{"id":"https://openalex.org/W855084716","doi":null,"title":"Contribution \u00e0 l'\u00e9tude de la radiobiologie des \u00e9metteurs de particules alpha et de leur impact sur l'immunog\u00e9nicit\u00e9 des tumeurs","display_name":"Contribution \u00e0 l'\u00e9tude de la radiobiologie des \u00e9metteurs de particules alpha et de leur impact sur l'immunog\u00e9nicit\u00e9 des tumeurs","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W855084716","mag":"855084716"},"language":"fr","primary_location":{"id":"mag:855084716","doi":null,"is_oa":false,"landing_page_url":"https://www.theses.fr/2013NANT13VS","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024785562","display_name":"Jean\u2010Baptiste Gorin","orcid":"https://orcid.org/0000-0003-4605-1375","observed_orcids":["https://orcid.org/0000-0003-4605-1375"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jean\u2010Baptiste Gorin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4605-1375","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5024785562"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0763000026345253,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radioimmunotherapy","display_name":"radioimmunotherapy","score":0.8140000104904175},{"id":"https://openalex.org/keywords/bismuth-213","display_name":"bismuth-213","score":0.9869999885559082},{"id":"https://openalex.org/keywords/immunogenic-cell-death","display_name":"immunogenic cell death","score":0.9359999895095825},{"id":"https://openalex.org/keywords/tumor-immunogenicity","display_name":"tumor immunogenicity","score":0.9010000228881836},{"id":"https://openalex.org/keywords/g2-cell-cycle-arrest","display_name":"G2 cell cycle arrest","score":0.8040000200271606},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/damage-associated-molecular-patterns","display_name":"damage-associated molecular patterns","score":0.8399999737739563},{"id":"https://openalex.org/keywords/dendritic-cell-activation","display_name":"dendritic cell activation","score":0.949999988079071},{"id":"https://openalex.org/keywords/tumor-cell-vaccination","display_name":"tumor cell vaccination","score":0.6980000138282776},{"id":"https://openalex.org/keywords/tumor-specific-t-cells","display_name":"tumor-specific T cells","score":0.9079999923706055},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8119999766349792},{"id":"https://openalex.org/keywords/alpha-emitters","display_name":"alpha-emitting radionuclides","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6263172626495361},{"id":"https://openalex.org/C2777877232","wikidata":"https://www.wikidata.org/wiki/Q17144704","display_name":"Immunogenic cell death","level":4,"score":0.6227246522903442},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5965017676353455},{"id":"https://openalex.org/C2776146153","wikidata":"https://www.wikidata.org/wiki/Q7281276","display_name":"Radioimmunotherapy","level":4,"score":0.5674301385879517},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.5564283132553101},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.4709806442260742},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4550427496433258},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3997395634651184},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3702394366264343},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35707369446754456},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32196277379989624},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.24598228931427002},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.20462951064109802},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.15736231207847595},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.11903378367424011},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0874444842338562},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:855084716","doi":null,"is_oa":false,"landing_page_url":"https://www.theses.fr/2013NANT13VS","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":221,"referenced_works":["https://openalex.org/W72089627","https://openalex.org/W96458819","https://openalex.org/W100467445","https://openalex.org/W149499477","https://openalex.org/W1484334610","https://openalex.org/W1490612320","https://openalex.org/W1497172665","https://openalex.org/W1503887828","https://openalex.org/W1514306610","https://openalex.org/W1535011199","https://openalex.org/W1536264784","https://openalex.org/W1549502431","https://openalex.org/W1551577300","https://openalex.org/W1594293927","https://openalex.org/W1754211297","https://openalex.org/W1839872679","https://openalex.org/W1867181351","https://openalex.org/W1889123695","https://openalex.org/W1896880039","https://openalex.org/W1901720315","https://openalex.org/W1950469074","https://openalex.org/W1952970584","https://openalex.org/W1963521777","https://openalex.org/W1965130745","https://openalex.org/W1967664788","https://openalex.org/W1968444524","https://openalex.org/W1969026489","https://openalex.org/W1972336737","https://openalex.org/