{"id":"https://openalex.org/W86541377","doi":null,"title":"The feed-back regulation of erythropoietin production in healthy humans.","display_name":"The feed-back regulation of erythropoietin production in healthy humans.","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W86541377","mag":"86541377","pmid":"https://pubmed.ncbi.nlm.nih.gov/9777287"},"language":"en","primary_location":{"id":"pmid:9777287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9777287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Danish medical bulletin","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111860253","display_name":"Thomas Levin Klausen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"T Klausen","raw_affiliation_strings":["Department of Haematology, Gentofte Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Gentofte Hospital","institution_ids":["https://openalex.org/I2802582725"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111860253"],"corresponding_institution_ids":["https://openalex.org/I2802582725"],"apc_list":null,"apc_paid":null,"fwci":0.6376,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.65778172,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"45","issue":"4","first_page":"345","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11968","display_name":"High Altitude and Hypoxia","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythropoietin","display_name":"erythropoietin","score":0.949999988079071},{"id":"https://openalex.org/keywords/erythropoietin-regulation","display_name":"erythropoietin regulation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/hypobaric-hypoxia","display_name":"hypobaric hypoxia","score":0.875},{"id":"https://openalex.org/keywords/altitude-exposure","display_name":"altitude exposure","score":0.8199999928474426},{"id":"https://openalex.org/keywords/hemoglobin-oxygen-affinity","display_name":"hemoglobin oxygen affinity","score":0.9490000009536743},{"id":"https://openalex.org/keywords/erythropoiesis","display_name":"erythropoiesis","score":0.8669999837875366},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8399999737739563},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9380000233650208},{"id":"https://openalex.org/keywords/normocapnia","display_name":"normocapnia","score":0.6769999861717224},{"id":"https://openalex.org/keywords/oxygen-deprivation","display_name":"oxygen deprivation","score":0.4189999997615814},{"id":"https://openalex.org/keywords/healthy-humans","display_name":"healthy humans","score":0.5950000286102295},{"id":"https://openalex.org/keywords/serum-erythropoietin","display_name":"serum erythropoietin","score":0.6850000023841858},{"id":"https://openalex.org/keywords/oxygen-saturation","display_name":"oxygen saturation","score":0.4749999940395355},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C2778534260","wikidata":"https://www.wikidata.org/wiki/Q218706","display_name":"Erythropoietin","level":2,"score":0.8569691181182861},{"id":"https://openalex.org/C2779703530","wikidata":"https://www.wikidata.org/wiki/Q837174","display_name":"Erythropoiesis","level":3,"score":0.7871780395507812},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6692115664482117},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5177389979362488},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46625837683677673},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4659472703933716},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.40011078119277954},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.22796881198883057},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1371052861213684},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9777287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9777287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Danish medical bulletin","raw_type":"Journal Article"},{"id":"mag:86541377","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9777287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1994412501","https://openalex.org/W1992437155","https://openalex.org/W7217002191","https://openalex.org/W1575304159","https://openalex.org/W2023493877","https://openalex.org/W2464182427","https://openalex.org/W2061146668","https://openalex.org/W2137009620","https://openalex.org/W2064493659","https://openalex.org/W1958683699"],"abstract_inverted_index":{"The":[0,31,323],"proposed":[1,75],"oxygen-dependent":[2],"feed-back":[3,32,76,120,127,288,461,475],"loop":[4,33,77,462,476],"regulation":[5,78,128,289,448,463,477],"of":[6,48,53,65,79,129,151,162,167,179,192,219,