{"id":"https://openalex.org/W8527673","doi":"https://doi.org/10.4049/jimmunol.190.supp.113.5","title":"Galectin-9 controls the activity of 4-1BB (CD137) (P1009)","display_name":"Galectin-9 controls the activity of 4-1BB (CD137) (P1009)","publication_year":2013,"publication_date":"2013-05-01","ids":{"openalex":"https://openalex.org/W8527673","doi":"https://doi.org/10.4049/jimmunol.190.supp.113.5","mag":"8527673"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.190.supp.113.5","doi":"https://doi.org/10.4049/jimmunol.190.supp.113.5","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.190.supp.113.5","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047594317","display_name":"Shravan Madireddi","orcid":"https://orcid.org/0000-0002-7069-1252","observed_orcids":["https://orcid.org/0000-0002-7069-1252"]},"institutions":[{"id":"https://openalex.org/I1311191458","display_name":"La Jolla Institute for Immunology","ror":"https://ror.org/05vkpd318","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1311191458"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shravan Madireddi","raw_affiliation_strings":["Division of Immune Regulation, La Jolla Inst. for Allergy & Immunology , La Jolla, CA","1Division of Immune Regulation, La Jolla Inst. for Allergy & Immunology, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immune Regulation, La Jolla Inst. for Allergy & Immunology , La Jolla, CA","institution_ids":["https://openalex.org/I1311191458"]},{"raw_affiliation_string":"1Division of Immune Regulation, La Jolla Inst. for Allergy & Immunology, La Jolla, CA","institution_ids":["https://openalex.org/I1311191458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079019198","display_name":"So-Young Eun","orcid":"https://orcid.org/0000-0002-7229-0372","observed_orcids":["https://orcid.org/0000-0002-7229-0372"]},"institutions":[{"id":"https://openalex.org/I1311191458","display_name":"La Jolla Institute for Immunology","ror":"https://ror.org/05vkpd318","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1311191458"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"So-Young Eun","raw_affiliation_strings":["Division of Immune Regulation, La Jolla Inst. for Allergy & Immunology , La Jolla, CA","1Division of Immune Regulation, La Jolla Inst. for Allergy & Immunology, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immune Regulation, La Jolla Inst. for Allergy & Immunology , La Jolla, CA","institution_ids":["https://openalex.org/I1311191458"]},{"raw_affiliation_string":"1Division of Immune Regulation, La Jolla Inst. for Allergy & Immunology, La Jolla, CA","institution_ids":["https://openalex.org/I1311191458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107502908","display_name":"Amit Kumar Mehta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1311191458","display_name":"La Jolla Institute for Immunology","ror":"https://ror.org/05vkpd318","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1311191458"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amit Mehta","raw_affiliation_strings":["Division of Immune Regulation, La Jolla Inst. for Allergy & Immunology , La Jolla, CA","1Division of Immune Regulation, La Jolla Inst. for Allergy & Immunology, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immune Regulation, La Jolla Inst. for Allergy & Immunology , La Jolla, CA","institution_ids":["https://openalex.org/I1311191458"]},{"raw_affiliation_string":"1Division of Immune Regulation, La Jolla Inst. for Allergy & Immunology, La Jolla, CA","institution_ids":["https://openalex.org/I1311191458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086884007","display_name":"Ivana Nem\u010dovi\u010dov\u00e1","orcid":"https://orcid.org/0000-0003-1733-9986","observed_orcids":["https://orcid.org/0000-0003-1733-9986"]},"institutions":[{"id":"https://openalex.org/I1311191458","display_name":"La Jolla Institute for Immunology","ror":"https://ror.org/05vkpd318","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1311191458"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivana Nemcovicova","raw_affiliation_strings":["Division of Cell Biology, La Jolla Inst. for Allergy & Immunology , La Jolla, CA","2Division of Cell Biology, La Jolla Inst. for Allergy & Immunology, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology, La Jolla Inst. for Allergy & Immunology , La Jolla, CA","institution_ids":["https://openalex.org/I1311191458"]},{"raw_affiliation_string":"2Division of Cell Biology, La Jolla Inst. for Allergy & Immunology, La Jolla, CA","institution_ids":["https://openalex.org/I1311191458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100403762","display_name":"Seung\u2010Woo Lee","orcid":"https://orcid.org/0000-0002-6714-2463","observed_orcids":["https://orcid.org/0000-0002-6714-2463"]},"institutions":[{"id":"https://openalex.org/I1311191458","display_name":"La Jolla Institute for Immunology","ror":"https://ror.org/05vkpd318","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1311191458"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seung-Woo Lee","raw_affiliation_strings":["Division