{"id":"https://openalex.org/W8714800","doi":null,"title":"[Iatropathogenic effect of Mevacor on vitamin D metabolism].","display_name":"[Iatropathogenic effect of Mevacor on vitamin D metabolism].","publication_year":1989,"publication_date":"1989-09-29","ids":{"openalex":"https://openalex.org/W8714800","mag":"8714800","pmid":"https://pubmed.ncbi.nlm.nih.gov/2582470"},"language":"cs","primary_location":{"id":"pmid:2582470","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2582470","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Casopis lekaru ceskych","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061860431","display_name":"H Wilczek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Wilczek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045967054","display_name":"J Sobra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Sobra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058961490","display_name":"V Justov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Justov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017005943","display_name":"R \u010ce\u0161ka","orcid":"https://orcid.org/0000-0002-2541-5179","observed_orcids":["https://orcid.org/0000-0002-2541-5179"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Ceska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074853567","display_name":"Z J\u016fzov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z J\u016fzov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090293257","display_name":"R Proch\u00e1zkov\u00e1","orcid":"https://orcid.org/0000-0002-8649-996X","observed_orcids":["https://orcid.org/0000-0002-8649-996X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Proch\u00e1zkov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048073441","display_name":"M Kvasilov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kvasilov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109812590","display_name":"V Pacovsk\u00fd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Pacovsk\u00fd","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.00067509,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"128","issue":"40","first_page":"1254","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lovastatin","display_name":"lovastatin","score":0.9549999833106995},{"id":"https://openalex.org/keywords/vitamin-d-metabolism","display_name":"vitamin D metabolism","score":0.8939999938011169},{"id":"https://openalex.org/keywords/familial-hypercholesterolemia","display_name":"familial hypercholesterolemia","score":0.8970000147819519},{"id":"https://openalex.org/keywords/heterozygotes","display_name":"heterozygotes","score":0.7409999966621399},{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d","display_name":"25-hydroxyvitamin D","score":0.8880000114440918},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d","display_name":"1,25-dihydroxyvitamin D","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hypolipidaemic-drugs","display_name":"hypolipidaemic drugs","score":0.7879999876022339},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.6079999804496765},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7030221223831177},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6996078491210938},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.5927119255065918},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5290682911872864},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5183175802230835},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.45945459604263306},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.4423612356185913},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3775617480278015},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3311573565006256},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.17168575525283813}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006938","descriptor_name":"Hyperlipoproteinemia Type II","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006938","descriptor_name":"Hyperlipoproteinemia Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008148","descriptor_name":"Lovastatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008148","descriptor_name":"Lovastatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2582470","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2582470","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Casopis lekaru ceskych","raw_type":"English Abstract"},{"id":"mag:8714800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2582470","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W32807566","https://openalex.org/W1539382539","https://openalex.org/W1589904698","https://openalex.org/W1982124198","https://openalex.org/W2002389556","https://openalex.org/W2016412760","https://openalex.org/W2027535947","https://openalex.org/W2031535635","https://openalex.org/W2032079752","https://openalex.org/W2043245549","https://openalex.org/W2043348610","https://openalex.org/W2052315307","https://openalex.org/W2056245005","https://openalex.org/W2064620600","https://openalex.org/W2071410402","https://openalex.org/W2083268222","https://openalex.org/W2093582145","https://openalex.org/W2111651546","https://openalex.org/W2145899456","https://openalex.org/W2287055415","https://openalex.org/W2317214795","https://openalex.org/W2318208376","https://openalex.org/W2318886793","https://openalex.org/W2319362418","https://openalex.org/W2320494497","https://openalex.org/W2329699098","https://openalex.org/W2412078313","https://openalex.org/W3129279971","https://openalex.org/W4230560034"],"related_works":["https://openalex.org/W2473327302","https://openalex.org/W179357765","https://openalex.org/W2409334172","https://openalex.org/W2118496778","https://openalex.org/W2055281491","https://openalex.org/W1965496665","https://openalex.org/W7096441203","https://openalex.org/W1989046290","https://openalex.org/W2090824424","https://openalex.org/W1995069196"],"abstract_inverted_index":{"The":[0,93],"authors":[1,94],"examined":[2],"18":[3],"heterozygotes":[4,97],"with":[5,79,98,141],"familial":[6,99],"hypercholesterolaemia":[7,100],"and":[8,17,71,107],"assessed":[9],"vitamin":[10,38,104,133,142],"D":[11,39,63,70,105,134,143],"metabolites,":[12],"parameters":[13,54],"of":[14,24,44,55,61,68,90,113,120],"phosphocalcium":[15,56],"homeostasis":[16],"blood":[18],"lipids.":[19],"They":[20,51,81],"investigated":[21],"the":[22,25,37,84,87,91,109,118,132],"effect":[23,89,112,130],"hypolipidaemic":[26],"drug":[27],"lovastatin":[28],"(Mevacor,":[29],"Merck,":[30],"Sharpe":[31],"Dohme,":[32],"tbl.":[33],"20":[34,45],"mg)":[35],"on":[36,131],"metabolism,":[40],"using":[41],"increasing":[42],"doses":[43],"to":[46],"80":[47],"mg":[48],"per":[49],"day.":[50],"found":[52],"normal":[53,58],"homeostasis,":[57,135],"plasma":[59,73],"concentrations":[60],"1,25-dihydroxyvitamin":[62],"but":[64],"low":[65],"basal":[66],"values":[67],"25-dihydroxyvitamin":[69],"elevated":[72],"levels":[74],"after":[75],"three":[76],"months'":[77],"treatment":[78],"MEVACOR.":[80],"confirmed":[82],"at":[83],"same":[85],"time":[86],"hypocholesterolaemic":[88],"drug.":[92],"conclude":[95],"that":[96,108],"may":[101],"suffer":[102],"from":[103],"deficiency":[106],"positive":[110],"iatropathogenic":[111],"MEVACOR,":[114],"a":[115,128],"substance":[116],"inhibiting":[117],"activity":[119],"3":[121],"hydroxymethylglutarate":[122],"coenzyme":[123],"A":[124],"reductase":[125],"can":[126],"have":[127],"supporting":[129],"in":[136,138],"particular":[137],"old":[139],"people":[140],"deficiency.":[144]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}