{"id":"https://openalex.org/W855840566","doi":null,"title":"Onconeural antibodies with special reference to anti-Yo","display_name":"Onconeural antibodies with special reference to anti-Yo","publication_year":2011,"publication_date":"2011-12-20","ids":{"openalex":"https://openalex.org/W855840566","mag":"855840566"},"language":"en","primary_location":{"id":"pmh:oai:bora.uib.no:1956/5526","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1956/5526","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1956/5526","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061735459","display_name":"Cecilie Totland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Cecilie Totland","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5061735459"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-yo-antibodies","display_name":"anti-Yo antibodies","score":0.8619999885559082},{"id":"https://openalex.org/keywords/anti-hu-antibodies","display_name":"anti-Hu antibodies","score":0.871999979019165},{"id":"https://openalex.org/keywords/paraneoplastic-cerebellar-degeneration","display_name":"paraneoplastic cerebellar degeneration","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cdr2","display_name":"CDR2","score":0.8889999985694885},{"id":"https://openalex.org/keywords/antibody-avidity","display_name":"antibody avidity","score":0.8870000243186951},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.8040000200271606},{"id":"https://openalex.org/keywords/paraneoplastic-antibodies","display_name":"paraneoplastic antibodies","score":0.7129999995231628},{"id":"https://openalex.org/keywords/immune-dysregulation","display_name":"immune dysregulation","score":0.7250000238418579},{"id":"https://openalex.org/keywords/paraneoplastic-encephalitis","display_name":"paraneoplastic encephalitis","score":0.6539999842643738},{"id":"https://openalex.org/keywords/paraneoplastic-neuropathy","display_name":"paraneoplastic neuropathy","score":0.6079999804496765},{"id":"https://openalex.org/keywords/paraneoplastic-myopathy","display_name":"paraneoplastic myopathy","score":0.625},{"id":"https://openalex.org/keywords/paraneoplastic-dermatosis","display_name":"paraneoplastic dermatosis","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.795728325843811},{"id":"https://openalex.org/C179223381","wikidata":"https://www.wikidata.org/wiki/Q419425","display_name":"Avidity","level":3,"score":0.7850275039672852},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7614961862564087},{"id":"https://openalex.org/C2778005360","wikidata":"https://www.wikidata.org/wiki/Q3508804","display_name":"Paraneoplastic cerebellar degeneration","level":4,"score":0.7397767305374146},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.6430403590202332},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5707466006278992},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5165066123008728},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5135024189949036},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.49495548009872437},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.4171033799648285},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12906667590141296}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:bora.uib.no:1956/5526","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1956/5526","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:855840566","doi":null,"is_oa":false,"landing_page_url":"https://bora.uib.no/bora-xmlui/bitstream/1956/5526/1/42204%20Totland%20main_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:bora.uib.no:1956/5526","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1956/5526","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":128,"referenced_works":["https://openalex.org/W356319","https://openalex.org/W7177680","https://openalex.org/W1488137412","https://openalex.org/W1488707762","https://openalex.org/W1497442951","https://openalex.org/W1526373153","https://openalex.org/W1570101174","https://openalex.org/W1595466746","https://openalex.org/W1669134410","https://openalex.org/W1781263092","https://openalex.org/W1923802408","https://openalex.org/W1965562360","https://openalex.org/W1966802947","https://openalex.org/W1968800228","https://openalex.org/W1969168264","https://openalex.org/W1970531293","https://openalex.org/W1972396626","https