of Immune Regulation, La Jolla Inst. for Allergy & Immunology , La Jolla, CA","1Division of Immune Regulation, La Jolla Inst. for Allergy & Immunology, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immune Regulation, La Jolla Inst. for Allergy & Immunology , La Jolla, CA","institution_ids":["https://openalex.org/I1311191458"]},{"raw_affiliation_string":"1Division of Immune Regulation, La Jolla Inst. for Allergy & Immunology, La Jolla, CA","institution_ids":["https://openalex.org/I1311191458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060156953","display_name":"Toshiro Niki","orcid":"https://orcid.org/0000-0003-4531-1331","observed_orcids":["https://orcid.org/0000-0003-4531-1331"]},"institutions":[{"id":"https://openalex.org/I201933988","display_name":"Kagawa University","ror":"https://ror.org/04j7mzp05","country_code":"JP","type":"education","lineage":["https://openalex.org/I201933988"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiro Niki","raw_affiliation_strings":["Immunology & Immunopathology, Faculty of Medicine, Kagawa Univ. , Kagawa,","3Immunology & Immunopathology, Faculty of Medicine, Kagawa Univ., Kagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology & Immunopathology, Faculty of Medicine, Kagawa Univ. , Kagawa,","institution_ids":["https://openalex.org/I201933988"]},{"raw_affiliation_string":"3Immunology & Immunopathology, Faculty of Medicine, Kagawa Univ., Kagawa, Japan","institution_ids":["https://openalex.org/I201933988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105881299","display_name":"Mitsuomi Hirashima","orcid":"https://orcid.org/0000-0002-4133-9524","observed_orcids":["https://orcid.org/0000-0002-4133-9524"]},"institutions":[{"id":"https://openalex.org/I201933988","display_name":"Kagawa University","ror":"https://ror.org/04j7mzp05","country_code":"JP","type":"education","lineage":["https://openalex.org/I201933988"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuomi Hirashima","raw_affiliation_strings":["Immunology & Immunopathology, Faculty of Medicine, Kagawa Univ. , Kagawa,","3Immunology & Immunopathology, Faculty of Medicine, Kagawa Univ., Kagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology & Immunopathology, Faculty of Medicine, Kagawa Univ. , Kagawa,","institution_ids":["https://openalex.org/I201933988"]},{"raw_affiliation_string":"3Immunology & Immunopathology, Faculty of Medicine, Kagawa Univ., Kagawa, Japan","institution_ids":["https://openalex.org/I201933988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048766408","display_name":"Dirk M. Zajonc","orcid":"https://orcid.org/0000-0001-7215-1981","observed_orcids":["https://orcid.org/0000-0001-7215-1981"]},"institutions":[{"id":"https://openalex.org/I1311191458","display_name":"La Jolla Institute for Immunology","ror":"https://ror.org/05vkpd318","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1311191458"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dirk Zajonc","raw_affiliation_strings":["Division of Cell Biology, La Jolla Inst. for Allergy & Immunology , La Jolla, CA","2Division of Cell Biology, La Jolla Inst. for Allergy & Immunology, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology, La Jolla Inst. for Allergy & Immunology , La Jolla, CA","institution_ids":["https://openalex.org/I1311191458"]},{"raw_affiliation_string":"2Division of Cell Biology, La Jolla Inst. for Allergy & Immunology, La Jolla, CA","institution_ids":["https://openalex.org/I1311191458"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036973489","display_name":"Michael Croft","orcid":"https://orcid.org/0000-0002-6062-3635","observed_orcids":["https://orcid.org/0000-0002-6062-3635","https://orcid.org/0000-0002-6263-7256"]},"institutions":[{"id":"https://openalex.org/I1311191458","display_name":"La Jolla Institute for Immunology","ror":"https://ror.org/05vkpd318","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1311191458"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Croft","raw_affiliation_strings":["Division of Immune Regulation, La Jolla Inst. for Allergy & Immunology , La Jolla, CA","1Division of Immune Regulation, La Jolla Inst. for Allergy & Immunology, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immune Regulation, La Jolla Inst. for Allergy & Immunology , La Jolla, CA","institution_ids":["https://openalex.org/I1311191458"]},{"raw_affiliation_string":"1Division of Immune Regulation, La Jolla Inst. for Allergy & Immunology, La Jolla, CA","institution_ids":["https://openalex.org/I1311191458"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"190","issue":"Supplement_1","first_page":"113.5","last_page":"113.5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/galectin-9","display_name":"galectin-9","score":0.9480000138282776},{"id":"https://openalex.org/keywords/4-1bb","display_name":"4-1BB","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tnf-receptor-superfamily","display_name":"TNF receptor superfamily","score":0.7559999823570251},{"id":"https://openalex.org/keywords/ligand-receptor-interactions","display_name":"ligand-receptor