{"id":"https://openalex.org/W865080982","doi":null,"title":"On the tissue-specific processing of procholecystokinin in the brain and gut--a short review.","display_name":"On the tissue-specific processing of procholecystokinin in the brain and gut--a short review.","publication_year":2003,"publication_date":"2003-12-01","ids":{"openalex":"https://openalex.org/W865080982","mag":"865080982","pmid":"https://pubmed.ncbi.nlm.nih.gov/15075450"},"language":"en","primary_location":{"id":"pmid:15075450","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15075450","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091673364","display_name":"Jens Frederik Rehfeld","orcid":"https://orcid.org/0000-0002-4718-9571","observed_orcids":["https://orcid.org/0000-0002-4718-9571"]},"institutions":[{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"J F Rehfeld","raw_affiliation_strings":["University Department of Clinical Biochemistry Rigshospitalet, Copenhagen, Denmark. rehfeld@rh.dk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Department of Clinical Biochemistry Rigshospitalet, Copenhagen, Denmark. rehfeld@rh.dk","institution_ids":["https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105396365","display_name":"J R Bungaard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J R Bungaard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019872451","display_name":"Lennart Jan Friis-Hansen","orcid":"https://orcid.org/0000-0002-7222-0163","observed_orcids":["https://orcid.org/0000-0002-7222-0163"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Friis-Hansen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5085229618","display_name":"Jens Peter Goetze","orcid":"https://orcid.org/0000-0001-6356-3829","observed_orcids":["https://orcid.org/0000-0001-6356-3829"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J P Goetze","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4007,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.4653877,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"54 Suppl 4","issue":null,"first_page":"73","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholecystokinin","display_name":"cholecystokinin","score":0.9779999852180481},{"id":"https://openalex.org/keywords/prohormone-convertase-1","display_name":"prohormone convertase 1","score":0.9369999766349792},{"id":"https://openalex.org/keywords/prohormone-convertase-2","display_name":"prohormone convertase 2","score":1.0},{"id":"https://openalex.org/keywords/cck-8","display_name":"CCK-8","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cck-33","display_name":"CCK-33","score":0.9120000004768372},{"id":"https://openalex.org/keywords/intestinal-endocrine-cells","display_name":"intestinal endocrine cells","score":0.7350000143051147},{"id":"https://openalex.org/keywords/brain-neurons","display_name":"brain neurons","score":0.6439999938011169},{"id":"https://openalex.org/keywords/peptide-hormones","display_name":"peptide hormones","score":0.5600000023841858},{"id":"https://openalex.org/keywords/peptide-neurotransmitters","display_name":"peptide neurotransmitters","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C2777593968","wikidata":"https://www.wikidata.org/wiki/Q60315441","display_name":"Cholecystokinin","level":3,"score":0.8152084946632385},{"id":"https://openalex.org/C103395026","wikidata":"https://www.wikidata.org/wiki/Q5380231","display_name":"Enteroendocrine cell","level":4,"score":0.7871756553649902},{"id":"https://openalex.org/C2780090379","wikidata":"https://www.wikidata.org/wiki/Q419119","display_name":"Prohormone","level":3,"score":0.7499791383743286},{"id":"https://openalex.org/C2910756308","wikidata":"https://www.wikidata.org/wiki/Q7250439","display_name":"Prohormone convertase","level":4,"score":0.5846887826919556},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5759600400924683},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49513497948646545},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4907160997390747},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46539080142974854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4168270230293274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3924318850040436},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3712913393974304},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.3674238920211792},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10438945889472961},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0768018364906311}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002766","descriptor_name":"Cholecystokinin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002766","descriptor_name":"Cholecystokinin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002766","descriptor_name":"Cholecystokinin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002766","descriptor_name":"Cholecystokinin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:15075450","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15075450","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Comparative