{"id":"https://openalex.org/W8600115","doi":"https://doi.org/10.1016/b978-0-08-027530-7.50014-5","title":"PCBs AS MICROSOMAL ENZYME INDUCERS: STRUCTURE-ACTIVITY RULES","display_name":"PCBs AS MICROSOMAL ENZYME INDUCERS: STRUCTURE-ACTIVITY RULES","publication_year":1981,"publication_date":"1981-01-01","ids":{"openalex":"https://openalex.org/W8600115","doi":"https://doi.org/10.1016/b978-0-08-027530-7.50014-5","mag":"8600115"},"language":"en","primary_location":{"id":"doi:10.1016/b978-0-08-027530-7.50014-5","doi":"https://doi.org/10.1016/b978-0-08-027530-7.50014-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-08-027530-7.50014-5","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology of Halogenated Hydrocarbons","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4212776326","display_name":"Toxicology of Halogenated Hydrocarbons"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036575223","display_name":"Stephen H Safe","orcid":"https://orcid.org/0000-0002-2115-3060","observed_orcids":["https://orcid.org/0000-0002-2115-3060"]},"institutions":[{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"S. Safe","raw_affiliation_strings":["The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph, Ontario N1G 2W1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph, Ontario N1G 2W1, Canada","institution_ids":["https://openalex.org/I79817857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112007839","display_name":"Andrew Parkinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"A. Parkinson","raw_affiliation_strings":["The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph, Ontario N1G 2W1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph, Ontario N1G 2W1, Canada","institution_ids":["https://openalex.org/I79817857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065258484","display_name":"Larry W. Robertson","orcid":"https://orcid.org/0000-0002-3926-501X","observed_orcids":["https://orcid.org/0000-0002-3926-501X"]},"institutions":[{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"L. Robertson","raw_affiliation_strings":["The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph, Ontario N1G 2W1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph, Ontario N1G 2W1, Canada","institution_ids":["https://openalex.org/I79817857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072091591","display_name":"R. Cockerline","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"R. Cockerline","raw_affiliation_strings":["The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph, Ontario N1G 2W1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph, Ontario N1G 2W1, Canada","institution_ids":["https://openalex.org/I79817857"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078757775","display_name":"Lorna M. Safe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"L. Safe","raw_affiliation_strings":["The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph, Ontario N1G 2W1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph, Ontario N1G 2W1, Canada","institution_ids":["https://openalex.org/I79817857"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79817857"],"apc_list":null,"apc_paid":null,"fwci":0.8265,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.62835249,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"106","last_page":"119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.13289999961853027,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polychlorinated-biphenyls","display_name":"polychlorinated biphenyls","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pcb-congeners","display_name":"PCB congeners","score":0.7509999871253967},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8550000190734863},{"id":"https://openalex.org/keywords/hepatic-microsomal-enzyme-induction","display_name":"hepatic microsomal enzyme induction","score":0.9259999990463257},{"id":"https://openalex.org/keywords/aroclor-1242","display_name":"Aroclor 1242","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C97343561","wikidata":"https://www.wikidata.org/wiki/Q18026873","display_name":"HEXA","level":2,"score":0.9163650274276733},{"id":"https://openalex.org/C2776365360","wikidata":"https://www.wikidata.org/wiki/Q211171","display_name":"Polychlorinated biphenyl","level":2,"score":0.7340249419212341},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.6172114014625549},{"id":"https://openalex.org/C2780591471","wikidata":"https://www.wikidata.org/wiki/Q410915","display_name":"Biphenyl","level":2,"score":0.5973191261291504},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5769863724708557},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5626658201217651},{"id":"https://openalex.org/C132154277","wikidata":"https://www.wikidata.org/wiki/Q5381545","display_name":"Enzyme inducer","level":3,"score":0.5487419962882996},{"id":"https://openalex.org/C2225953","wikidata":"https://www.wikidata.org/wiki/Q1661899","display_name":"Inducer","level":3,"score":0.5056302547454834},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4852618873119354},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.42184579372406006},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.211656391620636},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10138699412345886},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/b978-0-08-027530-7.50014-5","doi":"https://doi.org/10.1016/b978-0-08-027530-7.50014-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-08-027530-7.50014-5","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology of Halogenated Hydrocarbons","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W126145571","https://openalex.org/W1496489701","https://openalex.org/W1519694447","https://openalex.org/W1529330230","https://openalex.org/W1546369443","https://openalex.org/W1563928419","https://openalex.org/W1584235297","https://openalex.org/W1599349887","https://openalex.org/W1775964807","https://openalex.org/W1938244805","https://openalex.org/W1951469402","https://openalex.org/W1970206611","https://openalex.org/W1976078616","https://openalex.org/W1978067719","https://openalex.org/W1978765130","https://openalex.org/W1981035934","https://openalex.org/W1982208588","https://openalex.org/W2014989612","https://openalex.org/W2022800264","https://openalex.org/W2023749301","https://openalex.org/W2026774371","https://openalex.org/W2036208454","https://openalex.org/W2054792239","https://openalex.org/W2061427284","https://openalex.org/W2062156057","https://openalex.org/W2062617838","https://openalex.org/W2072260297","https://openalex.org/W2073709279","https://openalex.org/W2074843250","https://openalex.org/W2088731269","https://openalex.org/W2091816663","https://openalex.org/W2093092186","https://openalex.org/W2100837269","https://openalex.org/W2315704545","https://openalex.org/W2338536491","https://openalex.org/W2572790299","https://openalex.org/W4205791950","https://openalex.org/W6633906188","https://openalex.org/W6704121088"],"related_works":["https://openalex.org/W2021197281","https://openalex.org/W2144755352","https://openalex.org/W2440552656","https://openalex.org/W3008773107","https://openalex.org/W2038166603","https://openalex.org/W2033248946","https://openalex.org/W2074770987","https://openalex.org/W2078330011","https://openalex.org/W1978853059","https://openalex.org/W2010936040"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}