{"id":"https://openalex.org/W86769830","doi":null,"title":"[Hyperhomocysteinemia. A new coronary risk factor].","display_name":"[Hyperhomocysteinemia. A new coronary risk factor].","publication_year":2001,"publication_date":"2001-07-01","ids":{"openalex":"https://openalex.org/W86769830","mag":"86769830","pmid":"https://pubmed.ncbi.nlm.nih.gov/11519357"},"language":"es","primary_location":{"id":"pmid:11519357","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11519357","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gaceta medica de Mexico","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055250369","display_name":"Rogelio Zacar\u00edas-Castillo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114109","display_name":"Hospital General Dr. Manuel Gea Gonzalez","ror":"https://ror.org/025q7sd17","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210114109"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"R Zacar\u00edas-Castillo","raw_affiliation_strings":["Departamento de Medicina Interna, Hospital General Dr. Manuel Gea Gonz\u00e1lez, Calzada de Tlalpan 4800, CP 14000, M\u00e9xico, DF. rzac99@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Medicina Interna, Hospital General Dr. Manuel Gea Gonz\u00e1lez, Calzada de Tlalpan 4800, CP 14000, M\u00e9xico, DF. rzac99@hotmail.com","institution_ids":["https://openalex.org/I4210114109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077529962","display_name":"Alain Eduardo Hern\u00e1ndez-Rebollar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A E Hern\u00e1ndez-Rebollar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084654833","display_name":"A Zajarias-Rabchinskey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Zajarias-Rabchinskey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040619933","display_name":"David Gonz\u00e1lez-B\u00e1rcena","orcid":"https://orcid.org/0000-0002-9563-860X","observed_orcids":["https://orcid.org/0000-0002-9563-860X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Gonz\u00e1lez-B\u00e1rcena","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2673,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.59297734,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"137","issue":"4","first_page":"335","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13551","display_name":"Biochemical effects in animals","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperhomocysteinemia","display_name":"hyperhomocysteinemia","score":1.0},{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.9430000185966492},{"id":"https://openalex.org/keywords/coronary-risk-factors","display_name":"coronary risk factors","score":0.753000020980835},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/endothelial-injury","display_name":"endothelial injury","score":0.8489999771118164},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.996999979019165},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.7409999966621399},{"id":"https://openalex.org/keywords/folic-acid-supplementation","display_name":"folic acid supplementation","score":0.925000011920929},{"id":"https://openalex.org/keywords/vitamin-b6","display_name":"vitamin B6","score":0.9430000185966492},{"id":"https://openalex.org/keywords/vitamin-b12","display_name":"vitamin B12","score":0.925000011920929},{"id":"https://openalex.org/keywords/cardiovascular-risk-prevention","display_name":"cardiovascular risk prevention","score":0.32199999690055847}],"concepts":[{"id":"https://openalex.org/C2776523773","wikidata":"https://www.wikidata.org/wiki/Q1093815","display_name":"Hyperhomocysteinemia","level":3,"score":0.9010155200958252},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7591936588287354},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.7280107736587524},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5802105665206909},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5649272203445435},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.5597934722900391},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.536644458770752},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.532495379447937},{"id":"https://openalex.org/C2779750884","wikidata":"https://www.wikidata.org/wiki/Q187706","display_name":"Vitamin B12","level":2,"score":0.5228046178817749},{"id":"https://openalex.org/C3019085024","wikidata":"https://www.wikidata.org/wiki/Q7212330","display_name":"Cigarette smoking","level":2,"score":0.5070991516113281},{"id":"https://openalex.org/C193230392","wikidata":"https://www.wikidata.org/wiki/Q1663054","display_name":"Ingestion","level":2,"score":0.48062533140182495},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.4569140374660492},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.45376861095428467},{"id":"https://openalex.org/C2992130864","wikidata":"https://www.wikidata.org/wiki/Q127060","display_name":"Folic