{"id":"https://openalex.org/W8589271","doi":null,"title":"Aerosol orgotein (Ontosein) for the prevention of radiotherapy-induced adverse effects in head and neck cancer patients: a feasibility study.","display_name":"Aerosol orgotein (Ontosein) for the prevention of radiotherapy-induced adverse effects in head and neck cancer patients: a feasibility study.","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W8589271","mag":"8589271","pmid":"https://pubmed.ncbi.nlm.nih.gov/12098008"},"language":"en","primary_location":{"id":"pmid:12098008","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12098008","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasma","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110274721","display_name":"A. Escribano","orcid":"https://orcid.org/0009-0003-3318-5515","observed_orcids":["https://orcid.org/0009-0003-3318-5515"]},"institutions":[{"id":"https://openalex.org/I2800562746","display_name":"Hospital Universitario La Paz","ror":"https://ror.org/01s1q0w69","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800562746"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A Escribano","raw_affiliation_strings":["Department of Radiation Oncology, La Paz University Hospital, Madrid, 28046 Spain. irabanalr@seorl.org","Department of Radiation Oncology, La Paz University Hospital, Madrid, 28046 Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, La Paz University Hospital, Madrid, 28046 Spain. irabanalr@seorl.org","institution_ids":["https://openalex.org/I2800562746"]},{"raw_affiliation_string":"Department of Radiation Oncology, La Paz University Hospital, Madrid, 28046 Spain","institution_ids":["https://openalex.org/I2800562746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048713337","display_name":"Ar\u00e1nzazu Garc\u00eda\u2010Grande","orcid":"https://orcid.org/0000-0001-5737-8918","observed_orcids":["https://orcid.org/0000-0001-5737-8918"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Garc\u00eda-Grande","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"P Monta\u00f1\u00e9s","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Monta\u00f1\u00e9s","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030720356","display_name":"Lara Miralles","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Miralles","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"A Garc\u00eda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800562746","display_name":"Hospital Universitario La Paz","ror":"https://ror.org/01s1q0w69","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800562746"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A Garc\u00eda","raw_affiliation_strings":["Hospital Universitario La Paz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario La Paz","institution_ids":["https://openalex.org/I2800562746"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.00078153,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"49","issue":"3","first_page":"201","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.5669000148773193,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.5669000148773193,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":0.3862000107765198,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.016200000420212746,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orgotein","display_name":"orgotein","score":0.8870000243186951},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.8479999899864197},{"id":"https://openalex.org/keywords/aerosol-administration","display_name":"aerosol administration","score":0.7950000166893005},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.8619999885559082},{"id":"https://openalex.org/keywords/radiotherapy-complications","display_name":"radiotherapy complications","score":0.8320000171661377},{"id":"https://openalex.org/keywords/radiation-toxicity","display_name":"radiation toxicity","score":0.6000000238418579},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/acute-radiation-effects","display_name":"acute radiation effects","score":0.7390000224113464},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.625}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8837606906890869},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.82370924949646},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6359237432479858},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.536978542804718},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5086315870285034},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.49715331196784973},{"id":"https://openalex.org/C2777740455","wikidata":"https://www.wikidata.org/wiki/Q666412","display_name":"Cervix","level":3,"score":0.43629786372184753},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.42596733570098877},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.37404555082321167},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3479987382888794}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008667","descriptor_name":"Metalloproteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008667","descriptor_name":"Metalloproteins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008667","descriptor_name":"Metalloproteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011837","descriptor_name":"Radiation-Protective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011878","descriptor_name":"Radiotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:12098008","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12098008","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasma","raw_type":"Journal Article"},{"id":"mag:8589271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12098008","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2396234555","https://openalex.org/W2412984016","https://openalex.org/W2885446487","https://openalex.org/W2374245957","https://openalex.org/W2069086313","https://openalex.org/W1976010492","https://openalex.org/W2117180570","https://openalex.org/W4384380330","https://openalex.org/W2523248544","https://openalex.org/W2007853189"],"abstract_inverted_index":{"Orgotein":[0],"is":[1,15,38,138],"an":[2],"anti-inflammatory":[3],"superoxide":[4],"dismutase":[5],"agent":[6],"successfully":[7],"used":[8,17,51],"in":[9,18,23,60,86,110,122],"treating":[10,19],"several":[11],"inflammatory":[12],"diseases.":[13],"It":[14,37],"also":[16],"radiation-induced":[20,56,83,119],"adverse":[21,57,84,120],"effects":[22,58,85,121],"difference":[24],"malignancies,":[25],"notably":[26],"breast,":[27],"lung,":[28],"bladder,":[29],"prostate,":[30],"cervix,":[31],"and":[32,34,81,91,113,117,124,140,146],"head":[33,90,123],"neck":[35,92,125],"cancers.":[36],"administered":[39,100],"either":[40],"topically":[41],"or":[42,59],"parenterally.":[43],"To":[44],"our":[45],"knowledge,":[46],"it":[47],"has":[48],"never":[49],"been":[50],"before":[52,101],"for":[53,77,89,142],"prophylaxis":[54],"of":[55,79,115],"aerosol":[61,74,98,135],"form.":[62],"Here":[63],"we":[64],"report":[65],"on":[66,73],"the":[67,144,147],"results":[68,95],"from":[69],"a":[70],"feasibility":[71],"study":[72],"orgotein":[75,99,136],"(Ontosein)":[76],"prevention":[78],"acute":[80,116],"deferred":[82,118],"patients":[87],"treated":[88],"malignancies.":[93],"Our":[94],"show":[96],"that":[97],"each":[102],"radiation":[103],"therapy":[104],"session":[105],"may":[106],"impart":[107],"some":[108],"benefits":[109],"both":[111,143],"incidence":[112],"severity":[114],"cancer":[126],"patients,":[127],"when":[128],"compared":[129],"with":[130],"historical":[131],"controls.":[132],"In":[133],"addition,":[134],"administration":[137],"easy":[139],"convenient":[141],"patient":[145],"radiotherapist.":[148]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
