{"id":"https://openalex.org/W86565841","doi":null,"title":"Dietary Sodium Restriction and Vascular Dysfunction with Aging","display_name":"Dietary Sodium Restriction and Vascular Dysfunction with Aging","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W86565841","mag":"86565841"},"language":"en","primary_location":{"id":"pmh:oai:scholar.colorado.edu:iphy_gradetds-1007","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/iphy_gradetds/7","pdf_url":"https://scholar.colorado.edu/iphy_gradetds/7","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Integrative Physiology Graduate Theses &amp; Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholar.colorado.edu/iphy_gradetds/7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112153296","display_name":"Kristen Jablonski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kristen Jablonski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5112153296"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2147,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.60670841,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.5605000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.5605000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12075","display_name":"Sodium Intake and Health","score":0.43209999799728394,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dietary-sodium-restriction","display_name":"dietary sodium restriction","score":0.9800000190734863},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9900000095367432},{"id":"https://openalex.org/keywords/vascular-aging","display_name":"vascular aging","score":0.6460000276565552},{"id":"https://openalex.org/keywords/endothelium-dependent-dilation","display_name":"endothelium-dependent dilation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/flow-mediated-dilation","display_name":"flow-mediated dilation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/systolic-blood-pressure","display_name":"systolic blood pressure","score":0.8299999833106995},{"id":"https://openalex.org/keywords/nitric-oxide-bioavailability","display_name":"nitric oxide bioavailability","score":0.9639999866485596},{"id":"https://openalex.org/keywords/tetrahydrobiopterin","display_name":"tetrahydrobiopterin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9779999852180481},{"id":"https://openalex.org/keywords/3-nitrotyrosine","display_name":"nitrotyrosine","score":0.9480000138282776},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.8859999775886536},{"id":"https://openalex.org/keywords/middle-aged-and-older-adults","display_name":"middle-aged and older adults","score":0.8669999837875366},{"id":"https://openalex.org/keywords/hypertension-prevention","display_name":"hypertension prevention","score":0.5230000019073486},{"id":"https://openalex.org/keywords/dietary-intervention","display_name":"dietary intervention","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7727211713790894},{"id":"https://openalex.org/C2777604165","wikidata":"https://www.wikidata.org/wiki/Q503643","display_name":"Brachial artery","level":3,"score":0.7412301301956177},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7081236839294434},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.682910680770874},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6379365921020508},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.6066434383392334},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5801385641098022},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.5655070543289185},{"id":"https://openalex.org/C2910756435","wikidata":"https://www.wikidata.org/wiki/Q1132653","display_name":"High sodium","level":3,"score":0.4864601790904999},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.44453558325767517},{"id":"https://openalex.org/C2908747478","wikidata":"https://www.wikidata.org/wiki/Q3337048","display_name":"Dietary Sodium","level":3,"score":0.4383998513221741},{"id":"https://openalex.org/C2777193177","wikidata":"https://www.wikidata.org/wiki/Q7663896","display_name":"Systolic hypertension","level":3,"score":0.4353838264942169},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3572803735733032},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0686560869216919},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:scholar.colorado.edu:iphy_gradetds-1007","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/iphy_gradetds/7","pdf_url":"https://scholar.colorado.edu/iphy_gradetds/7","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Integrative Physiology Graduate Theses &amp; Dissertations","raw_type":"text"},{"id":"pmh:oai:pqdtoai.proquest.com:3489529","doi":null,"is_oa":false,"landing_page_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3489529","pdf_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3489529","source":{"id":"https://openalex.org/S7407064308","display_name":"ProQuest