{"id":"https://openalex.org/W858763553","doi":null,"title":"The microrna deregulation in Colorectal Cancer / Yong Fung Lin","display_name":"The microrna deregulation in Colorectal Cancer / Yong Fung Lin","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W858763553","mag":"858763553"},"language":"en","primary_location":{"id":"pmh:oai:studentsrepo.um.edu.my:4586","doi":null,"is_oa":false,"landing_page_url":"http://studentsrepo.um.edu.my/4586/1/Thesis_hardcover_YONG_FUNG_LIN.pdf","pdf_url":"http://studentsrepo.um.edu.my/4586/1/Thesis_hardcover_YONG_FUNG_LIN.pdf","source":{"id":"https://openalex.org/S4406922526","display_name":"University of Malaya Students Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026080405","display_name":"Fung Lin Yong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fung Lin Yong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5026080405"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mirna-dysregulation","display_name":"microRNA dysregulation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/blood-based-biomarkers","display_name":"blood-based biomarkers","score":0.6119999885559082},{"id":"https://openalex.org/keywords/mir-193a-3p","display_name":"miR-193a-3p","score":0.8450000286102295},{"id":"https://openalex.org/keywords/mir-23a","display_name":"miR-23a","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mir-338-5p","display_name":"miR-338-5p","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mir-150","display_name":"miR-150","score":0.7789999842643738},{"id":"https://openalex.org/keywords/mir-342-3p","display_name":"miR-342-3p","score":0.8799999952316284},{"id":"https://openalex.org/keywords/mir-483-3p","display_name":"miR-483-3p","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mir-23b","display_name":"miR-23b","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cancer-diagnosis","display_name":"cancer diagnosis","score":0.4300000071525574},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.640999972820282},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.597000002861023},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.9430000185966492},{"id":"https://openalex.org/keywords/microrna-target-validation","display_name":"miRNA target validation","score":0.6079999804496765},{"id":"https://openalex.org/keywords/mirna-mimics-and-inhibitors","display_name":"miRNA mimics and inhibitors","score":0.6830000281333923},{"id":"https://openalex.org/keywords/noninvasive-biomarkers","display_name":"non-invasive biomarkers","score":0.6510000228881836},{"id":"https://openalex.org/keywords/microrna-expression-profiling","display_name":"miRNA expression profiling","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.855923056602478},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7718042135238647},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6390026807785034},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5312872529029846},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.49609097838401794},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4890662133693695},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.4857623875141144},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42282626032829285},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.40383362770080566},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.39743196964263916},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3876186013221741},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33425450325012207},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30217045545578003},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29289764165878296},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1779729127883911}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:studentsrepo.um.edu.my:4586","doi":null,"is_oa":false,"landing_page_url":"http://studentsrepo.um.edu.my/4586/1/Thesis_hardcover_YONG_FUNG_LIN.pdf","pdf_url":"http://studentsrepo.um.edu.my/4586/1/Thesis_hardcover_YONG_FUNG_LIN.pdf","source":{"id":"https://openalex.org/S4406922526","display_name":"University of Malaya