{"id":"https://openalex.org/W86646423","doi":null,"title":"MicroRNAs: their discovery, biogenesis, function and potential use as biomarkers in non-invasive prenatal diagnostics.","display_name":"MicroRNAs: their discovery, biogenesis, function and potential use as biomarkers in non-invasive prenatal diagnostics.","publication_year":2011,"publication_date":"2011-08-30","ids":{"openalex":"https://openalex.org/W86646423","mag":"86646423","pmid":"https://pubmed.ncbi.nlm.nih.gov/21915364","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3166153"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2177307","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3166153","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3166153","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011214266","display_name":"Michael Ladomery","orcid":"https://orcid.org/0000-0001-8694-8545","observed_orcids":["https://orcid.org/0000-0001-8694-8545"]},"institutions":[{"id":"https://openalex.org/I178535277","display_name":"University of the West of England","ror":"https://ror.org/02nwg5t34","country_code":"GB","type":"education","lineage":["https://openalex.org/I178535277"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael R Ladomery","raw_affiliation_strings":["Centre for Research in Bioscience, Faculty of Health and Life Sciences, University of the West of England, Coldhar-bour Lane Bristol BS16 1QY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Research in Bioscience, Faculty of Health and Life Sciences, University of the West of England, Coldhar-bour Lane Bristol BS16 1QY, UK","institution_ids":["https://openalex.org/I178535277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081041030","display_name":"Deborah G. Maddocks","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deborah G Maddocks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040831929","display_name":"Ian D. Wilson","orcid":"https://orcid.org/0000-0002-0149-4757","observed_orcids":["https://orcid.org/0000-0002-0149-4757"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ian D Wilson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2659,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.78782308,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"2","issue":"3","first_page":"253","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9990000128746033},{"id":"https://openalex.org/keywords/microrna-biogenesis","display_name":"microRNA biogenesis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.7080000042915344},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.9020000100135803},{"id":"https://openalex.org/keywords/microrna-target-regulation","display_name":"microRNA target regulation","score":0.5690000057220459},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8759999871253967},{"id":"https://openalex.org/keywords/maternal-plasma","display_name":"maternal plasma","score":0.8799999952316284},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8009999990463257},{"id":"https://openalex.org/keywords/noninvasive-prenatal-diagnosis","display_name":"noninvasive prenatal diagnosis","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7397851943969727},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5943863987922668},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5852041840553284},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.5671133995056152},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4843634068965912},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.43004122376441956},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4237006604671478},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3176482617855072},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26090532541275024}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:2177307","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3166153","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:21915364","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21915364","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular epidemiology and genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3166153","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3166153/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Epidemiol Genet","raw_type":"Text"},{"id":"mag:86646423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21915364","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2177307","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3166153","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1913987579","https://openalex.org/W1965098283","https://openalex.org/W1975955509","https://openalex.org/W1976295224","https://openalex.org/W1984497969","https://openalex.org/W1986782449","https://openalex.org/W1995857529","https://openalex.org/W2001029058","https://openalex.org/W2001508508","https://openalex.org/W2003931043","https://openalex.org/W2021992979","https://openalex.org/W2025560247","https://openalex.org/W2046409229","https://openalex.org/W2052450852","https://openalex.org/W2079248832","https://openalex.org/W2100977485","https://openalex.org/W2107506912","https://openalex.org/W2109782005","https://openalex.org/W2111533160","https://openalex.org/W2120315162","https://openalex.org/W2130707276","https://openalex.org/W2131307159","https://openalex.org/W2133365560","https://openalex.org/W2138664009","https://openalex.org/W2150415023","https://openalex.org/W2151912077","https://openalex.org/W2151953896","https://openalex.org/W2162674813","https://openalex.org/W2172208918"],"related_works":["https://openalex.org/W7097488462","https://openalex.org/W7096569074","https://openalex.org/W2128949071","https://openalex.org/W1824405696","https://openalex.org/W2353137322","https://openalex.org/W2127495088","https://openalex.org/W2133365560","https://openalex.org/W203816441","https://openalex.org/W2565440492","https://openalex.org/W2091501609"],"abstract_inverted_index":{"MiRNAs":[0,64],"are":[1,59,65],"a":[2,68],"widespread":[3],"class":[4],"of":[5,43,47,70,79],"small":[6],"non-coding":[7],"RNAs":[8],"that":[9,95],"have":[10],"the":[11,29,50,100],"ability":[12],"to":[13,20,76,91],"silence":[14],"gene":[15],"expression":[16,44],"through":[17,52],"sequence":[18],"complementarity":[19],"their":[21,25,39,56,106],"targets.":[22],"We":[23],"describe":[24],"initial":[26],"discovery":[27],"in":[28,67,81,99,111],"nematode":[30],"C.elegans":[31],"and":[32,45,49,72,103],"review":[33,87],"what":[34],"is":[35],"currently":[36],"known":[37],"about":[38],"biogenesis.":[40],"The":[41],"regulation":[42],"processing":[46],"miRNAs,":[48],"mechanisms":[51],"which":[53],"miRNAs":[54,94],"locate":[55],"correct":[57],"targets":[58],"not":[60],"yet":[61],"fully":[62],"understood.":[63],"involved":[66],"multitude":[69],"developmental":[71],"pathological":[73],"processes":[74],"leading":[75],"an":[77],"explosion":[78],"research":[80],"disparate":[82],"subject":[83],"areas.":[84],"In":[85],"this":[86],"we":[88,104],"draw":[89],"attention":[90],"placentally":[92],"expressed":[93],"can":[96],"be":[97],"detected":[98],"maternal":[101],"plasma;":[102],"discuss":[105],"potential":[107],"use":[108],"as":[109],"biomarkers":[110],"non-invasive":[112],"prenatal":[113],"diagnostics.":[114]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}