{"id":"https://openalex.org/W853337683","doi":null,"title":"The regulation of p53-dependent microRNA expression in response to genotoxic stress","display_name":"The regulation of p53-dependent microRNA expression in response to genotoxic stress","publication_year":2014,"publication_date":"2014-02-01","ids":{"openalex":"https://openalex.org/W853337683","mag":"853337683"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/10160324","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/The_regulation_of_p53-dependent_microRNA_expression_in_response_to_genotoxic_stress/10160324","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057051841","display_name":"Nadia Sheree Purmessur","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nadia Sheree Purmessur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5057051841"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.06449999660253525,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9639999866485596},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6000000238418579},{"id":"https://openalex.org/keywords/mir-16","display_name":"miR-16","score":1.0},{"id":"https://openalex.org/keywords/mir-26a","display_name":"miR-26a","score":1.0},{"id":"https://openalex.org/keywords/genotoxic-stress","display_name":"genotoxic stress","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9599999785423279},{"id":"https://openalex.org/keywords/drosha","display_name":"Drosha","score":0.6269999742507935},{"id":"https://openalex.org/keywords/microrna-processing","display_name":"microRNA processing","score":0.7210000157356262},{"id":"https://openalex.org/keywords/cyclin-e","display_name":"cyclin E","score":0.8169999718666077},{"id":"https://openalex.org/keywords/chk1","display_name":"Chk1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/wee1","display_name":"WEE1","score":1.0},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.9049999713897705},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/p53-independent-regulation","display_name":"p53-independent regulation","score":0.7509999871253967},{"id":"https://openalex.org/keywords/e2f1","display_name":"E2F1","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cancer-survival","display_name":"cancer survival","score":0.671999990940094},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.859000027179718}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7307933568954468},{"id":"https://openalex.org/C78604142","wikidata":"https://www.wikidata.org/wiki/Q1640582","display_name":"Fight-or-flight response","level":3,"score":0.5079832673072815},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4760584533214569},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.42596036195755005},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.41744565963745117},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4021325409412384},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3887268006801605},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35044288635253906},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3042606711387634},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.21340584754943848},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14148908853530884},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.09922274947166443},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/10160324","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/The_regulation_of_p53-dependent_microRNA_expression_in_response_to_genotoxic_stress/10160324","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:lra.le.ac.uk:2381/28637","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2381/28637","pdf_url":null,"source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:853337683","doi":null,"is_oa":false,"landing_page_url":"http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.593771","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":244,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W164057326","https://openalex.org/W387410681","https://openalex.org/W1508255686","https://openalex.org/W1510669790","https://openalex.org/W1515564094","https://openalex.org/W1537708951","https://openalex.org/W1544032942","https://openalex.org/W1648301895","https://openalex.org/W1806610286","https://openalex.org/W1824671129","https://openalex.org/W1872348525","https://openalex.org/W1898075343","https://openalex.org/W1937607074","https://openalex.org/W1950559180","https://openalex.org/W1966383348","https://openalex.org/W1967381786","https://openalex.org/W1967408983","https://openalex.org/W1969104747","https://openalex.org/W1970431885","https://openalex.org/W1970829776","https://openalex.org/W1971966311","https://openalex.org/W1972702833","https://openalex.org/W1972989638","https://openalex.org/W1973979344","https://openalex.org/W1974666401","https://openalex.org/W1975222501","https://openalex.org/W1975990978","https://openalex.org/W1976873804","https://openalex.org/W1978259246","https://openalex.org/W1978337436","https://openalex.org/W1979268646","https://openalex.org/W1980269624","https://openalex.org/W1980847511","https://openalex.org/W1982657419","https://openalex.org/W1983171715","https://openalex.org/W1983751803","https://openalex.org/W1984247920","https://openalex.org