{"id":"https://openalex.org/W8559032","doi":"https://doi.org/10.1016/b978-0-12-383834-6.00176-2","title":"Psoriasis","display_name":"Psoriasis","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W8559032","doi":"https://doi.org/10.1016/b978-0-12-383834-6.00176-2","mag":"8559032"},"language":"en","primary_location":{"id":"doi:10.1016/b978-0-12-383834-6.00176-2","doi":"https://doi.org/10.1016/b978-0-12-383834-6.00176-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-12-383834-6.00176-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Emery and Rimoin's Principles and Practice of Medical Genetics","raw_type":"book-chapter"},"volume":null,"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058475475","display_name":"Johann Eli Gudjonsson","orcid":"https://orcid.org/0000-0002-0080-0812","observed_orcids":["https://orcid.org/0000-0002-0080-0812"]},"institutions":[{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Johann E. Gudjonsson","raw_affiliation_strings":["University of Michigan Health System, Ann Arbor, MI, USA","University of Michigan Health System , Ann Arbor, MI , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Health System, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I4210114445"]},{"raw_affiliation_string":"University of Michigan Health System , Ann Arbor, MI , USA","institution_ids":["https://openalex.org/I4210114445"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015004042","display_name":"James T. Elder","orcid":"https://orcid.org/0000-0003-4215-3294","observed_orcids":["https://orcid.org/0000-0003-4215-3294"]},"institutions":[{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James T. Elder","raw_affiliation_strings":["University of Michigan Health System, Ann Arbor, MI, USA","University of Michigan Health System , Ann Arbor, MI , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Health System, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I4210114445"]},{"raw_affiliation_string":"University of Michigan Health System , Ann Arbor, MI , USA","institution_ids":["https://openalex.org/I4210114445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210114445"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00543478,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":1.0},{"id":"https://openalex.org/keywords/autoimmune-skin-disease","display_name":"autoimmune skin disease","score":0.8960000276565552},{"id":"https://openalex.org/keywords/susceptibility-loci","display_name":"genetic susceptibility loci","score":0.9150000214576721},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.9789999723434448},{"id":"https://openalex.org/keywords/th1-th17-inflammation","display_name":"Th1/Th17 inflammation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/antigen-processing-and-presentation","display_name":"antigen processing and presentation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tnf-signaling","display_name":"TNF signaling","score":0.8009999990463257},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9369999766349792},{"id":"https://openalex.org/keywords/dendritic-cell-activation","display_name":"dendritic cell activation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/psoriatic-arthritis","display_name":"psoriatic arthritis","score":0.9020000100135803},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.7182208895683289},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5621804594993591},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5524208545684814},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5362441539764404},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5013601779937744},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4900030195713043},{"id":"https://openalex.org/C83464605","wikidata":"https://www.wikidata.org/wiki/Q575296","display_name":"Antigen presentation","level":4,"score":0.4450737237930298},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.43590623140335083},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3842555582523346},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33960196375846863},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32735955715179443},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.19098103046417236},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14211183786392212},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/b978-0-12-383834-6.00176-2","doi":"https://doi.org/10.1016/b978-0-12-383834-6.00176-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-12-383834-6.00176-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Emery and Rimoin's Principles and Practice of Medical