{"id":"https://openalex.org/W86430867","doi":null,"title":"Indices to assess patients with systemic lupus erythematosus in clinical trials, long-term observational studies, and clinical care.","display_name":"Indices to assess patients with systemic lupus erythematosus in clinical trials, long-term observational studies, and clinical care.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W86430867","mag":"86430867","pmid":"https://pubmed.ncbi.nlm.nih.gov/24238093"},"language":"en","primary_location":{"id":"pmid:24238093","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24238093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"I Castrej\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"I Castrej\u00f3n","raw_affiliation_strings":["Division of Rheumatology, Rush University School of Medicine, Chicago, USA. isabelcastrejonf@gmail.com","Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands. m.tsangasjoe@vumc.nl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Rush University School of Medicine, Chicago, USA. isabelcastrejonf@gmail.com","institution_ids":["https://openalex.org/I49886154"]},{"raw_affiliation_string":"Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands. m.tsangasjoe@vumc.nl","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C Tani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Tani","raw_affiliation_strings":["Rheumatology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Jolly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Jolly","raw_affiliation_strings":["Rheumatology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"A Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"M Mosca","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Mosca","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.3301,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.95761079,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"32","issue":"1","first_page":"95","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antimalarial-drugs","display_name":"antimalarial drugs","score":0.9309999942779541},{"id":"https://openalex.org/keywords/hydroxychloroquine","display_name":"hydroxychloroquine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/drug-intolerance","display_name":"drug intolerance","score":0.6119999885559082},{"id":"https://openalex.org/keywords/dosage","display_name":"dosage","score":0.4449999928474426},{"id":"https://openalex.org/keywords/lean-body-weight","display_name":"lean body weight","score":0.9259999990463257},{"id":"https://openalex.org/keywords/retinopathy","display_name":"retinopathy","score":0.7080000042915344},{"id":"https://openalex.org/keywords/lupus-nephritis","display_name":"lupus nephritis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/disease-duration","display_name":"disease duration","score":0.7350000143051147},{"id":"https://openalex.org/keywords/damage-accrual","display_name":"damage accrual","score":0.8619999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9326105713844299},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.8334134817123413},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.7863345146179199},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.6962692141532898},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6637668609619141},{"id":"https://openalex.org/C2775915377","wikidata":"https://www.wikidata.org/wiki/Q188297","display_name":"Lupus erythematosus","level":3,"score":0.5975344777107239},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5167917013168335},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.4508790373802185},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.4358583688735962},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.34580785036087036},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2799663245677948},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001291","descriptor_name":"Attitude of Health Personnel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006886","descriptor_name":"Hydroxychloroquine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006886","descriptor_name":"Hydroxychloroquine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007722","descriptor_name":"Health Knowledge, Attitudes, Practice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009426","descriptor_name":"Netherlands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010818","descriptor_name":"Practice Patterns, Physicians'","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017410","descriptor_name":"Practice Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017723","descriptor_name":"Drug Utilization Review","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019983","descriptor_name":"Guideline Adherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054796","descriptor_name":"Drug Dosage Calculations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:24238093","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24238093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Comparative