{"id":"https://openalex.org/W851824710","doi":null,"title":"THE EFFECTS OF INDIRUBIN DERIVITIVES ON GENE EXPRESSION AND CELLULAR FUNCTIONS IN THE MURINE MACROPHAGE","display_name":"THE EFFECTS OF INDIRUBIN DERIVITIVES ON GENE EXPRESSION AND CELLULAR FUNCTIONS IN THE MURINE MACROPHAGE","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W851824710","mag":"851824710"},"language":"en","primary_location":{"id":"pmh:oai:open.clemson.edu:all_dissertations-1277","doi":null,"is_oa":false,"landing_page_url":"https://open.clemson.edu/all_dissertations/277","pdf_url":null,"source":{"id":"https://openalex.org/S4377196397","display_name":"TigerPrints (Clemson University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8078737","host_organization_name":"Clemson University","host_organization_lineage":["https://openalex.org/I8078737"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"All Dissertations","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007247613","display_name":"Abigail Babcock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Abigail Babcock","raw_affiliation_strings":["Clemson University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clemson University","institution_ids":["https://openalex.org/I8078737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007247613"],"corresponding_institution_ids":["https://openalex.org/I8078737"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.5224999785423279,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.5224999785423279,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.19009999930858612,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/indirubin-derivatives","display_name":"indirubin derivatives","score":0.9959999918937683},{"id":"https://openalex.org/keywords/indirubin-3-monoxime","display_name":"indirubin-3'-monoxime","score":0.9760000109672546},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8600000143051147},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.9760000109672546},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7459999918937683},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8989999890327454},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.718999981880188},{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-inhibition","display_name":"cyclin-dependent kinase inhibition","score":0.7829999923706055},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.6029999852180481},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.6455804705619812},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5780737400054932},{"id":"https://openalex.org/C2779584974","wikidata":"https://www.wikidata.org/wiki/Q1661452","display_name":"Indirubin","level":3,"score":0.5544270873069763},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5416013598442078},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5316178202629089},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.48558610677719116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4307716190814972},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3995000123977661},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3545810282230377},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25828251242637634},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16175991296768188},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.10412636399269104},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.0},{"id":"https://openalex.org/C142316359","wikidata":"https://www.wikidata.org/wiki/Q5967009","display_name":"Indigo","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C153349607","wikidata":"https://www.wikidata.org/wiki/Q36649","display_name":"Visual arts","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:open.clemson.edu:all_dissertations-1277","doi":null,"is_oa":false,"landing_page_url":"https://open.clemson.edu/all_dissertations/277","pdf_url":null,"source":{"id":"https://openalex.org/S4377196397","display_name":"TigerPrints (Clemson University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8078737","host_organization_name":"Clemson University","host_organization_lineage":["https://openalex.org/I8078737"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"All Dissertations","raw_type":"text"},{"id":"pmh:oai:tigerprints.clemson.edu:all_dissertations-1277","doi":null,"is_oa":false,"landing_page_url":"https://tigerprints.clemson.edu/all_dissertations/277","pdf_url":null,"source":{"id":"https://openalex.org/S4377196397","display_name":"TigerPrints (Clemson University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8078737","host_organization_name":"Clemson University","host_organization_lineage":["https://openalex.org/I8078737"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"All