W1973457305","https://openalex.org/W1974266836","https://openalex.org/W1975605578","https://openalex.org/W1976881265","https://openalex.org/W1977499373","https://openalex.org/W1978529295","https://openalex.org/W1978659582","https://openalex.org/W1979366136","https://openalex.org/W1980796692","https://openalex.org/W1981705266","https://openalex.org/W1981817858","https://openalex.org/W1982096171","https://openalex.org/W1982467804","https://openalex.org/W1984849377","https://openalex.org/W1985023250","https://openalex.org/W1987566410","https://openalex.org/W1989297035","https://openalex.org/W1991148746","https://openalex.org/W1997367417","https://openalex.org/W1997928845","https://openalex.org/W1998785875","https://openalex.org/W1999998145","https://openalex.org/W2001015172","https://openalex.org/W2004266769","https://openalex.org/W2004630197","https://openalex.org/W2007684687","https://openalex.org/W2008816272","https://openalex.org/W2009644403","https://openalex.org/W2010849237","https://openalex.org/W2012058153","https://openalex.org/W2014505054","https://openalex.org/W2014654561","https://openalex.org/W2015095309","https://openalex.org/W2015894534","https://openalex.org/W2015948025","https://openalex.org/W2016612145","https://openalex.org/W2018649196","https://openalex.org/W2019276374","https://openalex.org/W2019773562","https://openalex.org/W2019917003","https://openalex.org/W2022609922","https://openalex.org/W2023973219","https://openalex.org/W2025421597","https://openalex.org/W2025617630","https://openalex.org/W2026377273","https://openalex.org/W2026401336","https://openalex.org/W2029683286","https://openalex.org/W2030296746","https://openalex.org/W2030864103","https://openalex.org/W2032000215","https://openalex.org/W2032968239","https://openalex.org/W2034152106","https://openalex.org/W2034269086","https://openalex.org/W2034897608","https://openalex.org/W2036230815","https://openalex.org/W2039719043","https://openalex.org/W2040722278","https://openalex.org/W2041607504","https://openalex.org/W2043319149","https://openalex.org/W2043904711","https://openalex.org/W2044225326","https://openalex.org/W2044835625","https://openalex.org/W2045516109","https://openalex.org/W2046972425","https://openalex.org/W2048668469","https://openalex.org/W2049108649","https://openalex.org/W2049173806","https://openalex.org/W2049856484","https://openalex.org/W2052382617","https://openalex.org/W2054650618","https://openalex.org/W2054995801","https://openalex.org/W2057274775","https://openalex.org/W2058188455","https://openalex.org/W2058542714","https://openalex.org/W2061907588","https://openalex.org/W2062420041","https://openalex.org/W2066405941","https://openalex.org/W2066671159","https://openalex.org/W2067420088","https://openalex.org/W2068971398","https://openalex.org/W2070276655","https://openalex.org/W2073728593","https://openalex.org/W2074730941","https://openalex.org/W2077731318","https://openalex.org/W2078439219","https://openalex.org/W2078443143","https://openalex.org/W2079853578","https://openalex.org/W2083016680","https://openalex.org/W2083792010","https://openalex.org/W2084142018","https://openalex.org/W2084547941","https://openalex.org/W2087920955","https://openalex.org/W2088332148","https://openalex.org/W2088413560","https://openalex.org/W2089804431","https://openalex.org/W2090750060","https://openalex.org/W2090851364","https://openalex.org/W2091630347","https://openalex.org/W2092999710","https://openalex.org/W2093172507","https://openalex.org/W2093294401","https://openalex.org/W2093424661","https://openalex.org/W2093567292","https://openalex.org/W2094108414","https://openalex.org/W2095472825","https://openalex.org/W2096136751","https://openalex.org/W2098005365","https://openalex.org/W2099990554","https://openalex.org/W2100336633","https://openalex.org/W2100917698","https://openalex.org/W2100961085","https://openalex.org/W2101153911","https://openalex.org/W2106263390","https://openalex.org/W2106772945","https://openalex.org/W2106845620","https://openalex.org/W2107562621","https://openalex.org/W2108235071","https://openalex.org/W2108574760","https://openalex.org/W2108789863","https://openalex.org/W2109933893","https://openalex.org/W2110646221","https://openalex.org/W2112965316","https://openalex.org/W2113019203","https://openalex.org/W2113510389","https://openalex.org/W2114445825","https://openalex.org/W2116237926","https://openalex.org/W2117280704","https://openalex.org/W2117692326","https://openalex.org/W2117878645","https://openalex.org/W2118096781","https://openalex.org/W2119002293","https://openalex.org/W2120426523","https://openalex.org/W2121626779","https://openalex.org/W2121651045","https://openalex.org/W2123389140","https://openalex.org/W2123431188","https://openalex.org/W2123953807","https://openalex.org/W2125382661","https://openalex.org/W2126614953","https://openalex.org/W2127733313","https://openalex.org/W2127892610","https://openalex.org/W2128238997","https://openalex.org/W2129663524","https://openalex.org/W2130153302","https