{"id":"https://openalex.org/W86844394","doi":null,"title":"HIV, aging, and cognition: emerging issues.","display_name":"HIV, aging, and cognition: emerging issues.","publication_year":2013,"publication_date":"2013-07-01","ids":{"openalex":"https://openalex.org/W86844394","mag":"86844394","pmid":"https://pubmed.ncbi.nlm.nih.gov/23981600","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6148873"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:5099832","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6148873","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6148873","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057274213","display_name":"Victor Valcour","orcid":"https://orcid.org/0000-0003-1981-4832","observed_orcids":["https://orcid.org/0000-0003-1981-4832"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Victor G Valcour","raw_affiliation_strings":["Department of Neurology, Division of Geriatric Medicine, University of California San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Division of Geriatric Medicine, University of California San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5057274213"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":null,"apc_paid":null,"fwci":2.1771,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.87837838,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":"3","first_page":"119","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-associated-neurocognitive-disorders","display_name":"HIV-associated neurocognitive disorders","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.44999998807907104},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.777999997138977},{"id":"https://openalex.org/keywords/mild-neurocognitive-disorder","display_name":"mild neurocognitive disorder","score":0.9070000052452087},{"id":"https://openalex.org/keywords/asymptomatic-neurocognitive-impairment","display_name":"asymptomatic neurocognitive impairment","score":0.9959999918937683},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.8190000057220459},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.8650000095367432},{"id":"https://openalex.org/keywords/age-related-comorbidities","display_name":"age-related comorbidities","score":0.9079999923706055},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.6869999766349792},{"id":"https://openalex.org/keywords/antiretroviral-therapy-adherence","display_name":"antiretroviral therapy adherence","score":0.9020000100135803},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8525418043136597},{"id":"https://openalex.org/C172467417","wikidata":"https://www.wikidata.org/wiki/Q1670397","display_name":"Neurocognitive","level":3,"score":0.8513720631599426},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6508646011352539},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.5710752606391907},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.44824346899986267},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.41974157094955444},{"id":"https://openalex.org/C2779898580","wikidata":"https://www.wikidata.org/wiki/Q6934593","display_name":"Multicenter AIDS Cohort Study","level":5,"score":0.41834694147109985},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.38314396142959595},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.35971927642822266},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.3481009006500244},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3211578130722046},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3077808618545532},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.30213281512260437},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.22736847400665283},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21558350324630737}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015526","descriptor_name":"AIDS Dementia Complex","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true}],"locations_count":7,"locations":[{"id":"pmh:oai:europepmc.org:5099832","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6148873","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6148873","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6148873","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Top Antivir Med","raw_type":"Text"},{"id":"pmid:23981600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23981600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Topics in antiviral medicine","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt45m0g843","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/45m0g843","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Topics in antiviral medicine, vol 21, iss 3","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt97x4d5wj","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/97x4d5wj","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Topics in antiviral medicine, vol 21, iss 3","raw_type":"article"},{"id":"pmh:qt97x4d5wj","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/97x4d5wj","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Valcour, VG. (2013). HIV, aging, and cognition: Emerging issues. Topics in Antiviral Medicine, 21(3), 119 - 123. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/97x4d5wj","raw_type":"article"},{"id":"mag:86844394","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/articles/PMC6148873","pdf_url":null,"source":{"id":"https://openalex.org/S2765072364","display_name":"Topics in antiviral medicine","issn_l":"2161-5853","issn":["2161-5853","2161-5861"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","poland-100","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Topics in antiviral medicine","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5099832","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6148873","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1550885843","https://openalex.org/W1974336332","https://openalex.org/W1976252539","https://openalex.org/W1979053558","https://openalex.org/W1981552723","https://openalex.org/W1995832661","https://openalex.org/W1997835133","https://openalex.org/W2019602756","https://openalex.org/W2023876571","https://openalex.org/W2032973872","https://openalex.org/W2033154907","https://openalex.org/W2045044146","https://openalex.org/W2047022422","https://openalex.org/W2087423729","https://openalex.org/W2093635022","https://openalex.org/W2099556941","https://openalex.org/W2109624357","https://openalex.org/W2115118763","https://openalex.org/W2129030266","https://openalex.org/W2137321682","https://openalex.org/W2162166621"],"related_works":["https://openalex.org/W2093009817","https://openalex.org/W2036171227","https://openalex.org/W2610734785","https://openalex.org/W2921328235","https://openalex.org/W4298087257","https://openalex.org/W7221256999","https://openalex.org/W2555666040","https://openalex.org/W3042917851","https://openalex.org/W2327172784","https://openalex.org/W7098540100"],"abstract_inverted_index":{"The":[0,42],"prevalence":[1],"of":[2,44,58,79,88,113,116,137],"HIV-associated":[3,40],"neurocognitive":[4,26,32],"disorder":[5,27],"has":[6],"not":[7,167],"changed":[8],"from":[9,154],"the":[10,13,77,114,121,191],"pre-":[11],"to":[12,101,147],"potent":[14],"antiretroviral":[15,97,117,148,158],"therapy":[16,98,149,159],"era,":[17],"remaining":[18],"at":[19,190],"approximately":[20],"50%.":[21],"In":[22,85],"research":[23],"settings,":[24],"mild":[25,163],"(MND)":[28],"and":[29,56,69,109,131,145,150,156],"so-called":[30],"asymptomatic":[31],"impairment":[33,81,103,138,165],"(ANI)":[34],"are":[35,62,143],"now":[36],"more":[37],"common":[38],"than":[39],"dementia.":[41],"diagnosis":[43],"ANI":[45,68],"is":[46,166],"misleading":[47],"because":[48],"functional":[49],"deficits,":[50],"when":[51],"tested":[52],"in":[53,65,82,119,197,200],"a":[54,86,110,177,183],"laboratory,":[55],"degree":[57],"neuropsychologic":[59],"testing":[60],"abnormalities":[61],"often":[63],"comparable":[64],"patients":[66,89,142,161],"with":[67,71,95,126,162],"those":[70],"symptomatic":[72],"MND.":[73],"Age-related":[74],"comorbidities":[75],"increase":[76],"risk":[78],"cognitive":[80,102,164],"HIV":[83],"infection.":[84],"cohort":[87],"aged":[90],"60":[91],"years":[92],"or":[93],"older":[94],"excellent":[96],"adherence,":[99],"correlates":[100],"were":[104],"apolipoprotein":[105],"(Apo)":[106],"E4":[107],"genotype":[108],"novel":[111],"measure":[112],"effectiveness":[115],"drugs":[118],"monocytes,":[120],"monocyte":[122],"efficacy":[123],"(ME)":[124],"score,":[125],"trend":[127],"associations":[128],"for":[129,160],"diabetes":[130],"nadir":[132],"CD4+":[133],"cell":[134],"count.":[135],"Management":[136],"includes":[139],"ensuring":[140],"that":[141],"on":[144,176],"adhere":[146],"addressing":[151],"comorbidities.":[152],"Switching":[153],"effective":[155],"well-tolerated":[157],"routinely":[168],"recommended,":[169],"but":[170],"this":[171],"must":[172],"still":[173],"be":[174],"addressed":[175],"case-by-case":[178],"basis.":[179],"This":[180],"article":[181],"summarizes":[182],"presentation":[184],"by":[185],"Victor":[186],"G.":[187],"Valcour,":[188],"MD,":[189],"IAS-USA":[192],"continuing":[193],"education":[194],"program":[195],"held":[196],"Atlanta,":[198],"Georgia,":[199],"April":[201],"2013.":[202]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}