Study"},{"id":"pmid:25365095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25365095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},{"id":"pmh:oai:arpi.unipi.it:11568/765638","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/765638","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:86430867","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25365095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W475345","https://openalex.org/W55550856","https://openalex.org/W78569768","https://openalex.org/W93190295","https://openalex.org/W95171655","https://openalex.org/W125583516","https://openalex.org/W143178846","https://openalex.org/W1491121546","https://openalex.org/W1542566329","https://openalex.org/W1549502118","https://openalex.org/W1560659636","https://openalex.org/W1587415643","https://openalex.org/W1965683411","https://openalex.org/W1975640941","https://openalex.org/W1979673901","https://openalex.org/W1985153254","https://openalex.org/W1987449933","https://openalex.org/W1989281294","https://openalex.org/W1989525615","https://openalex.org/W1992526360","https://openalex.org/W1995157280","https://openalex.org/W1995365224","https://openalex.org/W1999052930","https://openalex.org/W2000779116","https://openalex.org/W2004135257","https://openalex.org/W2004761057","https://openalex.org/W2008221974","https://openalex.org/W2014873778","https://openalex.org/W2015040567","https://openalex.org/W2017110723","https://openalex.org/W2022376170","https://openalex.org/W2029002123","https://openalex.org/W2035752671","https://openalex.org/W2037377025","https://openalex.org/W2040247545","https://openalex.org/W2046409618","https://openalex.org/W2053709659","https://openalex.org/W2064999867","https://openalex.org/W2070527591","https://openalex.org/W2076393555","https://openalex.org/W2080370529","https://openalex.org/W2089461179","https://openalex.org/W2091468965","https://openalex.org/W2091679727","https://openalex.org/W2092648035","https://openalex.org/W2093460800","https://openalex.org/W2094250030","https://openalex.org/W2096286605","https://openalex.org/W2099430274","https://openalex.org/W2106654072","https://openalex.org/W2108905161","https://openalex.org/W2110793425","https://openalex.org/W2111416025","https://openalex.org/W2112641935","https://openalex.org/W2119837784","https://openalex.org/W2126563911","https://openalex.org/W2127487651","https://openalex.org/W2128859662","https://openalex.org/W2130385572","https://openalex.org/W2133925071","https://openalex.org/W2134233670","https://openalex.org/W2135252441","https://openalex.org/W2136149088","https://openalex.org/W2137889661","https://openalex.org/W2140753074","https://openalex.org/W2156489607","https://openalex.org/W2157038471","https://openalex.org/W2158927265","https://openalex.org/W2162542566","https://openalex.org/W2168146874","https://openalex.org/W2170961264","https://openalex.org/W2235150943","https://openalex.org/W2265349279","https://openalex.org/W2268633996","https://openalex.org/W2358445529","https://openalex.org/W2408763971","https://openalex.org/W2414252266","https://openalex.org/W2467392721"],"related_works":["https://openalex.org/W2315588532","https://openalex.org/W3163864569","https://openalex.org/W4297374890","https://openalex.org/W4404622494","https://openalex.org/W4379649916","https://openalex.org/W4403078774","https://openalex.org/W2021408551","https://openalex.org/W4397042100","https://openalex.org/W4285588030","https://openalex.org/W2951264388"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Antimalarials":[1],"(AMs)":[2],"have":[3],"been":[4],"demonstrated":[5],"to":[6,88,135,185],"reduce":[7],"disease":[8,48,72,173,196],"activity":[9],"and":[10,39,71,78,201],"prevent":[11],"damage":[12,199],"accrual":[13,200],"in":[14,21,59,65,100,130,217,226],"SLE.":[15,25],"Recent":[16],"guidelines":[17],"advise":[18],"prescribing":[19],"AMs":[20,107,155,190],"all":[22,60],"patients":[23,63,99,227],"with":[24,52,193,228],"We":[26],"present":[27],"data":[28],"from":[29,241],"the":[30,101,147,158,212],"Amsterdam":[31],"Lupus":[32],"Cohort":[33],"on":[34],"use,":[35],"reasons":[36],"for":[37,157,223],"non-use,":[38],"dosage":[40,124],"related":[41,49],"intolerance":[42,161],"of":[43,80,84,96,125,144,189,204,211,214,236],"AMs,":[44],"as":[45,47],"well":[46],"variables":[50],"associated":[51,192],"non-use.":[53],"METHODS:":[54],"AM":[55,215],"use":[56,154],"was":[57,127,191],"assessed":[58],"our":[61],"SLE":[62,98],"included":[64],"a":[66,165,194,202],"longitudinal":[67],"cohort":[68],"study.":[69],"Demographic":[70],"characteristics":[73],"were":[74,92,105],"compared":[75],"between":[76],"users":[77],"non-users":[79],"AMs.":[81,122],"Daily":[82,123,234],"dosages":[83,143,235],"hydroxychloroquine":[85,237],"(HCQ)":[86],"according":[87],"lean":[89,136],"body":[90,137],"weight":[91],"calculated.":[93],"RESULTS:":[94],"Out":[95],"190":[97],"cohort,":[102],"139":[103],"(73.2%)":[104],"using":[106],"during":[108],"their":[109],"last":[110],"visit,":[111],"predominantly":[112],"HCQ":[113,126,145,183],"(136/139,":[114],"97.8%),":[115],"while":[116],"92.1%":[117],"(175/190)":[118],"had":[119,141],"ever":[120],"used":[121],"400":[128],"mg":[129],"115/136":[131],"(84.6%)":[132],"patients.":[133],"According":[134],"weight,":[138],"119/136":[139],"(87.5%)":[140],"daily":[142],"above":[146],"recommended":[148],"6.5":[149],"mg/kg.":[150],"Patients":[151],"did":[152],"not":[153],"(n=51)":[156],"following":[159],"reasons:":[160],"(n=16),":[162],"discontinued":[163,182],"without":[164],"documented":[166],"reason":[167],"(n=11),":[168],"never":[169],"initiated":[170],"(n=9),":[171],"quiescent":[172],"(n=7),":[174],"contraindication":[175],"(n=2),":[176],"other":[177],"(n=6).":[178],"Only":[179],"one":[180],"patient":[181],"due":[184],"AM-related":[186],"retinopathy.":[187],"Non-use":[188],"longer":[195],"duration,":[197],"higher":[198],"history":[203],"lupus":[205,229],"nephritis.":[206],"CONCLUSIONS:":[207],"Despite":[208],"increased":[209],"awareness":[210],"importance":[213],"treatment":[216],"SLE,":[218],"there":[219],"is":[220],"still":[221],"room":[222],"improvement,":[224],"especially":[225],"nephritis":[230],"and/or":[231],"long-standing":[232],"disease.":[233],"often":[238],"exceeded":[239],"recommendations":[240],"guidelines,":[242],"but":[243],"are":[244],"generally":[245],"well-tolerated.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}