{"id":"https://openalex.org/W866224173","doi":null,"title":"ROLE OF ANGIOTENSIN CONVERTING ENZYMES ACE AND ACE2 IN DIABETES INDUCED CARDIOVASCULAR DYSFUNCTION","display_name":"ROLE OF ANGIOTENSIN CONVERTING ENZYMES ACE AND ACE2 IN DIABETES INDUCED CARDIOVASCULAR DYSFUNCTION","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W866224173","mag":"866224173"},"language":"en","primary_location":{"id":"pmh:oai:etd.ohiolink.edu:wright1196272791","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=wright1196272791","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=wright1196272791","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=wright1196272791","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://rave.ohiolink.edu/etdc/view?acc_num=wright1196272791","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023955266","display_name":"Keerthy Kanakamedala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19648265","display_name":"Wright State University","ror":"https://ror.org/04qk6pt94","country_code":"US","type":"education","lineage":["https://openalex.org/I19648265"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Keerthy Kanakamedala","raw_affiliation_strings":["Wright State University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wright State University;","institution_ids":["https://openalex.org/I19648265"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023955266"],"corresponding_institution_ids":["https://openalex.org/I19648265"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.09719931,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":92},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-converting-enzyme","display_name":"angiotensin-converting enzyme","score":0.9639999866485596},{"id":"https://openalex.org/keywords/ace2","display_name":"ACE2","score":0.9520000219345093},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.9039999842643738},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.949999988079071},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7289999723434448},{"id":"https://openalex.org/keywords/db-db-mice","display_name":"db/db mice","score":0.9580000042915344},{"id":"https://openalex.org/keywords/mean-arterial-pressure","display_name":"mean arterial pressure","score":0.8529999852180481},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.7919999957084656},{"id":"https://openalex.org/keywords/angiotensin-1-7","display_name":"angiotensin-(1-7)","score":0.9330000281333923}],"concepts":[{"id":"https://openalex.org/C2775946041","wikidata":"https://www.wikidata.org/wiki/Q14875321","display_name":"Angiotensin-converting enzyme 2","level":5,"score":0.7302290201187134},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7272170782089233},{"id":"https://openalex.org/C2910482119","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Peptidyl-Dipeptidase A","level":4,"score":0.5607464909553528},{"id":"https://openalex.org/C2909708631","wikidata":"https://www.wikidata.org/wiki/Q15332826","display_name":"Angiotensin 1","level":4,"score":0.556890070438385},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.515726625919342},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5017740726470947},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4837384521961212},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.45765411853790283},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.43667975068092346},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42422378063201904},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24470552802085876},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2443121373653412},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2154264748096466},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20200809836387634},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.19501662254333496},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:etd.ohiolink.edu:wright1196272791","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=wright1196272791","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=wright1196272791","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=wright1196272791","raw_type":"text"},{"id":"pmh:oai:corescholar.libraries.wright.edu:etd_all-1339","doi":null,"is_oa":false,"landing_page_url":"https://corescholar.libraries.wright.edu/etd_all/200","pdf_url":null,"source":{"id":"https://openalex.org/S2737205702","display_name":"Journal of Bioresource Management","issn_l":"2309-3854","issn":["2309-3854"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","erih-plus"],"host_organization":"https://openalex.org/P4310316536","host_organization_name":"Bioresource Research Center (BRC), Islamabad","host_organization_lineage":["https://openalex.org/P4310316536"],"host_organization_lineage_names":["Bioresource Research Center (BRC), Islamabad"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Browse all Theses and Dissertations","raw_type":"text"},{"id":"mag:866224173","doi":null,"is_oa":false,"landing_page_url":"https://corescholar.libraries.wright.edu/cgi/viewcontent.cgi?article=1339&context=etd_all","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etd.ohiolink.edu:wright1196272791","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=wright1196272791","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=wright1196272791","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=wright1196272791","raw_type":"text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W866224173.pdf","grobid_xml":"https://content.openalex.org/works/W866224173.