://openalex.org/W1973301923","https://openalex.org/W1974394249","https://openalex.org/W1975620817","https://openalex.org/W1977346161","https://openalex.org/W1978286483","https://openalex.org/W1979034465","https://openalex.org/W1983628591","https://openalex.org/W1985361393","https://openalex.org/W1985705893","https://openalex.org/W1985956159","https://openalex.org/W1986320586","https://openalex.org/W1987726574","https://openalex.org/W1988566386","https://openalex.org/W1990525811","https://openalex.org/W1991893050","https://openalex.org/W1995195280","https://openalex.org/W1995276486","https://openalex.org/W1995820181","https://openalex.org/W1996978711","https://openalex.org/W1998268789","https://openalex.org/W1998393524","https://openalex.org/W1999178192","https://openalex.org/W1999276043","https://openalex.org/W1999968624","https://openalex.org/W2004630197","https://openalex.org/W2006459773","https://openalex.org/W2010776016","https://openalex.org/W2013702603","https://openalex.org/W2015868606","https://openalex.org/W2017345506","https://openalex.org/W2018012666","https://openalex.org/W2024877152","https://openalex.org/W2025325056","https://openalex.org/W2025414558","https://openalex.org/W2026726511","https://openalex.org/W2030543234","https://openalex.org/W2031896543","https://openalex.org/W2032174342","https://openalex.org/W2032942231","https://openalex.org/W2034118847","https://openalex.org/W2034431725","https://openalex.org/W2039176721","https://openalex.org/W2039182850","https://openalex.org/W2042595197","https://openalex.org/W2045529714","https://openalex.org/W2046553158","https://openalex.org/W2048886638","https://openalex.org/W2055617739","https://openalex.org/W2056911223","https://openalex.org/W2058132241","https://openalex.org/W2062803124","https://openalex.org/W2067685678","https://openalex.org/W2068972095","https://openalex.org/W2071472322","https://openalex.org/W2072513771","https://openalex.org/W2072715438","https://openalex.org/W2073050254","https://openalex.org/W2074395026","https://openalex.org/W2074526615","https://openalex.org/W2076008898","https://openalex.org/W2078953664","https://openalex.org/W2084352685","https://openalex.org/W2085106063","https://openalex.org/W2086584562","https://openalex.org/W2086769431","https://openalex.org/W2087601187","https://openalex.org/W2089387559","https://openalex.org/W2089421858","https://openalex.org/W2091211966","https://openalex.org/W2092712542","https://openalex.org/W2092876789","https://openalex.org/W2094208803","https://openalex.org/W2094222401","https://openalex.org/W2100948701","https://openalex.org/W2104950011","https://openalex.org/W2105459360","https://openalex.org/W2106925712","https://openalex.org/W2108809782","https://openalex.org/W2110817748","https://openalex.org/W2113206255","https://openalex.org/W2118234704","https://openalex.org/W2119563670","https://openalex.org/W2119814354","https://openalex.org/W2124074488","https://openalex.org/W2124472369","https://openalex.org/W2126142449","https://openalex.org/W2126786112","https://openalex.org/W2126962846","https://openalex.org/W2130407607","https://openalex.org/W2131583903","https://openalex.org/W2133263385","https://openalex.org/W2134611639","https://openalex.org/W2135199735","https://openalex.org/W2146468028","https://openalex.org/W2146998614","https://openalex.org/W2154710868","https://openalex.org/W2157533109","https://openalex.org/W2159270737","https://openalex.org/W2159289827","https://openalex.org/W2161969523","https://openalex.org/W2162839806","https://openalex.org/W2164409378","https://openalex.org/W2167675656","https://openalex.org/W2169871816","https://openalex.org/W2171490333","https://openalex.org/W2295170052","https://openalex.org/W2315537939","https://openalex.org/W2316085157","https://openalex.org/W2325494665","https://openalex.org/W2328983104","https://openalex.org/W2402709357"],"related_works":["https://openalex.org/W2048886638","https://openalex.org/W7100489032","https://openalex.org/W2411745457","https://openalex.org/W2029647691","https://openalex.org/W6980459588","https://openalex.org/W2947011111","https://openalex.org/W2016035979","https://openalex.org/W6903483732","https://openalex.org/W3031253785","https://openalex.org/W2060965236"],"abstract_inverted_index":{"The":[0,63,261],"mechanisms":[1],"behind":[2],"