{"id":"https://openalex.org/W86682289","doi":null,"title":"A review of picotamide in the reduction of cardiovascular events in diabetic patients.","display_name":"A review of picotamide in the reduction of cardiovascular events in diabetic patients.","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W86682289","mag":"86682289","pmid":"https://pubmed.ncbi.nlm.nih.gov/17583179","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1994050"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1994050","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1994050","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vasc Health Risk Manag","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1994050","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069814815","display_name":"Andrea Celestini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Celestini","raw_affiliation_strings":["IV Divisione di Clinica Medica, Department of Experimental Medicine and Pathology, University of Rome \u201cLa Sapienza\u201d, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IV Divisione di Clinica Medica, Department of Experimental Medicine and Pathology, University of Rome \u201cLa Sapienza\u201d, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076547685","display_name":"Francesco Violi","orcid":"https://orcid.org/0000-0002-6610-7068","observed_orcids":["https://orcid.org/0000-0002-6610-7068"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesco Violi","raw_affiliation_strings":["Internal Medicine and Medical Specialties"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine and Medical Specialties","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6695,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.74193782,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"3","issue":"1","first_page":"93","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10926","display_name":"Peripheral Artery Disease Management","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/picotamide","display_name":"picotamide","score":1.0},{"id":"https://openalex.org/keywords/antiplatelet-therapy","display_name":"antiplatelet therapy","score":0.8529999852180481},{"id":"https://openalex.org/keywords/thromboxane-synthase-inhibition","display_name":"thromboxane synthase inhibition","score":0.9739999771118164},{"id":"https://openalex.org/keywords/peripheral-arterial-disease","display_name":"peripheral arterial disease","score":0.7300000190734863},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.902999997138977},{"id":"https://openalex.org/keywords/atherothrombosis","display_name":"atherothrombosis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cardiovascular-events","display_name":"cardiovascular events","score":0.8759999871253967},{"id":"https://openalex.org/keywords/aspirin-comparison","display_name":"aspirin comparison","score":0.6100000143051147},{"id":"https://openalex.org/keywords/microalbuminuria","display_name":"microalbuminuria","score":0.8069999814033508},{"id":"https://openalex.org/keywords/carotid-plaque","display_name":"carotid plaque","score":0.8709999918937683},{"id":"https://openalex.org/keywords/mortality-reduction","display_name":"mortality reduction","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9130144119262695},{"id":"https://openalex.org/C2781024287","wikidata":"https://www.wikidata.org/wiki/Q774909","display_name":"Thromboxane A2","level":3,"score":0.6680587530136108},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6642134785652161},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.6518629789352417},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5815711617469788},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5604812502861023},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4417238235473633},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.33977800607681274},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.29164713621139526},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.1934158205986023},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05704817175865173},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010795","descriptor_name":"Phthalic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1994050","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1994050","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vasc Health Risk Manag","raw_type":"Text"},{"id":"pmid:17583179","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17583179","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vascular health and risk management","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.280.3026","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.280.3026","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/98/ac/Vasc_Health_Risk_Manag_2007_Feb_3(1)_93-98.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:6ea0fced0f2c4803a439236ce08b7262","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6ea0fced0f2c4803a439236ce08b7262","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vascular Health and Risk Management, Vol Volume 3, Pp 93-98 (2007)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1994050","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1994050","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vasc Health Risk Manag","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1480729244","https://openalex.org/W1803320375","https://openalex.org/W1914256601","https://openalex.org/W1989795073","https://openalex.org/W1990667484","https://openalex.org/W1993059222","https://openalex.org/W2000782164","https://openalex.org/W2024352468","https://openalex.org/W2031261592","https://openalex.org/W2033549823","https://openalex.org/W2038519917","https://openalex.org/W2046790845","https://openalex.org/W2053411744","https://openalex.org/W2054499451","https://openalex.org/W2054538991","https://openalex.org/W2068973732","https://openalex.org/W2069475893","https://openalex.org/W2078071419","https://openalex.org/W2085798133","https://openalex.org/W2087724955","https://openalex.org/W2094910754","https://openalex.org/W2095554158","https://openalex.org/W2122137974","https://openalex.org/W2128300830","https://openalex.org/W2128491499","https://openalex.org/W2132244121","https://openalex.org/W2150144608","https://openalex.org/W2404343508","https://openalex.org/W2411033149","https://openalex.org/W2426190701","https://openalex.org/W2475256982","https://openalex.org/W4299531217"],"related_works":["https://openalex.org/W2051938674","https://openalex.org/W2000782164","https://openalex.org/W2046790845","https://openalex.org/W2053411744","https://openalex.org/W7099835849","https://openalex.org/W4243695372","https://openalex.org/W1912074997","https://openalex.org/W2437798365","https://openalex.org/W7037473263","https://openalex.org/W7097979794"],"abstract_inverted_index":{"Picotamide":[0],"is":[1],"an":[2,151],"antiplatelet":[3],"drug":[4,153],"with":[5,24,29,91,105],"a":[6,73,82,115],"dual":[7],"inhibitory":[8],"action.":[9],"Thus,":[10],"picotamide":[11,47,65,80,109,123,127,148],"inhibits":[12],"both":[13],"thromboxane":[14],"A2":[15],"(TxA2)":[16],"receptors":[17],"and":[18,136],"TxA2":[19],"synthase":[20],"and,":[21],"at":[22,50],"variance":[23],"aspirin,":[25],"does":[26],"not":[27,71],"interfere":[28],"endothelial":[30],"prostacyclin":[31],"(PGI2)":[32],"production.":[33],"Two":[34],"large":[35],"randomized":[36,63,107],"trials":[37,160],"have":[38],"been":[39],"performed":[40],"to":[41,64,108,154],"assess":[42],"the":[43,98,112,122,132,137,162],"clinical":[44],"efficacy":[45],"of":[46,52,76,118,134,139,141],"in":[48,89,121,129,158,161],"patients":[49,62,90,104],"risk":[51],"atherothrombosis.":[53],"The":[54],"ADEP":[55],"study":[56,69,100],"compared":[57],"peripheral":[58],"artery":[59],"disease":[60],"(PAD)":[61],"or":[66],"placebo.":[67],"This":[68],"did":[70],"show":[72],"significant":[74,116],"reduction":[75,117,133],"cardiovascular":[77],"events":[78],"by":[79],"but":[81],"subgroup":[83],"analysis":[84],"showed":[85,114],"its":[86],"potential":[87],"usefulness":[88],"diabetes.":[92],"To":[93],"investigate":[94],"this":[95],"issue":[96],"further,":[97],"DAVID":[99],"recently":[101],"enrolled":[102],"diabetic":[103],"PAD":[106],"versus":[110],"aspirin;":[111],"results":[113],"overall":[119],"mortality":[120],"group.":[124],"Moreover":[125],"long-term":[126],"treatment":[128],"diabetes":[130],"promotes":[131],"microalbuminuria":[135],"inhibition":[138],"growth":[140],"carotid":[142],"plaques.":[143],"These":[144],"data":[145],"suggest":[146],"that":[147],"may":[149],"represent":[150],"interesting":[152],"be":[155],"further":[156],"investigated":[157],"future":[159],"atherothrombotic":[163],"setting.":[164]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
