{"id":"https://openalex.org/W85616151","doi":null,"title":"Evaluation of drug release kinetics from ibuprofen matrix tablets using HPMC.","display_name":"Evaluation of drug release kinetics from ibuprofen matrix tablets using HPMC.","publication_year":2006,"publication_date":"2006-04-01","ids":{"openalex":"https://openalex.org/W85616151","mag":"85616151","pmid":"https://pubmed.ncbi.nlm.nih.gov/16751122"},"language":"en","primary_location":{"id":"pmid:16751122","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16751122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan journal of pharmaceutical sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://eprints.hud.ac.uk/id/eprint/19640/1/MerchantEvalShoaib_et_al_Pak_J_Pharm_Sci_2006.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044779249","display_name":"Muhammad Harris Shoaib","orcid":"https://orcid.org/0000-0002-3639-0026","observed_orcids":["https://orcid.org/0000-0002-3639-0026"]},"institutions":[{"id":"https://openalex.org/I193670377","display_name":"University of Karachi","ror":"https://ror.org/05bbbc791","country_code":"PK","type":"education","lineage":["https://openalex.org/I193670377"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"M Harris Shoaib","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan. harrisshoaib2000@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan. harrisshoaib2000@yahoo.com","institution_ids":["https://openalex.org/I193670377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038347772","display_name":"Jaweria Tazeen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaweria Tazeen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005594065","display_name":"Hamid A. Merchant","orcid":"https://orcid.org/0000-0002-7668-5013","observed_orcids":["https://orcid.org/0000-0002-7668-5013"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hamid A Merchant","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111467201","display_name":"Rabia Ismail Yousuf","orcid":"https://orcid.org/0000-0003-2341-3011","observed_orcids":["https://orcid.org/0000-0003-2341-3011"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rabia Ismail Yousuf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.662,"has_fulltext":true,"cited_by_count":287,"citation_normalized_percentile":{"value":0.60158042,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"19","issue":"2","first_page":"119","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.6679999828338623,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.6679999828338623,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.31839999556541443,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ibuprofen","display_name":"ibuprofen","score":1.0},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.6740000247955322},{"id":"https://openalex.org/keywords/matrix-tablets","display_name":"matrix tablets","score":0.9700000286102295},{"id":"https://openalex.org/keywords/hydroxypropyl-methylcellulose","display_name":"hydroxypropyl methylcellulose","score":0.996999979019165},{"id":"https://openalex.org/keywords/drug-release-kinetics","display_name":"drug release kinetics","score":0.8709999918937683},{"id":"https://openalex.org/keywords/higuchi-kinetics","display_name":"Higuchi model","score":0.7620000243186951},{"id":"https://openalex.org/keywords/dissolution-modeling","display_name":"dissolution modeling","score":0.5270000100135803},{"id":"https://openalex.org/keywords/swelling","display_name":"swelling","score":0.46399998664855957},{"id":"https://openalex.org/keywords/erosion","display_name":"erosion","score":0.781000018119812},{"id":"https://openalex.org/keywords/avicel-ph-101","display_name":"Avicel PH 101","score":0.8209999799728394},{"id":"https://openalex.org/keywords/direct-compression","display_name":"direct compression","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C2778572730","wikidata":"https://www.wikidata.org/wiki/Q416713","display_name":"Magnesium stearate","level":3,"score":0.7933873534202576},{"id":"https://openalex.org/C2779944601","wikidata":"https://www.wikidata.org/wiki/Q186969","display_name":"Ibuprofen","level":2,"score":0.7674470543861389},{"id":"https://openalex.org/C2778540859","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Swelling","level":2,"score":0.6830138564109802},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.586295485496521},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.574009120464325},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.5531863570213318},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5220211148262024},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.5091401934623718},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.506072461605072},{"id":"https://openalex.org/C14029885","wikidata":"https://www.wikidata.org/wiki/Q5282807","display_name":"Dissolution testing","level":4,"score":0.44491615891456604},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.44114840030670166},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.43803948163986206},{"id":"https://openalex.org/C2777239854","wikidata":"https://www.wikidata.org/wiki/Q902638","display_name":"Excipient","level":2,"score":0.4108462929725647},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.29080069065093994},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2842683792114258},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09903401136398315},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.06453657150268555},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.061817288398742676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05474981665611267},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C2781430271","wikidata":"https://www.wikidata.org/wiki/Q278760","display_name":"Biopharmaceutics