Dissertations","raw_type":"text"},{"id":"mag:851824710","doi":null,"is_oa":false,"landing_page_url":"https://tigerprints.clemson.edu/all_dissertations/277/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1507242444","https://openalex.org/W1540820582","https://openalex.org/W1542771964","https://openalex.org/W1545201063","https://openalex.org/W1549972928","https://openalex.org/W1588673533","https://openalex.org/W1872412793","https://openalex.org/W1938935030","https://openalex.org/W1964378600","https://openalex.org/W1965261663","https://openalex.org/W1967900006","https://openalex.org/W1969989426","https://openalex.org/W1970197612","https://openalex.org/W1971772902","https://openalex.org/W1976846448","https://openalex.org/W1979235424","https://openalex.org/W1982803105","https://openalex.org/W1986333080","https://openalex.org/W1989060543","https://openalex.org/W1989671723","https://openalex.org/W1989986502","https://openalex.org/W1994602411","https://openalex.org/W2000618405","https://openalex.org/W2006793400","https://openalex.org/W2021722888","https://openalex.org/W2035636513","https://openalex.org/W2038773971","https://openalex.org/W2043986908","https://openalex.org/W2047701232","https://openalex.org/W2051204898","https://openalex.org/W2052276044","https://openalex.org/W2060065906","https://openalex.org/W2066170973","https://openalex.org/W2077945512","https://openalex.org/W2079808944","https://openalex.org/W2081311459","https://openalex.org/W2085637638","https://openalex.org/W2093261447","https://openalex.org/W2097719809","https://openalex.org/W2107474707","https://openalex.org/W2123711126","https://openalex.org/W2126416392","https://openalex.org/W2129026083","https://openalex.org/W2136328669","https://openalex.org/W2136992802","https://openalex.org/W2138170278","https://openalex.org/W2139905874","https://openalex.org/W2144062280","https://openalex.org/W2159113211","https://openalex.org/W2161831252","https://openalex.org/W2170628857"],"related_works":["https://openalex.org/W803799796","https://openalex.org/W2032853472","https://openalex.org/W1965261663","https://openalex.org/W7046279353","https://openalex.org/W1971763871","https://openalex.org/W2126416392","https://openalex.org/W2221773054","https://openalex.org/W177003137","https://openalex.org/W2997889629","https://openalex.org/W4281551664"],"abstract_inverted_index":{"Indirubin":[0,92],"is":[1,14,25,93,104,112],"the":[2,6,26,31,59,115,134,154,169],"active":[3],"ingredient":[4],"in":[5,70,126,168],"ancient":[7],"herbal":[8],"remedy,":[9],"Danggui":[10],"Longhui":[11],"Wan,":[12],"which":[13,108],"used":[15],"as":[16,83,119],"an":[17],"anti-leukemic,":[18],"anti-inflammatory,":[19],"and":[20,42,50,73,89,117,131,147,165,218,231],"detoxification":[21],"treatment.":[22],"Indirubin-3'-monoxime":[23],"(IO)":[24],"most":[27],"widely":[28],"studied":[29],"of":[30,55,133,156,184,200],"indirubin":[32,185,210],"derivatives.":[33],"Most":[34],"have":[35,80],"been":[36],"shown":[37,235],"to":[38,114,206,216,236],"inhibit":[39],"cyclin-dependent":[40],"kinases":[41,63],"glycogen":[43],"synthase":[44],"kinases,":[45],"triggering":[46],"cell":[47,135,172],"cycle":[48],"arrest":[49],"apoptosis":[51],"with":[52,242],"different":[53,182],"levels":[54],"activity":[56,177],"depending":[57],"on":[58,159],"particular":[60],"structure.":[61],"These":[62],"inhibited":[64],"by":[65],"indirubin(s)":[66],"play":[67],"key":[68],"roles":[69],"cellular":[71,166,195],"proliferation":[72],"immune":[74],"functions,":[75,196],"therefore":[76],"synthetic":[77,209],"indirubins":[78,158],"may":[79,186],"significant":[81],"applications":[82],"therapeutic":[84],"agents":[85],"for":[86,123],"cancer,":[87],"inflammation,":[88],"neurological":[90],"diseases.":[91],"also":[94,248],"a":[95,105,120,208],"potent":[96,239],"aryl":[97],"hydrocarbon":[98],"receptor":[99],"(AhR)":[100],"agonist.":[101],"The":[102,202],"AhR":[103,163,189,240],"cytosolic":[106],"protein,":[107],"upon":[109],"ligand":[110],"binding":[111],"translocated":[113],"nucleus":[116],"acts":[118],"transcription":[121],"factor":[122],"genes":[124],"involved":[125],"drug":[127],"metabolism,":[128],"oxidative":[129],"stress,":[130],"inhibitors":[132],"cycle.":[136],"Known":[137],"anthropogenic":[138],"ligands":[139,241],"(PCBs,":[140],"dioxins,":[141],"PAHs":[142],"etc.)":[143],"are":[144],"mutagenic,":[145],"carcinogenic,":[146],"immunotoxic.":[148],"In":[149],"this":[150,226],"study,":[151],"I":[152],"examined":[153],"effects":[155],"select":[157],"gene/protein":[160],"expression":[161],"profiles,":[162],"activation,":[164,190],"functions":[167],"mouse":[170],"macrophage":[171],"line":[173],"RAW":[174],"264.7.":[175],"Structure":[176],"relationships":[178],"(SAR)":[179],"show":[180],"that":[181,212,250],"derivatives":[183],"differentially":[187],"affect":[188],"kinase":[191],"inhibition,":[192],"and/or":[193],"other":[194],"including":[197],"intracellular":[198],"killing":[199],"bacteria.":[201],"ultimate":[203],"goal":[204],"was":[205],"identify":[207],"derivative":[211],"would":[213],"be":[214,237],"beneficial":[215],"cancer":[217],"inflammation":[219],"research":[220],"without":[221],"being":[222],"overtly":[223],"toxic.":[224],"From":[225],"research,":[227],"Indirubin-3'-(2,3":[228],"dihydroxypropyl)-oximether)":[229],"(E804),":[230],"6-bromoindirubin-3-monoxime":[232],"(BIO)":[233],"were":[234],"very":[238],"strong":[243],"anti-inflammatory":[244],"properties.":[245],"This":[246],"study":[247],"shows":[249],"E804":[251],"has":[252],"more":[253,258],"clinical":[254],"promise":[255],"than":[256],"its":[257],"famous":[259],"counterpart":[260],"indirubin-3'-monoxime.":[261]},"counts_by_year":[],"updated_date":"2026-08-18T07:49:30.821534","created_date":"2016-06-24T00:00:00"}
