{"id":"https://openalex.org/W8630125","doi":"https://doi.org/10.1182/blood.v79.3.666.666","title":"Flow cytometric assessment of human T-cell differentiation in thymus and bone marrow","display_name":"Flow cytometric assessment of human T-cell differentiation in thymus and bone marrow","publication_year":1992,"publication_date":"1992-02-01","ids":{"openalex":"https://openalex.org/W8630125","doi":"https://doi.org/10.1182/blood.v79.3.666.666","mag":"8630125","pmid":"https://pubmed.ncbi.nlm.nih.gov/1370641"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v79.3.666.666","doi":"https://doi.org/10.1182/blood.v79.3.666.666","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v79.3.666.666","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006731477","display_name":"Leon W.M.M. Terstappen","orcid":"https://orcid.org/0000-0001-5944-3787","observed_orcids":["https://orcid.org/0000-0001-5944-3787"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"LW Terstappen","raw_affiliation_strings":["Becton Dickinson Immunocytometry Systems, San Jose, CA 95131"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Becton Dickinson Immunocytometry Systems, San Jose, CA 95131","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069403333","display_name":"Sherry C. Huang","orcid":"https://orcid.org/0000-0002-5457-5040","observed_orcids":["https://orcid.org/0000-0002-5457-5040"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Huang","raw_affiliation_strings":["Becton Dickinson Immunocytometry Systems, San Jose, CA 95131"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Becton Dickinson Immunocytometry Systems, San Jose, CA 95131","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088595140","display_name":"Louis J. Picker","orcid":"https://orcid.org/0000-0003-0546-398X","observed_orcids":["https://orcid.org/0000-0003-0546-398X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"LJ Picker","raw_affiliation_strings":["Becton Dickinson Immunocytometry Systems, San Jose, CA 95131"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Becton Dickinson Immunocytometry Systems, San Jose, CA 95131","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":11.1151,"has_fulltext":false,"cited_by_count":234,"citation_normalized_percentile":{"value":0.98856068,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"79","issue":"3","first_page":"666","last_page":"677"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-differentiation","display_name":"T cell differentiation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/thymocytes","display_name":"thymocytes","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cd34","display_name":"CD34","score":0.8939999938011169},{"id":"https://openalex.org/keywords/lecam-1","display_name":"LECAM-1","score":0.7379999756813049},{"id":"https://openalex.org/keywords/cd3","display_name":"CD3","score":0.4729999899864197},{"id":"https://openalex.org/keywords/cd4","display_name":"CD4","score":0.44699999690055847},{"id":"https://openalex.org/keywords/cd8","display_name":"CD8","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prothymocytes","display_name":"prothymocytes","score":0.8220000267028809},{"id":"https://openalex.org/keywords/fetal-thymus","display_name":"fetal thymus","score":0.765999972820282},{"id":"https://openalex.org/keywords/pediatric-thymus","display_name":"pediatric thymus","score":0.9620000123977661},{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.4480000138282776},{"id":"https://openalex.org/keywords/cd38","display_name":"CD38","score":0.46299999952316284},{"id":"https://openalex.org/keywords/cd1","display_name":"CD1","score":0.5490000247955322},{"id":"https://openalex.org/keywords/cd10","display_name":"CD10","score":0.843999981880188},{"id":"https://openalex.org/keywords/cd7","display_name":"CD7","score":0.4339999854564667},{"id":"https://openalex.org/keywords/cd5","display_name":"CD5","score":0.7400000095367432},{"id":"https://openalex.org/keywords/cd2","display_name":"CD2","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cd45ra","display_name":"CD45RA","score":0.7239999771118164},{"id":"https://openalex.org/keywords/integrin-alpha4","display_name":"CD49d","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.7557931542396545},{"id":"https://openalex.org/C159912055","wikidata":"https://www.wikidata.org/wiki/Q14885119","display_name":"CD38","level":4,"score":0.6920583248138428},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.598746657371521},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5668661594390869},{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.5299787521362305},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5294228196144104},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5052629113197327},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.46343833208084106},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4602282643318176},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.4504365921020508},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43483906984329224},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4300052523612976},{"id":"https://openalex.org/C113067387","wikidata":"https://www.wikidata.org/wiki/Q14912836","display_name":"CD5","level":3,"score":0.4248325526714325},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3649793565273285},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3333802819252014},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13800689578056335}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000945","descriptor_name":"Antigens, Differentiation, T-Lymphocyte","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v79.3.666.666","doi":"https://doi.org/10.1182/blood.v79.3.666.666","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v79.3.666.666","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v79.3.666.bloodjournal793666","doi":"https://doi.org/10.1182