{"id":"https://openalex.org/W852664261","doi":"https://doi.org/10.25772/0eb3-kz74","title":"Analysis of the role of outer surface protein C (OspC) in Borrelia burgdorferi pathogenesis","display_name":"Analysis of the role of outer surface protein C (OspC) in Borrelia burgdorferi pathogenesis","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W852664261","doi":"https://doi.org/10.25772/0eb3-kz74","mag":"852664261"},"language":"en","primary_location":{"id":"pmh:oai:scholarscompass.vcu.edu:etd-1249","doi":null,"is_oa":true,"landing_page_url":"https://scholarscompass.vcu.edu/etd/250","pdf_url":"https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1249&context=etd","source":{"id":"https://openalex.org/S4377196340","display_name":"VCU Scholars Compass (Virginia Commonwealth University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184840846","host_organization_name":"Virginia Commonwealth University","host_organization_lineage":["https://openalex.org/I184840846"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1249&context=etd","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036002160","display_name":"DeLacy V. L. Rhodes","orcid":"https://orcid.org/0000-0003-1945-3360","observed_orcids":["https://orcid.org/0000-0003-1945-3360"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rhodes, DeLacy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5036002160"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12134","display_name":"Insect symbiosis and bacterial influences","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/borrelia-burgdorferi","display_name":"Borrelia burgdorferi","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ospc","display_name":"OspC","score":0.968999981880188},{"id":"https://openalex.org/keywords/lyme-disease","display_name":"Lyme disease","score":0.8019999861717224},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.7279999852180481},{"id":"https://openalex.org/keywords/ligand-binding-domain","display_name":"ligand-binding domain","score":0.8259999752044678},{"id":"https://openalex.org/keywords/plasminogen-binding","display_name":"plasminogen binding","score":0.921999990940094},{"id":"https://openalex.org/keywords/oligomerization","display_name":"oligomerization","score":0.6430000066757202},{"id":"https://openalex.org/keywords/host-specificity","display_name":"host specificity","score":0.6769999861717224},{"id":"https://openalex.org/keywords/ixodes-ticks","display_name":"Ixodes ticks","score":0.8230000138282776},{"id":"https://openalex.org/keywords/surface-charge","display_name":"surface charge","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C2779159148","wikidata":"https://www.wikidata.org/wiki/Q2723634","display_name":"Borrelia burgdorferi","level":3,"score":0.8952692747116089},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7023749351501465},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5356001853942871},{"id":"https://openalex.org/C2780508971","wikidata":"https://www.wikidata.org/wiki/Q115528","display_name":"Borrelia","level":4,"score":0.4815655052661896},{"id":"https://openalex.org/C2777553296","wikidata":"https://www.wikidata.org/wiki/Q201989","display_name":"Lyme disease","level":2,"score":0.4574325680732727},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.45615094900131226},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36770209670066833},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2433088719844818},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2234455645084381}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:scholarscompass.vcu.edu:etd-1249","doi":null,"is_oa":true,"landing_page_url":"https://scholarscompass.vcu.edu/etd/250","pdf_url":"https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1249&context=etd","source":{"id":"https://openalex.org/S4377196340","display_name":"VCU Scholars Compass (Virginia Commonwealth University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184840846","host_organization_name":"Virginia Commonwealth University","host_organization_lineage":["https://openalex.org/I184840846"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations","raw_type":"text"},{"id":"mag:852664261","doi":null,"is_oa":false,"landing_page_url":"https://scholarscompass.vcu.edu/etd/250/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"doi:10.25772/0eb3-kz74","doi":"https://doi.org/10.25772/0eb3-kz74","is_oa":true,"landing_page_url":"https://doi.org/10.25772/0eb3-kz74","pdf_url":null,"source":{"id":"https://openalex.org/S7407053258","display_name":"VCULIBRARIES","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184840846","host_organization_name":"Virginia Commonwealth University","host_organization_lineage":["https://openalex.org/I184840846"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"}],"best_oa_location":{"id":"pmh:oai:scholarscompass.vcu.edu:etd-1249","doi":null,"is_oa":true,"landing_page_url":"https://scholarscompass.vcu.edu/etd/250","pdf_url":"https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1249&context=etd","source":{"id":"https://openalex.org/S4377196340","display_name":"VCU Scholars Compass (Virginia Commonwealth University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184840846","host_organization_name":"Virginia Commonwealth University","host_organization_lineage":["https://openalex.org/I184840846"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations","raw_type":"text"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W852664261.pdf","grobid_xml":"https://content.openalex.org/works/W852664261.