Genetics","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":266,"referenced_works":["https://openalex.org/W37375382","https://openalex.org/W41246149","https://openalex.org/W88373170","https://openalex.org/W107113289","https://openalex.org/W125377420","https://openalex.org/W161004844","https://openalex.org/W177522477","https://openalex.org/W183089507","https://openalex.org/W205493927","https://openalex.org/W256876936","https://openalex.org/W596521437","https://openalex.org/W653185463","https://openalex.org/W1497536259","https://openalex.org/W1513014113","https://openalex.org/W1528069886","https://openalex.org/W1554203461","https://openalex.org/W1557275443","https://openalex.org/W1562174992","https://openalex.org/W1569068313","https://openalex.org/W1576903429","https://openalex.org/W1741681584","https://openalex.org/W1779926382","https://openalex.org/W1868478050","https://openalex.org/W1898779455","https://openalex.org/W1916477545","https://openalex.org/W1963819091","https://openalex.org/W1964651502","https://openalex.org/W1964995490","https://openalex.org/W1966007013","https://openalex.org/W1966584334","https://openalex.org/W1966922291","https://openalex.org/W1970373563","https://openalex.org/W1971328622","https://openalex.org/W1971708477","https://openalex.org/W1975162362","https://openalex.org/W1975389063","https://openalex.org/W1976382352","https://openalex.org/W1976457453","https://openalex.org/W1976833736","https://openalex.org/W1976892095","https://openalex.org/W1977146735","https://openalex.org/W1978171344","https://openalex.org/W1979058179","https://openalex.org/W1980991473","https://openalex.org/W1981714996","https://openalex.org/W1981746803","https://openalex.org/W1981924240","https://openalex.org/W1984336432","https://openalex.org/W1985849948","https://openalex.org/W1986455689","https://openalex.org/W1986612603","https://openalex.org/W1988021062","https://openalex.org/W1988794459","https://openalex.org/W1991030828","https://openalex.org/W1991217781","https://openalex.org/W1991658642","https://openalex.org/W1991844077","https://openalex.org/W1993273784","https://openalex.org/W1993526807","https://openalex.org/W1997033456","https://openalex.org/W1997276741","https://openalex.org/W1998886148","https://openalex.org/W2000851235","https://openalex.org/W2001750507","https://openalex.org/W2001965675","https://openalex.org/W2002124107","https://openalex.org/W2002616613","https://openalex.org/W2002987322","https://openalex.org/W2004024617","https://openalex.org/W2004372679","https://openalex.org/W2005062591","https://openalex.org/W2005428052","https://openalex.org/W2005576094","https://openalex.org/W2006298064","https://openalex.org/W2006651440","https://openalex.org/W2007533329","https://openalex.org/W2012077729","https://openalex.org/W2013304729","https://openalex.org/W2013488106","https://openalex.org/W2014118159","https://openalex.org/W2014320592","https://openalex.org/W2015215849","https://openalex.org/W2015347941","https://openalex.org/W2016325865","https://openalex.org/W2016525911","https://openalex.org/W2017531605","https://openalex.org/W2017583377","https://openalex.org/W2017829850","https://openalex.org/W2017893786","https://openalex.org/W2020906240","https://openalex.org/W2022665587","https://openalex.org/W2022667850","https://openalex.org/W2023073368","https://openalex.org/W2024863517","https://openalex.org/W2029219177","https://openalex.org/W2029292942","https://openalex.org/W2029331076","https://openalex.org/W2031622194","https://openalex.org/W2032110831","https://openalex.org/W2032510762","https://openalex.org/W2033342396","https://openalex.org/W2034464736","https://openalex.org/W2034666462","https://openalex.org/W2035464895","https://openalex.org/W2035546749","https://openalex.org/W2036595120","https://openalex.org/W2037882607","https://openalex.org/W2038226782","https://openalex.org/W2038309633","https://openalex.org/W2040041622","https://openalex.org/W2041593528","https://openalex.org/W2041635511","https://openalex.org/W2042103448","https://openalex.org/W2042194530","https://openalex.org/W2042229295","https://openalex.org/W2042607648","https://openalex.org/W2043801813","https://openalex.org/W2044307655","https://openalex.org/W2045113343","https://openalex.org/W2048702501","https://openalex.org/W2048748522","https://openalex.org/W2049572499","https://openalex.org/W2055311201","https://openalex.org/W2055514573","https://openalex.org/W2056996834","https://openalex.org/W2058401000","https://openalex.org/W2058863496","https://openalex.org/W2059686909","https://openalex.org/W2061473393","https://openalex.org/W2062110203","https://openalex.org/W2063582479","https://openalex.org/W2064464816","https://openalex.org/W2065290004","https://openalex.org/W2066723587","https://openalex.org/W2067117198","https://openalex.org/W2069063919","https://openalex.org/W2073167340","https://openalex.org/W2073453659","https://openalex.org/W2074574224","https://openalex.org/W2074753880","https://openalex.org