{"id":"https://openalex.org/W85560443","doi":null,"title":"Modulation of density-fractionated RBC deformability by nitric oxide.","display_name":"Modulation of density-fractionated RBC deformability by nitric oxide.","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W85560443","mag":"85560443","pmid":"https://pubmed.ncbi.nlm.nih.gov/16317245"},"language":"en","primary_location":{"id":"pmid:16317245","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16317245","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical hemorheology and microcirculation","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055933848","display_name":"Melek Bor-K\u00fc\u00e7\u00fckatay","orcid":"https://orcid.org/0000-0002-9366-0205","observed_orcids":["https://orcid.org/0000-0002-9366-0205"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Melek Bor-Kucukatay","raw_affiliation_strings":["Department of Physiology, Pamukkale University Faculty of Medicine, Denizli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Pamukkale University Faculty of Medicine, Denizli, Turkey","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019403591","display_name":"Herbert J. Meiselman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Herbert J Meiselman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103355048","display_name":"Oguz Kerim Baskurt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oguz K Ba\u015fkurt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1916,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.54605619,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"33","issue":"4","first_page":"363","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9018999934196472,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9018999934196472,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0421999990940094,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.03139999881386757,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9599999785423279},{"id":"https://openalex.org/keywords/erythrocyte-deformability","display_name":"erythrocyte deformability","score":0.9919999837875366},{"id":"https://openalex.org/keywords/density-fractionation","display_name":"density fractionation","score":0.6729999780654907},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-inhibition","display_name":"nitric oxide synthase inhibition","score":0.8119999766349792},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.8799999952316284},{"id":"https://openalex.org/keywords/sodium-nitroprusside","display_name":"sodium nitroprusside","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ektacytometry","display_name":"ektacytometry","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C2779610285","wikidata":"https://www.wikidata.org/wiki/Q27108300","display_name":"Sodium nitroprusside","level":3,"score":0.8914649486541748},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.8877967596054077},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.7460323572158813},{"id":"https://openalex.org/C2776185378","wikidata":"https://www.wikidata.org/wiki/Q5396464","display_name":"Erythrocyte deformability","level":3,"score":0.6481186151504517},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6386979818344116},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.5900898575782776},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.45075932145118713},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3432426452636719},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2846439778804779},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16929882764816284},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1263292133808136},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002458","descriptor_name":"Cell Fractionation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004907","descriptor_name":"Erythrocyte Deformability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009599","descriptor_name":"Nitroprusside","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020030","descriptor_name":"Nitric Oxide Donors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16317245","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16317245","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical hemorheology and microcirculation","raw_type":"Journal Article"},{"id":"mag:85560443","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16317245","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8305194470","display_name":"COMPREHENSIVE SICKLE CELL CENTER","funder_award_id":"5u54hl070595-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W852894586","https://openalex.org/W1757857404","https://openalex.org/W1808892728","https://openalex.org/W1959998098","https://openalex.org/W1972618484","https://openalex.org/W1974549029","https://openalex.org/W2046008499","https://openalex.org/W2096465912","https://openalex.org/W2127291397","https://openalex.org/W2138407815","https://openalex.org/W2253598100","https://openalex.org/W2278308791","https://openalex.org/W2417853926","https://openalex.org/W2466012275","https://openalex.org/W2492798948"],"related_works":["https://openalex.org/W2096465912","https://openalex.org/W1989575161","https://openalex.org/W2980107085","https://openalex.org/W1974549029","https://openalex.org/W2385578584","https://openalex.org/W7100208281","https://openalex.org/W2801708763","https://openalex.org/W1993466365","https://openalex.org/W1959998098","https://openalex.org/W4244405874"],"abstract_inverted_index":{"The":[0,20],"role":[1],"of":[2,11,22,32,52,66,106,131],"nitric":[3,60],"oxide":[4,61],"(NO)":[5],"in":[6,38,88,114,120,142],"maintaining":[7],"normal":[8],"mechanical":[9,30],"behavior":[10],"red":[12],"blood":[13,72],"cell":[14],"(RBC)":[15],"has":[16],"been":[17],"previously":[18],"demonstrated.":[19],"effects":[21],"NO":[23,108,157,166,173],"donor":[24,62,109],"and":[25,55,80,159],"NOS":[26,43,136],"inhibitor":[27],"on":[28,111],"the":[29,89,107,115,123,129,143,169],"properties":[31],"density":[33,90],"fractionated":[34,91],"RBC":[35,81,92,118,151],"were":[36],"tested":[37],"this":[39],"study.":[40],"A":[41],"non-specific":[42],"inhibitor,":[44],"N-omega-nitro-L-arginine":[45],"methyl":[46],"ester":[47],"(L-NAME)":[48],"at":[49,63,97],"a":[50,59,64],"concentration":[51,65],"10(-3)":[53],"M":[54,68],"sodium":[56],"nitroprusside":[57],"(SNP),":[58],"10(-6)":[67],"was":[69,83,102,140],"added":[70],"to":[71,77,134,164],"samples":[73],"with":[74,122],"hematocrit":[75],"adjusted":[76],"0.4":[78],"l/l":[79],"deformability":[82,113,133],"measured":[84],"by":[85,138,154],"an":[86],"ektacytometer":[87],"after":[93],"one":[94],"hour":[95],"incubation":[96],"37":[98],"degrees":[99],"C.":[100],"There":[101],"no":[103],"significant":[104],"effect":[105],"SNP":[110],"cellular":[112,132],"older":[116,144,150],"(denser)":[117],"fraction":[119],"contrast":[121],"younger":[124],"(least":[125],"dense)":[126],"fraction.":[127,145],"Alternatively,":[128],"sensitivity":[130],"competitive":[135],"inhibition":[137],"L-NAME":[139],"greater":[141],"These":[146],"findings":[147],"suggest":[148],"that":[149,168],"are":[152,160],"characterized":[153],"diminished":[155],"internal":[156],"synthesis":[158],"also":[161,175],"less":[162],"sensitive":[163],"external":[165],"indicating":[167],"target":[170],"mechanisms":[171],"for":[172],"may":[174],"be":[176],"deteriorated.":[177]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}