interactions","score":0.7200000286102295},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.5519999861717224},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":1.0},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.8880000114440918},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.5379999876022339},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.9449999928474426},{"id":"https://openalex.org/keywords/receptor-oligomerization","display_name":"receptor oligomerization","score":0.875}],"concepts":[{"id":"https://openalex.org/C2780249625","wikidata":"https://www.wikidata.org/wiki/Q14913226","display_name":"CD137","level":4,"score":0.7003461122512817},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6211388111114502},{"id":"https://openalex.org/C156293190","wikidata":"https://www.wikidata.org/wiki/Q83138026","display_name":"Galectin","level":2,"score":0.5788225531578064},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5662333369255066},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4865626394748688},{"id":"https://openalex.org/C2779919695","wikidata":"https://www.wikidata.org/wiki/Q4201963","display_name":"CD11c","level":4,"score":0.48059436678886414},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4423692524433136},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4423052668571472},{"id":"https://openalex.org/C2778735756","wikidata":"https://www.wikidata.org/wiki/Q18028523","display_name":"Galectin-1","level":2,"score":0.4293716549873352},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3806031346321106},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.36383694410324097},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.3546709418296814},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2486276924610138},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19595488905906677},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.1249147355556488},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1110098659992218},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.190.supp.113.5","doi":"https://doi.org/10.4049/jimmunol.190.supp.113.5","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.190.supp.113.5","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1513178816","https://openalex.org/W3206049488","https://openalex.org/W3175064359","https://openalex.org/W2052937977","https://openalex.org/W1505145311","https://openalex.org/W2153742280","https://openalex.org/W2287738525","https://openalex.org/W4285891189","https://openalex.org/W2081704009","https://openalex.org/W8527673"],"abstract_inverted_index":{"Abstract":[0],"4-1BB":[1,52,109,130,144,165,208],"is":[2],"an":[3,162],"inducible":[4],"stimulatory":[5,106,139],"molecule":[6,32],"in":[7,101,114,156,185,197,213],"the":[8,29,45,60,81,105],"TNFR":[9],"superfamily":[10],"expressed":[11],"on":[12,112,146],"activated":[13],"T":[14,120,124],"cells,":[15,17,19,118,121,125,174],"dendritic":[16,147],"NK":[18,117],"and":[20,76,95,158,202],"other":[21,138],"lymphoid":[22],"cell":[23],"types.":[24],"Although":[25],"known":[26],"to":[27,55,209],"bind":[28,54],"TNF":[30],"family":[31],"4-1BBL,":[33],"we":[34,175],"searched":[35],"for":[36,74],"novel":[37,193],"binding":[38,62,83],"partners":[39],"that":[40,51,80,104,115,177,204,216],"might":[41],"modulate":[42],"or":[43,122],"control":[44],"activity":[46,107,136,145],"of":[47,59,86,108,164,171,181,195,220],"4-1BB.":[48],"We":[49],"found":[50,176],"can":[53,166],"Galectin-9,":[56],"a":[57,192,214],"member":[58],"beta-galactoside":[61],"lectins":[63],"containing":[64],"homologous":[65],"carbohydrate":[66],"recognition":[67],"domains":[68],"(CRDs).":[69],"Surface":[70],"plasmon":[71],"resonance":[72],"analysis":[73],"mouse":[75],"human":[77],"molecules":[78],"demonstrated":[79],"equilibrium":[82],"constant":[84],"(KD)":[85],"this":[87,178],"interaction":[88],"was":[89,110,131,149,153,183],"very":[90],"strong":[91],"at":[92],"~11":[93],"nM":[94,97],"~85":[96],"respectively.":[98],"Functional":[99],"studies":[100],"vitro":[102],"showed":[103],"dependent":[111],"Galectin-9":[113,152,196,205],"Galectin-9-/-":[116,186],"CD4":[119],"CD8":[123],"were":[126,141],"largely":[127],"unresponsive":[128],"when":[129,137,151],"ligated":[132],"but":[133],"had":[134],"normal":[135],"receptors":[140],"engaged.":[142],"Similarly,":[143],"cells":[148],"impaired":[150],"absent.":[154],"Additionally,":[155],"EAE":[157],"Asthma":[159],"models,":[160],"where":[161],"agonist":[163],"suppress":[167],"disease":[168],"via":[169],"induction":[170],"CD8\u03b2+CD11c+":[172],"regulatory":[173],"protective":[179],"effect":[180],"anti-4-1BB":[182],"lost":[184],"mice.":[187],"Thus,":[188],"our":[189],"data":[190],"demonstrate":[191],"function":[194],"facilitating":[198],"signaling":[199,222],"through":[200],"4-1BB,":[201],"suggest":[203],"may":[206],"allow":[207],"oligomerize":[210],"and/or":[211],"cluster":[212],"manner":[215],"allows":[217],"efficient":[218],"engagement":[219],"intracellular":[221],"pathways.":[223]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}