/W2077373325","https://openalex.org/W2078157933","https://openalex.org/W2080090843","https://openalex.org/W2081078817","https://openalex.org/W2081905124","https://openalex.org/W2082379549","https://openalex.org/W2082515801","https://openalex.org/W2083331025","https://openalex.org/W2083449096","https://openalex.org/W2083823425","https://openalex.org/W2084951281","https://openalex.org/W2086334974","https://openalex.org/W2088429799","https://openalex.org/W2088802427","https://openalex.org/W2090587274","https://openalex.org/W2090774988","https://openalex.org/W2091681488","https://openalex.org/W2092836731","https://openalex.org/W2092916655","https://openalex.org/W2092983518","https://openalex.org/W2093794297","https://openalex.org/W2093899015","https://openalex.org/W2093949724","https://openalex.org/W2094863064","https://openalex.org/W2096379390","https://openalex.org/W2098701094","https://openalex.org/W2099141194","https://openalex.org/W2099731455","https://openalex.org/W2101806086","https://openalex.org/W2103018315","https://openalex.org/W2104737564","https://openalex.org/W2104777875","https://openalex.org/W2104919278","https://openalex.org/W2105239414","https://openalex.org/W2105415988","https://openalex.org/W2105842551","https://openalex.org/W2109460336","https://openalex.org/W2110031819","https://openalex.org/W2110269506","https://openalex.org/W2110888991","https://openalex.org/W2112267975","https://openalex.org/W2112408854","https://openalex.org/W2113369166","https://openalex.org/W2115331141","https://openalex.org/W2116828514","https://openalex.org/W2116956799","https://openalex.org/W2117446594","https://openalex.org/W2117646004","https://openalex.org/W2117697063","https://openalex.org/W2118781731","https://openalex.org/W2118794770","https://openalex.org/W2120169468","https://openalex.org/W2120765296","https://openalex.org/W2123114243","https://openalex.org/W2123306118","https://openalex.org/W2123679910","https://openalex.org/W2124277514","https://openalex.org/W2124678205","https://openalex.org/W2124896761","https://openalex.org/W2125190716","https://openalex.org/W2125681068","https://openalex.org/W2128218039","https://openalex.org/W2131493069","https://openalex.org/W2131889332","https://openalex.org/W2132092500","https://openalex.org/W2132991384","https://openalex.org/W2134783591","https://openalex.org/W2135298542","https://openalex.org/W2135949473","https://openalex.org/W2136157736","https://openalex.org/W2139008734","https://openalex.org/W2140118273","https://openalex.org/W2141016525","https://openalex.org/W2142391899","https://openalex.org/W2143294211","https://openalex.org/W2143429821","https://openalex.org/W2144265655","https://openalex.org/W2144294851","https://openalex.org/W2144974645","https://openalex.org/W2145958269","https://openalex.org/W2146293362","https://openalex.org/W2149566497","https://openalex.org/W2151566115","https://openalex.org/W2151734278","https://openalex.org/W2152507275","https://openalex.org/W2152664025","https://openalex.org/W2153511580","https://openalex.org/W2154375899","https://openalex.org/W2154780633","https://openalex.org/W2155779547","https://openalex.org/W2158620918","https://openalex.org/W2160498502","https://openalex.org/W2162362550","https://openalex.org/W2163504863","https://openalex.org/W2164880184","https://openalex.org/W2167239291","https://openalex.org/W2167963388","https://openalex.org/W2169758620","https://openalex.org/W2170138746","https://openalex.org/W2171208909","https://openalex.org/W2171624524","https://openalex.org/W2180106819","https://openalex.org/W2215489080","https://openalex.org/W2217809488","https://openalex.org/W2287967910","https://openalex.org/W2316254340","https://openalex.org/W2337429169","https://openalex.org/W2396446363","https://openalex.org/W2404743161","https://openalex.org/W2412327653","https://openalex.org/W2414878616","https://openalex.org/W2561759163","https://openalex.org/W4210999603","https://openalex.org/W4211046919","https://openalex.org/W4233722063","https://openalex.org/W4240857676","https://openalex.org/W4248269869","https://openalex.org/W4251839213","https://openalex.org/W4319308347","https://openalex.org/W6606508765","https://openalex.org/W6645172339","https://openalex.org/W6651253139","https://openalex.org/W6652166964","https://openalex.org/W6668760010","https://openalex.org/W6683694474","https://openalex.org/W6712962737"],"related_works":["https://openalex.org/W4210767205","https://openalex.org/W2418145303","https://openalex.org/W2391784904","https://openalex.org/W2347638186","https://openalex.org/W4381512312","https://openalex.org/W3032407075","https://openalex.org/W2118575191","https://openalex.org/W3088742859","https://openalex.org/W2410175218","https://openalex.org/W2347453583"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
