{"id":"https://openalex.org/W858887","doi":null,"title":"NMR-based metabolomics: translational application and treatment of cancer.","display_name":"NMR-based metabolomics: translational application and treatment of cancer.","publication_year":2007,"publication_date":"2007-12-01","ids":{"openalex":"https://openalex.org/W858887","mag":"858887","pmid":"https://pubmed.ncbi.nlm.nih.gov/18041668"},"language":"en","primary_location":{"id":"pmid:18041668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18041668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in molecular therapeutics","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025904775","display_name":"Natalie Julie Serkova","orcid":"https://orcid.org/0000-0002-4573-3895","observed_orcids":["https://orcid.org/0000-0002-4573-3895"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie J Serkova","raw_affiliation_strings":["University of Colorado Health Sciences Center, Department of Anesthesiology and Radiology, Denver, CO 80262, USA. Natalie.Serkova@uchsc.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Health Sciences Center, Department of Anesthesiology and Radiology, Denver, CO 80262, USA. Natalie.Serkova@uchsc.edu","institution_ids":["https://openalex.org/I4210087413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008288310","display_name":"Jennifer L. Spratlin","orcid":"https://orcid.org/0000-0003-3304-1784","observed_orcids":["https://orcid.org/0000-0003-3304-1784"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L Spratlin","raw_affiliation_strings":["University of Colorado, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado, Denver","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048907012","display_name":"S. Gail Eckhardt","orcid":"https://orcid.org/0000-0002-8103-1620","observed_orcids":["https://orcid.org/0000-0002-8103-1620"]},"institutions":[{"id":"https://openalex.org/I1305023659","display_name":"Livestrong Foundation","ror":"https://ror.org/04ndvz759","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305023659"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Gail Eckhardt","raw_affiliation_strings":["LiveSTRONG Cancer Institutes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LiveSTRONG Cancer Institutes","institution_ids":["https://openalex.org/I1305023659"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1553,"has_fulltext":false,"cited_by_count":96,"citation_normalized_percentile":{"value":0.92986249,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"6","first_page":"572","last_page":"85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nmr-based-metabolomics","display_name":"NMR metabolomics","score":0.9010000228881836},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.9440000057220459},{"id":"https://openalex.org/keywords/n-acetylaspartate","display_name":"N-acetylaspartate","score":0.8180000185966492},{"id":"https://openalex.org/keywords/myo-inositol","display_name":"myo-inositol","score":0.9739999771118164},{"id":"https://openalex.org/keywords/citrate","display_name":"citrate","score":0.8960000276565552},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.7540000081062317},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.9470000267028809},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/treatment-response-monitoring","display_name":"treatment response monitoring","score":0.8619999885559082},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.9620000123977661},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9079999923706055},{"id":"https://openalex.org/keywords/metabolic-regulators","display_name":"metabolic modulators","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tissue-biopsy","display_name":"tissue biopsy","score":0.8330000042915344},{"id":"https://openalex.org/keywords/body-fluids","display_name":"biological fluids","score":0.9179999828338623},{"id":"https://openalex.org/keywords/non-invasive-metabolic-imaging","display_name":"non-invasive metabolic imaging","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.8625081777572632},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.6199158430099487},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.5734381675720215},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5114051699638367},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.5110260248184204},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4383810758590698},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4069954752922058},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3844268321990967},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3787761330604553},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3623753786087036},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3432140350341797},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3249410390853882},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3212081491947174},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3145524561405182},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2188573181629181}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:18041668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18041668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in molecular therapeutics","raw_type":"Journal Article"},{"id":"mag:858887","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18041668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8443509570","display_name":"Metabolic Signature of Imatinib Resistance","funder_award_id":"R21CA108624","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000891461","display_name":"University of Colorado Cancer Center Support Grant","funder_award_id":"P30CA046934","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2399821676","https://openalex.org/W2405805588"],"related_works":["https://openalex.org/W2107226796","https://openalex.org/W187554151","https://openalex.org/W3082821198","https://openalex.org/W7099881112","https://openalex.org/W2566661696","https://openalex.org/W2133307402","https://openalex.org/W7161486131","https://openalex.org/W2104230701","https://openalex.org/W7030248263","https://openalex.org/W2890734918"],"abstract_inverted_index":{"Cancer":[0],"cells":[1],"possess":[2],"a":[3,84,100,113],"highly":[4],"unique":[5],"metabolic":[6,33,115,137,154,160,171],"phenotype":[7],"which":[8,120],"is":[9],"characterized":[10],"by":[11],"high":[12],"glucose":[13],"uptake,":[14],"increased":[15,25],"glycolytic":[16],"activity,":[17,20],"decreased":[18],"mitochondrial":[19],"low":[21],"bioenergetic":[22],"expenditure":[23],"and":[24,58,72,142,145,170],"phospholipid":[26],"turnover.":[27],"In":[28,156],"addition":[29],"to":[30,69,77,111,125,152,162],"these":[31],"general":[32],"markers":[34],"of":[35,75,148],"malignancy,":[36],"tissue-specific":[37],"biochemistry":[38],"has":[39,104,108],"identified":[40],"specific":[41],"endogenous":[42],"metabolites":[43],"found":[44],"in":[45,53,56,60,95,139],"particular":[46],"tumors":[47],"types.":[48],"These":[49],"include":[50],"N-acetyl":[51],"aspartate":[52],"neuroblastoma,":[54],"myo-inositol":[55],"gliomas":[57],"citrate":[59],"prostate":[61],"cancer.":[62],"Metabolic":[63],"profiles":[64],"can":[65,121],"be":[66,123],"readily":[67],"assessed":[68],"monitor":[70],"responsiveness":[71],"the":[73,146],"development":[74],"resistance":[76],"novel":[78,163],"targeted":[79,164],"drugs,":[80,165],"for":[81,135],"example,":[82],"where":[83],"cytostatic":[85],"effect":[86],"rather":[87],"than":[88],"cytotoxicity":[89],"occurs.":[90],"Using":[91],"modern":[92],"analytical":[93],"technologies":[94],"combination":[96],"with":[97],"statistical":[98],"approaches,":[99],"methodology":[101],"termed":[102],"'metabolomics'":[103],"been":[105,109],"developed.":[106],"Metabolomics":[107],"used":[110,124],"generate":[112],"global":[114,136],"profile":[116],"on":[117,159],"patient":[118],"samples,":[119],"then":[122],"determine":[126],"treatment":[127],"response.":[128],"This":[129],"review":[130],"describes":[131],"existing":[132],"NMR-based":[133],"approaches":[134],"profiling":[138],"tissue":[140],"biopsies":[141],"body":[143],"fluids":[144],"use":[147],"non-invasive":[149],"radiological":[150],"techniques":[151],"assess":[153],"biomarkers.":[155],"addition,":[157],"studies":[158],"responses":[161],"including":[166],"tyrosine":[167],"kinase":[168],"inhibitors":[169],"modulators,":[172],"are":[173],"evaluated.":[174]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