/blood.v79.3.666.bloodjournal793666","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v79.3.666.bloodjournal793666","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:1370641","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1370641","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W66436105","https://openalex.org/W74017565","https://openalex.org/W87179495","https://openalex.org/W113943006","https://openalex.org/W281852963","https://openalex.org/W1484655458","https://openalex.org/W1493836238","https://openalex.org/W1548353348","https://openalex.org/W1606710461","https://openalex.org/W1637823542","https://openalex.org/W1661591147","https://openalex.org/W1663602567","https://openalex.org/W1839387778","https://openalex.org/W1996787107","https://openalex.org/W2016191371","https://openalex.org/W2025572360","https://openalex.org/W2030641259","https://openalex.org/W2035135369","https://openalex.org/W2038879439","https://openalex.org/W2045683721","https://openalex.org/W2053164836","https://openalex.org/W2053350302","https://openalex.org/W2074731733","https://openalex.org/W2095688897","https://openalex.org/W2097231057","https://openalex.org/W2109553674","https://openalex.org/W2122959032","https://openalex.org/W2123487912","https://openalex.org/W2137696432","https://openalex.org/W2152881005","https://openalex.org/W2163757105","https://openalex.org/W2173828780","https://openalex.org/W2263367672","https://openalex.org/W2410128635","https://openalex.org/W2410813489","https://openalex.org/W2411074463","https://openalex.org/W2413474868","https://openalex.org/W2467457560","https://openalex.org/W2468843753"],"related_works":["https://openalex.org/W7095124901","https://openalex.org/W2050990545","https://openalex.org/W7099953727","https://openalex.org/W242181897","https://openalex.org/W2402443265","https://openalex.org/W2566238648","https://openalex.org/W7096574681","https://openalex.org/W2079576390","https://openalex.org/W7099783609","https://openalex.org/W1548353348"],"abstract_inverted_index":{"Using":[0],"multidimensional":[1],"flow":[2,311,350],"cytometry":[3,351],"we":[4],"have":[5],"defined":[6,341],"and":[7,24,39,53,76,87,96,121,165,318,334,346],"quantified":[8],"the":[9,20,36,113,127,151,162,219,223,237,255,279,282,286,295,310,327,356],"human":[10,48,230],"T-cell":[11,234,336],"differentiation":[12,177,315],"pathway,":[13],"focusing":[14],"on":[15,145],"those":[16],"events":[17,358],"occurring":[18],"among":[19,161],"most":[21],"immature":[22],"thymocytes":[23,31,63,90,147,154,226],"putative":[25,287],"bone":[26],"marrow":[27,345],"(BM)":[28],"T-precursors.":[29],"Early":[30],"were":[32,64,77,202,245],"found":[33],"to":[34,331],"express":[35],"CD34":[37,100,137],"antigen":[38,182],"consisted":[40],"of":[41,45,94,115,119,129,133,142,153,175,186,216,222,254,272,281,285,297,312,339,355],"a":[42,105,171],"mean":[43],"1.2%":[44],"cells":[46,196,217,274,303],"within":[47],"pediatric":[49,164,209],"(n":[50,58],"=":[51,59,212],"9)":[52],"2.0%":[54],"in":[55,108,205,229,248,264,304,326,344],"fetal":[56,167,207,249,305],"thymi":[57,210],"4).":[60],"All":[61],"CD34+":[62,225,256],"atypical":[65],"blast":[66],"by":[67,112,294,348],"morphology,":[68],"expressed":[69,275],"intracytoplasmatic,":[70],"but":[71,98,258],"not":[72,203,260],"cell":[73,78,189,313],"surface,":[74],"CD3,":[75,277],"surface":[79,92,314],"CD2+,":[80,243],"CD5+,":[81,242],"CD7+,":[82,241,299],"CD38+,":[83],"CD45+,":[84],"CD45RA+,":[85],"CD49d+,":[86],"LECAM-1(Leu8)high.":[88],"CD34high":[89],"lacked":[91],"expression":[93,101,118,132,141,183],"CD4":[95,109],"CD8,":[97],"as":[99,150],"diminished":[102,135],"there":[103],"was":[104,158,227,291],"coordinate":[106],"increase":[107],"levels,":[110],"followed":[111],"appearance":[114],"CD8.":[116],"The":[117,139,214,329],"CD1":[120],"CD10":[122],"also":[123],"increased":[124],"concomitant":[125],"with":[126,136,181,218,236,268],"loss":[128],"CD34,":[130],"whereas":[131],"LECAM-1":[134],"downregulation.":[138],"differential":[140],"these":[143,156,273],"antigens":[144],"early":[146,176],"(as":[148],"well":[149],"number":[152],"displaying":[155],"patterns)":[157],"highly":[159],"reproducible":[160],"nine":[163],"four":[166],"specimens":[168,250],"examined,":[169],"suggesting":[170,278],"precise,":[172],"stereotyped":[173],"regulation":[174],"events.":[178],"Cell":[179],"populations":[180,338],"patterns":[184],"suggestive":[185],"pluripotent":[187],"stem":[188,195],"(CD34high,":[190],"CD38-),":[191],"or":[192,199,208],"non-T-lineage":[193],"committed":[194],"(CD34+,":[197,240],"CD33+":[198],"CD34+,":[200],"CD19+)":[201],"identified":[204,247],"either":[206],"(sensitivity":[211],"1/10(4)).":[213],"presence":[215,280],"antigenic":[220],"profile":[221],"earliest":[224],"explored":[228],"BM.":[231,328],"Putative":[232],"BM":[233],"precursors":[235],"appropriate":[238],"phenotype":[239],"LECAM-1high)":[244],"readily":[246],"(constituting":[251],"+/-":[252],"2%":[253],"population),":[257],"could":[259],"be":[261],"reliably":[262],"detected":[263],"adults.":[265],"In":[266],"contrast":[267],"thymi,":[269],"only":[270],"13%":[271],"cytoplasmatic":[276],"immediate":[283],"precursor":[284,337],"prothymocyte":[288],"population.":[289],"This":[290],"further":[292],"supported":[293],"detection":[296],"CD34bright,":[298],"CD2-,":[300],"CD5-,":[301],"LECAM-1moderate":[302],"specimens.":[306],"Our":[307],"results":[308],"document":[309],"during":[316],"T-lymphopoiesis":[317],"suggest":[319],"that":[320],"T-lineage":[321,360],"features":[322],"are":[323],"first":[324],"acquired":[325],"ability":[330],"reproducibly":[332],"identify":[333],"isolate":[335],"precisely":[340],"maturational":[342],"stage":[343],"thymus":[347],"multiparameter":[349],"will":[352],"facilitate":[353],"characterization":[354],"molecular":[357],"controlling":[359],"differentiation.":[361]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
