{"id":"https://openalex.org/W87198259","doi":"https://doi.org/10.1007/978-3-642-18547-2_20","title":"Vorhersage des Ansprechens von Rektumkarzinomen auf eine neoadjuvante Radiochemotherapie mit Hilfe von Genexpressionsanalysen","display_name":"Vorhersage des Ansprechens von Rektumkarzinomen auf eine neoadjuvante Radiochemotherapie mit Hilfe von Genexpressionsanalysen","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W87198259","doi":"https://doi.org/10.1007/978-3-642-18547-2_20","mag":"87198259"},"language":"de","primary_location":{"id":"doi:10.1007/978-3-642-18547-2_20","doi":"https://doi.org/10.1007/978-3-642-18547-2_20","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-18547-2_20","pdf_url":null,"source":{"id":"https://openalex.org/S4210224138","display_name":"Langenbecks Archiv f\u00fcr Chirurgie. Supplement","issn_l":"1432-9336","issn":["1432-9336"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Deutsche Gesellschaft f\u00fcr Chirurgie","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2503019933","display_name":"Chirurgisches Forum 2004"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000607231","display_name":"\u0392. Michael Ghadimi","orcid":"https://orcid.org/0000-0002-0767-6009","observed_orcids":["https://orcid.org/0000-0002-0767-6009"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B. M Ghadimi","raw_affiliation_strings":["Klinik f\u00fcr Allgemeinchirurgie, Universit\u00e4tsklinik G\u00f6ttingen, Robert-Koch-Stra\u00dfe 40, 37075, G\u00f6ttingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik f\u00fcr Allgemeinchirurgie, Universit\u00e4tsklinik G\u00f6ttingen, Robert-Koch-Stra\u00dfe 40, 37075, G\u00f6ttingen","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041792287","display_name":"Marian Grade","orcid":"https://orcid.org/0000-0001-9527-5362","observed_orcids":["https://orcid.org/0000-0001-9527-5362"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Grade","raw_affiliation_strings":["Klinik f\u00fcr Allgemeinchirurgie, Universit\u00e4tsklinik G\u00f6ttingen, Robert-Koch-Stra\u00dfe 40, 37075, G\u00f6ttingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik f\u00fcr Allgemeinchirurgie, Universit\u00e4tsklinik G\u00f6ttingen, Robert-Koch-Stra\u00dfe 40, 37075, G\u00f6ttingen","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101715307","display_name":"Richard M Simon","orcid":"https://orcid.org/0000-0003-3558-4598","observed_orcids":["https://orcid.org/0000-0003-3558-4598"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Simon","raw_affiliation_strings":["Biometrics Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biometrics Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027059333","display_name":"Torsten Liersch","orcid":"https://orcid.org/0000-0001-7024-7306","observed_orcids":["https://orcid.org/0000-0001-7024-7306"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Liersch","raw_affiliation_strings":["Klinik f\u00fcr Allgemeinchirurgie, Universit\u00e4tsklinik G\u00f6ttingen, Robert-Koch-Stra\u00dfe 40, 37075, G\u00f6ttingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik f\u00fcr Allgemeinchirurgie, Universit\u00e4tsklinik G\u00f6ttingen, Robert-Koch-Stra\u00dfe 40, 37075, G\u00f6ttingen","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021976335","display_name":"Claus Langer","orcid":"https://orcid.org/0009-0008-3601-3408","observed_orcids":["https://orcid.org/0009-0008-3601-3408"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Langer","raw_affiliation_strings":["Klinik f\u00fcr Allgemeinchirurgie, Universit\u00e4tsklinik G\u00f6ttingen, Robert-Koch-Stra\u00dfe 40, 37075, G\u00f6ttingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik f\u00fcr Allgemeinchirurgie, Universit\u00e4tsklinik G\u00f6ttingen, Robert-Koch-Stra\u00dfe 40, 37075, G\u00f6ttingen","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031392514","display_name":"Thomas Ried","orcid":"https://orcid.org/0000-0002-0767-6009","observed_orcids":["https://orcid.org/0000-0002-0767-6009"]},"institutions":[{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Ried","raw_affiliation_strings":["Genetics Branch, Center for Cancer Research, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Branch, Center for Cancer Research, USA","institution_ids":["https://openalex.org/I4210149717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081345687","display_name":"Heinz Becker A","orcid":"https://orcid.org/0009-0008-8886-2866","observed_orcids":["https://orcid.org/0009-0008-8886-2866"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. Becker","raw_affiliation_strings":["Klinik f\u00fcr Allgemeinchirurgie, Universit\u00e4tsklinik G\u00f6ttingen, Robert-Koch-Stra\u00dfe 40, 37075, G\u00f6ttingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik f\u00fcr Allgemeinchirurgie, Universit\u00e4tsklinik G\u00f6ttingen, Robert-Koch-Stra\u00dfe 40, 37075, G\u00f6ttingen","institution_ids":["https://openalex.org/I4210116730"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03935599,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"63","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.6948000192642212,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.6948000192642212,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.20190000534057617,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0803999975323677,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rectal-cancer","display_name":"rectal cancer","score":0.9049999713897705},{"id":"https://openalex.org/keywords/neoadjuvant-chemoradiotherapy","display_name":"neoadjuvant chemoradiotherapy","score":0.9729999899864197},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.8899999856948853},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.9079999923706055},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7789999842643738},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.8859999775886536},{"id":"https://openalex.org/keywords/locally-advanced-rectal-cancer","display_name":"locally advanced rectal cancer","score":0.9340000152587891},{"id":"https://openalex.org/keywords/patient-stratification","display_name":"patient stratification","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8515241146087646},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5694168210029602},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5418688654899597},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5117763876914978},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.4521295726299286},{"id":"https://openalex.org/C3019096185","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Complete response","level":3,"score":0.41904884576797485},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.40293368697166443},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25025373697280884},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.10269537568092346}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-642-18547-2_20","doi":"https://doi.org/10.1007/978-3-642-18547-2_20","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-18547-2_20","pdf_url":null,"source":{"id":"https://openalex.org/S4210224138","display_name":"Langenbecks Archiv f\u00fcr Chirurgie. Supplement","issn_l":"1432-9336","issn":["1432-9336"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Deutsche Gesellschaft f\u00fcr Chirurgie","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W398613451","https://openalex.org/W2016407928","https://openalex.org/W2039634280","https://openalex.org/W2138090660","https://openalex.org/W2139954541"],"related_works":["https://openalex.org/W2025949040","https://openalex.org/W2141440482","https://openalex.org/W2075306269","https://openalex.org/W110889902","https://openalex.org/W1993916717","https://openalex.org/W3199931616","https://openalex.org/W2101006433","https://openalex.org/W2146693519","https://openalex.org/W4245108582","https://openalex.org/W2065571847"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}