/W1985064409","https://openalex.org/W1985216024","https://openalex.org/W1986179131","https://openalex.org/W1986706724","https://openalex.org/W1988125845","https://openalex.org/W1990508187","https://openalex.org/W1990840476","https://openalex.org/W1992598298","https://openalex.org/W1993246806","https://openalex.org/W1993423395","https://openalex.org/W1995856480","https://openalex.org/W1996649572","https://openalex.org/W1999746960","https://openalex.org/W2000511163","https://openalex.org/W2001326517","https://openalex.org/W2002995168","https://openalex.org/W2003355291","https://openalex.org/W2005109475","https://openalex.org/W2005542290","https://openalex.org/W2006173503","https://openalex.org/W2006797972","https://openalex.org/W2007023752","https://openalex.org/W2007956118","https://openalex.org/W2008535165","https://openalex.org/W2010402627","https://openalex.org/W2010706742","https://openalex.org/W2011096245","https://openalex.org/W2012053348","https://openalex.org/W2012753961","https://openalex.org/W2014114389","https://openalex.org/W2014141863","https://openalex.org/W2014938226","https://openalex.org/W2017379014","https://openalex.org/W2018385269","https://openalex.org/W2020808779","https://openalex.org/W2022936085","https://openalex.org/W2023486531","https://openalex.org/W2023495875","https://openalex.org/W2023599593","https://openalex.org/W2024480685","https://openalex.org/W2024741088","https://openalex.org/W2024775285","https://openalex.org/W2024964669","https://openalex.org/W2025476423","https://openalex.org/W2025722611","https://openalex.org/W2025951391","https://openalex.org/W2028459159","https://openalex.org/W2030362521","https://openalex.org/W2030430085","https://openalex.org/W2032109237","https://openalex.org/W2034562270","https://openalex.org/W2036923470","https://openalex.org/W2037670899","https://openalex.org/W2038167014","https://openalex.org/W2038599271","https://openalex.org/W2038689662","https://openalex.org/W2039485415","https://openalex.org/W2039876499","https://openalex.org/W2041387751","https://openalex.org/W2041825143","https://openalex.org/W2041945875","https://openalex.org/W2042316019","https://openalex.org/W2043694444","https://openalex.org/W2045001930","https://openalex.org/W2045031047","https://openalex.org/W2045552152","https://openalex.org/W2045756360","https://openalex.org/W2046780997","https://openalex.org/W2046930479","https://openalex.org/W2047262284","https://openalex.org/W2049527615","https://openalex.org/W2049763628","https://openalex.org/W2050850788","https://openalex.org/W2054016503","https://openalex.org/W2054308913","https://openalex.org/W2055595037","https://openalex.org/W2058632806","https://openalex.org/W2059971436","https://openalex.org/W2060051809","https://openalex.org/W2060618478","https://openalex.org/W2063427682","https://openalex.org/W2063822655","https://openalex.org/W2063877452","https://openalex.org/W2064194464","https://openalex.org/W2064802374","https://openalex.org/W2065543285","https://openalex.org/W2068348383","https://openalex.org/W2068371312","https://openalex.org/W2068419083","https://openalex.org/W2068691401","https://openalex.org/W2069452349","https://openalex.org/W2070578980","https://openalex.org/W2070854644","https://openalex.org/W2072319696","https://openalex.org/W2073568919","https://openalex.org/W2074210527","https://openalex.org/W2075300416","https://openalex.org/W2076059928","https://openalex.org/W2082541302","https://openalex.org/W2083255319","https://openalex.org/W2084733813","https://openalex.org/W2085195718","https://openalex.org/W2086227770","https://openalex.org/W2086417754","https://openalex.org/W2087404852","https://openalex.org/W2087438476","https://openalex.org/W2087685591","https://openalex.org/W2092308103","https://openalex.org/W2092466076","https://openalex.org/W2092722802","https://openalex.org/W2094184203","https://openalex.org/W2095402954","https://openalex.org/W2096276671","https://openalex.org/W2096293110","https://openalex.org/W2096744132","https://openalex.org/W2097933346","https://openalex.org/W2098276373","https://openalex.org/W2099517697","https://openalex.org/W2099692224","https://openalex.org/W2100545500","https://openalex.org/W2101910453","https://openalex.org/W2103302926","https://openalex.org/W2103616303","https://openalex.org/W2104146201","https://openalex.org/W2106493014","https://openalex.org/W2107752042","https://openalex.org/W2108017320","https://openalex.org/W2108786888","https://openalex.org/W2108931268","https://openalex.org/W2109183374","https://openalex.org/W2109511371","https://openalex.org/W2110269282","https://openalex.org/W2114205900","https://openalex.org/W2115858839","https://openalex.org/W2116755440","https://openalex.org/W2117391818","https://openalex.org/W2117912210","https://openalex.org/W2117933664","https://openalex.org/W2119197345","https://openalex.org/W2121013761","https://openalex.org/W2123827665","https://openalex.org/W2124268899","https://openalex.org/W2124818074","https://openalex.org/W2126426563","https://openalex.org/W2126679757","https://openalex.org/W2128080369","https://openalex.org/W2128410594","https://openalex.org/W2130521757","https://openalex.org/W2130979840","https://openalex.org/W2131592745","https://openalex.org/W2133452708","