{"id":"https://openalex.org/W87188441","doi":"https://doi.org/10.2165/00137696-200604030-00004","title":"Brain-Targeted Delivery of Estradiol","display_name":"Brain-Targeted Delivery of Estradiol","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W87188441","doi":"https://doi.org/10.2165/00137696-200604030-00004","mag":"87188441"},"language":"en","primary_location":{"id":"doi:10.2165/00137696-200604030-00004","doi":"https://doi.org/10.2165/00137696-200604030-00004","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00137696-200604030-00004","pdf_url":null,"source":{"id":"https://openalex.org/S47580435","display_name":"American Journal of Drug Delivery","issn_l":"1175-9038","issn":["1175-9038","2230-6072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Drug Delivery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000618782","display_name":"Nicholas S. Bodor","orcid":"https://orcid.org/0000-0002-6286-5312","observed_orcids":["https://orcid.org/0000-0002-6286-5312"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I61515104","display_name":"University of Florida Health Science Center","ror":"https://ror.org/0419bgt07","country_code":"US","type":"education","lineage":["https://openalex.org/I61515104"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nicholas Bodor","raw_affiliation_strings":["Center for Drug Discovery, University of Florida, Health Science Center, PO Box 100497, Gainesville, Florida, 32610-0497, USA","Center for Drug Discovery, University of Florida, Health Science Center, Gainesville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Drug Discovery, University of Florida, Health Science Center, PO Box 100497, Gainesville, Florida, 32610-0497, USA","institution_ids":["https://openalex.org/I33213144","https://openalex.org/I61515104"]},{"raw_affiliation_string":"Center for Drug Discovery, University of Florida, Health Science Center, Gainesville, USA","institution_ids":["https://openalex.org/I33213144","https://openalex.org/I61515104"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008179475","display_name":"P\u00e9ter Buchwald","orcid":"https://orcid.org/0000-0003-2732-8180","observed_orcids":["https://orcid.org/0000-0003-2732-8180"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Buchwald","raw_affiliation_strings":["IVAX Research Inc., Miami, Florida, USA","IVAX Research Inc., Miami, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IVAX Research Inc., Miami, Florida, USA","institution_ids":[]},{"raw_affiliation_string":"IVAX Research Inc., Miami, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000618782"],"corresponding_institution_ids":["https://openalex.org/I33213144","https://openalex.org/I61515104"],"apc_list":null,"apc_paid":null,"fwci":0.6533,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.70001877,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"4","issue":"3","first_page":"161","last_page":"175"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.36010000109672546,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.36010000109672546,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.326200008392334,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.17020000517368317,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9940000176429749},{"id":"https://openalex.org/keywords/drug-delivery-to-the-brain","display_name":"brain drug delivery","score":0.925000011920929},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9330000281333923},{"id":"https://openalex.org/keywords/redox-responsive-drug-delivery","display_name":"redox-responsive drug delivery","score":0.6240000128746033},{"id":"https://openalex.org/keywords/chemical-delivery-systems","display_name":"chemical delivery systems","score":0.5659999847412109},{"id":"https://openalex.org/keywords/menopausal-vasomotor-symptoms","display_name":"menopausal vasomotor symptoms","score":0.7850000262260437},{"id":"https://openalex.org/keywords/hot-flashes","display_name":"hot flashes","score":0.9750000238418579},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.6930000185966492},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9890000224113464},{"id":"https://openalex.org/keywords/sexual-dysfunction","display_name":"sexual dysfunction","score":0.968999981880188},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9810000061988831},{"id":"https://openalex.org/keywords/hormone-therapy","display_name":"hormone therapy","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7964043021202087},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6115473508834839},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5821957588195801},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5294510722160339},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5271786451339722},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.5001828670501709},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.473824143409729},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.4512925148010254},{"id":"https://openalex.org/C44796713","wikidata":"https://www.wikidata.org/wiki/Q2659374","display_name":"Neuroactive steroid","level":4,"score":0.43276020884513855},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4061836898326874},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3926008343696594},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.39235982298851013},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29412588477134705},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12841129302978516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12503105401992798},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2165/00137696-200604030-00004","doi":"https://doi.org/10.2165/00137696-200604030-00004","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00137696-200604030-00004","pdf_url":null,"source":{"id":"https://openalex.org/S47580435","display_name":"American Journal of Drug Delivery","issn_l":"1175-9038","issn":["1175-9038","2230-6072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Drug