811523},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.268888920545578},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26244235038757324},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19965612888336182},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.17582491040229797},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.05836218595504761},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.186.supp.107.16","doi":"https://doi.org/10.4049/jimmunol.186.supp.107.16","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.186.supp.107.16","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W27684365","https://openalex.org/W1994562323","https://openalex.org/W2000708353","https://openalex.org/W2006013044","https://openalex.org/W2113734515","https://openalex.org/W2083142097","https://openalex.org/W2742493474","https://openalex.org/W2751425165","https://openalex.org/W7111145438","https://openalex.org/W2036413106"],"abstract_inverted_index":{"Abstract":[0],"Cytosolic":[1],"Ca2+":[2,43,85,188],"changes":[3],"in":[4,45,119,149],"mast":[5,25,206],"cells":[6,47],"are":[7],"central":[8],"for":[9,23,136,181,198],"driving":[10],"their":[11,29],"activation.":[12],"Thus,":[13],"pharmacological":[14],"tools":[15],"that":[16,35,82,173],"inhibit":[17],"this":[18,112],"process":[19],"represent":[20],"unique":[21],"strategies":[22],"inhibiting":[24],"cell":[26],"function":[27],"and":[28,48,74,100,130,145,191,204],"contribution":[30],"to":[31],"disease.":[32],"We":[33],"find":[34],"the":[36,55,89,126,137,150,163,178,182,199],"pyrazole":[37,148,174],"compound":[38,129],"BTP2":[39,83,96,114,127,193],"inhibited":[40,97,115],"Fc\u03f5RI-triggered":[41,98],"sustained":[42],"influx":[44],"RBL-2H3":[46],"murine":[49],"BMMCs":[50],"with":[51,104,111,156],"little":[52],"effect":[53,160],"on":[54],"tyrosine":[56],"phosphorylation":[57,67],"of":[58,68,106,122,147,152,154,184,187,201],"cellular":[59],"proteins.":[60],"It":[61],"also":[62],"did":[63],"not":[64],"affect":[65],"Fc\u03f5RI-induced":[66],"mitogen-activated":[69],"protein":[70],"kinases":[71],"Erk1/2,":[72],"JNK,":[73],"p38":[75],"nor":[76],"downstream":[77],"c-fos":[78],"expression.":[79],"This":[80],"suggests":[81],"inhibits":[84],"mobilization":[86],"without":[87],"affecting":[88],"Fc\u03f5RI":[90],"signal":[91],"transduction":[92],"cascade.":[93],"In":[94,168],"vitro,":[95],"degranulation":[99,153],"cytokine":[101],"secretion,":[102],"correlating":[103],"inhibition":[105,151],"NFAT":[107],"nuclear":[108],"translocation.":[109],"Consistent":[110],"effect,":[113],"antigen-induced":[116],"histamine":[117],"release":[118],"vivo.":[120],"Analysis":[121],"structure-function":[123],"relationships":[124],"between":[125],"parent":[128],"its":[131],"derivatives":[132],"implicate":[133],"a":[134,157,195],"role":[135],"trifluoromethyl":[138,164],"group":[139,165],"at":[140,166],"both":[141],"carbon":[142],"positions":[143],"3":[144],"5":[146],"BMMCs,":[155],"more":[158],"dominant":[159],"evoked":[161],"by":[162],"C3.":[167],"conclusion,":[169],"our":[170],"studies":[171],"indicate":[172],"compounds":[175],"can":[176],"provide":[177],"molecular":[179],"framework":[180],"design":[183],"specific":[185],"inhibitors":[186],"entry":[189],"mechanisms":[190],"further":[192],"as":[194],"medicinal":[196],"candidate":[197],"treatment":[200],"allergic":[202],"reactions":[203],"other":[205],"cell-mediated":[207],"diseases.":[208]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
