{"id":"https://openalex.org/W855489349","doi":null,"title":"Biochemical Kinetics Model of DSB Repair and GammaH2AX FOCI by Non-homologous End Joining","display_name":"Biochemical Kinetics Model of DSB Repair and GammaH2AX FOCI by Non-homologous End Joining","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W855489349","mag":"855489349"},"language":"en","primary_location":{"id":"mag:855489349","doi":null,"is_oa":false,"landing_page_url":"https://ntrs.nasa.gov/api/citations/20070021528/downloads/20070021528.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306402118","display_name":"NASA Technical Reports Server (NASA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210124779","host_organization_name":"National Aeronautics and Space Administration","host_organization_lineage":["https://openalex.org/I4210124779"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109883541","display_name":"Francis A. Cucinotta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francis A. Cucinotta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008813757","display_name":"Janice M. Pluth","orcid":"https://orcid.org/0000-0002-8370-506X","observed_orcids":["https://orcid.org/0000-0002-8370-506X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janice M. Pluth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jennifer A. Anderson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer A. Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109471232","display_name":"Jane V. Harper","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jane Harper","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110851784","display_name":"Peter O\u2019Neill","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter O\u2019Neill","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1088,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.40999197,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8676999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8676999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.12430000305175781,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.8500000238418579},{"id":"https://openalex.org/keywords/non-homologous-end-joining","display_name":"non-homologous end joining","score":0.9769999980926514},{"id":"https://openalex.org/keywords/gamma-h2ax-foci","display_name":"\u03b3H2AX foci","score":0.8939999938011169},{"id":"https://openalex.org/keywords/ku70-80","display_name":"Ku70/80","score":0.8240000009536743},{"id":"https://openalex.org/keywords/dna-pkcs","display_name":"DNA-PKcs","score":0.9660000205039978},{"id":"https://openalex.org/keywords/autophosphorylation","display_name":"autophosphorylation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/low-let-radiation","display_name":"low-LET radiation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/dose-rate-effects","display_name":"dose rate dependence","score":0.5460000038146973},{"id":"https://openalex.org/keywords/low-dose-radiation","display_name":"low-dose radiation","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C175114707","wikidata":"https://www.wikidata.org/wiki/Q408483","display_name":"DNA ligase","level":3,"score":0.6392549872398376},{"id":"https://openalex.org/C122917832","wikidata":"https://www.wikidata.org/wiki/Q2065945","display_name":"Non-homologous end joining","level":4,"score":0.5981349945068359},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.5300992131233215},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5283506512641907},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4634734094142914},{"id":"https://openalex.org/C150109051","wikidata":"https://www.wikidata.org/wiki/Q3630494","display_name":"Autophosphorylation","level":4,"score":0.4573172926902771},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.4435267448425293},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.4389099180698395},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4314316511154175},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4276210069656372},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4273645281791687},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4115082919597626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3257320523262024},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.31080982089042664},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17429840564727783},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13293245434761047},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:855489349","doi":null,"is_oa":false,"landing_page_url":"https://ntrs.nasa.gov/api/citations/20070021528/downloads/20070021528.