Delivery","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7900000214576721}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":177,"referenced_works":["https://openalex.org/W966257","https://openalex.org/W9210012","https://openalex.org/W41240510","https://openalex.org/W100641258","https://openalex.org/W111781460","https://openalex.org/W135253325","https://openalex.org/W171118067","https://openalex.org/W175903304","https://openalex.org/W198863681","https://openalex.org/W209586682","https://openalex.org/W293341562","https://openalex.org/W321770982","https://openalex.org/W560678598","https://openalex.org/W570438860","https://openalex.org/W589081946","https://openalex.org/W629992290","https://openalex.org/W634159334","https://openalex.org/W1255362595","https://openalex.org/W1480675308","https://openalex.org/W1486452262","https://openalex.org/W1491199435","https://openalex.org/W1505327746","https://openalex.org/W1516221483","https://openalex.org/W1532243186","https://openalex.org/W1564115604","https://openalex.org/W1575257247","https://openalex.org/W1586699954","https://openalex.org/W1593442063","https://openalex.org/W1792575995","https://openalex.org/W1869767898","https://openalex.org/W1932154717","https://openalex.org/W1963092557","https://openalex.org/W1963783263","https://openalex.org/W1965646889","https://openalex.org/W1966043498","https://openalex.org/W1966708506","https://openalex.org/W1966759687","https://openalex.org/W1967210270","https://openalex.org/W1971457115","https://openalex.org/W1971476985","https://openalex.org/W1971602737","https://openalex.org/W1971932631","https://openalex.org/W1973084192","https://openalex.org/W1973326518","https://openalex.org/W1974081580","https://openalex.org/W1974371491","https://openalex.org/W1975947373","https://openalex.org/W1977374270","https://openalex.org/W1980724469","https://openalex.org/W1981637193","https://openalex.org/W1983139451","https://openalex.org/W1984121926","https://openalex.org/W1984360588","https://openalex.org/W1987141364","https://openalex.org/W1989643757","https://openalex.org/W1992411114","https://openalex.org/W1994321590","https://openalex.org/W1999976079","https://openalex.org/W2000172037","https://openalex.org/W2002318735","https://openalex.org/W2002680581","https://openalex.org/W2003431229","https://openalex.org/W2004844617","https://openalex.org/W2005769596","https://openalex.org/W2005994343","https://openalex.org/W2006143195","https://openalex.org/W2007980908","https://openalex.org/W2008079372","https://openalex.org/W2011716448","https://openalex.org/W2013145243","https://openalex.org/W2014081495","https://openalex.org/W2015723079","https://openalex.org/W2015880099","https://openalex.org/W2016381910","https://openalex.org/W2017111453","https://openalex.org/W2017952116","https://openalex.org/W2020291065","https://openalex.org/W2022429315","https://openalex.org/W2023710427","https://openalex.org/W2024451669","https://openalex.org/W2024911447","https://openalex.org/W2025176790","https://openalex.org/W2027487760","https://openalex.org/W2030637641","https://openalex.org/W2032562748","https://openalex.org/W2032679733","https://openalex.org/W2033593865","https://openalex.org/W2037148314","https://openalex.org/W2037536875","https://openalex.org/W2040436786","https://openalex.org/W2041683554","https://openalex.org/W2043355351","https://openalex.org/W2045531300","https://openalex.org/W2045671770","https://openalex.org/W2047349398","https://openalex.org/W2049158573","https://openalex.org/W2051207687","https://openalex.org/W2051228951","https://openalex.org/W2052189366","https://openalex.org/W2053666225","https://openalex.org/W2057765023","https://openalex.org/W2058548783","https://openalex.org/W2058612914","https://openalex.org/W2059222966","https://openalex.org/W2059592013","https://openalex.org/W2063105575","https://openalex.org/W2063496676","https://openalex.org/W2066077729","https://openalex.org/W2067124119","https://openalex.org/W2067372612","https://openalex.org/W2067814588","https://openalex.org/W2068987609","https://openalex.org/W2071757804","https://openalex.org/W2071913508","https://openalex.org/W2073640827","https://openalex.org/W2074263673","https://openalex.org/W2075114033","https://openalex.org/W2077257261","https://openalex.org/W2078890435","https://openalex.org/W2082006898","https://openalex.org/W2082648762","https://openalex.org/W2083251488","https://openalex.org/W2083397462","https://openalex.org/W2083468582","https://openalex.org/W2084667554","https://openalex.org/W2084823166","https://openalex.org/W2087594390","https://openalex.org/W2087932044","https://openalex.org/W2089092547","https://openalex.org/W2089158506","https://openalex.org/W2090724400","https://openalex.org/W2092374375","https://openalex.org/W2093083896","https://openalex.org/W2098533587","https://openalex.org/W2100690704","https://openalex.org/W2102585588","https://openalex.org/W2107243749","https://openalex.org/W2109262924","https://openalex.org/W2110502449","https://openalex.org/W2111714831","https://openalex.org/W2117265627","https://openalex.org/W2119504151","https://openalex.org/W2120130577","https://openalex.org/W2121214791","https://openalex.org/W2123652060","https://openalex.org/W2123958716","https://openalex.org/W2126066542","https://openalex.org/W2128175744","https://openalex.org/W2128432420","https://openalex.org/W2131266318","https://openalex.org/W2131722081","https://openalex.org/W2135070485","https://openalex.org/W2135910109","https://openalex.org/W2136868915","https://openalex.org/W2147454031","https://openalex.org/W2149487349","https://openalex.org/W2150192236","https://openalex.org/W2151668202","https://openalex.org/W2157613085","https://openalex.org/W2159984609","https://openalex.org/W2161695527","https://openalex.org/W2165807863","https://openalex.org/W2167771764","https://openalex.org/W2316212696","https://openalex.org/W2409686106","https://openalex.org/W2410079210","https://openalex.org/W2412994601","https://openalex.org/W2435065832","https://openalex.org/W2626454710","https://openalex.org/W2745757450","https://openalex.org/W2950780616","https://openalex.org/W3012034939","https://openalex.org/W3100475845","https://openalex.org/W3102158213","https://openalex.org/W4211259290","https://openalex.org/W4214829914","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1966708506","https://openalex.org/W2005657170","https://openalex.org/W2398922633","https://openalex.org/W1999688326","https://openalex.org/W321770982","https://openalex.org/W2083468582","https://openalex.org/W1973361094","https://openalex.org/W2117265627","https://openalex.org/W998628704","https://openalex.org/W1975947373"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