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2762283928","https://openalex.org/W7115611995","https://openalex.org/W2154514594","https://openalex.org/W3176320608","https://openalex.org/W1977904572","https://openalex.org/W7115614470","https://openalex.org/W2243007003","https://openalex.org/W2007576699","https://openalex.org/W2038264912","https://openalex.org/W2166361383"],"abstract_inverted_index":{"Lyme":[0],"disease":[1],"is":[2,7,47,58,86,101,105,312],"an":[3,22,275,285],"emerging":[4],"infection":[5,95,218],"that":[6,35,68,296,310,316],"caused":[8],"by":[9,261],"the":[10,40,44,49,72,88,97,123,128,147,156,191,212,230,256,329,336,344],"Borrelia":[11],"burgdorferi":[12,188,209],"sensu":[13],"lato":[14],"complex.":[15],"These":[16],"bacteria":[17],"exist":[18],"in":[19,43,110,115,181,184,217,266,271,282,303,320],"nature":[20],"through":[21,48],"enzootic":[23,45],"life":[24],"cycle":[25,46],"involving":[26],"Ixodes":[27],"ticks":[28],"and":[29,75,79,114,131,163,175,183,196,249,335],"various":[30],"reservoir":[31,111],"hosts.":[32],"One":[33],"way":[34],"this":[36,100,135,176,215,332],"bacterium":[37],"adapts":[38],"to":[39,92,107,120,279,327,342],"different":[41,129,241],"hosts":[42],"expression":[50],"of":[51,82,99,126,134,142,201,214,223,233,255,259,269,299,331,347],"outer":[52],"surface":[53,60,74,231,257],"protein":[54,136,315,334],"C":[55],"(OspC).":[56],"OspC":[57,104,143,179,224,242,252,276,293,300,311],"a":[59,202,245,267],"exposed":[61],"lipoprotein":[62],"encoded":[63],"on":[64,71],"circular":[65],"plasmid":[66],"26":[67],"forms":[69],"homodimers":[70],"bacterial":[73],"has":[76],"distinct":[77],"conserved":[78,130,140,148],"variable":[80,132,221],"portions":[81,133,141],"sequence.":[83],"When":[84],"ospC":[85],"deleted,":[87],"spirochetes":[89],"are":[90,301],"unable":[91],"cause":[93],"mammalian":[94],"although":[96],"mechanism":[98],"unknown.":[102],"Additionally,":[103],"thought":[106],"be":[108,280,340],"involved":[109,302],"host":[112],"specificity/association":[113],"tissue":[116],"dissemination.":[117],"In":[118],"order":[119],"better":[121],"understand":[122],"functional":[124],"domains":[125,298],"OspC,":[127],"were":[137,144],"investigated.":[138],"Three":[139],"investigated:":[145],"(1)":[146,228],"cysteine":[149],"residue":[150,172,204],"at":[151],"position":[152],"130":[153],"(C130),":[154],"(2)":[155,239],"last":[157],"ten":[158],"C-terminal":[159],"amino":[160],"acids":[161],"(C10),":[162],"(3)":[164,250],"ligand":[165,234],"binding":[166,235],"domain":[167,216,236],"1":[168],"(LBD1).":[169],"The":[170,199,220,322],"C130":[171],"was":[173,225,289],"mutated":[174],"substitution":[177],"disrupted":[178],"oligomerization":[180],"vitro":[182],"vivo.":[185],"A":[186],"B.":[187,208],"strain":[189],"lacking":[190],"C10":[192],"retained":[193],"full":[194,345],"infectivity":[195,288],"plasminogen":[197],"binding.":[198],"mutation":[200],"single":[203],"within":[205],"LBD1":[206],"rendered":[207],"noninfectious,":[210],"indicating":[211],"importance":[213],"establishment.":[219],"portion":[222],"investigated":[226],"by:":[227],"altering":[229],"charge":[232,258],"2":[237],"(LBD2),":[238],"inserting":[240,274],"types":[243],"into":[244,284],"constant":[246],"genetic":[247],"background,":[248],"creating":[251],"hybrids.":[253],"Alteration":[254],"LBD2":[260],"site":[262],"directed":[263],"mutagenesis":[264],"resulted":[265],"lack":[268],"persistence":[270],"mice.":[272],"By":[273],"type":[277],"known":[278],"noninfectious":[281],"mice":[283],"infectious":[286],"strain,":[287],"abolished.":[290],"Strains":[291],"expressing":[292],"hybrids":[294],"indicated":[295],"multiple":[297,318],"species":[304],"specificity.":[305],"Together":[306],"these":[307],"analyses":[308],"demonstrated":[309],"as":[313],"important":[314],"plays":[317],"roles":[319],"pathogenesis.":[321],"work":[323],"presented":[324],"here":[325],"helps":[326],"increase":[328],"understanding":[330],"crucial":[333],"strains":[337],"described":[338],"can":[339],"used":[341],"decipher":[343],"function":[346],"OspC.":[348]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}