{"id":"https://openalex.org/W868623926","doi":"https://doi.org/10.2174/1871527314666150529144329","title":"From Ancient Chinese Medicine to a Novel Approach to Treat Cocaine Addiction","display_name":"From Ancient Chinese Medicine to a Novel Approach to Treat Cocaine Addiction","publication_year":2015,"publication_date":"2015-06-24","ids":{"openalex":"https://openalex.org/W868623926","doi":"https://doi.org/10.2174/1871527314666150529144329","mag":"868623926","pmid":"https://pubmed.ncbi.nlm.nih.gov/26022266"},"language":"en","primary_location":{"id":"doi:10.2174/1871527314666150529144329","doi":"https://doi.org/10.2174/1871527314666150529144329","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1871527314666150529144329","pdf_url":null,"source":{"id":"https://openalex.org/S148418319","display_name":"CNS & Neurological Disorders - Drug Targets","issn_l":"1568-007X","issn":["1568-007X","1871-5273","1996-3181","2212-5299"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS & Neurological Disorders - Drug Targets","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109052756","display_name":"Ivan Diamond","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivan Diamond","raw_affiliation_strings":["Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404, USA. ivan.diamond@ucsf.edu","Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404, USA. ivan.diamond@ucsf.edu","institution_ids":["https://openalex.org/I4210140816"]},{"raw_affiliation_string":"Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404, USA","institution_ids":["https://openalex.org/I4210140816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011607483","display_name":"Lina Yao","orcid":"https://orcid.org/0000-0003-1018-5646","observed_orcids":["https://orcid.org/0000-0003-1018-5646"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lina Yao","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2323,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.43477735,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"14","issue":"6","first_page":"716","last_page":"726"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.04830000177025795,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cocaine-dependence","display_name":"cocaine dependence","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tetrahydropapaveroline","display_name":"tetrahydropapaveroline","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase-inhibition","display_name":"tyrosine hydroxylase inhibition","score":0.9490000009536743},{"id":"https://openalex.org/keywords/nucleus-accumbens-dopamine","display_name":"nucleus accumbens dopamine","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cue-induced-relapse","display_name":"cue-induced relapse","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cocaine-self-administration","display_name":"cocaine self-administration","score":0.8069999814033508},{"id":"https://openalex.org/keywords/alcohol-relapse","display_name":"alcohol relapse","score":0.5600000023841858},{"id":"https://openalex.org/keywords/drug-seeking-behavior","display_name":"drug-seeking behavior","score":0.6990000009536743},{"id":"https://openalex.org/keywords/dopamine-clearance","display_name":"dopamine clearance","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C3175096","wikidata":"https://www.wikidata.org/wiki/Q2640417","display_name":"ALDH2","level":4,"score":0.7856606245040894},{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.6660816073417664},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.6593462228775024},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6370998024940491},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.591070830821991},{"id":"https://openalex.org/C25747580","wikidata":"https://www.wikidata.org/wiki/Q423792","display_name":"Aldehyde dehydrogenase","level":3,"score":0.5326442718505859},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.515501081943512},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.49205678701400757},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.48147860169410706},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40300506353378296},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39599311351776123},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.39116743206977844},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2603931427001953},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12487724423408508},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.118324875831604},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000071396","descriptor_name":"Aldehyde