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306402118","display_name":"NASA Technical Reports Server (NASA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210124779","host_organization_name":"National Aeronautics and Space Administration","host_organization_lineage":["https://openalex.org/I4210124779"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W292040930","https://openalex.org/W587937822","https://openalex.org/W631732704","https://openalex.org/W1564224574","https://openalex.org/W1967264277","https://openalex.org/W1967497561","https://openalex.org/W1979568780","https://openalex.org/W1983626749","https://openalex.org/W1985775217","https://openalex.org/W1986320226","https://openalex.org/W1999037466","https://openalex.org/W1999644099","https://openalex.org/W1999940496","https://openalex.org/W2009579361","https://openalex.org/W2016949180","https://openalex.org/W2019219567","https://openalex.org/W2019405732","https://openalex.org/W2022811243","https://openalex.org/W2028957578","https://openalex.org/W2034582922","https://openalex.org/W2043990544","https://openalex.org/W2061060103","https://openalex.org/W2061414735","https://openalex.org/W2068283077","https://openalex.org/W2075175820","https://openalex.org/W2077922140","https://openalex.org/W2082981258","https://openalex.org/W2090002227","https://openalex.org/W2103007290","https://openalex.org/W2105277962","https://openalex.org/W2114745290","https://openalex.org/W2119100786","https://openalex.org/W2120810793","https://openalex.org/W2121672275","https://openalex.org/W2127323791","https://openalex.org/W2137239016","https://openalex.org/W2143629217","https://openalex.org/W2150067158","https://openalex.org/W2163476495","https://openalex.org/W2168865603","https://openalex.org/W2176001433","https://openalex.org/W2178785249","https://openalex.org/W2474647034"],"related_works":["https://openalex.org/W2152042169","https://openalex.org/W2143301911","https://openalex.org/W2057252512","https://openalex.org/W2117599408","https://openalex.org/W2024848275","https://openalex.org/W2914087883","https://openalex.org/W1975030858","https://openalex.org/W2601456493","https://openalex.org/W2045802588","https://openalex.org/W601284338"],"abstract_inverted_index":{"We":[0],"developed":[1,90],"a":[2,104,128,183],"biochemical":[3],"kinetics":[4],"approach":[5],"to":[6,101,109,121],"describe":[7],"the":[8,26,41,58,92,116,119,153,163,172],"repair":[9,88],"of":[10,28,34,43,64,70,83,87,97,152,155,162,165,174,189],"double":[11],"strand":[12],"breaks":[13],"(DSB)":[14],"produced":[15],"by":[16,20,147],"low":[17,178],"LET":[18],"radiation":[19,76],"modeling":[21],"molecular":[22],"events":[23],"associated":[24],"with":[25,91,127],"mechanisms":[27],"non-homologous":[29],"end-joining":[30],"(NHEJ).":[31],"A":[32,80],"system":[33],"coupled":[35],"non-linear":[36],"ordinary":[37],"differential":[38],"equations":[39],"describes":[40],"induction":[42,69,154,164],"DSB":[44,125,143],"and":[45,57,67,103,158,180],"activation":[46],"pathways":[47],"for":[48,131,171],"major":[49],"NHEJ":[50,99,175],"components":[51,100,176],"including":[52,142],"Ku(sub":[53,166],"70/80),":[54],"DNA-PK(sub":[55,65,84],"cs),":[56],"Ligase":[59,110],"IV-XRCC4":[60],"hetero-dimer.":[61],"The":[62,134],"autophosphorylation":[63],"cs":[66],"subsequent":[68],"gamma-H2AX":[71,156],"foci":[72],"observed":[73],"after":[74],"ionizing":[75],"exposure":[77],"were":[78],"modeled.":[79],"two-step":[81],"model":[82,113,135],"cs)":[85],"regulation":[86],"was":[89],"initial":[93],"step":[94,106],"allowing":[95],"access":[96,108],"other":[98],"breaks,":[102],"second":[105],"limiting":[107],"IV-XRCC4.":[111],"Our":[112],"assumes":[114],"that":[115],"transition":[117],"from":[118],"first":[120],"second-step":[122],"depends":[123],"on":[124],"complexity,":[126],"much":[129],"slower-rate":[130],"complex":[132],"DSB.":[133],"faithfully":[136],"reproduced":[137],"several":[138],"experimental":[139],"data":[140],"sets,":[141],"rejoining":[144],"as":[145],"measured":[146],"pulsed-field":[148],"electrophoresis":[149],"(PFGE),":[150],"quantification":[151],"foci,":[157],"live":[159],"cell":[160],"imaging":[161],"70/80).":[167],"Predictions":[168],"are":[169],"made":[170],"behaviors":[173],"at":[177,187],"doses":[179],"dose-rates,":[181],"where":[182],"steady-state":[184],"is":[185],"found":[186],"dose-rates":[188],"0.1":[190],"Gy/hr":[191],"or":[192],"lower.":[193]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}