Classification System","level":3,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007052","descriptor_name":"Ibuprofen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008747","descriptor_name":"Methylcellulose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008747","descriptor_name":"Methylcellulose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013678","descriptor_name":"Technology, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D065347","descriptor_name":"Hypromellose Derivatives","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:16751122","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16751122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan journal of pharmaceutical sciences","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.hud.ac.uk:19640","doi":null,"is_oa":true,"landing_page_url":"http://eprints.hud.ac.uk/id/eprint/19640/1/MerchantEvalShoaib_et_al_Pak_J_Pharm_Sci_2006.pdf","pdf_url":"http://eprints.hud.ac.uk/id/eprint/19640/1/MerchantEvalShoaib_et_al_Pak_J_Pharm_Sci_2006.pdf","source":{"id":"https://openalex.org/S4306401852","display_name":"University of Huddersfield Repository (University of Huddersfield)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I133837150","host_organization_name":"University of Huddersfield","host_organization_lineage":["https://openalex.org/I133837150"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1400131","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1400131/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pak J Pharm Sci , 19 (2) pp. 119-124. (2006)","raw_type":"Article"},{"id":"mag:85616151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16751122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:eprints.hud.ac.uk:19640","doi":null,"is_oa":true,"landing_page_url":"http://eprints.hud.ac.uk/id/eprint/19640/1/MerchantEvalShoaib_et_al_Pak_J_Pharm_Sci_2006.pdf","pdf_url":"http://eprints.hud.ac.uk/id/eprint/19640/1/MerchantEvalShoaib_et_al_Pak_J_Pharm_Sci_2006.pdf","source":{"id":"https://openalex.org/S4306401852","display_name":"University of Huddersfield Repository (University of Huddersfield)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I133837150","host_organization_name":"University of Huddersfield","host_organization_lineage":["https://openalex.org/I133837150"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W85616151.pdf","grobid_xml":"https://content.openalex.org/works/W85616151.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W197368718","https://openalex.org/W1601534629","https://openalex.org/W1977072597","https://openalex.org/W1981215463","https://openalex.org/W1993524583","https://openalex.org/W2004328494","https://openalex.org/W2041467324","https://openalex.org/W2053630373","https://openalex.org/W2054505016","https://openalex.org/W2054975248","https://openalex.org/W2060320802","https://openalex.org/W2086130473","https://openalex.org/W2091371232","https://openalex.org/W2103957380","https://openalex.org/W2332887643"],"related_works":["https://openalex.org/W2383143623","https://openalex.org/W2091148013","https://openalex.org/W2187051498","https://openalex.org/W3196014795","https://openalex.org/W7042625643","https://openalex.org/W2051893430","https://openalex.org/W2247046036","https://openalex.org/W2361123987","https://openalex.org/W2089159002","https://openalex.org/W7100476414"],"abstract_inverted_index":{"The":[0,55,104],"aim":[1],"of":[2,14,102,123],"this":[3],"study":[4],"is":[5],"to":[6,25,38,78,84,110],"develop":[7],"a":[8,120],"once-daily":[9],"sustained":[10,41],"release":[11,21,28,33,42,80,86,106,115],"matrix":[12],"tablet":[13],"ibuprofen":[15],"using":[16,48],"hydroxypropyl":[17],"methylcellulose":[18],"(HPMC)":[19],"as":[20,30,119],"controlling":[22],"factor":[23],"and":[24,52,63,66,88,126],"evaluate":[26,85],"drug":[27,79,105],"parameters":[29,65],"per":[31],"various":[32],"kinetic":[34],"models.":[35],"In":[36],"order":[37,83],"achieve":[39],"required":[40],"profile":[43],"tablets":[44,57],"were":[45,58,68,76],"directly":[46],"compressed":[47],"Avicel":[49],"pH":[50],"101":[51],"Magnesium":[53],"stearate.":[54],"formulated":[56],"also":[59],"characterized":[60],"by":[61],"physical":[62],"chemical":[64],"results":[67],"found":[69,118],"in":[70,82],"acceptable":[71],"limits.":[72],"Different":[73],"dissolution":[74],"models":[75],"applied":[77],"data":[81,107],"mechanisms":[87],"kinetics.":[89],"Criteria":[90],"for":[91],"selecting":[92],"the":[93,111],"most":[94],"appropriate":[95],"model":[96],"was":[97,117],"based":[98],"on":[99],"linearity":[100],"(coefficient":[101],"correlation).":[103],"fit":[108],"well":[109],"Higuchi":[112],"expression.":[113],"Drug":[114],"mechanism":[116],"complex":[121],"mixture":[122],"diffusion,":[124],"swelling":[125],"erosion.":[127]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":29},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":28},{"year":2013,"cited_by_count":27},{"year":2012,"cited_by_count":28}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}