{"id":"https://openalex.org/W856865508","doi":null,"title":"[Expression of Caspase-8 and Bcl-2 in the cartilage loose bodies in patients with Kashin-Beck disease].","display_name":"[Expression of Caspase-8 and Bcl-2 in the cartilage loose bodies in patients with Kashin-Beck disease].","publication_year":2011,"publication_date":"2011-08-01","ids":{"openalex":"https://openalex.org/W856865508","mag":"856865508","pmid":"https://pubmed.ncbi.nlm.nih.gov/21868312"},"language":"zh","primary_location":{"id":"pmid:21868312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21868312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nan fang yi ke da xue xue bao = Journal of Southern Medical University","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082623866","display_name":"\u738b\u83b9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Wang","raw_affiliation_strings":["Department of Public Health, Xi'an Jiaotong University College of Medicine, Xi'an 710061, China. wy0625rainbow@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health, Xi'an Jiaotong University College of Medicine, Xi'an 710061, China. wy0625rainbow@gmail.com","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033395738","display_name":"\u90ed\u96c4","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiong Guo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074598690","display_name":"\u5f20\u589e\u94c1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zeng-tie Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086216182","display_name":"\u738b\u6c11","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5033763267","display_name":"\u738b\u4e16\u6377","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shi-jie Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4012,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.63874748,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"31","issue":"8","first_page":"1314","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12209","display_name":"Bone and Joint Diseases","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kashin-beck-disease","display_name":"Kashin-Beck disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/loose-bodies","display_name":"loose bodies","score":0.7979999780654907},{"id":"https://openalex.org/keywords/cartilage","display_name":"cartilage","score":0.6420000195503235},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.8709999918937683},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7089999914169312},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.9330000281333923},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/articular-cartilage","display_name":"articular cartilage","score":0.6819999814033508},{"id":"https://openalex.org/keywords/chondrocyte-hypertrophy","display_name":"chondrocyte hypertrophy","score":0.703000009059906},{"id":"https://openalex.org/keywords/cartilage-pathology","display_name":"cartilage pathology","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C48297814","wikidata":"https://www.wikidata.org/wiki/Q14911965","display_name":"Caspase 8","level":5,"score":0.42817339301109314},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34966588020324707},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.2954980731010437},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26909035444259644},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.21146470308303833},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16365185379981995},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007594","descriptor_name":"Joint Loose Bodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053181","descriptor_name":"Caspase 8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057767","descriptor_name":"Kashin-Beck Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057767","descriptor_name":"Kashin-Beck Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:21868312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21868312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nan fang yi ke da xue xue bao = Journal of Southern Medical University","raw_type":"English Abstract"},{"id":"mag:2372251929","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21868312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:856865508","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/91170A/201108/38848947.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306545097","display_name":"\u5357\u65b9\u533b\u79d1\u5927\u5b66\u5b66\u62a5","issn_l":"1000-2588","issn":["1000-2588","1673-4254"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["ki-jl-1","medline","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u5357\u65b9\u533b\u79d1\u5927\u5b66\u5b66\u62a5","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3029042393","https://openalex.org/W622017208","https://openalex.org/W1125918667","https://openalex.org/W3029534627","https://openalex.org/W924654155","https://openalex.org/W1504049553","https://openalex.org/W898100534","https://openalex.org/W1178565725","https://openalex.org/W186151562","https://openalex.org/W7109459127"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,10,34,62,65,73,92,107,114,127,132,139,168,175],"role":[4],"of":[5,12,21,36,75,91,117,150,161,171,178],"Caspase-8":[6,59,81,99,121,162],"and":[7,33,58,80,83,96,110,120,156],"Bcl-2":[8,57,79,119,155],"in":[9,15,61,64,106,126,131,135,167],"formation":[11],"loose":[13,23,66,71,108,144],"bodies":[14,24,145],"Kashin-Beck":[16],"disease":[17],"(KBD).":[18],"METHODS:":[19],"Specimens":[20],"cartilage":[22,38,133,169],"were":[25,39,86,123],"collected":[26,40],"from":[27,41],"50":[28],"adult":[29],"patients":[30],"with":[31],"KBD,":[32],"samples":[35],"articular":[37],"10":[42],"healthy":[43],"adults":[44],"to":[45,55,102,138,174],"serve":[46],"as":[47],"control.":[48],"Avidin-biotin":[49],"alkaline":[50],"phosphatase":[51],"immunohistochemistry":[52],"was":[53,100,163],"employed":[54],"examine":[56],"positivities":[60,122],"chondrocytes":[63,76,130,152],"bodies.":[67],"RESULTS:":[68],"In":[69],"KBD":[70,143,172],"bodies,":[72,109],"percentage":[74,149],"positive":[77,153],"for":[78,154],"[(18.40\u22138.78)%":[82],"(67.54\u221312.29)%,":[84],"respectively]":[85],"significantly":[87],"higher":[88],"than":[89],"those":[90],"control":[93],"group":[94],"[(12.25\u22131.58)%":[95],"(24.70\u22134.35)%,":[97],"respectively].":[98],"found":[101,124],"promote":[103],"chondrocyte":[104],"apoptosis":[105],"this":[111],"effect":[112,116,160,177],"overrode":[113],"apoptosis-suppressing":[115,176],"Bcl-2.":[118,179],"mainly":[125],"deep":[128],"hypertrophic":[129],"or":[134],"cells":[136],"adjacent":[137],"bone":[140],"tissues.":[141],"CONCLUSION:":[142],"contain":[146],"an":[147],"increased":[148],"apoptotic":[151],"Caspase-8.":[157],"The":[158],"apoptosis-inducing":[159],"a":[164],"dominant":[165],"feature":[166],"pathology":[170],"compared":[173]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