Students Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:858763553","doi":null,"is_oa":false,"landing_page_url":"http://studentsrepo.um.edu.my/4586/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2527781763","https://openalex.org/W1971115903","https://openalex.org/W2057318887","https://openalex.org/W2049247618","https://openalex.org/W4377565566","https://openalex.org/W2600274123","https://openalex.org/W4225287555","https://openalex.org/W2797487216","https://openalex.org/W2983266748","https://openalex.org/W2037764834"],"abstract_inverted_index":{"Colorectal":[0],"cancer":[1,21,152,185],"(CRC)":[2],"is":[3,16,403],"the":[4,7,12,17,25,33,46,61,99,102,109,122,126,130,135,216,246,324,378,388,401,408,436],"carcinoma":[5],"of":[6,32,48,63,65,77,116,125,132,183,215,251,274,326,332,380,405,415,439],"colon":[8],"and":[9,24,37,42,107,111,120,157,190,203,226,237,248,255,280,290,298,303,314,335,341,348,361,393,418,441,449],"rectum":[10],"in":[11,22,27,60,129,234,245,337,357,387,400,407,446],"gastrointestinal":[13],"system.":[14],"CRC":[15,40,118,265,305,339,358,409,427],"third":[18],"most":[19],"common":[20],"men":[23],"second":[26],"women":[28],"worldwide.":[29],"The":[30,329,411,429],"limitations":[31],"currently":[34],"available":[35],"biomarkers":[36,425],"technologies":[38],"for":[39,264,323,426],"screening":[41],"surveillance":[43],"have":[44,56,434],"highlighted":[45,435],"necessity":[47],"finding":[49],"novel":[50],"biomarkers.":[51,97],"Recently,":[52],"microRNA":[53],"(miRNA)-based":[54],"studies":[55,294,433],"rendered":[57],"remarkable":[58],"contribution":[59],"elucidation":[62],"mechanisms":[64],"carcinogenesis.":[66],"miRNAs":[67,128,219,258,285],"are":[68],"short,":[69],"non-coding":[70],"RNA":[71,82],"molecules":[72],"that":[73,406],"act":[74],"as":[75,95,261,422],"regulators":[76],"gene":[78],"expression":[79,90,114,330],"through":[80],"messenger":[81],"(mRNA)":[83],"degradation":[84],"or":[85],"translational":[86],"inhibition.":[87],"Blood":[88],"miRNA":[89,113,136,148,296,398,413],"profiles":[91],"offer":[92],"great":[93],"potential":[94,423,437],"non-invasive":[96],"In":[98,396],"present":[100],"study,":[101],"aims":[103],"were":[104,209,228,243,259,286,308,317,321,344],"to":[105,211,230,288,354,369],"characterise":[106],"correlate":[108],"tissue":[110,236,247],"blood":[112,158,191,238,249,402,424],"patterns":[115],"primary":[117],"patients,":[119],"establish":[121],"functional":[123,289],"roles":[124],"identified":[127,353],"carcinogenesis":[131],"CRC.":[133],"Firstly,":[134],"profiling":[137],"study":[138],"was":[139,352,367],"divided":[140],"into":[141],"two":[142],"phases:":[143],"(I)":[144],"marker":[145,169],"discovery":[146],"by":[147,171,363,374],"microarray":[149],"using":[150,179,346],"paired":[151,184],"tissues":[153,186],"(n":[154,187],"=":[155,162,166,188,195,199],"30)":[156,189],"samples":[159,192,340],"(CRC,":[160,193],"n":[161,165,194,198],"42;":[163],"control,":[164,197],"18);":[167],"(II)":[168],"validation":[170,293,325,432],"reverse":[172],"transcription-quantitative":[173],"real-time":[174],"polymerase":[175],"chain":[176],"reaction":[177],"(RT-qPCR)":[178],"an":[180],"independent":[181],"set":[182],"70;":[196],"32).":[200],"Logistic":[201],"regression":[202],"receiver":[204,269],"operating":[205,270],"characteristic":[206,271],"curve":[207,272],"analyses":[208],"applied":[210],"obtain":[212],"diagnostic":[213],"utility":[214],"miRNAs.":[217],"Seven":[218],"(miR-150,":[220],"miR-193a-3p,":[221,252,416],"miR-23a,":[222],"miR-23b,":[223],"miR-338-5p,":[224],"miR-342-3p":[225],"miR-483-3p)":[227],"found":[229],"be":[231,355],"differentially":[232],"expressed":[233],"both":[235],"samples.":[239],"Significant":[240],"positive":[241],"correlations":[242],"observed":[244],"levels":[250,331],"miR-":[253,442],"23a":[254],"miR-338-5p.":[256],"These":[257],"demonstrated":[260],"a":[262,268],"classifier":[263,414],"detection,":[266],"with":[267],"area":[273],"0.887":[275],"(80.0%":[276],"sensitivity,":[277],"84.4%":[278],"specificity":[279],"83.3%":[281],"accuracy).":[282],"Next,":[283],"these":[284],"subjected":[287],"miRNA:mRNA":[291,430],"target":[292,327,333,431],"via":[295],"mimics":[297],"iv":[299],"inhibitors":[300],"transfections.":[301],"SW480":[302],"SW620":[304],"cell":[306,342,359,389],"lines":[307,343],"utilised.":[309],"Cell":[310],"viability,":[311,390],"apoptosis,":[312,391],"migration":[313,360,392],"invasion":[315,362,394],"assays":[316,320],"conducted.":[318],"Luciferase":[319],"performed":[322],"mRNAs.":[328],"mRNAs":[334],"proteins":[336],"clinical":[338],"assessed":[345],"RT-qPCR":[347],"Western":[349],"blot.":[350],"miR-193a-3p":[351],"involved":[356],"targeting":[364,375],"FOXO4.":[365],"miR-23a":[366,417],"determined":[368],"possess":[370],"apoptosis":[371],"resistance":[372],"function":[373],"APAF1.":[376],"However,":[377],"transfection":[379],"miR-338-5p":[381,419],"did":[382],"not":[383],"reveal":[384],"significant":[385],"findings":[386],"analyses.":[395],"conclusion,":[397],"deregulation":[399],"reflective":[404],"tissue.":[410],"triple":[412],"may":[420],"serve":[421],"detection.":[428],"application":[438],"miR-193a-3p:FOXO4":[440],"23a:APAF1":[443],"regulation":[444],"axes":[445],"miRNA-based":[447],"therapy":[448],"prognostication.":[450]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
