{"id":"https://openalex.org/W855670062","doi":null,"title":"A functional role for hippocampal non-local activity and a method to interfere with functional circuits","display_name":"A functional role for hippocampal non-local activity and a method to interfere with functional circuits","publication_year":2014,"publication_date":"2014-08-28","ids":{"openalex":"https://openalex.org/W855670062","mag":"855670062"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1436373","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1436373/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031536509","display_name":"H. Freyja \u00d3lafsd\u00f3ttir","orcid":"https://orcid.org/0000-0003-2416-0589","observed_orcids":["https://orcid.org/0000-0003-2416-0589"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"HF \u00d3lafsd\u00f3ttir","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5031536509"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11904","display_name":"Spatial Cognition and Navigation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9570000171661377},{"id":"https://openalex.org/keywords/place-cells","display_name":"place cells","score":0.921999990940094},{"id":"https://openalex.org/keywords/spatial-cognition","display_name":"spatial cognition","score":0.6539999842643738},{"id":"https://openalex.org/keywords/goal-directed-navigation","display_name":"goal-directed navigation","score":0.6309999823570251},{"id":"https://openalex.org/keywords/laser-ablation","display_name":"laser ablation","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.8585209846496582},{"id":"https://openalex.org/C2781369091","wikidata":"https://www.wikidata.org/wiki/Q2303730","display_name":"Place cell","level":3,"score":0.8288127183914185},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7566307187080383},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.644976019859314},{"id":"https://openalex.org/C2984127161","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neural activity","level":2,"score":0.5024359226226807},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.48811325430870056},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.47826898097991943},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4694630205631256},{"id":"https://openalex.org/C117838684","wikidata":"https://www.wikidata.org/wiki/Q533483","display_name":"Local field potential","level":2,"score":0.4535362422466278},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4489636719226837},{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.4202168583869934},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38807618618011475}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1436373","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1436373/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:855670062","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1436373","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":249,"referenced_works":["https://openalex.org/W160899559","https://openalex.org/W594632875","https://openalex.org/W644076287","https://openalex.org/W1511193166","https://openalex.org/W1515214283","https://openalex.org/W1547944497","https://openalex.org/W1562811233","https://openalex.org/W1568903867","https://openalex.org/W1571164133","https://openalex.org/W1580901834","https://openalex.org/W1582697909","https://openalex.org/W1585564530","https://openalex.org/W1591353378","https://openalex.org/W1673926418","https://openalex.org/W1704778993","https://openalex.org/W1748459183","https://openalex.org/W1826201647","https://openalex.org/W1889678891","https://openalex.org/W1896376703","https://openalex.org/W1898031307","https://openalex.org/W1928342057","https://openalex.org/W1950640079","https://openalex.org/W1966924926","https://openalex.org/W1967273876","https://openalex.org/W1967456522","https://openalex.org/W1968023011","https://openalex.org/W1968533788","https://openalex.org/W1969255675","https://openalex.org/W1969769253","https://openalex.org/W1970792572","https://openalex.org/W1970929159","https://openalex.org/W1971392964","https://openalex.org/W1971466598","https://openalex.org/W1973372728","https://openalex.org/W1975917180","https://openalex.org/W1975958074","https://openalex.org/W1979533714","https://openalex.org/W1979866646","https://openalex.org/W1980009209","https://openalex.org/W1980737345","https://openalex.org/W1980796284","https://openalex.org/W1981737644","https://openalex.org/W1981998044","https://openalex.org/W1982298223","https://openalex.org/W1982918139","https://openalex.org/W1983726109","https://openalex.org/W1984871000","https://openalex.org/W1984915263","https://openalex.org/W1985879131","https://openalex.org/W1985934255","https://openalex.org/W1986015216","https://openalex.org/W1987898718","https://openalex.org/W1988751593","https://openalex.org/W1988831155","https://openalex.org/W1989470236","https://openalex.org/W1989477529","https://openalex.org/W1989932452","https://openalex.org/W1990421122","https://openalex.org/W1990627393","https://openalex.org/W1990914734","https://openalex.org/W