{"id":"https://openalex.org/W86839090","doi":null,"title":"Iodine and Cognition in Young Adults: A Randomised, Placebo-Controlled Trial","display_name":"Iodine and Cognition in Young Adults: A Randomised, Placebo-Controlled Trial","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W86839090","mag":"86839090"},"language":"en","primary_location":{"id":"pmh:oai:ourarchive.otago.ac.nz:10523/2341","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10523/2341","pdf_url":null,"source":{"id":"https://openalex.org/S4306402094","display_name":"Otago University Research Archive (University of Otago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80281795","host_organization_name":"University of Otago","host_organization_lineage":["https://openalex.org/I80281795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025790108","display_name":"Kahla Redman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kahla Redman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5025790108"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iodine-supplementation","display_name":"iodine supplementation","score":0.6819999814033508},{"id":"https://openalex.org/keywords/iodine-deficiency","display_name":"iodine deficiency","score":0.906000018119812},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.7350000143051147},{"id":"https://openalex.org/keywords/young-adults","display_name":"young adults","score":0.9610000252723694},{"id":"https://openalex.org/keywords/mild-iodine-deficiency","display_name":"mild iodine deficiency","score":0.7770000100135803},{"id":"https://openalex.org/keywords/myelination","display_name":"myelination","score":0.7960000038146973},{"id":"https://openalex.org/keywords/white-matter-maturation","display_name":"white matter maturation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.718999981880188},{"id":"https://openalex.org/keywords/intellectual-disability","display_name":"intellectual disability","score":0.5820000171661377},{"id":"https://openalex.org/keywords/cretinism","display_name":"cretinism","score":0.781000018119812},{"id":"https://openalex.org/keywords/iodine-status","display_name":"iodine status","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5517515540122986},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5427078008651733},{"id":"https://openalex.org/C539932907","wikidata":"https://www.wikidata.org/wiki/Q1103","display_name":"Iodine","level":2,"score":0.5229264497756958},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41058894991874695},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.38745468854904175},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.32032281160354614},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.20598414540290833},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.18122598528862},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.12123891711235046},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07958346605300903},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ourarchive.otago.ac.nz:10523/2341","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10523/2341","pdf_url":null,"source":{"id":"https://openalex.org/S4306402094","display_name":"Otago University Research Archive (University of Otago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80281795","host_organization_name":"University of Otago","host_organization_lineage":["https://openalex.org/I80281795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},{"id":"mag:86839090","doi":null,"is_oa":false,"landing_page_url":"https://ourarchive.otago.ac.nz/handle/10523/2341","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":99,"referenced_works":["https://openalex.org/W157785466","https://openalex.org/W204160447","https://openalex.org/W1484864026","https://openalex.org/W1569967369","https://openalex.org/W1595726542","https://openalex.org/W1598379667","https://openalex.org/W1764972970","https://openalex.org/W1794414524","https://openalex.org/W1835580293","https://openalex.org/W1858379610","https://openalex.org/