232,295,302,315,343,381,411,422,430,435,449,464,478,496],"EPO":[7,67,80,93,130,173,184,195,221,250,265,297,376,388,402,426,451,465,479,498],"production":[8,94,131,185,222,266,342,377,389,403,499],"(Fogh":[9],"1978,":[10],"Erslev":[11],"1991,":[12,16],"LeHir":[13],"et":[14],"al":[15],"Nielsen":[17],"1991)":[18],"is":[19,71,95,101,107,136,267,454],"mainly":[20,285],"supported":[21],"by":[22,42,148,164,408,483],"data":[23],"from":[24],"studies":[25,43,366,484],"in":[26,44,91,113,142,183,207,215,240,278,286,292,309,360,364,367,378,386,392,417,485],"animals":[27],"and":[28,34,55,103,209,236,270,275,329,334,355,396,433,446,487],"cell":[29],"cultures.":[30],"its":[35],"dependence":[36],"on":[37,375],"oxygen":[38,63,273,459],"was":[39,186,199,223,307,349],"therefore":[40],"challenged":[41],"healthy":[45,310,397],"humans:":[46],"Exposure":[47,82],"humans":[49,208,311,361],"to":[50,83,109,118,197,201,212,226,246,252,493],"different":[51],"levels":[52,301],"acute":[54],"continued":[56,84,133],"altitude":[57,85,257,316],"hypobaria":[58,86],"provided":[59],"evidence":[60],"for":[61],"an":[62,98,152,442],"dependency":[64],"the":[66,74,89,114,119,126,143,149,160,176,190,193,217,233,248,256,279,287,293,303,335,379,458,468,474,494],"response.":[68],"This":[69],"response":[70,196,251],"consistent":[72],"with":[73,255,320,457],"production.":[81,174,298,466],"demonstrated":[87,158,262,441],"that":[88,104,125,159,263,276,368,473],"decline":[90,106],"human":[92,172,194,220,249,264,296,387,425,450,497],"initiated":[96],"before":[97],"EPO-induced":[99],"erythropoiesis":[100],"detectable,":[102],"this":[105,122],"related":[108,225],"a":[110,140,227,283,347,372,420],"concomitant":[111],"decrease":[112,141],"haemoglobin-oxygen":[115,144,234,243,280],"affinity.":[116],"Contrary":[117,211],"loop,":[121],"time-relation":[123],"indicate":[124],"during":[132,312],"hypobaric":[134],"hypoxia":[135,198],"exerted":[137],"primarily":[138],"through":[139],"affinity,":[145,235,244],"rather":[146,290],"than":[147,204,291],"effects":[150],"EPO-stimulated":[153],"erythropoiesis.":[154],"A":[155],"laboratory":[156],"experiment":[157],"lowering":[161],"PaO2":[163],"short-term":[165],"breathing":[166],"hypoxic":[168,228],"gas":[169],"could":[170,404],"trigger":[171],"Since":[175],"possible":[177],"influence":[178],"spontaneous":[180],"non-hypoxic":[181],"variations":[182,385],"taken":[187],"into":[188],"account,":[189],"magnitude":[191],"found":[200,308],"be":[202,406,491],"less":[203],"formerly":[205],"observed":[206],"rodents.":[210],"former":[213],"observations":[214,359],"rodents,":[216],"triggering":[218,294],"not":[224,340,405],"or":[229,242],"normoxic":[230],"increase":[231],"normocapnia,":[237],"without":[238,500],"changes":[239,277,416],"pH":[241],"sufficed":[245],"suppress":[247],"hypoxia.":[253,382],"Together":[254],"studies,":[258],"these":[259],"results":[260,439],"have":[261,371,440,471],"dependent":[268,460],"on,":[269],"triggered":[271,407],"by,":[272],"deprivation,":[274],"affinity":[281],"play":[282],"role":[284,374],"Increased":[299],"circulating":[300],"proinflammatory":[304,325],"cytokine":[305],"IL-6":[306,338,369],"four":[313],"days":[314],"exposure":[317],"as":[318,481],"compared":[319],"sea":[321],"level.":[322],"other":[324],"cytokines":[326],"IL-1":[327],"beta,":[328],"TNF":[330],"alpha":[331],"remained":[332],"unchanged,":[333],"increased":[336],"serum":[337,352,356,428],"did":[339],"induce":[341],"c-reactive":[344],"protein.":[345],"However,":[346],"relation":[348,423],"shown":[350,391,472],"between":[351,424],"IL-6,":[353],"SaO2,":[354],"EPO.":[357],"These":[358,438],"confirm":[362],"earlier":[363],"vitro":[365],"may":[370],"co-stimulatory":[373],"presence":[380],"Comparable":[383],"circadian":[384],"were":[390],"sedentary":[393],"subjects,":[394],"athletes,":[395],"but":[398],"hypoxaemic":[399],"subjects.":[400],"Human":[401],"one":[409],"hour":[410],"high-intensity":[412],"exercise,":[413],"whereas":[414],"longitudinal":[415],"exercise":[418],"showed":[419],"trend":[421],"production,":[427,452,480],"concentration":[429],"free":[431],"testosterone,":[432],"indices":[434],"body":[436],"composition.":[437],"endogenous,":[443],"probably":[444],"hormonal,":[445],"oxygen-independent":[447],"which":[453],"at":[455],"variance":[456],"Conclusively,":[467],"present":[469],"investigations":[470],"described":[482],"rodents":[486],"cell-culture":[488],"models,":[489],"cannot":[490],"applied":[492],"physiology":[495],"modifications.":[501]},"counts_by_year":[{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}