{"id":"https://openalex.org/W85640122","doi":null,"title":"Adipose-derived stem and stromal cells for cell-based therapy: current status of preclinical studies and clinical trials.","display_name":"Adipose-derived stem and stromal cells for cell-based therapy: current status of preclinical studies and clinical trials.","publication_year":2010,"publication_date":"2010-08-01","ids":{"openalex":"https://openalex.org/W85640122","mag":"85640122","pmid":"https://pubmed.ncbi.nlm.nih.gov/20677095"},"language":"en","primary_location":{"id":"pmid:20677095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20677095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in molecular therapeutics","raw_type":"Journal Article"},"parent_works":[],"lineage":["https://openalex.org/W85640122"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103070488","display_name":"Hiroshi Mizuno","orcid":"https://orcid.org/0000-0002-0975-1076","observed_orcids":["https://orcid.org/0000-0002-0975-1076"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroshi Mizuno","raw_affiliation_strings":["Juntendo University School of Medicine, Department of Plastic and Reconstructive Surgery, 2-1-1 Hongo Bunkyo-ku, Tokyo 1138421, Japan. hmizuno@juntendo.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Juntendo University School of Medicine, Department of Plastic and Reconstructive Surgery, 2-1-1 Hongo Bunkyo-ku, Tokyo 1138421, Japan. hmizuno@juntendo.ac.jp","institution_ids":["https://openalex.org/I34077901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103070488"],"corresponding_institution_ids":["https://openalex.org/I34077901"],"apc_list":null,"apc_paid":null,"fwci":4.7082,"has_fulltext":false,"cited_by_count":104,"citation_normalized_percentile":{"value":0.96072337,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"12","issue":"4","first_page":"442","last_page":"449"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adipose-derived-stem-cells","display_name":"adipose-derived stem cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/stromal-cells","display_name":"stromal cells","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"regenerative medicine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tissue-regeneration","display_name":"tissue regeneration","score":0.6710000038146973},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.6330000162124634},{"id":"https://openalex.org/keywords/preclinical-research","display_name":"preclinical research","score":0.9779999852180481},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.7850000262260437},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/autologous-cells","display_name":"autologous cells","score":0.5989999771118164},{"id":"https://openalex.org/keywords/mesodermal-lineage","display_name":"mesodermal lineage","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.8070594072341919},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7631967067718506},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.6584406495094299},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.611802875995636},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5684876441955566},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.540664553642273},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5286011695861816},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5171605944633484},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.48925209045410156},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.4199204444885254},{"id":"https://openalex.org/C2779389132","wikidata":"https://www.wikidata.org/wiki/Q1533033","display_name":"Stem-cell therapy","level":3,"score":0.4157225787639618},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41485393047332764},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39985191822052},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38646358251571655},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3482900559902191},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.27966558933258057},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16949677467346191},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.055303990840911865},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D033581","descriptor_name":"Stem Cell Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D033581","descriptor_name":"Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D044968","descriptor_name":"Regenerative Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D044968","descriptor_name":"Regenerative Medicine","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:20677095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20677095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in molecular therapeutics","raw_type":"Journal Article"},{"id":"mag:85640122","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20677095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W150471657","https://openalex.org/W2623421744","https://openalex.org/W2033641981","https://openalex.org/W2036534893","https://openalex.org/W2804930188","https://openalex.org/W2551777899","https://openalex.org/W2281615815","https://openalex.org/W2939063728","https://openalex.org/W4288061669","https://openalex.org/W2983078710"],"abstract_inverted_index":{"The":[0,30],"potential":[1],"use":[2,32,116,152],"of":[3,12,33,46,74,86,99,117,153,163],"stem":[4,36,41,65,75],"cell-based":[5,165],"therapies":[6],"for":[7,27,54,77],"the":[8,52,115,151,160],"repair":[9],"and":[10,15,51,90,93,135,138,143,147,158],"regeneration":[11],"various":[13],"tissues":[14,137],"organs":[16],"offers":[17],"a":[18],"paradigm":[19],"shift":[20],"that":[21,82,114],"may":[22],"provide":[23],"alternative":[24],"therapeutic":[25],"solutions":[26],"several":[28],"diseases.":[29],"clinical":[31,148],"either":[34],"embryonic":[35],"cells":[37,42,59,66,76],"or":[38],"induced":[39],"pluripotent":[40],"remains":[43],"limited":[44,124],"because":[45,98],"cell":[47],"regulations,":[48],"ethical":[49,101],"considerations":[50],"requirement":[53],"genetic":[55],"manipulation,":[56],"although":[57],"these":[58],"are":[60,84,94],"theoretically":[61],"highly":[62],"beneficial.":[63],"Adipose-derived":[64],"(ASCs)":[67],"appear":[68],"to":[69,125,132],"be":[70],"an":[71],"ideal":[72],"population":[73],"practical":[78],"regenerative":[79,120,156],"medicine,":[80],"given":[81],"they":[83],"plentiful,":[85],"autologous":[87],"tissue":[88],"origin":[89],"thus":[91],"non-immunogenic,":[92],"more":[95],"easily":[96],"available":[97],"minimal":[100],"considerations.":[102],"Although":[103],"ASCs":[104,118,154],"originate":[105],"from":[106],"mesodermal":[107,126],"lineages,":[108],"recent":[109],"preclinical":[110,146],"studies":[111],"have":[112],"demonstrated":[113],"in":[119,155],"medicine":[121,157],"is":[122],"not":[123],"tissue,":[127],"but":[128],"can":[129],"also":[130],"extend":[131],"both":[133],"exodermal":[134],"endodermal":[136],"organs.":[139],"This":[140],"review":[141],"summarizes":[142],"discusses":[144,159],"current":[145],"data":[149],"on":[150],"future":[161],"applications":[162],"such":[164],"therapies.":[166]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}