https://openalex.org/W2134175830","https://openalex.org/W2134340554","https://openalex.org/W2134524871","https://openalex.org/W2135314242","https://openalex.org/W2135810600","https://openalex.org/W2135836598","https://openalex.org/W2136411119","https://openalex.org/W2137132557","https://openalex.org/W2138024602","https://openalex.org/W2138324018","https://openalex.org/W2138664009","https://openalex.org/W2141136258","https://openalex.org/W2141915880","https://openalex.org/W2142718844","https://openalex.org/W2144694610","https://openalex.org/W2145021085","https://openalex.org/W2145349694","https://openalex.org/W2145503772","https://openalex.org/W2145727462","https://openalex.org/W2147114301","https://openalex.org/W2150536104","https://openalex.org/W2150710841","https://openalex.org/W2150965482","https://openalex.org/W2151160119","https://openalex.org/W2152147560","https://openalex.org/W2152733195","https://openalex.org/W2155363874","https://openalex.org/W2155487288","https://openalex.org/W2155570392","https://openalex.org/W2156457292","https://openalex.org/W2157145997","https://openalex.org/W2159807040","https://openalex.org/W2160178368","https://openalex.org/W2160968516","https://openalex.org/W2162324431","https://openalex.org/W2162487261","https://openalex.org/W2162674813","https://openalex.org/W2163106706","https://openalex.org/W2165762583","https://openalex.org/W2165764599","https://openalex.org/W2168084973","https://openalex.org/W2168230240","https://openalex.org/W2168695528","https://openalex.org/W2168979257","https://openalex.org/W2169621060","https://openalex.org/W2170622332","https://openalex.org/W2170952313","https://openalex.org/W2171407623","https://openalex.org/W2172142216","https://openalex.org/W2295431183","https://openalex.org/W2322926939","https://openalex.org/W2334464812","https://openalex.org/W2335924353","https://openalex.org/W4300555137","https://openalex.org/W7098400432"],"related_works":["https://openalex.org/W2003933871","https://openalex.org/W2799723921","https://openalex.org/W4213097311","https://openalex.org/W2168290712","https://openalex.org/W1967180140","https://openalex.org/W2072479381","https://openalex.org/W2146656223","https://openalex.org/W2326750180","https://openalex.org/W2159266275","https://openalex.org/W2020165617"],"abstract_inverted_index":{"INTRODUCTION:":[0],"miR-16":[1,35,53,96,128,145,162,180,186,200,232,258],"and":[2,36,38,54,80,97,103,110,129,139,146,148,163,179,187,191,209,233,241,259,266,279,287],"miR-26a":[3,37,55,98,130,164,172,188,234,260],"have":[4],"been":[5],"identified":[6],"as":[7,251],"key":[8],"effectors":[9],"of":[10,26,34,40,52,72,119,152,169,198,211,216],"the":[11,46,69,116,167,194,207],"p53":[12,31,47,76,149,157,175],"pathway":[13],"in":[14,45,193,206,227,293],"response":[15,90,228],"to":[16,60,88,91,161,165,176,229,283],"genotoxic":[17,92],"stress.":[18,93],"This":[19],"work":[20],"is":[21],"focused":[22],"on":[23,65,154,219],"preliminary":[24],"elucidation":[25],"regulatory":[27,141],"mechanisms":[28,142],"by":[29,58,75,122,239],"which":[30],"controls":[32,150,214,273],"expression":[33,50,131,151,215,235],"characterisation":[39],"their":[41],"gene":[42],"targets":[43,99],"involved":[44],"network.\\nMETHODS:":[48],"Microarray":[49],"analysis":[51],"was":[56],"followed":[57],"Q-PCR":[59],"confirm":[61],"these":[62,73,85,170],"miRNAs":[63,74,86,153],"dependence":[64],"p53.":[66,199,212],"We":[67,83,113],"analysed":[68,115],"transcriptional":[70,117,221],"regulation":[71,118],"via":[77,124],"luciferase":[78,111,125],"assay":[79],"ChIP":[81],"assay.":[82,112],"investigated":[84],"contribution":[87],"p53-dependent":[89,138,240],"To":[94],"validate":[95],"(Cyclin":[100],"E,":[101,264],"CHK1,":[102,265],"WEE1)":[104],"we":[105],"employed":[106],"Q-PCR,":[107],"western":[108],"blotting":[109],"also":[114,201,255],"Cyclin":[120,203,217,263,274,289],"E":[121,204,218,275,290],"SET9":[123,213,271],"assay.\\nRESULTS:":[126],"High":[127],"are":[132,237],"associated":[133],"with":[134,174],"increased":[135,294],"cancer":[136],"survival.":[137],"-independent":[140],"exist":[143],"for":[144,268],"miR-26a,":[147],"several":[155],"levels.":[156],"recruits":[158],"Drosha":[159],"complex":[160],"facilitate":[166],"processing":[168],"miRNAs.":[171],"cooperates":[173],"induce":[177],"apoptosis":[178,300],"enhances":[181],"p53-mediated":[182],"cell":[183],"cycle":[184],"arrest.":[185,296],"regulates":[189],"CHK1":[190,278],"WEE1,":[192],"presence":[195,208],"or":[196],"absence":[197,210],"reduces":[202],"levels,":[205],"a":[220,298],"level.\\nCONCLUSIONS:":[222],"Our":[223,253],"results":[224,292],"showed":[225],"that":[226,257],"DNA":[230],"damage,":[231],"levels":[236,281,291],"controlled":[238],"p53-independent":[242],"mechanisms,":[243],"potentially":[244],"involving":[245],"other":[246],"stress-response":[247],"transcription":[248],"factors":[249],"such":[250],"E2F1.":[252],"data":[254],"confirms":[256],"directly":[261,272],"target":[262],"WEE1":[267,280],"down-regulation.":[269],"Additonally,":[270],"expression.":[276],"Reduced":[277],"leads":[282],"decreased":[284],"G2/M":[285],"arrest,":[286],"reduced":[288],"G1/S":[295],"As":[297],"consequence,":[299],"occurs.":[301]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