Study"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/a400a372-c753-4354-b57b-1cc197c8e54c","doi":null,"is_oa":false,"landing_page_url":"https://www.scopus.com/pages/publications/31044453754","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rehfeld, J F, Bungaard, J R, Friis-Hansen, L & Goetze, J P 2003, 'On the tissue-specific processing of procholecystokinin in the brain and gut--a short review.', Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, vol. 54 Suppl 4, pp. 73-79.","raw_type":"info:eu-repo/semantics/review"},{"id":"mag:865080982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15075450","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W14408915","https://openalex.org/W122818534","https://openalex.org/W164162904","https://openalex.org/W1682371140","https://openalex.org/W1978521428","https://openalex.org/W1986645508","https://openalex.org/W2000337400","https://openalex.org/W2013280701","https://openalex.org/W2013400253","https://openalex.org/W2022527113","https://openalex.org/W2126681559","https://openalex.org/W2140638986","https://openalex.org/W2156711661","https://openalex.org/W2164369519","https://openalex.org/W2168501870"],"related_works":["https://openalex.org/W2036077009","https://openalex.org/W2164369519","https://openalex.org/W2075067131","https://openalex.org/W2021637956","https://openalex.org/W2559836489","https://openalex.org/W1986405955","https://openalex.org/W1982042370","https://openalex.org/W2034326835","https://openalex.org/W2017219686","https://openalex.org/W2056535755"],"abstract_inverted_index":{"Cholecystokinin":[0],"(CCK)":[1],"is":[2,66],"a":[3,11,78,139,163,204,266,278],"major":[4,12],"peptide":[5,13,213],"hormone":[6],"in":[7,15,42,98,118,149,166,214,228,248,281,287],"the":[8,16,51,58,61,68,72,99,109,145,152,167,173,184,193,215,243,252,260,282,288,293],"gut":[9,74,216],"and":[10,28,38,45,60,82,96,115,120,125,129,182,198,223],"transmitter":[14],"brain.":[17],"Its":[18],"synthesis":[19],"requires":[20],"endoproteolytic":[21],"cleavage":[22],"of":[23,53,80,85,94,101,111,123,144,155,169,176,186,195,207,217,234,245,254,263,284,295],"proCCK":[24,54,102,156,177,235,264],"at":[25,239],"several":[26],"mono-":[27],"dibasic":[29],"sites":[30],"by":[31,107,242,272],"prohormone":[32,273],"convertases":[33],"(PCs).":[34],"Of":[35],"these,":[36],"PC1":[37,95,124,135,160,218,246,276],"PC2":[39,97,126,146,291],"are":[40],"expressed":[41],"cerebral":[43,121,153,232],"neurons":[44],"intestinal":[46,170,174],"endocrine":[47,73],"cells.":[48],"Characteristically,":[49],"however,":[50,237],"processing":[52,100,113,154,168,188,233,262,294],"varies":[55],"markedly":[56],"between":[57],"brain":[59,296],"gut.":[62],"In":[63],"neurons,":[64],"CCK-8":[65],"always":[67],"predominating":[69],"form,":[70],"whereas":[71,290],"cells":[75],"(I-cells)":[76],"contain":[77],"mixture":[79],"small":[81],"larger":[83],"CCK-peptides":[84],"which":[86],"CCK-33":[87],"or":[88],"CCK-22":[89],"often":[90],"predominate.":[91],"The":[92,134,209,231,256],"role":[93,280],"have":[103],"now":[104],"been":[105],"examined":[106],"measuring":[108],"concentrations":[110,185],"prohormone,":[112],"intermediates":[114,189],"amidated":[116],"end-products":[117],"jejunal":[119],"extracts":[122],"deficient":[127,219],"mice":[128,137,220],"corresponding":[130],"wild":[131],"type":[132],"controls.":[133],"null":[136,147],"revealed":[138],"pattern":[140],"opposite":[141],"to":[142,203,251,265],"that":[143,259],"mice,":[148],"whom":[150],"only":[151,210,227],"was":[157,178,201,221,225],"affected.":[158],"Thus":[159],"knockouts":[161],"reveal":[162],"severe":[164],"block":[165],"proCCK.":[171,297],"Accordingly,":[172],"concentration":[175,194],"many":[179],"fold":[180],"increased,":[181],"also":[183],"different":[187],"were":[190],"raised;":[191],"but":[192],"bioactive,":[196],"alpha-amidated":[197],"O-sulfated":[199],"CCK":[200,212,286],"reduced":[202],"few":[205],"percent":[206],"normal.":[208],"bioactive":[211],"CCK-22,":[222],"it":[224],"present":[226],"trace":[229],"amounts.":[230],"was,":[236],"not":[238],"all":[240],"affected":[241],"lack":[244],"-":[247],"sharp":[249],"contrast":[250],"effect":[253],"PC2.":[255],"results":[257],"show":[258],"tissue-specific":[261],"large":[267],"extent":[268],"can":[269],"be":[270],"explained":[271],"convertases,":[274],"as":[275],"plays":[277],"decisive":[279],"maturation":[283],"hormonal":[285],"gut,":[289],"governs":[292]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}