1992856299","https://openalex.org/W1992949974","https://openalex.org/W1993353270","https://openalex.org/W1997888430","https://openalex.org/W1998078493","https://openalex.org/W1999542375","https://openalex.org/W2000214310","https://openalex.org/W2001222407","https://openalex.org/W2001257668","https://openalex.org/W2001383746","https://openalex.org/W2002272109","https://openalex.org/W2002914396","https://openalex.org/W2003175354","https://openalex.org/W2004030401","https://openalex.org/W2004725045","https://openalex.org/W2005725359","https://openalex.org/W2006760951","https://openalex.org/W2007442485","https://openalex.org/W2008710509","https://openalex.org/W2008936540","https://openalex.org/W2009102686","https://openalex.org/W2011835662","https://openalex.org/W2012568486","https://openalex.org/W2013076359","https://openalex.org/W2013438045","https://openalex.org/W2013651799","https://openalex.org/W2014792483","https://openalex.org/W2014861008","https://openalex.org/W2015779050","https://openalex.org/W2016985810","https://openalex.org/W2017169966","https://openalex.org/W2017766656","https://openalex.org/W2017937012","https://openalex.org/W2018529924","https://openalex.org/W2018964056","https://openalex.org/W2020972983","https://openalex.org/W2022283229","https://openalex.org/W2023321272","https://openalex.org/W2025164836","https://openalex.org/W2025167511","https://openalex.org/W2026393786","https://openalex.org/W2026624422","https://openalex.org/W2028054593","https://openalex.org/W2028223342","https://openalex.org/W2028727099","https://openalex.org/W2029210342","https://openalex.org/W2030396712","https://openalex.org/W2030621225","https://openalex.org/W2032438999","https://openalex.org/W2032559179","https://openalex.org/W2033851827","https://openalex.org/W2037877714","https://openalex.org/W2038926537","https://openalex.org/W2041152585","https://openalex.org/W2041225019","https://openalex.org/W2041510555","https://openalex.org/W2041800086","https://openalex.org/W2043106712","https://openalex.org/W2043183159","https://openalex.org/W2043534501","https://openalex.org/W2046964936","https://openalex.org/W2047750300","https://openalex.org/W2049026260","https://openalex.org/W2051100750","https://openalex.org/W2051448570","https://openalex.org/W2056336718","https://openalex.org/W2058491602","https://openalex.org/W2059148040","https://openalex.org/W2060589548","https://openalex.org/W2060671266","https://openalex.org/W2060841481","https://openalex.org/W2061663541","https://openalex.org/W2061922686","https://openalex.org/W2062822447","https://openalex.org/W2062979941","https://openalex.org/W2063303712","https://openalex.org/W2063379973","https://openalex.org/W2063983402","https://openalex.org/W2067150535","https://openalex.org/W2067474937","https://openalex.org/W2067765425","https://openalex.org/W2067933183","https://openalex.org/W2067944500","https://openalex.org/W2068793916","https://openalex.org/W2069090835","https://openalex.org/W2069785065","https://openalex.org/W2070288489","https://openalex.org/W2071290167","https://openalex.org/W2072843066","https://openalex.org/W2073145989","https://openalex.org/W2073213998","https://openalex.org/W2076188357","https://openalex.org/W2076471532","https://openalex.org/W2076735150","https://openalex.org/W2078219183","https://openalex.org/W2078575897","https://openalex.org/W2079161053","https://openalex.org/W2079390801","https://openalex.org/W2079785206","https://openalex.org/W2082115891","https://openalex.org/W2082235945","https://openalex.org/W2083060092","https://openalex.org/W2083102884","https://openalex.org/W2083866613","https://openalex.org/W2084588382","https://openalex.org/W2085768069","https://openalex.org/W2087298647","https://openalex.org/W2087660090","https://openalex.org/W2088358452","https://openalex.org/W2092053118","https://openalex.org/W2092580449","https://openalex.org/W2092873052","https://openalex.org/W2093018428","https://openalex.org/W2093069982","https://openalex.org/W2093540238","https://openalex.org/W2094842904","https://openalex.org/W2094933391","https://openalex.org/W2096032973","https://openalex.org/W2098161132","https://openalex.org/W2098371930","https://openalex.org/W2099512174","https://openalex.org/W2099630522","https://openalex.org/W2100211448","https://openalex.org/W2101290001","https://openalex.org/W2103655875","https://openalex.org/W2103853773","https://openalex.org/W2107852368","https://openalex.org/W2108501592","https://openalex.org/W2109059823","https://openalex.org/W2109062476","https://openalex.org/W2109234881","https://openalex.org/W2111405228","https://openalex.org/W2113972883","https://openalex.org/W2114501218","https://openalex.org/W2114786345","https://openalex.org/W2115107366","https://openalex.org/W2116524658","https://openalex.org/W2119051448","https://openalex.org/W2119565218","https://openalex.org/W2119610099","https://openalex.org/W2119835435","https://openalex.org/W2124727398","https://openalex.org/W2126268407","https://openalex.org/W2128063722","https://openalex.org/W2129707824","https://openalex.org/W2131336446","https://openalex.org/W2134170969","https://openalex.org/W2137172397","https://openalex.org/W2139681697","https://openalex.org/W2143838564","https://openalex.org/W2143853187","https://openalex.org/W2144232743","https://openalex.org/W2145409044","https://openalex.org/W2146367411","https://openalex.org/W2146561158","https://openalex.org/W2147027939","https://openalex.org/W2148740848","https://openalex.org/W2148741637","https://openalex.org/W2151108396","https://openalex.org/W2152372327","https://openalex.org/W2152829138","https://openalex.org/W2153695024","https://openalex.org/W2155505956","https://openalex.org/W2155547196","https://openalex.org/W2155654111","https://openalex.org/W2156728993","https://openalex.org/W2159574392","https://openalex.org/W2161012188","https://openalex.org/W2161437069","https://openalex.org/W2161980192","https://openalex.org/W2163336335","https://openalex.org/W2164262638","https://openalex.org/W2166343885","https://openalex.org/W2166620359","https://openalex.org/W2167938504","https://openalex.org/W2168101731","https://openalex.org/W2170347881","https://openalex.org/W2171332611","https://openalex.org/W2194582951","https://openalex.org/W2326238228","https://openalex.org/W2396598205","https://openalex.org/W2402236720","https://openalex.org/W2410446460","https://openalex.org/W2416119024","https://openalex.org/W2430578952","https://openalex.org/W2474960112","https://openalex.org/W2764433274","https://openalex.org/W7095648823","https://openalex.org/W7100348451"],"related_works":["https://openalex.org/W4237809438","https://openalex.org/W3095668735","https://openalex.org/W53354751","https://openalex.org/W2222535540","https://openalex.org/W2034043732","https://openalex.org/W1998078493","https://openalex.org/W2943796075","https://openalex.org/W3083836359","https://openalex.org/W1974741249","https://openalex.org/W3156839718"],"abstract_inverted_index":{"The":[0,70,121,181,259],"hippocampus":[1,13],"has":[2,223],"been":[3,44],"implicated":[4],"in":[5,10,18,107,149,178,205,265,275],"spatial":[6,16],"cognition.":[7],"Pyramidal":[8],"cells":[9,52],"the":[11,83,113,150,164,172,185,193,206,239,250,263,279,281,287],"rodent":[12,207],"show":[14,75,158,215],"a":[15,64,86,133,197,224],"correlate":[17],"their":[19,25,31,55],"activity,":[20],"such":[21,91],"that":[22,90,159],"they":[23],"increase":[24],"activity":[26,50,79,93,104,115,271],"when":[27,51],"an":[28],"animal":[29],"enters":[30],"principal":[32],"firing":[33],"field":[34],"(\u2018place":[35],"field\u2019).":[36],"However,":[37],"behavioural":[38],"state":[39],"and":[40,89,169,222,257,278],"task":[41],"demands":[42],"have":[43],"found":[45],"to":[46,96,118,199,286],"influence":[47],"place":[48,56,77,127],"cell":[49,78,128],"are":[53],"outside":[54],"field.":[57],"This":[58,140],"thesis":[59],"will":[60,74],"report":[61],"findings":[62,100,157,183],"implying":[63],"functional":[65,189,254],"role":[66],"for":[67,248],"\u2018out-of-field\u2019":[68],"activity.":[69],"first":[71],"experimental":[72,123,236],"chapter":[73,124,261],"ensemble":[76],"is":[80,94,219,245],"highest":[81],"at":[82],"start":[84],"of":[85,166,187,203,211,227,238,267,289],"goal-directed":[87,167],"trajectory,":[88],"enhanced":[92,114],"related":[95],"navigational":[97,119,176],"performance.":[98],"These":[99],"accord":[101],"with":[102],"hippocampal":[103,126,151,270,290],"patterns":[105],"observed":[106],"human":[108],"studies.":[109],"Moreover,":[110,232],"we":[111,154,233],"speculate":[112],"may":[116,170,272],"relate":[117],"planning.":[120],"second":[122],"shows":[125],"sequences":[129],"during":[130],"rest":[131],"preplay":[132,160],"future,":[134],"motivationally-relevant":[135],"trajectory":[136],"through":[137],"unexplored":[138],"space.":[139],"effect":[141],"could":[142],"not":[143],"be":[144,162,273],"explained":[145],"by":[146,209],"simple":[147],"preconfiguration":[148],"circuitry.":[152],"Thus,":[153],"conclude":[155],"these":[156],"can":[161,284],"under":[163],"control":[165],"influences":[168],"represent":[171],"neural":[173,190,255],"signature":[174],"underlying":[175],"planning":[177,277],"novel":[179],"environments.":[180],"aforementioned":[182],"emphasise":[184],"importance":[186],"studying":[188],"circuits.":[191],"Consequently,":[192],"final":[194,260],"study":[195,288],"describes":[196],"method":[198,218,244,283],"perform":[200],"targeted":[201],"ablations":[202],"single-cells":[204],"brain,":[208],"means":[210],"laser":[212],"irradiation.":[213],"We":[214,241],"this":[216,243],"lesioning":[217],"spatially":[220],"precise":[221],"depth":[225],"limitation":[226],"~400\u03bcm":[228],"below":[229],"brain":[230],"surface.":[231],"describe":[234],"one":[235],"application":[237],"method.":[240],"suggest":[242],"well":[246],"suited":[247],"addressing":[249],"causal":[251],"links":[252],"between":[253],"circuits":[256],"behaviour.":[258],"discusses":[262],"data":[264],"terms":[266],"how":[268],"out-of-field":[269],"involved":[274],"future":[276],"contribution":[280],"ablation":[282],"make":[285],"function.":[291]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}