W1876061808","https://openalex.org/W1897711211","https://openalex.org/W1900556344","https://openalex.org/W1901020111","https://openalex.org/W1963307369","https://openalex.org/W1963987006","https://openalex.org/W1970214149","https://openalex.org/W1977370225","https://openalex.org/W1978102086","https://openalex.org/W1983014081","https://openalex.org/W1986620468","https://openalex.org/W1991332383","https://openalex.org/W1991880111","https://openalex.org/W1994916609","https://openalex.org/W1998490449","https://openalex.org/W1999299319","https://openalex.org/W2002132239","https://openalex.org/W2002358001","https://openalex.org/W2003952669","https://openalex.org/W2005643116","https://openalex.org/W2013269949","https://openalex.org/W2015097208","https://openalex.org/W2019565508","https://openalex.org/W2021636122","https://openalex.org/W2021842362","https://openalex.org/W2023028582","https://openalex.org/W2024053893","https://openalex.org/W2028661968","https://openalex.org/W2032655354","https://openalex.org/W2032832443","https://openalex.org/W2032884772","https://openalex.org/W2039594007","https://openalex.org/W2041889235","https://openalex.org/W2043012281","https://openalex.org/W2043495725","https://openalex.org/W2045184927","https://openalex.org/W2045380026","https://openalex.org/W2052693888","https://openalex.org/W2054612454","https://openalex.org/W2054853144","https://openalex.org/W2055769507","https://openalex.org/W2058396154","https://openalex.org/W2063633162","https://openalex.org/W2074626322","https://openalex.org/W2075058580","https://openalex.org/W2082117755","https://openalex.org/W2082798839","https://openalex.org/W2084007108","https://openalex.org/W2092452346","https://openalex.org/W2095235225","https://openalex.org/W2105848614","https://openalex.org/W2106041086","https://openalex.org/W2106227634","https://openalex.org/W2107294026","https://openalex.org/W2110742166","https://openalex.org/W2111652158","https://openalex.org/W2112407311","https://openalex.org/W2115585096","https://openalex.org/W2119238604","https://openalex.org/W2120095635","https://openalex.org/W2120880744","https://openalex.org/W2123556420","https://openalex.org/W2124793537","https://openalex.org/W2125422131","https://openalex.org/W2125650861","https://openalex.org/W2129072480","https://openalex.org/W2130631987","https://openalex.org/W2132801576","https://openalex.org/W2136765851","https://openalex.org/W2136833412","https://openalex.org/W2137606863","https://openalex.org/W2138343146","https://openalex.org/W2146916553","https://openalex.org/W2149780985","https://openalex.org/W2150710228","https://openalex.org/W2152292563","https://openalex.org/W2153927401","https://openalex.org/W2159107533","https://openalex.org/W2160166542","https://openalex.org/W2160536166","https://openalex.org/W2163934468","https://openalex.org/W2167300118","https://openalex.org/W2168999334","https://openalex.org/W2169494468","https://openalex.org/W2169695661","https://openalex.org/W2264614968","https://openalex.org/W2323489987","https://openalex.org/W2336907646","https://openalex.org/W2403894051"],"related_works":["https://openalex.org/W168378333","https://openalex.org/W3176931814","https://openalex.org/W2129072480","https://openalex.org/W2161974364","https://openalex.org/W2164331551","https://openalex.org/W2136833412","https://openalex.org/W6986628652","https://openalex.org/W4306362200","https://openalex.org/W2152763238","https://openalex.org/W2122264322"],"abstract_inverted_index":{"Iodine":[0,54,98],"is":[1,5,29,56,76,79,358],"a":[2,216,260],"micronutrient":[3],"which":[4,78,136,151,264],"essential":[6],"to":[7,108,206,257,364,403],"the":[8,19,25,30,47,59,118,124,127,165,172,199,226,269,277,287,321,325,354,384,395],"production":[9],"of":[10,24,49,65,89,117,150,175,198,324,356,375,397],"thyroid":[11,52],"hormones.":[12],"Thyroid":[13],"hormone":[14],"functions":[15,28],"are":[16,44,155,372],"prevalent":[17,62],"throughout":[18],"human":[20],"body,":[21],"but":[22],"one":[23],"most":[26,61,69],"important":[27],"influence":