{"id":"https://openalex.org/W85641929","doi":null,"title":"Chemotherapy and cerebrovascular disease.","display_name":"Chemotherapy and cerebrovascular disease.","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W85641929","mag":"85641929","pmid":"https://pubmed.ncbi.nlm.nih.gov/18404783"},"language":"en","primary_location":{"id":"pmid:18404783","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18404783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of B.U.ON. : official journal of the Balkan Union of Oncology","raw_type":"Journal Article"},"parent_works":[],"lineage":["https://openalex.org/W85641929"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033480747","display_name":"Mert Saynak","orcid":"https://orcid.org/0000-0002-4176-5910","observed_orcids":["https://orcid.org/0000-0002-4176-5910"]},"institutions":[{"id":"https://openalex.org/I12387023","display_name":"Trakya University","ror":"https://ror.org/00xa0xn82","country_code":"TR","type":"education","lineage":["https://openalex.org/I12387023"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"M Saynak","raw_affiliation_strings":["Department of Radiation Oncology, Trakya University, Faculty of Medicine, Edirne, Turkey. mertsaynak@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Trakya University, Faculty of Medicine, Edirne, Turkey. mertsaynak@gmail.com","institution_ids":["https://openalex.org/I12387023"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085705572","display_name":"Ru\u015fen Co\u015far","orcid":"https://orcid.org/0000-0002-7953-8887","observed_orcids":["https://orcid.org/0000-0002-7953-8887"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Cosar-Alas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005014951","display_name":"Vuslat Yurut\u2010Caloglu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Yurut-Caloglu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043998702","display_name":"Murat \u00c7alo\u011flu","orcid":"https://orcid.org/0000-0003-2102-6034","observed_orcids":["https://orcid.org/0000-0003-2102-6034"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Caloglu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043658666","display_name":"Zafer Ko\u00e7ak","orcid":"https://orcid.org/0000-0003-1918-7795","observed_orcids":["https://orcid.org/0000-0003-1918-7795"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z Kocak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5046498017","display_name":"Cem Uzal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Uzal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3016,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.79134053,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":"1","first_page":"31","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.5776000022888184,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.5776000022888184,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.11100000143051147,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.051500000059604645,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.7900000214576721},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.7319999933242798},{"id":"https://openalex.org/keywords/cerebral-hemorrhage","display_name":"cerebral hemorrhage","score":0.7229999899864197},{"id":"https://openalex.org/keywords/l-asparaginase","display_name":"L-asparaginase","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":1.0},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9990000128746033},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":1.0},{"id":"https://openalex.org/keywords/endothelial-cell-cytotoxicity","display_name":"endothelial cell cytotoxicity","score":0.9150000214576721},{"id":"https://openalex.org/keywords/coagulopathy","display_name":"coagulopathy","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cancer-patients","display_name":"cancer patients","score":0.4819999933242798},{"id":"https://openalex.org/keywords/treatment-planning","display_name":"treatment planning","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8935484886169434},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.7073792219161987},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.649791955947876},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6453129053115845},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.556837797164917},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5523685216903687},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.4390891194343567},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43253594636917114},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40980541706085205},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3706250786781311},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.34249037504196167},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001215","descriptor_name":"Asparaginase","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:18404783","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18404783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of B.U.ON. : official journal of the Balkan Union of Oncology","raw_type":"Journal Article"},{"id":"pmh:oai:acikerisim.trakya.edu.tr:20.500.14551/19702","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14551/19702","pdf_url":null,"source":{"id":"https://openalex.org/S4306401406","display_name":"Trakya University's Institutional Open Access System (Trakya University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12387023","host_organization_name":"Trakya University","host_organization_lineage":["https://openalex.org/I12387023"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Review Article"},{"id":"mag:85641929","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18404783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2108636140","https://openalex.org/W2038359280","https://openalex.org/W4226323195","https://openalex.org/W4293176536","https://openalex.org/W2095323022","https://openalex.org/W3015943958","https://openalex.org/W2969966651","https://openalex.org/W4211252557","https://openalex.org/W3128318686","https://openalex.org/W2065336608"],"abstract_inverted_index":{"Cerebrovascular":[0],"disease":[1,20],"is":[2,101,107],"common":[3],"in":[4,142],"cancer":[5,25,112,122,143,148],"patients.":[6,144],"Some":[7],"tumors":[8],"are":[9,36,56,60],"at":[10],"high":[11],"risk":[12],"for":[13],"cerebrovascular":[14,19,134,160],"complications.":[15,161],"The":[16,66],"development":[17],"of":[18,34,81,138,159],"may":[21,72],"be":[22,151],"provoked":[23],"by":[24,68,109,153],"treatment.":[26,132],"No":[27],"well-planned":[28],"prospective":[29],"studies":[30],"about":[31,42],"other":[32],"causes":[33],"thrombosis":[35,43],"available,":[37],"although":[38],"various":[39],"case":[40],"reports":[41],"related":[44],"to":[45,62,64,74,103],"chemotherapy":[46,91,110],"have":[47],"been":[48],"published.":[49],"L-asparaginase,":[50],"cisplatin,":[51],"5-fluorouracil":[52],"(5-FU)":[53],"and":[54,79,140],"methotrexate":[55],"anticancer":[57],"agents":[58,71],"which":[59,69],"reported":[61],"relate":[63],"stroke.":[65],"mechanisms":[67],"antineoplastic":[70],"lead":[73],"stroke":[75,106],"include":[76],"endothelium":[77],"toxicity":[78],"abnormalities":[80],"coagulation":[82],"factors.":[83],"Also,":[84],"brain":[85],"hemorrhages":[86],"that":[87],"could":[88],"result":[89],"from":[90,121,130],"effects":[92],"on":[93],"the":[94,127,157],"hemostatic":[95],"system":[96],"were":[97],"reported.":[98],"Besides,":[99],"it":[100],"difficult":[102],"determine":[104],"whether":[105],"caused":[108],"or":[111],"itself.":[113],"Clinicians":[114],"deal":[115],"not":[116],"only":[117],"with":[118,126],"problems":[119],"originating":[120],"itself,":[123],"but":[124],"also":[125],"complications":[128],"resulting":[129],"its":[131],"Treatment-induced":[133],"disorders":[135],"affect":[136],"quality":[137],"life":[139],"survival":[141],"For":[145],"this":[146],"reason,":[147],"treatment":[149],"should":[150],"planned":[152],"taking":[154],"into":[155],"consideration":[156],"possibility":[158]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}