{"id":"https://openalex.org/W86637930","doi":null,"title":"Interleukin-6 augments hepatocyte growth factor-induced liver regeneration; involvement of STAT3 activation.","display_name":"Interleukin-6 augments hepatocyte growth factor-induced liver regeneration; involvement of STAT3 activation.","publication_year":2004,"publication_date":"2004-11-01","ids":{"openalex":"https://openalex.org/W86637930","mag":"86637930","pmid":"https://pubmed.ncbi.nlm.nih.gov/15532800"},"language":"en","primary_location":{"id":"pmid:15532800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15532800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068214663","display_name":"Toshimi Kaido","orcid":"https://orcid.org/0000-0001-9409-3188","observed_orcids":["https://orcid.org/0000-0001-9409-3188"]},"institutions":[{"id":"https://openalex.org/I4210093634","display_name":"Otsu Municipal Hospital","ror":"https://ror.org/00jm9xh53","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210093634"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshimi Kaido","raw_affiliation_strings":["Department of Surgery, Otsu Municipal Hospital, Shiga, Japan. kaido3@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Otsu Municipal Hospital, Shiga, Japan. kaido3@hotmail.com","institution_ids":["https://openalex.org/I4210093634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067998179","display_name":"Hideaki Oe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hideaki Oe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112489436","display_name":"Masayuki Imamura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masayuki Imamura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5898,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.71446296,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"51","issue":"60","first_page":"1667","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.996999979019165},{"id":"https://openalex.org/keywords/stat3-activation","display_name":"STAT3 activation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/compensatory-hypertrophy","display_name":"compensatory hypertrophy","score":0.7559999823570251},{"id":"https://openalex.org/keywords/hepatocyte-dna-synthesis","display_name":"hepatocyte DNA synthesis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/growth-factor-synergy","display_name":"growth factor synergy","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C2776795407","wikidata":"https://www.wikidata.org/wiki/Q19597761","display_name":"Liver regeneration","level":3,"score":0.8651723861694336},{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.8506858348846436},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.7563115358352661},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.6435001492500305},{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.6359705924987793},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5361708402633667},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4686431586742401},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4520426392555237},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4408888518810272},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.42979487776756287},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4266803562641144},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3283931314945221},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31397128105163574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.305202841758728},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.27875545620918274},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.22458034753799438},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20403987169265747},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1005840003490448},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07832968235015869},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07436764240264893},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008026","descriptor_name":"Ligation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008106","descriptor_name":"Liver Cirrhosis, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008106","descriptor_name":"Liver Cirrhosis, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008115","descriptor_name":"Liver Regeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008115","descriptor_name":"Liver Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15532800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15532800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Comparative Study"},{"id":"mag:86637930","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15532800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W32599780","https://openalex.org/W1987042805","https://openalex.org/W2090563155","https://openalex.org/W2025421728","https://openalex.org/W2052467994","https://openalex.org/W1981936620","https://openalex.org/W1998640618","https://openalex.org/W3195355751","https://openalex.org/W1992110197","https://openalex.org/W1989052869"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"In":[1],"liver":[2,37,57,131,146,195],"regeneration,":[3],"quiescent":[4],"hepatocytes":[5,138,187],"need":[6],"to":[7,15,30,128],"be":[8,207],"primed":[9],"before":[10],"they":[11],"can":[12],"fully":[13],"respond":[14],"growth":[16,21],"factors":[17],"such":[18],"as":[19,177,179],"hepatocyte":[20],"factor":[22],"(HGF).":[23],"Recently,":[24],"interleukin-6":[25],"(IL-6)":[26],"has":[27],"been":[28],"shown":[29],"play":[31],"an":[32],"important":[33],"role":[34],"in":[35,68,113,139,144,186,213],"initiating":[36],"regeneration":[38,58,196,201],"via":[39],"activating":[40],"signal":[41],"transducer":[42],"and":[43,59,82,102,132,152,158,171,197],"activator":[44],"of":[45,54,78,110,124,137,156,167],"transcription":[46],"3":[47],"(STAT3).":[48],"We":[49],"therefore":[50],"investigated":[51],"the":[52,79,120,125,129,133,164,168,172,189],"effect":[53],"IL-6":[55,64,91,157,192,219],"on":[56,101],"examined":[60,117,148],"STAT3":[61,142,184,211],"activation":[62,185,212],"following":[63],"and/or":[65],"HGF":[66,94,159,176,204],"treatment":[67,205],"rats.":[69],"METHODOLOGY:":[70],"The":[71,108],"animals":[72,181],"underwent":[73],"portal":[74],"branch":[75],"ligation":[76],"(PBL)":[77],"left":[80],"lateral":[81],"median":[83],"branches.":[84],"They":[85],"were":[86],"intravenously":[87],"treated":[88],"with":[89,210],"either":[90],"(500":[92],"microg/kg),":[93,96],"(50":[95],"both,":[97],"or":[98],"vehicle":[99],"alone":[100],"every":[103],"12":[104],"h":[105],"after":[106],"PBL.":[107],"degree":[109],"compensatory":[111],"hypertrophy":[112],"unoccluded":[114,126,169],"lobes":[115,127,170],"was":[116,147],"by":[118,149,203,218],"measuring":[119],"wet":[121,165],"weight":[122,166],"ratios":[123],"whole":[130],"5-bromo-2'-deoxyuridine":[134],"labeling":[135],"index":[136],"each":[140],"group.":[141],"expression":[143],"regenerating":[145],"Western":[150],"blotting":[151],"immunohistochemistry.":[153],"RESULTS:":[154],"Coadministration":[155],"most":[160],"effectively":[161],"increased":[162],"both":[163],"hepatocellular":[173,198],"DNA":[174],"synthesis.":[175],"well":[178],"IL-6-treated":[180],"showed":[182],"moderate":[183],"throughout":[188],"experiment.":[190],"CONCLUSIONS:":[191],"augmented":[193],"HGF-induced":[194],"replication.":[199],"Liver":[200],"stimulated":[202],"may":[206],"closely":[208],"involved":[209],"a":[214],"different":[215],"manner":[216],"induced":[217],"treatment.":[220]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
