{"id":"https://openalex.org/W85760765","doi":"https://doi.org/10.4049/jimmunol.178.supp.46.10","title":"Functionally impaired T cell-dependent immunopathology in FK506-treated mice with LCMV infection (46.10)","display_name":"Functionally impaired T cell-dependent immunopathology in FK506-treated mice with LCMV infection (46.10)","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W85760765","doi":"https://doi.org/10.4049/jimmunol.178.supp.46.10","mag":"85760765"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.178.supp.46.10","doi":"https://doi.org/10.4049/jimmunol.178.supp.46.10","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.178.supp.46.10","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038996345","display_name":"Koichi Araki","orcid":"https://orcid.org/0000-0003-3478-6315","observed_orcids":["https://orcid.org/0000-0003-3478-6315"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Koichi Araki","raw_affiliation_strings":["Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine , G211 Rollins Research Building, 1510 Clifton Road, Atlanta, GA, 30322","1Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, G211 Rollins Research Building, 1510 Clifton Road, Atlanta, GA, 30322,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine , G211 Rollins Research Building, 1510 Clifton Road, Atlanta, GA, 30322","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"1Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, G211 Rollins Research Building, 1510 Clifton Road, Atlanta, GA, 30322,","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066705529","display_name":"Shivaprakash Gangappa","orcid":"https://orcid.org/0000-0001-6217-9665","observed_orcids":["https://orcid.org/0000-0001-6217-9665"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shivaprakash Gangappa","raw_affiliation_strings":["Emory Transplant Center, Department of Surgery, Emory University School of Medicine , 101 Woodruff Circle, Suite 5105, Atlanta, GA, 30322","2Emory Transplant Center, Department of Surgery, Emory University School of Medicine, 101 Woodruff Circle, Suite 5105, Atlanta, GA, 30322,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory Transplant Center, Department of Surgery, Emory University School of Medicine , 101 Woodruff Circle, Suite 5105, Atlanta, GA, 30322","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"2Emory Transplant Center, Department of Surgery, Emory University School of Medicine, 101 Woodruff Circle, Suite 5105, Atlanta, GA, 30322,","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013287504","display_name":"Barry T. Rouse","orcid":"https://orcid.org/0000-0002-8829-0334","observed_orcids":["https://orcid.org/0000-0002-8829-0334"]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry T Rouse","raw_affiliation_strings":["Department of Microbiology and Pathobiology, College of Veterinary Medicine, University of Tennessee , M409 Walters Life Sciences Building, Knoxville, TN, 37996","3Department of Microbiology and Pathobiology, College of Veterinary Medicine, University of Tennessee, M409 Walters Life Sciences Building, Knoxville, TN, 37996"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Pathobiology, College of Veterinary Medicine, University of Tennessee , M409 Walters Life Sciences Building, Knoxville, TN, 37996","institution_ids":["https://openalex.org/I75027704"]},{"raw_affiliation_string":"3Department of Microbiology and Pathobiology, College of Veterinary Medicine, University of Tennessee, M409 Walters Life Sciences Building, Knoxville, TN, 37996","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062306820","display_name":"Christian P. Larsen","orcid":"https://orcid.org/0000-0001-6573-2649","observed_orcids":["https://orcid.org/0000-0001-6573-2649"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian P Larsen","raw_affiliation_strings":["Emory Transplant Center, Department of Surgery, Emory University School of Medicine , 101 Woodruff Circle, Suite 5105, Atlanta, GA, 30322","2Emory Transplant Center, Department of Surgery, Emory University School of Medicine, 101 Woodruff Circle, Suite 5105, Atlanta, GA, 30322,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory Transplant Center, Department of Surgery, Emory University School of Medicine , 101 Woodruff Circle, Suite 5105, Atlanta, GA, 30322","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"2Emory Transplant Center, Department of Surgery, Emory University School of Medicine, 101 Woodruff Circle, Suite 5105, Atlanta, GA, 30322,","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016808814","display_name":"Rafi Ahmed","orcid":"https://orcid.org/0000-0002-9591-2621","observed_orcids":["https://orcid.org/0000-0002-9591-2621"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rafi Ahmed","raw_affiliation_strings":["Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine , G211 Rollins Research Building, 1510 Clifton Road, Atlanta, GA, 30322","1Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, G211 Rollins Research Building, 1510 Clifton Road, Atlanta, GA, 30322,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine , G211 Rollins Research Building, 1510 Clifton Road, Atlanta, GA, 30322","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"1Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, G211 Rollins Research Building, 1510 Clifton Road, Atlanta, GA, 