anti-Yo":[3,40,469,482],"mediated":[4],"paraneoplastic":[5,80,100,267,453],"cerebellar":[6],"degeneration":[7],"is":[8,15,67,269,376,477],"still":[9],"not":[10,270,338,377,458],"understood,":[11],"and":[12,41,54,73,76,103,256,330,383,396,400,415,441,483],"very":[13],"little":[14,424],"known":[16],"about":[17],"the":[18,30,46,77,96,108,139,143,146,182,194,219,223,232,277,292,299,318,370,468],"function":[19],"of":[20,32,65,71,79,145,152,240,250,279,325,351,374,467],"CDR2.":[21,352],"In":[22],"our":[23],"studies":[24],"we":[25,160,167,333],"have":[26,226],"tried":[27],"to":[28,274,289,296,380,389,460],"elucidate":[29],"properties":[31],"Yo":[33,121,173,200,224,254,280,328,384,403,416],"antibodies,":[34,101,193,474],"potential":[35],"antibodies":[36,66,81,115,122,125,174,201,210,225,255,268,281,329,404,417,421,456],"that":[37,107,180,208,320,335,356,372,418,431],"coexist":[38],"with":[39,69,95,113,120,126,131,170,191,199,310,413],"whether":[42,276,446],"sequence":[43,294],"variants":[44,290],"in":[45,51,90,138,218,282,291,298,305,436],"CDR2":[47,52,300,336,357,381],"gene":[48],"or":[49,148,172,295,302,462],"differences":[50,89,137,316],"transcription":[53],"expression":[55,382],"could":[56,206,321],"explain":[57,322],"why":[58,263,323],"some":[59,264,283,324],"patients":[60,94,112,119,130,169,190,198,252,265,286,309,319],"develop":[61,253,259,266,327],"PCD.":[62,260,331],"avidity":[64,78,92,110,128,156,183,195],"associated":[68],"onset":[70],"disease":[72,74,147,220],"severity,":[75],"has":[82],"never":[83],"been":[84],"examined":[85],"before.":[86],"We":[87,105,272,313,409,429,443],"compared":[88],"antibody":[91,109,155,385,448],"among":[93,111,317],"two":[97],"most":[98,189,405],"common":[99],"anti-Hu":[102],"anti-Yo.":[104],"found":[106,314,430],"these":[114,251],"was":[116,337,434,449],"heterogeneous,":[117],"but":[118,246,387],"generally":[123],"had":[124,472],"higher":[127],"than":[129,237,363],"Hu":[132,171,192,209],"antibodies.":[133],"This":[134,177,205],"might":[135],"reflect":[136],"patient\u2019s":[140],"immune":[141,390],"response,":[142],"severity":[144],"different":[149],"time":[150,159,187,216],"points":[151],"sampling.":[153],"Since":[154],"increase":[157],"over":[158,175,186],"also":[161,368,388,419,471],"did":[162],"a":[163,229,411,423,450,478],"longitudinal":[164],"study":[165,178,275],"where":[166],"followed":[168],"time.":[176],"showed":[179],"while":[181,222,230],"indexes":[184,196],"increased":[185],"for":[188,197,228],"were":[202,287,457],"fairly":[203],"constant.":[204],"indicate":[207,355],"are":[211],"discovered":[212],"at":[213],"an":[214],"earlier":[215],"point":[217],"progress,":[221],"persisted":[227],"before":[231],"neurological":[233],"symptoms":[234],"developed.":[235],"More":[236],"60":[238],"%":[239,249,466],"all":[241],"ovarian":[242,284,311,346],"tumours":[243],"express":[244],"CDR2,":[245],"only":[247],"2.3":[248],"even":[257],"fewer":[258],"reason":[262],"known.":[271],"wanted":[273],"production":[278],"cancer":[285,461],"related":[288,379,459],"cDNA":[293],"difference":[297],"mRNA":[301],"protein":[303,426,433],"level":[304],"tumour":[306,342],"tissue":[307,347],"from":[308],"cancer.":[312],"no":[315],"them":[326],"However,":[332,464],"observed":[334],"solely":[339,378],"expressed":[340,348,435],"by":[341],"cells.":[343,402],"Also":[344],"normal":[345],"low":[349],"levels":[350],"These":[353],"findings":[354,367],"may":[358],"be":[359],"more":[360],"widely":[361],"distributed":[362],"previously":[364],"reported.":[365],"Our":[366],"support":[369],"hypothesis":[371],"development":[373],"PCD":[375,414],"synthesis,":[386],"dysregulation,":[391],"such":[392],"as":[393],"antigen":[394],"presentation":[395],"cooperation":[397],"between":[398,481],"B":[399],"T":[401],"commonly":[406],"appear":[407],"alone.":[408],"identified":[410],"patient":[412],"harboured":[420],"towards":[422],"described":[425],"called":[427],"CCDC104.":[428],"this":[432,447],"several":[437],"tissues,":[438],"especially":[439],"brain":[440],"testis.":[442],"further":[444],"investigated":[445],"potentially":[451],"new":[452],"marker.":[454],"CCDC104":[455,473],"PNS.":[463],"10.5":[465],"sera":[470],"suggesting":[475],"there":[476],"significant":[479],"association":[480],"anti-CCDC104.":[484]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