Dehydrogenase, Mitochondrial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008516","descriptor_name":"Medicine, Chinese Traditional","qualifier_ui":"Q000266","qualifier_name":"history","is_major_topic":true},{"descriptor_ui":"D019970","descriptor_name":"Cocaine-Related Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D029908","descriptor_name":"Pueraria","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049690","descriptor_name":"History, Ancient","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065086","descriptor_name":"Acetaldehyde Dehydrogenase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/1871527314666150529144329","doi":"https://doi.org/10.2174/1871527314666150529144329","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1871527314666150529144329","pdf_url":null,"source":{"id":"https://openalex.org/S148418319","display_name":"CNS & Neurological Disorders - Drug Targets","issn_l":"1568-007X","issn":["1568-007X","1871-5273","1996-3181","2212-5299"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS & Neurological Disorders - Drug Targets","raw_type":"journal-article"},{"id":"pmid:26022266","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26022266","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS & neurological disorders drug targets","raw_type":"Historical Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1545782352","https://openalex.org/W1780379214","https://openalex.org/W1963653828","https://openalex.org/W1964753852","https://openalex.org/W1993305928","https://openalex.org/W2007792880","https://openalex.org/W2019709536","https://openalex.org/W2023504580","https://openalex.org/W2048657949","https://openalex.org/W2055319462","https://openalex.org/W2061325288","https://openalex.org/W2061837033","https://openalex.org/W2065530251","https://openalex.org/W2070663300","https://openalex.org/W2071230039","https://openalex.org/W2078777307","https://openalex.org/W2089587500","https://openalex.org/W2094332976","https://openalex.org/W2120246941","https://openalex.org/W2123923673","https://openalex.org/W2127190848","https://openalex.org/W2139207170","https://openalex.org/W2141410612","https://openalex.org/W2148336481","https://openalex.org/W2152644961","https://openalex.org/W2160142439","https://openalex.org/W2313335813","https://openalex.org/W3027015460"],"related_works":["https://openalex.org/W2007792880","https://openalex.org/W2606299085","https://openalex.org/W2079027571","https://openalex.org/W4232891566","https://openalex.org/W2967769346","https://openalex.org/W1999847083","https://openalex.org/W2078777307","https://openalex.org/W2052599384","https://openalex.org/W2334923716","https://openalex.org/W2016658603"],"abstract_inverted_index":{"Pharmacologic":[0],"agents":[1],"for":[2,139,148],"CNS":[3],"disorders":[4],"are":[5],"often":[6],"inhibitors":[7,62],"that":[8,33,47,64],"occupy":[9],"receptors,":[10],"with":[11,111],"frequent":[12],"unavoidable":[13],"side":[14],"effects":[15],"likely":[16],"due":[17],"to":[18,49,109,113,126,135],"continuous":[19],"binding.":[20],"This":[21],"review":[22],"summarizes":[23],"development":[24],"of":[25,52,79,87,93,95,132],"a":[26,44,144],"novel":[27,60],"aldehyde":[28,101],"dehydrogenase":[29],"2":[30],"(ALDH2)":[31],"inhibitor":[32],"specifically":[34],"targets":[35],"unique":[36],"drug":[37,142],"related":[38],"episodic":[39],"surges":[40,70],"in":[41,71],"dopamine":[42,100],"(DA),":[43],"pathophysiologic":[45],"mechanism":[46,92],"appears":[48,134],"underlie":[50],"much":[51],"drug-seeking":[53],"behavior.":[54,90],"We":[55],"have":[56,136],"synthesized":[57],"highly":[58],"selective":[59],"ALDH2":[61,133],"(ALDH2i)":[63],"block":[65],"alcohol-":[66],"and":[67,76,85],"cocaine":[68,83,88],"cue-induced":[69,141],"nucleus":[72],"accumbens":[73],"(NAc)":[74],"DA":[75,112,128],"prevent":[77],"reinstatement":[78,86],"alcohol":[80],"heavy":[81],"drinking,":[82],"self-administration":[84],"relapse-like":[89],"The":[91],"action":[94],"ALDH2i":[96],"depends":[97],"on":[98],"inhibiting":[99],"(DOPAL)":[102],"clearance":[103],"by":[104],"ALDH2,":[105],"enabling":[106],"unmetabolized":[107],"DOPAL":[108],"condense":[110],"generate":[114],"tetrahydropapaveroline":[115],"(THP).":[116],"THP":[117],"selectively":[118],"inhibits":[119],"the":[120],"activated":[121],"(phosphorylated)":[122],"tyrosine":[123],"hydroxylase":[124],"(TH)":[125],"suppress":[127],"synthesis.":[129],"Selective":[130],"inhibition":[131],"therapeutic":[137],"potential":[138],"treating":[140,149],"relapse,":[143],"major":[145],"unmet":[146],"need":[147],"addicted":[150],"subjects.":[151]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}