acid","level":2,"score":0.4394938349723816},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.39037802815437317},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34940439462661743}],"mesh":[{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006710","descriptor_name":"Homocysteine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D020138","descriptor_name":"Hyperhomocysteinemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020138","descriptor_name":"Hyperhomocysteinemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D020138","descriptor_name":"Hyperhomocysteinemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11519357","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11519357","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gaceta medica de Mexico","raw_type":"English Abstract"},{"id":"mag:86769830","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11519357","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W90081202","https://openalex.org/W1525699662","https://openalex.org/W1853715951","https://openalex.org/W1883798927","https://openalex.org/W1971594119","https://openalex.org/W1975357252","https://openalex.org/W1977349752","https://openalex.org/W1979647910","https://openalex.org/W1985846516","https://openalex.org/W1985850018","https://openalex.org/W1990603205","https://openalex.org/W1990926399","https://openalex.org/W1997067835","https://openalex.org/W1997995656","https://openalex.org/W2010202776","https://openalex.org/W2014205090","https://openalex.org/W2014759828","https://openalex.org/W2022553195","https://openalex.org/W2022764590","https://openalex.org/W2026008649","https://openalex.org/W2027665192","https://openalex.org/W2048978309","https://openalex.org/W2064871885","https://openalex.org/W2064912482","https://openalex.org/W2065039512","https://openalex.org/W2068655336","https://openalex.org/W2070933212","https://openalex.org/W2073751205","https://openalex.org/W2074129239","https://openalex.org/W2079604516","https://openalex.org/W2087461651","https://openalex.org/W2088162597","https://openalex.org/W2088243607","https://openalex.org/W2088562611","https://openalex.org/W2089720163","https://openalex.org/W2108484297","https://openalex.org/W2109986734","https://openalex.org/W2115237405","https://openalex.org/W2125497070","https://openalex.org/W2131581679","https://openalex.org/W2137570167","https://openalex.org/W2141324606","https://openalex.org/W2146905815","https://openalex.org/W2156158060","https://openalex.org/W2158420594","https://openalex.org/W2164721380","https://openalex.org/W2166235806","https://openalex.org/W2168514834","https://openalex.org/W2317172136","https://openalex.org/W2323783182","https://openalex.org/W2332619349","https://openalex.org/W2335455113","https://openalex.org/W2337184574","https://openalex.org/W2342150662","https://openalex.org/W2471038349","https://openalex.org/W3145726055"],"related_works":["https://openalex.org/W2008642312","https://openalex.org/W2405989673","https://openalex.org/W2405711129","https://openalex.org/W1984183706","https://openalex.org/W2090730785","https://openalex.org/W2403694630","https://openalex.org/W2074129239","https://openalex.org/W1999417712","https://openalex.org/W2312339914","https://openalex.org/W2108484297"],"abstract_inverted_index":{"Cardiovascular":[0],"disease":[1],"is":[2,73],"the":[3,47,57,95,103,128],"leading":[4],"cause":[5],"of":[6,70,78,84,97,105,118,132],"mortality":[7],"in":[8,13,56,75,94,127],"Mexico,":[9],"as":[10,12,23],"well":[11],"other":[14,98],"Western":[15],"countries.":[16],"Conventional":[17],"risk":[18,100],"factors":[19],"for":[20],"atherosclerosis,":[21],"such":[22],"cigarette":[24],"smoking,":[25],"systemic":[26],"hypertension,":[27],"diabetes":[28],"mellitus,":[29],"and":[30,53,109,112,121,130],"hypercholesterolemia,":[31],"do":[32],"not":[33],"explain":[34],"this":[35,85],"association":[36],"completely.":[37],"Recently,":[38],"it":[39],"has":[40],"been":[41],"recognized":[42],"that":[43],"hyperhomocysteinemia":[44],"contributes":[45],"to":[46],"atherosclerotic":[48,133],"process,":[49],"promoting":[50],"endothelial":[51],"damage":[52],"oxidative":[54],"stress":[55],"vascular":[58,134],"wall.":[59],"Homocysteine,":[60],"an":[61,124],"amino":[62,86],"acid":[63,87,108],"generated":[64],"under":[65],"physiologic":[66],"conditions":[67],"after":[68],"ingestion":[69],"protein-rich":[71],"foods,":[72],"used":[74],"a":[76],"variety":[77],"metabolic":[79],"pathways.":[80],"Elevated":[81],"plasma":[82,116],"levels":[83,117],"(higher":[88],"than":[89],"15":[90],"mmol/L":[91],"or":[92],"lower":[93],"presence":[96],"cardiovascular":[99],"factors)":[101],"promote":[102],"development":[104],"atherosclerosis.":[106],"Folic":[107],"vitamin":[110],"B6":[111],"B12":[113],"supplements":[114],"decrease":[115],"homocysteine":[119],"effectively":[120],"may":[122],"play":[123],"important":[125],"role":[126],"prevention":[129],"treatment":[131],"disease.":[135]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
