{"id":"https://openalex.org/W85705405","doi":null,"title":"[131I]metaiodobenzylguanidine therapy after conventional therapy for neuroblastoma.","display_name":"[131I]metaiodobenzylguanidine therapy after conventional therapy for neuroblastoma.","publication_year":1991,"publication_date":"1991-10-01","ids":{"openalex":"https://openalex.org/W85705405","mag":"85705405","pmid":"https://pubmed.ncbi.nlm.nih.gov/1823819"},"language":"en","primary_location":{"id":"pmid:1823819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1823819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear biology and medicine (Turin, Italy : 1991)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109190554","display_name":"Cornelis A. Hoefnagel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"C A Hoefnagel","raw_affiliation_strings":["Department of Nuclear Medicine, The Netherlands Cancer Institute, Amsterdam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, The Netherlands Cancer Institute, Amsterdam","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110120739","display_name":"P.A. Vo\u00fbte","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P A Vo\u00fbte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109211632","display_name":"Jan de Kraker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J De Kraker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5075922470","display_name":"Renato A. Vald\u00e9s Olmos","orcid":"https://orcid.org/0000-0001-5458-1144","observed_orcids":["https://orcid.org/0000-0001-5458-1144"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R A Vald\u00e9s Olmos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7185,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.72959279,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"35","issue":"4","first_page":"202","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/131i-mibg-therapy","display_name":"131I-MIBG therapy","score":0.8790000081062317},{"id":"https://openalex.org/keywords/metaiodobenzylguanidine","display_name":"metaiodobenzylguanidine","score":0.9509999752044678},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/relapsed-neuroblastoma","display_name":"relapsed neuroblastoma","score":0.9549999833106995},{"id":"https://openalex.org/keywords/palliative-care","display_name":"palliative care","score":0.6119999885559082},{"id":"https://openalex.org/keywords/remission","display_name":"remission","score":0.4410000145435333},{"id":"https://openalex.org/keywords/soft-tissue-disorders","display_name":"soft tissue disorders","score":0.6370000243186951},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.7480000257492065},{"id":"https://openalex.org/keywords/radioactive-iodine-therapy","display_name":"radioiodine therapy","score":0.593999981880188},{"id":"https://openalex.org/keywords/neural-crest-tumors","display_name":"neural crest tumors","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8666762709617615},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.8659335374832153},{"id":"https://openalex.org/C2993559085","wikidata":"https://www.wikidata.org/wiki/Q2126444","display_name":"Radionuclide therapy","level":2,"score":0.7389647960662842},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6853123903274536},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5816488862037659},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.504663348197937},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5010688304901123},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.49589046835899353},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.477345734834671},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40056341886520386},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3453415632247925},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3214843273162842},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004341","descriptor_name":"Drug Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007462","descriptor_name":"Iodobenzenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009426","descriptor_name":"Netherlands","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019797","descriptor_name":"3-Iodobenzylguanidine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1823819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1823819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear biology and medicine (Turin, Italy : 1991)","raw_type":"Journal Article"},{"id":"mag:85705405","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1823819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2442096161","https://openalex.org/W2419309174","https://openalex.org/W2064907862","https://openalex.org/W2018642945","https://openalex.org/W7216685368","https://openalex.org/W2907249708","https://openalex.org/W2419134812","https://openalex.org/W2417925492","https://openalex.org/W2409225667","https://openalex.org/W2022945976"],"abstract_inverted_index":{"[131I]Metaiodobenzylguanidine":[0],"(131I-MIBG)":[1],"is":[2,46,176,216],"used":[3],"for":[4,55,87,221],"diagnostic":[5],"scintigraphy":[6],"and":[7,27,35,38,98,111,160,198,210],"targeted":[8],"therapy":[9,80,90,180,202,215],"in":[10,30,42,50,71,104,144,185],"a":[11,39,64,182],"range":[12],"of":[13,100,121,131,188,200,207],"neural":[14],"crest":[15],"tumors,":[16],"which":[17],"exhibit":[18],"an":[19],"active":[20],"uptake-1":[21],"mechanism":[22],"at":[23],"the":[24,43,48,53,84,122,153,161,166,173,186,196,217],"cell":[25],"membrane":[26],"cytoplasmatic":[28],"storage":[29],"neurosecretory":[31],"granules.":[32],"A":[33],"good":[34],"selective":[36],"concentration":[37],"long":[40],"retention":[41],"tumor,":[44],"as":[45],"generally":[47],"case":[49],"neuroblastoma,":[51],"are":[52],"basis":[54,86],"successful":[56],"131I-MIBG":[57,89,179,214],"treatment.":[58],"At":[59],"The":[60,118,129,139],"Netherlands":[61],"Cancer":[62],"Institute":[63],"phase":[65],"II":[66],"study":[67],"was":[68,114,127,155,163,169],"carried":[69],"out":[70],"53":[72],"patients":[73,107,145,222],"with":[74,146,205,223],"progressive":[75,109],"recurrent":[76,225],"disease":[77,101,110],"after":[78,190],"conventional":[79,191],"had":[81,108],"failed.":[82,194],"Despite":[83],"unfavorable":[85],"treatment,":[88],"induced":[91],"7":[92],"complete":[93],"remissions,":[94],"23":[95],"partial":[96],"remissions":[97,132],"arrest":[99],"(no":[102],"change)":[103],"10.":[105],"Nine":[106],"one":[112],"patient":[113],"lost":[115],"to":[116,136],"follow-up.":[117],"palliative":[119,219],"effect":[120],"treatment":[123,154,187,192,220],"under":[124],"these":[125],"conditions":[126],"impressive.":[128],"duration":[130],"varied":[133],"from":[134],"2":[135],"38":[137],"months.":[138],"best":[140,218],"results":[141],"were":[142],"obtained":[143],"voluminous":[147],"soft":[148],"tissue":[149],"disease.":[150,174],"In":[151],"general":[152],"well":[156],"tolerated":[157],"by":[158,172],"children":[159],"toxicity":[162,199],"mild,":[164],"provided":[165],"bone":[167],"marrow":[168],"not":[170],"invaded":[171],"It":[175],"concluded":[177],"that":[178,206],"has":[181,193],"definitive":[183],"place":[184],"neuroblastoma":[189],"As":[195],"invasiveness":[197],"this":[201],"compare":[203],"favorably":[204],"chemotherapy,":[208],"immunotherapy":[209],"external":[211],"beam":[212],"radiotherapy,":[213],"advanced":[224],"neuroblastoma.":[226]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}