Demo Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},{"id":"pmh:oai:cuscholar:vq27zn48d","doi":null,"is_oa":false,"landing_page_url":"https://scholar.colorado.edu/concern/graduate_thesis_or_dissertations/vq27zn48d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:86565841","doi":null,"is_oa":false,"landing_page_url":"https://scholar.colorado.edu/iphy_gradetds/7/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:scholar.colorado.edu:iphy_gradetds-1007","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/iphy_gradetds/7","pdf_url":"https://scholar.colorado.edu/iphy_gradetds/7","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Integrative Physiology Graduate Theses &amp; Dissertations","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W86565841.pdf","grobid_xml":"https://content.openalex.org/works/W86565841.grobid-xml"},"referenced_works_count":135,"referenced_works":["https://openalex.org/W144257253","https://openalex.org/W1496671849","https://openalex.org/W1535396345","https://openalex.org/W1538110087","https://openalex.org/W1542806971","https://openalex.org/W1555489744","https://openalex.org/W1577665082","https://openalex.org/W1595822167","https://openalex.org/W1608211496","https://openalex.org/W1639251217","https://openalex.org/W1769035943","https://openalex.org/W1837525702","https://openalex.org/W1849785625","https://openalex.org/W1861519250","https://openalex.org/W1898810368","https://openalex.org/W1923790355","https://openalex.org/W1965491619","https://openalex.org/W1966365575","https://openalex.org/W1970516435","https://openalex.org/W1971322168","https://openalex.org/W1975475560","https://openalex.org/W1978682267","https://openalex.org/W1980445357","https://openalex.org/W1981107600","https://openalex.org/W1982630941","https://openalex.org/W1983372621","https://openalex.org/W1983986440","https://openalex.org/W1984884442","https://openalex.org/W1987511404","https://openalex.org/W1991833325","https://openalex.org/W1993952575","https://openalex.org/W1998801880","https://openalex.org/W2002797825","https://openalex.org/W2004714829","https://openalex.org/W2006884514","https://openalex.org/W2009300287","https://openalex.org/W2012092765","https://openalex.org/W2014145970","https://openalex.org/W2015612576","https://openalex.org/W2016460283","https://openalex.org/W2017236551","https://openalex.org/W2019054755","https://openalex.org/W2019338486","https://openalex.org/W2026425756","https://openalex.org/W2035632881","https://openalex.org/W2036389244","https://openalex.org/W2037365395","https://openalex.org/W2037909970","https://openalex.org/W2038273086","https://openalex.org/W2038686627","https://openalex.org/W2042038416","https://openalex.org/W2042959178","https://openalex.org/W2045084428","https://openalex.org/W2045378100","https://openalex.org/W2045585480","https://openalex.org/W2047423571","https://openalex.org/W2048664920","https://openalex.org/W2053908791","https://openalex.org/W2055207018","https://openalex.org/W2056586447","https://openalex.org/W2059311419","https://openalex.org/W2063506869","https://openalex.org/W2064313497","https://openalex.org/W2065566393","https://openalex.org/W2065967466","https://openalex.org/W2073898414","https://openalex.org/W2082525790","https://openalex.org/W2084956254","https://openalex.org/W2085355921","https://openalex.org/W2087375327","https://openalex.org/W2088639163","https://openalex.org/W2088740123","https://openalex.org/W2095957083","https://openalex.org/W2097750015","https://openalex.org/W2097957951","https://openalex.org/W2099211927","https://openalex.org/W2100193805","https://openalex.org/W2100312221","https://openalex.org/W2101762356","https://openalex.org/W2102196626","https://openalex.org/W2102693401","https://openalex.org/W2103981791","https://openalex.org/W2105833062","https://openalex.org/W2111677326","https://openalex.org/W2113214088","https://openalex.org/W2114222172","https://openalex.org/W2116450173","https://openalex.org/W2118260369","https://openalex.org/W2118874116","https://openalex.org/W2119545067","https://openalex.org/W2124561899","https://openalex.org/W2126525811","https://openalex.org/W2131399515","https://openalex.org/W2135312900","https://openalex.org/W2138955883","https://openalex.org/W2139500689","https://openalex.org/W2142037089","https://openalex.org/W2143860777","https://openalex.org/W2145200932","https://openalex.org/W2145989311","https://openalex.org/W2147994649","https://openalex.org/W2148346218","https://openalex.org/W2153294507","https://openalex.org/W2153802091","https://openalex.org/W2154055479","https://openalex.org/W2154375091","https://openalex.org/W2154944101","https://openalex.org/W2155267716","https://openalex.org/W2155937098","https://openalex.org/W2156121263","https://openalex.org/W2157326702","https://openalex.org/W2159314805","https://openalex.org/W2160375807","https://openalex.org/W2161635709","https://openalex.org/W2161846196","https://openalex.org/W2161938174","https://openalex.org/W2163261367","https://openalex.org/W2164979547","https://openalex.org/W2166665077","https://openalex