[31],"on":[32,126,171,413],"brain":[33],"development.":[34],"Central":[35],"nervous":[36],"system":[37],"components":[38],"such":[39],"as":[40,58,295,392,394],"myelin":[41,390],"and":[42,51,143,154,209,248,258,308,353,366,388],"neurotransmission":[43,153],"affected":[45],"by":[46,81,135],"levels":[48],"iodine":[50,74,90,103,137,168,187,213,267,290,317,322,346,399,406],"hormone.":[53],"deficiency":[55,75,91,104,400],"recognised":[57],"world\u2019s":[60],"preventable":[63],"cause":[64],"intellectual":[66],"disability.":[67],"The":[68,115,161,271,282],"severe":[70,82],"condition":[71],"resulting":[72],"from":[73,225],"cretinism,":[77],"characterised":[80],"cognitive":[83,96,113,173,194,335,415],"impairment.":[84,97],"However,":[85],"even":[86],"milder":[87],"forms":[88],"may":[92,342],"result":[93,109],"in":[94,100,110,112,157,193,218,334,361,373,401,408],"some":[95],"supplementation":[99,169],"individuals":[101,184],"with":[102,123,301,331],"has":[105,120,170],"been":[106,344],"shown":[107],"improvements":[111],"scores.":[114,336],"majority":[116],"work":[119],"investigated":[121,164],"children,":[122],"effect":[125,166,412],"young":[128,178],"adult":[129,389],"population":[130],"largely":[131],"unknown.":[132],"Potential":[133],"mechanisms":[134],"affects":[138],"cognition":[139,293,348],"include":[140],"enhancing":[141,351],"neurotransmitters":[142],"assisting":[144],"myelination":[145,357],"(white":[146],"matter":[147],"maturation),":[148],"both":[149,255,303],"facilitate":[152,292],"malleable":[156],"this":[158,219,341],"age":[159],"group.":[160,201],"present":[162],"study":[163],"that":[167,183,197,274,289,340],"scores":[174,195,252],"mildly":[176,280],"iodine-deficient":[177],"adults.":[179],"It":[180],"was":[181],"hypothesised":[182],"who":[185],"took":[186,266],"supplements":[188,214],"would":[189,291],"show":[190],"an":[191,332,411],"improvement":[192],"above":[196],"placebo":[200],"Participants":[202],"were":[203,210,233,253,279,297,328],"aged":[204],"18":[205],"30":[207],"years,":[208],"given":[211],"either":[212],"or":[215,268],"placebo,":[217],"double-blind,":[220],"randomised-controlled":[221],"trial.":[222],"Seven":[223],"subtests":[224],"Wechsler":[227],"Adult":[228],"Intelligence":[229],"Scale-Fourth":[230],"Edition":[231],"(WAIS-IV)":[232],"used":[234],"including:":[235],"Block":[236],"Design,":[237],"Digit":[238],"Span":[239],"Backwards,":[240],"Matrix":[241],"Reasoning,":[242],"Symbol":[243],"Search,":[244],"Visual":[245],"Puzzles,":[246],"Coding,":[247],"Letter-Number":[249],"Sequencing.":[250],"Cognitive":[251],"measured":[254],"prior":[256],"after":[259],"32-week":[261],"period":[262],"during":[263],"participants":[265,278,311],"placebo.":[270],"results":[272,283],"showed":[273],"at":[275],"baseline,":[276],"iodine-deficient.":[281],"did":[284],"not":[285,329],"support":[286],"hypothesis":[288],"however,":[294],"there":[296],"consistent":[298],"non-significant":[299],"associations":[300],"iodine,":[302],"when":[304],"comparing":[305],"treatment":[306],"groups":[307],"across":[309],"all":[310],"within":[312],"examined":[313],"time":[314],"points.":[315],"Thus,":[316],"supplements,":[318],"while":[319],"improving":[320],"status":[323],"supplement":[326],"group,":[327],"associated":[330],"increase":[333],"Furthermore,":[337],"I":[338],"speculated":[339],"have":[343,410],"because":[345],"facilitates":[347],"primarily":[349],"through":[350],"myelination,":[352],"process":[355],"more":[359],"complete":[360],"adulthood":[362],"compared":[363],"childhood,":[365],"therefore":[367],"less":[368],"malleable.":[369],"These":[370],"speculations":[371],"need":[374],"future":[376],"research":[377,380],"however.":[378],"Future":[379],"could":[381],"further":[382],"investigate":[383],"differences":[385],"between":[386],"child":[387],"development,":[391],"well":[393],"impact":[396],"mild":[398],"adults,":[402],"determine":[404],"whether":[405],"does,":[407],"fact,":[409],"adults\u2019":[414],"ability.":[416]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}