30322,","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00852898,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"178","issue":"1_Supplement","first_page":"S62","last_page":"S63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.4779999852180481,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.4779999852180481,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.16249999403953552,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.049300000071525574,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lymphocytic-choriomeningitis-virus","display_name":"lymphocytic choriomeningitis virus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fk506","display_name":"FK506","score":0.9419999718666077},{"id":"https://openalex.org/keywords/calcineurin-inhibitors","display_name":"calcineurin inhibitors","score":0.8399999737739563},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8840000033378601},{"id":"https://openalex.org/keywords/virus-specific-t-cells","display_name":"virus-specific T cells","score":0.8669999837875366},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cytokine-overproduction","display_name":"cytokine overproduction","score":0.9879999756813049},{"id":"https://openalex.org/keywords/transplant-related-infections","display_name":"transplant infection","score":0.4580000042915344},{"id":"https://openalex.org/keywords/t-cell-signaling","display_name":"T cell signaling","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C2780190958","wikidata":"https://www.wikidata.org/wiki/Q1878776","display_name":"Lymphocytic choriomeningitis","level":4,"score":0.9722409248352051},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.7392023801803589},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6701910495758057},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6163431406021118},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6004883050918579},{"id":"https://openalex.org/C128057223","wikidata":"https://www.wikidata.org/wiki/Q420566","display_name":"Calcineurin","level":3,"score":0.5519501566886902},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5461845993995667},{"id":"https://openalex.org/C2779574689","wikidata":"https://www.wikidata.org/wiki/Q2368907","display_name":"Arenavirus","level":5,"score":0.5282617807388306},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47795605659484863},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.46842730045318604},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4573156535625458},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4204910695552826},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26476550102233887},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.23560714721679688},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1011696457862854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07543385028839111},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.178.supp.46.10","doi":"https://doi.org/10.4049/jimmunol.178.supp.46.10","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.178.supp.46.10","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8799999952316284}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2140965118","https://openalex.org/W1997244328","https://openalex.org/W2159415448","https://openalex.org/W1989287598","https://openalex.org/W2017221157","https://openalex.org/W2149670992","https://openalex.org/W2114287233","https://openalex.org/W2409248077","https://openalex.org/W2283954283","https://openalex.org/W2065372388"],"abstract_inverted_index":{"Abstract":[0],"Lymphocytic":[1],"choriomeningitis":[2],"virus":[3,39],"(LCMV)":[4],"was":[5,114],"recently":[6],"shown":[7],"to":[8,56,101,128,154],"contaminate":[9],"transplanted":[10],"organs":[11],"with":[12,52],"lethal":[13],"consequences":[14],"in":[15,60,83,144,150],"transplant":[16,57],"recipients.":[17],"The":[18,79],"diagnosis":[19],"of":[20,25,29,45,86,105,107,119,132],"LCMV":[21,35,61,151],"as":[22,110],"a":[23,37,84],"cause":[24],"death":[26,99],"under":[27],"circumstances":[28],"immunosuppression":[30],"is":[31,36,41],"somewhat":[32],"paradoxical":[33],"since":[34],"non-cytolytic":[38],"and":[40,89,98],"the":[42,68,103,117,130,133,156],"classic":[43],"example":[44],"immune-mediated":[46],"disease.":[47],"To":[48],"understand":[49],"how":[50],"treatment":[51,81],"immunosuppressive":[53],"drugs":[54],"given":[55],"recipients":[58],"results":[59,137],"disease,":[62],"we":[63],"have":[64],"initiated":[65],"studies":[66],"using":[67],"calcineurin":[69],"inhibitor":[70],"FK506.":[71],"Surprisingly,":[72],"FK506-treated":[73],"LCMV-infected":[74],"mice":[75],"showed":[76],"high":[77],"lethality.":[78],"drug":[80,145],"resulted":[82],"failure":[85],"infection":[87],"control":[88],"interestingly":[90],"induced":[91],"functionally":[92,140],"impaired":[93,141],"virus-specific":[94],"T":[95,120,142],"cells.":[96],"Lesions":[97],"appeared":[100,126],"be":[102,129],"consequence":[104],"overproduction":[106],"cytokines,":[108],"such":[109],"TNF-alpha.":[111],"This":[112],"response":[113],"dependent":[115],"on":[116],"presence":[118],"cells":[121,124,143,149],"but":[122],"these":[123],"themselves":[125],"not":[127],"source":[131],"disease-producing":[134],"cytokines.":[135],"Our":[136],"suggest":[138],"that":[139],"treated":[146],"animals":[147],"signal":[148],"infected":[152],"tissues":[153],"overproduce":[155],"cytokines":[157],"responsible":[158],"for":[159],"lesions.":[160]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}