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W180946569","https://openalex.org/W1821554906","https://openalex.org/W1947768747","https://openalex.org/W1965097617","https://openalex.org/W1974548284","https://openalex.org/W1977597520","https://openalex.org/W1979749207","https://openalex.org/W1980086892","https://openalex.org/W1989813262","https://openalex.org/W1992871075","https://openalex.org/W1998585557","https://openalex.org/W2000040025","https://openalex.org/W2003670762","https://openalex.org/W2003901778","https://openalex.org/W2004211100","https://openalex.org/W2004840558","https://openalex.org/W2005951646","https://openalex.org/W2010466875","https://openalex.org/W2015111258","https://openalex.org/W2017872838","https://openalex.org/W2020053653","https://openalex.org/W2020877653","https://openalex.org/W2025523187","https://openalex.org/W2025672718","https://openalex.org/W2028521865","https://openalex.org/W2034458729","https://openalex.org/W2036706643","https://openalex.org/W2039406812","https://openalex.org/W2049355787","https://openalex.org/W2054990010","https://openalex.org/W2056976690","https://openalex.org/W2060204625","https://openalex.org/W2066425811","https://openalex.org/W2075052319","https://openalex.org/W2079862400","https://openalex.org/W2083695720","https://openalex.org/W2084682056","https://openalex.org/W2089713276","https://openalex.org/W2090895117","https://openalex.org/W2094858676","https://openalex.org/W2097160762","https://openalex.org/W2099131776","https://openalex.org/W2104103470","https://openalex.org/W2108312009","https://openalex.org/W2111190158","https://openalex.org/W2117137750","https://openalex.org/W2119534102","https://openalex.org/W2121697655","https://openalex.org/W2122228543","https://openalex.org/W2122820776","https://openalex.org/W2124032410","https://openalex.org/W2128741160","https://openalex.org/W2131884876","https://openalex.org/W2140446943","https://openalex.org/W2143808203","https://openalex.org/W2148519356","https://openalex.org/W2149146712","https://openalex.org/W2149729817","https://openalex.org/W2156121263","https://openalex.org/W2161399617","https://openalex.org/W2163193431","https://openalex.org/W2166528460","https://openalex.org/W2168276527","https://openalex.org/W2289116881","https://openalex.org/W2414961032","https://openalex.org/W2913696875","https://openalex.org/W4298498024"],"related_works":["https://openalex.org/W2040416968","https://openalex.org/W2148281534","https://openalex.org/W1973263005","https://openalex.org/W2762866715","https://openalex.org/W177210107","https://openalex.org/W2592237527","https://openalex.org/W2104103470","https://openalex.org/W3176314353","https://openalex.org/W2149729817","https://openalex.org/W634603280"],"abstract_inverted_index":{"Cardiovascular":[0],"disease":[1],"is":[2,19,56,71],"a":[3,11,152,171,235,279,335,360,372],"long":[4],"term":[5],"complication":[6],"of":[7,14,24,42,50,65,76,112,340,349,356,363,379],"diabetes,":[8],"which":[9],"remains":[10],"leading":[12],"cause":[13,368],"mortality":[15],"and":[16,33,81,100,119,129,192,212,219,241,268,274,278,328],"morbidity.":[17],"There":[18,55,309],"recent":[20],"evidence":[21,36],"for":[22,109,226,369],"activation":[23],"the":[25,39,51,74,157,316,346,367],"Renin":[26],"angiotensin":[27,77],"system":[28],"(RAS)":[29],"in":[30,62,83,131,156,175,179,196,198,217,238,243,248,286,304,315,321,325,342,345,375],"diabetic":[31,91],"animals":[32],"humans.":[34],"Emerging":[35],"shows":[37],"that":[38,232],"vasoconstrictor":[40],"actions":[41],"Ang":[43,53],"II":[44],"may":[45,333],"be":[46,366],"opposed":[47],"by":[48],"formation":[49],"vasodilator,":[52],"(1-7).":[54],"limited":[57],"data":[58],"on":[59],"blood":[60],"pressure":[61],"murine":[63,92,377],"models":[64,94],"type":[66,89],"2":[67,90],"diabetes.":[68,351,381],"The":[69,353],"aim":[70],"to":[72,135,161,183,205,255],"study":[73],"role":[75],"converting":[78],"enzymes":[79],"ACE":[80,177,194,211,245,267,276,306,357],"ACE2":[82,190,213,240,269,282,332,364],"diabetes":[84],"induced":[85],"cardiovascular":[86],"dysfunction":[87],"using":[88],"mouse":[93],"(db/db":[95],"mice).":[96],"Both":[97],"db/db":[98,158,180,202,252,290,297,343],"mice":[99,125,159,168,181,203,253,298,344],"their":[101,136,256],"controls":[102,138],"were":[103,284,299],"implanted":[104],"with":[105,359],"carotid":[106],"telemetric":[107],"probes":[108],"chronic":[110],"monitoring":[111],"MAP":[113,140],"(Mean":[114],"Arterial":[115],"pressure),":[116],"heart":[117,322],"rate":[118,323],"activity.":[120,307],"At":[121,144],"8-9":[122],"weeks":[123,200,250,288],"age,":[124],"showed":[126],"hyperinsulinemia,":[127],"hyperglycemia":[128],"increase":[130,174,237,303,314],"body":[132],"weight":[133],"compared":[134,160,182,204,254],"lean":[137,257],"while":[139],"was":[141,151,170,188,215,234,263,310],"not":[142],"altered.":[143],"an":[145,302,311],"older":[146],"age":[147,312],"(14-15":[148],"weeks)":[149,166],"there":[150,169,187,233],"significantly":[153],"increased":[154,189],"BP":[155,317],"controls.":[162,184,206,258],"In":[163,185,221,259,292],"young":[164,327],"(8":[165],"normotensive":[167,300],"highly":[172],"significant":[173,208,236],"plasma":[176,273,305],"activity":[178,191,195,214,277,283],"contrast":[186],"decreased":[193,280],"kidney":[197,239,244,275,281],"8":[199,249],"old":[201,251,289,329],"No":[207],"difference":[209,262],"between":[210,265],"observed":[216,264,285],"lungs":[218],"brain.":[220],"addition":[222,260],"western":[223],"blot":[224],"analysis":[225],"ACE/ACE2":[227],"protein":[228,246,270],"expression":[229,247],"also":[230],"revealed":[231],"decrease":[242],"no":[261,319],"lung":[266],"expression.":[271],"Increased":[272],"24":[287],"mice.":[291,330],"conclusion:":[293],"1.":[294],"Eight":[295],"weeks'":[296],"despite":[301],"2.":[308],"dependent":[313],"but":[318],"change":[320],"(HR)":[324],"both":[326],"3.":[331],"play":[334],"compensatory":[336],"mechanism":[337],"against":[338],"development":[339],"hypertension":[341,370],"early":[347],"stage":[348,374],"type2":[350,380],"4.":[352],"up":[354],"regulation":[355,362],"coupled":[358],"down":[361],"might":[365],"at":[371],"later":[373],"this":[376],"model":[378]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