.org/W2166838509","https://openalex.org/W2167102952","https://openalex.org/W2169182236","https://openalex.org/W2169887452","https://openalex.org/W2171284332","https://openalex.org/W2217533211","https://openalex.org/W2266830123","https://openalex.org/W2298868338","https://openalex.org/W2321007701","https://openalex.org/W2335161036","https://openalex.org/W2400014242","https://openalex.org/W2402886149","https://openalex.org/W2415290605","https://openalex.org/W2614781785","https://openalex.org/W2615043561","https://openalex.org/W3015544325"],"related_works":["https://openalex.org/W335622116","https://openalex.org/W2152944003","https://openalex.org/W1978682267","https://openalex.org/W3175397148","https://openalex.org/W2047273470","https://openalex.org/W2499373958","https://openalex.org/W4411876009","https://openalex.org/W2021280090","https://openalex.org/W1560438230","https://openalex.org/W2742380188"],"abstract_inverted_index":{"Endothelial":[0],"dysfunction,":[1],"commonly":[2],"assessed":[3,33],"as":[4,34,41],"a":[5,12,64],"decline":[6],"in":[7,60,124,139,156,166,227,255,301],"endothelium-dependent":[8],"dilation":[9,38,168],"(EDD),":[10],"is":[11,22,63,73,84,119],"clinically":[13],"important":[14],"predictor":[15],"of":[16,54,80,100,108,205,259,323,334],"future":[17],"cardiovascular":[18,97],"diseases":[19],"(CVD).":[20],"EDD":[21,59,123,138,193,228],"reduced":[23,116,278,291],"with":[24,121,130,257,274,287,303],"age":[25],"and":[26,87,126,142,197,235,277,282,310,313,330],"elevated":[27,132,305],"systolic":[28],"blood":[29,44],"pressure":[30],"(SBP),":[31],"whether":[32],"brachial":[35],"artery":[36],"flow-mediated":[37],"(FMDBA)":[39,196],"or":[40,171],"the":[42,52,78,106,144,176,190,318,331],"forearm":[43],"flow":[45],"response":[46],"to":[47,112,183],"acetylcholine":[48],"(FBFACh).":[49],"Thus,":[50,317],"establishing":[51],"efficacy":[53],"interventions":[55],"that":[56],"may":[57,339],"preserve":[58],"this":[61,140],"population":[62],"high":[65,89],"biomedical":[66],"research":[67],"priority.":[68],"Dietary":[69],"sodium":[70,81,91,117,160,185,207,212],"restriction":[71],"(DSR)":[72],"one":[74],"potential":[75,332],"intervention.":[76],"While":[77],"influence":[79],"on":[82,96,103],"BP":[83,327],"widely":[85],"documented":[86],"appreciated,":[88],"dietary":[90,184],"has":[92],"other":[93,172,236],"adverse":[94],"effects":[95],"health,":[98],"independent":[99],"its":[101],"effect":[102],"BP.":[104],"Accordingly,":[105],"purpose":[107],"these":[109],"studies":[110],"was":[111,153,180,194],"determine":[113],"a)":[114],"if":[115,135],"intake":[118,161,186,215],"associated":[120],"enhanced":[122],"middle-aged":[125],"older":[127],"adults":[128],"(MA/O)":[129],"moderately":[131,304],"SBP;":[133],"b)":[134],"DSR":[136,297,324,335],"improves":[137],"group;":[141],"c)":[143],"physiological":[145,319],"mechanisms":[146,320],"mediating":[147],"any":[148],"improvements.\\nIn":[149],"cross-sectional":[150],"analyses,":[151],"FMDBA":[152,179],"52%":[154],"higher":[155,201],"subjects":[157],"self-reporting":[158],"low":[159,206],"(73\u00b16":[162],"mmol/d),":[163],"without":[164],"differences":[165],"endothelium-independent":[167],"(EID),":[169],"SBP":[170,306],"subject":[173,237],"characteristics.":[174],"In":[175],"entire":[177],"cohort,":[178],"inversely":[181],"related":[182],"(%\u0394":[187],"r=-0.53,":[188],"p<0.01).\\nIn":[189],"intervention":[191],"study,":[192],"71%":[195],"53%":[198],"(peak":[199],"FBFACh)":[200],"following":[202],"4":[203],"weeks":[204],"(70\u00b18":[208],"mmol/day)":[209,214],"vs.":[210],"normal":[211],"(153\u00b17":[213],"(p<0.05;":[216],"randomized":[217],"cross-over":[218],"design),":[219],"whereas":[220],"EID":[221],"did":[222,240],"not":[223,241],"change.":[224,242],"The":[225],"improvements":[226,244],"remained":[229],"significant":[230],"when":[231],"correcting":[232],"for":[233],"SBP,":[234],"characteristics/dietary":[238],"factors":[239],"Functional":[243],"were":[245],"mediated":[246],"by":[247,307],"increased":[248,266],"nitric":[249,262],"oxide":[250,263],"(NO)":[251],"bioavailability":[252,269,312],"(significant":[253],"reduction":[254],"FBFACh":[256,283],"co-infusion":[258],"an":[260],"endothelial":[261,292,299],"synthase":[264],"inhibitor),":[265],"tetrahydrobiopterin":[267],"(BH4)":[268],"(FMDBA":[270,281],"no":[271,284],"longer":[272,285],"improved":[273,286],"oral":[275],"BH4)":[276],"oxidative":[279,315],"stress":[280],"ascorbic":[288],"acid":[289],"infusion;":[290],"cell":[293],"nitrotyrosine":[294],"abundance).\\nIn":[295],"conclusion,":[296],"reverses":[298],"dysfunction":[300],"MA/O":[302],"enhancing":[308],"NO":[309],"BH4":[311],"reducing":[314],"stress.":[316],"modulating":[321],"benefits":[322],"are":[325],"beyond":[326],"lowering":[328],"alone,":[329],"impact":[333],"upon":[336],"CVD":[337],"risk":[338],"be":[340],"even":[341],"greater":[342],"than":[343],"previously":[344],"appreciated.":[345]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}