{"id":"https://openalex.org/W85556996","doi":null,"title":"Maturation and sex differences in stress sensitivity","display_name":"Maturation and sex differences in stress sensitivity","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W85556996","mag":"85556996"},"language":"en","primary_location":{"id":"pmh:oai:repository.upenn.edu:dissertations-8912","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/dissertations/AAI3381613","pdf_url":null,"source":{"id":"https://openalex.org/S4377196331","display_name":"Scholarly Commons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations available from ProQuest","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034694557","display_name":"Nirupa Goel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nirupa Goel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5034694557"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stress-sensitivity","display_name":"stress sensitivity","score":0.8299999833106995},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9679999947547913},{"id":"https://openalex.org/keywords/puberty","display_name":"puberty","score":0.8830000162124634},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.8360000252723694},{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.9210000038146973},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.7279999852180481},{"id":"https://openalex.org/keywords/fos-protein","display_name":"Fos protein","score":0.6779999732971191},{"id":"https://openalex.org/keywords/gonadectomy","display_name":"gonadectomy","score":0.7870000004768372},{"id":"https://openalex.org/keywords/glucocorticoid-regulation","display_name":"glucocorticoid regulation","score":0.6620000004768372},{"id":"https://openalex.org/keywords/gaba","display_name":"GABA","score":0.7870000004768372},{"id":"https://openalex.org/keywords/adrenal-gland","display_name":"adrenal gland","score":0.5979999899864197},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.7689999938011169},{"id":"https://openalex.org/keywords/mood-disorders","display_name":"mood disorders","score":0.8149999976158142},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.39100000262260437},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.8529999852180481},{"id":"https://openalex.org/keywords/gonadal-hormones","display_name":"gonadal hormones","score":0.5289999842643738},{"id":"https://openalex.org/keywords/sexual-differentiation-of-the-brain","display_name":"sexual differentiation of the brain","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.5266696810722351},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.5178852081298828},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.36185044050216675},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08777067065238953},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.upenn.edu:dissertations-8912","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/dissertations/AAI3381613","pdf_url":null,"source":{"id":"https://openalex.org/S4377196331","display_name":"Scholarly Commons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations available from ProQuest","raw_type":"text"},{"id":"mag:85556996","doi":null,"is_oa":false,"landing_page_url":"http://gradworks.umi.com/33/81/3381613.html","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2158117270","https://openalex.org/W1983123817","https://openalex.org/W2039419866","https://openalex.org/W2296005196","https://openalex.org/W2971090769","https://openalex.org/W2922516799","https://openalex.org/W4387653297","https://openalex.org/W6961228950","https://openalex.org/W2986182493","https://openalex.org/W4387700788"],"abstract_inverted_index":{"Dysregulation":[0],"of":[1,10,16,27,43,57,60,84,92,120,144,154,161,196,209,274,291,308],"stress":[2,31,72,86,101,109,134,155,188,204,244,263,328,335],"neurocircuitry":[3,336],"has":[4,213],"been":[5],"implicated":[6],"in":[7,21,24,98,111,125,128,152,158,185,202,228,238,248,252,257,289,326,334],"the":[8,34,41,61,121,142,159,197,210,218,243,258,262,309],"etiology":[9],"depressive":[11],"and":[12,29,33,63,132,157,173,190,250,304,330],"anxiety":[13],"disorders,":[14],"both":[15],"which":[17],"are":[18],"more":[19],"prevalent":[20],"women":[22],"than":[23,271],"men.":[25],"Examination":[26,195],"physiological":[28],"behavioral":[30],"responses":[32,50],"mechanisms":[35,198],"underlying":[36,199],"elevated":[37],"sensitivity":[38,110,135,189],"may":[39,297,337],"elucidate":[40],"neurobiology":[42],"affective":[44,76,344],"disorders.":[45,345],"The":[46],"circuitry":[47],"mediating":[48],"these":[49,192],"is":[51,322],"highly":[52],"dynamic,":[53],"changing":[54],"during":[55,104,146,183,319],"periods":[56,321],"sexual":[58],"differentiation":[59],"brain":[62,239],"with":[64],"exposure":[65,182,247,318],"to":[66,75,107,115,339,343],"gonadal":[67],"hormones.":[68],"To":[69],"investigate":[70],"how":[71],"pathways":[73,102,156],"contribute":[74,338],"disease":[77],"vulnerability,":[78],"we":[79,285],"utilized":[80],"a":[81,149,214,299,323],"genetic":[82,118],"model":[83],"heightened":[85],"responsivity":[87,329],"as":[88,90,113,136],"well":[89],"examination":[91],"sex":[93,162,193,200,255,287,332],"differences.":[94,163,194],"We":[95,138,178],"found":[96,179,286],"that":[97,141,180,207,241,295,316,331],"male":[99],"mice,":[100],"mature":[103],"puberty,":[105],"leading":[106],"decreased":[108,300],"adults":[112],"compared":[114],"juveniles.":[116],"However,":[117],"dysregulation":[119],"corticotropin-releasing":[122],"factor":[123,325],"system":[124,212],"males":[126,253],"results":[127],"altered":[129],"maturational":[130],"processes":[131],"increased":[133,340],"adults.":[137],"therefore":[139],"hypothesized":[140],"rise":[143],"testosterone":[145,181,317],"puberty":[147,184],"plays":[148],"crucial":[150],"role":[151],"maturation":[153],"development":[160],"As":[164],"adults,":[165],"females":[166,186,233,249,266,296],"exhibit":[167],"greater":[168,174,215,275],"hypothalamic-pituitary-adrenal":[169],"(HPA)":[170],"axis":[171],"activity":[172],"passive":[175],"stress-coping":[176],"behaviors.":[177],"decreases":[187],"diminishes":[191],"differences":[201,227,256,288,333],"HPA":[203,220,310],"response":[205,223],"revealed":[206],"stimulation":[208],"serotonin":[211],"impact":[216],"on":[217,261],"female":[219,341],"axis.":[221,245,311],"This":[222],"was":[224],"supported":[225],"by":[226],"serotonin-induced":[229],"neural":[230],"activation":[231],"where":[232],"displayed":[234],"lower":[235],"fos":[236],"protein":[237],"regions":[240],"inhibit":[242],"Testosterone":[246,278],"gonadectomy":[251],"ameliorated":[254],"serotonergic":[259],"influence":[260],"circuitry.":[264],"Moreover,":[265],"exhibited":[267],"heavier":[268],"adrenal":[269],"glands":[270],"males,":[272],"indicative":[273],"corticosterone":[276],"synthesis.":[277],"again":[279],"masculinized":[280],"this":[281,313],"difference.":[282],"In":[283],"addition,":[284],"expression":[290],"stress-relevant":[292],"genes":[293],"indicating":[294],"have":[298],"capacity":[301],"for":[302],"glucocorticoid-":[303],"GABA-mediated":[305],"negative":[306],"regulation":[307],"Overall,":[312],"work":[314],"demonstrates":[315],"developmental":[320],"major":[324],"reducing":[327],"vulnerability":[342]},"counts_by_year":[],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2016-06-24T00:00:00"}