{"id":"https://openalex.org/W86939627","doi":null,"title":"Cell-penetrating peptides : Uptake, stability and biological activity","display_name":"Cell-penetrating peptides : Uptake, stability and biological activity","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W86939627","mag":"86939627"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:su-55664","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-55664","pdf_url":null,"source":{"id":"https://openalex.org/S4306400561","display_name":"DiVA (Stockholm University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161593684","host_organization_name":"Stockholm University","host_organization_lineage":["https://openalex.org/I161593684"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-55664","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090414346","display_name":"Tina Holm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tina Holm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5090414346"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-penetrating-peptides","display_name":"cell-penetrating peptides","score":1.0},{"id":"https://openalex.org/keywords/peptide-absorption","display_name":"peptide absorption","score":0.6660000085830688},{"id":"https://openalex.org/keywords/peptide-degradation","display_name":"peptide degradation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/yeast","display_name":"yeast","score":0.4560000002384186},{"id":"https://openalex.org/keywords/protein-mimicry","display_name":"protein mimicry","score":0.824999988079071},{"id":"https://openalex.org/keywords/p14arf","display_name":"p14ARF","score":0.8930000066757202},{"id":"https://openalex.org/keywords/peptide-nucleic-acid","display_name":"peptide nucleic acid","score":0.9160000085830688},{"id":"https://openalex.org/keywords/protein-delivery","display_name":"protein delivery","score":0.9129999876022339},{"id":"https://openalex.org/keywords/d-amino-acids","display_name":"D-amino acids","score":0.906000018119812},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7300000190734863},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7059999704360962},{"id":"https://openalex.org/keywords/drug-delivery-vectors","display_name":"drug delivery vectors","score":0.6610000133514404},{"id":"https://openalex.org/keywords/peptide-stability","display_name":"peptide stability","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37186968326568604}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:su-55664","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-55664","pdf_url":null,"source":{"id":"https://openalex.org/S4306400561","display_name":"DiVA (Stockholm University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161593684","host_organization_name":"Stockholm University","host_organization_lineage":["https://openalex.org/I161593684"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:86939627","doi":null,"is_oa":false,"landing_page_url":"http://su.diva-portal.org/smash/get/diva2:405976/FULLTEXT01","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:su-55664","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-55664","pdf_url":null,"source":{"id":"https://openalex.org/S4306400561","display_name":"DiVA (Stockholm University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161593684","host_organization_name":"Stockholm University","host_organization_lineage":["https://openalex.org/I161593684"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":127,"referenced_works":["https://openalex.org/W127183670","https://openalex.org/W1560780012","https://openalex.org/W1574601702","https://openalex.org/W1584683177","https://openalex.org/W1860047905","https://openalex.org/W1885102277","https://openalex.org/W1963662573","https://openalex.org/W1963819255","https://openalex.org/W1971919281","https://openalex.org/W1972711580","https://openalex.org/W1973767316","https://openalex.org/W1973886069","https://openalex.org/W1983138928","https://openalex.org/W1984470696","https://openalex.org/W1988176449","https://openalex.org/W1989019324","https://openalex.org/W1989168159","https://openalex.org/W1989410545","https://openalex.org/W1990220833","https://openalex.org/W1992230504","https://openalex.org/W1992861793","https://openalex.org/W1995518628","https://openalex.org/W2000238072","https://openalex.org/W2001802384","https://openalex.org/W2001980248","https://openalex.org/W2004706142","https://openalex.org/W2007103864","https://openalex.org/W2007888673","https://openalex.org/W2008813620","https://openalex.org/W2008845432","https://openalex.org/W2009684692","https://openalex.org/W2012107438","https://openalex.org/W2015704490","https://openalex.org/W2016984872","https://openalex.org/W2017201573","https://openalex.org/W2019818589","https://openalex.org/W2020820485","https://openalex.org/W2022726845","https://openalex.org/W2023486531","https://openalex.org/W2028035233","https://openalex.org/W2033832266","https://openalex.org/W2034508297","https://openalex.org/W2036169673","https://openalex.org/W2037219974","https://openalex.org/W2040135588","https://openalex.org/W2040820110","https://openalex.org/W2041568308","https://openalex.org/W2041922085","https://openalex.org/W2042143995","https://openalex.org/W2042804489","https://openalex.org/W2043944480","https://openalex.org/W2044164984","https://openalex.org/W2045279426","https://openalex.org/W2049779453","https://openalex.org/W2051512001","https://openalex.org/W2052419122","https://openalex.org/W2052530916","https://openalex.org/W2053048007","https://openalex.org/W2054717287","https://openalex.org/W2055296721","https://openalex.org/W2056760423","https://openalex.org/W2057870351","https://openalex.org/W2058056641","https://openalex.org/W2058907087","https://openalex.org/W2059088518","https://openalex.org/W2060092504","https://openalex.org/W2064242356","https://openalex.org/W2065310958","https://openalex.org/W2066936722","https://openalex.org/W2067671651","https://openalex.org/W2069202451","https://openalex.org/W2069244797","https://openalex.org/W2069900557","https://openalex.org/W2080971086","https://openalex.org/W2087269855","https://openalex.org/W2088960285","https://openalex.org/W2089421206","https://openalex.org/W2089657872","https://openalex.org/W2090471601","https://openalex.org/W2091677322","https://openalex.org/W2092000721","https://openalex.org/W2092327932","https://openalex.org/W2092726726","https://openalex.org/W2093862878","https://openalex.org/W2096088010","https://openalex.org/W2098559851","https://openalex.org/W2099327548","https://openalex.org/W2101235425","https://openalex.org/W2104603012","https://openalex.org/W2108100159","https://openalex.org/W2111994795","https://openalex.org/W2113311595","https://openalex.org/W2113888821","https://openalex.org/W2120100584","https://openalex.org/W2122240471","https://openalex.org/W2123650819","https://openalex.org/W2124754800","https://openalex.org/W2125450037","https://openalex.org/W2127677388","https://openalex.org/W2129123695","https://openalex.org/W2130779504","https://openalex.org/W2134392026","https://openalex.org/W2134398178","https://openalex.org/W2138059603","https://openalex.org/W2140059341","https://openalex.org/W2140456056","https://openalex.org/W2140600651","https://openalex.org/W2143263113","https://openalex.org/W2144568772","https://openalex.org/W2150685110","https://openalex.org/W2151448282","https://openalex.org/W2152624614","https://openalex.org/W2153689647","https://openalex.org/W2155802295","https://openalex.org/W2158143481","https://openalex.org/W2160038308","https://openalex.org/W2160863389","https://openalex.org/W2162505525","https://openalex.org/W2162764803","https://openalex.org/W2166187330","https://openalex.org/W2167806590","https://openalex.org/W2172036813","https://openalex.org/W2320556745","https://openalex.org/W2325707043","https://openalex.org/W2329716392","https://openalex.org/W2400728565","https://openalex.org/W2402625550"],"related_works":["https://openalex.org/W1973200333","https://openalex.org/W1995518628","https://openalex.org/W2000238072","https://openalex.org/W1526572051","https://openalex.org/W2001802384","https://openalex.org/W1825085207","https://openalex.org/W263462159","https://openalex.org/W2394188521","https://openalex.org/W2357933959","https://openalex.org/W2064242356"],"abstract_inverted_index":{"Cell-penetrating":[0],"peptides":[1,215,293],"(CPPs)":[2],"have":[3],"emerged":[4,96],"as":[5,97,142,221,281,290,299],"a":[6,98,124,143,149,171,250],"group":[7],"of":[8,43,61,68,151,202,233,270,278],"remarkable":[9],"delivery":[10,36,100,201,301],"vectors":[11,282],"for":[12,138],"various":[13],"hydrophilic":[14],"macromolecules,":[15],"otherwise":[16],"excluded":[17],"from":[18,63,127],"cells":[19,264,288],"due":[20],"to":[21,77,135,162,176,183,194,197],"the":[22,41,128,167,210,231,247,262,276],"protective":[23],"plasma":[24],"membrane.":[25],"Unbiased":[26],"conclusions":[27],"regarding":[28],"e.g.":[29],"uptake":[30,80],"mechanism,":[31],"intracellular":[32],"distribution":[33],"and":[34,81,91,120,154,207,239,286,289],"cargo":[35],"efficacy":[37],"is":[38,225,303,308,318],"complicated":[39],"by":[40,47,227],"use":[42],"different":[44,48,64],"methodological":[45],"parameters":[46,86],"laboratories.":[49],"The":[50,272],"first":[51],"paper":[52,75,122,189],"in":[53,74,83,102,121,156,200,219,246,283,319],"this":[54],"thesis":[55],"introduced":[56],"unifying":[57],"protocols":[58],"enabling":[59],"comparison":[60],"results":[62,212,274],"research":[65],"groups.":[66],"One":[67],"these":[69,213],"methods,":[70],"HPLC,":[71],"was":[72,116,133,181,192,259],"used":[73],"II":[76],"investigate":[78],"CPP":[79,155],"degradation":[82,307],"yeasts.":[84],"Both":[85],"varied":[87],"depending":[88],"on":[89],"peptide":[90,126,147,175,204,306],"yeast":[92,103,285],"species;":[93],"however":[94],"pVEC":[95],"promising":[99,211],"vector":[101],"since":[104],"it":[105,191],"internalized":[106],"into":[107],"both":[108,203,284],"species":[109],"tested":[110],"without":[111],"concomitant":[112],"degradation.":[113,229],"Protein":[114],"mimicry":[115],"another":[117],"investigated":[118],"phenomenon":[119],"III":[123],"22-mer":[125],"p14Arf":[129],"protein":[130,291],"(Arf":[131],"(1-22))":[132],"found":[134,182],"be":[136,184,195],"sufficient":[137],"retaining":[139],"its":[140],"function":[141],"tumor":[144],"suppressor.":[145],"This":[146],"comprised":[148],"combination":[150],"apoptogenic":[152],"property":[153],"one":[157],"unity,":[158],"thus":[159],"providing":[160],"opportunity":[161],"conjugate":[163],"cytotoxic":[164],"agents":[165,302],"boosting":[166],"tumoricidal":[168],"activity.":[169,296],"Surprisingly,":[170],"partially":[172],"inverted":[173],"control":[174],"Arf":[177,237],"(1-22),":[178],"called":[179,252],"M918,":[180],"an":[185,309],"extraordinary":[186],"CPP.":[187],"In":[188],"IV,":[190],"shown":[193],"superior":[196],"well-established":[198],"CPPs":[199],"nucleic":[205],"acids":[206,245],"proteins.":[208],"Albeit":[209],"two":[214],"displayed,":[216],"their":[217,235],"utility":[218],"vivo,":[220],"with":[222,243,294],"all":[223],"peptides,":[224],"hampered":[226],"rapid":[228],"With":[230],"aim":[232],"improving":[234],"stability,":[236],"(1-22)":[238],"M918":[240],"were":[241],"synthesized":[242],"D-amino":[244],"reverse":[248],"order,":[249],"modification":[251],"retro-inverso":[253],"(RI)":[254],"isomerization.":[255],"Their":[256,297],"cell-penetrating":[257],"ability":[258],"retained,":[260],"but":[261],"treated":[263],"displayed":[265],"unexpected":[266],"morphological":[267],"alterations":[268],"indicative":[269],"apoptosis.":[271],"presented":[273],"demonstrate":[275],"versatility":[277],"CPPs,":[279],"functioning":[280],"mammalian":[287],"mimicking":[292],"biological":[295],"potential":[298],"drug":[300],"obvious;":[304],"however,":[305],"issue":[310],"that":[311],"requires":[312],"further":[313],"improvements":[314],"before":[315],"clinical":[316],"success":[317],"reach.":[320]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-08-08T01:25:22.217667","created_date":"2016-06-24T00:00:00"}