://openalex.org/W2130211103","https://openalex.org/W2130746306","https://openalex.org/W2130883309","https://openalex.org/W2131903890","https://openalex.org/W2132439768","https://openalex.org/W2132923173","https://openalex.org/W2133739473","https://openalex.org/W2134565827","https://openalex.org/W2137289789","https://openalex.org/W2140828776","https://openalex.org/W2140890983","https://openalex.org/W2141104573","https://openalex.org/W2141165347","https://openalex.org/W2141438911","https://openalex.org/W2143818728","https://openalex.org/W2144318283","https://openalex.org/W2144595733","https://openalex.org/W2145736817","https://openalex.org/W2148198816","https://openalex.org/W2149171028","https://openalex.org/W2150594596","https://openalex.org/W2150636854","https://openalex.org/W2151094750","https://openalex.org/W2153327231","https://openalex.org/W2153942473","https://openalex.org/W2156320420","https://openalex.org/W2156383220","https://openalex.org/W2159445294","https://openalex.org/W2162113821","https://openalex.org/W2162686939","https://openalex.org/W2164660906","https://openalex.org/W2165130376","https://openalex.org/W2165308087","https://openalex.org/W2165382252","https://openalex.org/W2165447245","https://openalex.org/W2166990279","https://openalex.org/W2168244200","https://openalex.org/W2168929741","https://openalex.org/W2170008898","https://openalex.org/W2170612601","https://openalex.org/W2183470050","https://openalex.org/W2213133654","https://openalex.org/W2233228483","https://openalex.org/W2316160054","https://openalex.org/W2437003065","https://openalex.org/W2468284879","https://openalex.org/W2489751990","https://openalex.org/W2895774400","https://openalex.org/W3011071920"],"related_works":["https://openalex.org/W2163861968","https://openalex.org/W2600570158","https://openalex.org/W2016398657","https://openalex.org/W6964991587","https://openalex.org/W2175781977","https://openalex.org/W2041607504","https://openalex.org/W614834794","https://openalex.org/W6928977359","https://openalex.org/W113972808","https://openalex.org/W2402501232"],"abstract_inverted_index":{"Radioimmunotherapy":[0],"(RIT)":[1],"is":[2,64,107,195],"a":[3,25,188],"therapeutic":[4],"modality":[5],"that":[6,83,158,194,205],"allows":[7],"delivering":[8],"of":[9,34,47,94,127,142,147,179,222],"ionizing":[10],"radiation":[11,116,224],"(IR)":[12],"directly":[13],"to":[14,51,68,123,137,229,233],"targeted":[15],"cancer":[16,230],"cells.":[17,176,201],"Conventional":[18],"RIT":[19,247],"uses":[20],"\u03b2-emitting":[21],"radioisotopes,":[22],"but":[23,105],"recently":[24],"growing":[26,79],"interest":[27],"has":[28,81,120],"emerged":[29],"for":[30,41,242],"the":[31,92,125,131,139,220,226],"clinical":[32],"development":[33],"\u03b1":[35,102,115,128,206,223,246],"particles.":[36],"Alpha":[37],"emitters":[38],"are":[39],"ideal":[40],"killing":[42],"isolated":[43],"or":[44,73],"small":[45],"clusters":[46],"tumor":[48,148,185,198],"cells":[49,149,161,186],"thanks":[50],"their":[52],"high":[53],"linear":[54],"energy":[55],"transfer":[56],"and":[57,117,145,173,212],"short":[58],"path":[59],"in":[60,166,192],"tissue.":[61],"Their":[62],"efficacy":[63],"also":[65],"less":[66],"sensitive":[67],"dose":[69],"rate,":[70],"tissue":[71],"oxygenation":[72],"cell":[74,96,110,143,163],"cycle":[75,164],"status.":[76],"In":[77,154],"parallel,":[78],"evidence":[80],"shown":[82],"IR":[84],"can":[85,208],"foster":[86],"an":[87,214],"anti-tumor":[88,190],"immune":[89,132,227],"response":[90,144,191,228],"through":[91],"induction":[93],"immunogenic":[95],"death.":[97],"Several":[98],"studies":[99,156],"have":[100,232],"described":[101],"emitter":[103],"radiobiology":[104],"little":[106],"known":[108],"about":[109],"death":[111],"mechanisms":[112,141],"induced":[113],"after":[114,150],"no":[118],"investigation":[119],"been":[121],"undertaken":[122],"analyze":[124],"impact":[126,221],"particles":[129],"on":[130,225],"response.":[133],"Therefore,":[134],"we":[135],"decided":[136],"investigate":[138],"molecular":[140],"immunogenicity":[146],"bismuth-213":[151],"(213Bi)":[152],"irradiation.":[153],"vitro":[155],"demonstrated":[157],"213Bi":[159,183],"treated":[160],"undergo":[162],"arrest":[165],"G2":[167],"phase,":[168],"activate":[169,174],"autophagy,":[170],"release":[171],"DAMPs":[172],"dendritic":[175],"Besides,":[177],"vaccination":[178],"immunocompetent":[180],"mice":[181],"with":[182,248],"irradiated":[184],"induce":[187],"protective":[189],"vivo":[193],"mediated":[196],"by":[197],"specific":[199],"T":[200],"Our":[202],"results":[203],"demonstrate":[204],"irradiation":[207],"stimulate":[209],"adaptive":[210],"immunity":[211],"elicit":[213],"efficient":[215],"anti-tumour":[216],"protection.":[217],"Even":[218],"though":[219],"will":[231],"be":[234],"further":[235],"characterized,":[236],"this":[237],"study":[238],"opens":[239],"new":[240],"perspectives":[241],"combinatory":[243],"treatments":[244],"using":[245],"immunotherapy.":[249]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}
