{"id":"https://openalex.org/W850557044","doi":null,"title":"A physicochemical and biophysical investigation into the role of lysyl- phosphatidylglycerol in the membrane of Staphylococcus aureus under mild acidic conditions","display_name":"A physicochemical and biophysical investigation into the role of lysyl- phosphatidylglycerol in the membrane of Staphylococcus aureus under mild acidic conditions","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W850557044","mag":"850557044"},"language":"en","primary_location":{"id":"pmh:oai:uilis.unsyiah.ac.id:20661","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/20661","pdf_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/20661","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"book"},"volume":null,"type":"book","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/20661","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000209954","display_name":"Reg Rehal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Reg Rehal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5000209954"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5548,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.64583333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.10490000247955322,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.05079999938607216,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysyl-phosphatidylglycerol","display_name":"lysyl-phosphatidylglycerol","score":0.9919999837875366},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bacterial-plasma-membrane","display_name":"bacterial plasma membrane","score":0.7139999866485596},{"id":"https://openalex.org/keywords/cationic-antimicrobial-peptides","display_name":"cationic antimicrobial peptides","score":0.9710000157356262},{"id":"https://openalex.org/keywords/membrane-charge","display_name":"membrane charge","score":0.5659999847412109},{"id":"https://openalex.org/keywords/membrane-lipid-packing","display_name":"membrane lipid packing","score":0.5619999766349792},{"id":"https://openalex.org/keywords/mprf","display_name":"mprF","score":0.734000027179718},{"id":"https://openalex.org/keywords/membrane-permeability","display_name":"membrane permeability","score":0.593999981880188},{"id":"https://openalex.org/keywords/antimicrobial-agents","display_name":"antimicrobial agents","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C2780726299","wikidata":"https://www.wikidata.org/wiki/Q3078751","display_name":"Phosphatidylglycerol","level":5,"score":0.8314453363418579},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.7417593598365784},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5731180906295776},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.4885457456111908},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4480498433113098},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23103326559066772},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19577375054359436},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.16056787967681885},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.06619882583618164},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uilis.unsyiah.ac.id:20661","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/20661","pdf_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/20661","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"book"},{"id":"mag:850557044","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.628453","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uilis.unsyiah.ac.id:20661","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/20661","pdf_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/20661","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"book"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W850557044.pdf","grobid_xml":"https://content.openalex.org/works/W850557044.grobid-xml"},"referenced_works_count":101,"referenced_works":["https://openalex.org/W41165184","https://openalex.org/W572894140","https://openalex.org/W576529305","https://openalex.org/W612074286","https://openalex.org/W1491362469","https://openalex.org/W1522819451","https://openalex.org/W1530643833","https://openalex.org/W1535081360","https://openalex.org/W1541778702","https://openalex.org/W1563420615","https://openalex.org/W1570906939","https://openalex.org/W1572375307","https://openalex.org/W1583480464","https://openalex.org/W1597808068","https://openalex.org/W1603301534","https://openalex.org/W1606415723","https://openalex.org/W1676917713","https://openalex.org/W1697678018","https://openalex.org/W1910093388","https://openalex.org/W1964137818","https://openalex.org/W1965614061","https://openalex.org/W1966479702","https://openalex.org/W1973109843","https://openalex.org/W1979921424","https://openalex.org/W1983475495","https://openalex.org/W1985749206","https://openalex.org/W1994941496","https://openalex.org/W1996468857","https://openalex.org/W2001873754","https://openalex.org/W2003709444","https://openalex.org/W2004946906","https://openalex.org/W2008931830","https://openalex.org/W2016960960","https://openalex.org/W2019078959","https://openalex.org/W2022871075","https://openalex.org/W2024437960","https://openalex.org/W2028858784","https://openalex.org/W2031189675","https://openalex.org/W2032019813","https://openalex.org/W2034376222","https://openalex.org/W2034705390","https://openalex.org/W2036331313","https://openalex.org/W2042876400","https://openalex.org/W2046221594","https://openalex.org/W2047261116","https://openalex.org/W2050302554","https://openalex.org/W2058707261","https://openalex.org/W2062070676","https://openalex.org/W2062322163","https://openalex.org/W2062343328","https://openalex.org/W2063775095","https://openalex.org/W2065098180","https://openalex.org/W2065753344","https://openalex.org/W2066695319","https://openalex.org/W2067434107","https://openalex.org/W2068636421","https://openalex.org/W2069149753","https://openalex.org/W2069864951","https://openalex.org/W2070154306","https://openalex.org/W2070962887","https://openalex.org/W2071572118","https://openalex.org/W2074989047","https://openalex.org/W2076257060","https://openalex.org/W2083610397","https://openalex.org/W2085728487","https://openalex.org/W2089388387","https://openalex.org/W2092834625","https://openalex.org/W2094036261","https://openalex.org/W2099952421","https://openalex.org/W2102258368","https://openalex.org/W2106704490","https://openalex.org/W2108341245","https://openalex.org/W2114570899","https://openalex.org/W2121682672","https://openalex.org/W2122803099","https://openalex.org/W2124988447","https://openalex.org/W2126022890","https://openalex.org/W2131192673","https://openalex.org/W2131523916","https://openalex.org/W2134517965","https://openalex.org/W2138909823","https://openalex.org/W2145595952","https://openalex.org/W2145726848","https://openalex.org/W2146544625","https://openalex.org/W2146894318","https://openalex.org/W2148668176","https://openalex.org/W2152311269","https://openalex.org/W2157877237","https://openalex.org/W2158714788","https://openalex.org/W2160679445","https://openalex.org/W2162850330","https://openalex.org/W2166223049","https://openalex.org/W2166791780","https://openalex.org/W2168482920","https://openalex.org/W2169308762","https://openalex.org/W2171385213","https://openalex.org/W2323319362","https://openalex.org/W2324908510","https://openalex.org/W2340137164","https://openalex.org/W2419109843","https://openalex.org/W2996107678"],"related_works":["https://openalex.org/W2672496435","https://openalex.org/W2900898855","https://openalex.org/W4408951858","https://openalex.org/W2010808387","https://openalex.org/W4415203554","https://openalex.org/W2071572118","https://openalex.org/W7096327816","https://openalex.org/W4237966496","https://openalex.org/W2050302554","https://openalex.org/W2156536559"],"abstract_inverted_index":{"Background:":[0],"Staphylococcus":[1],"aureus":[2,25,131,146,260],"readily":[3],"colonises":[4],"human":[5],"epithelia":[6],"despite":[7],"the":[8,33,59,69,80,158,217,250],"presence":[9],"of":[10,23,36,71,84,106,127,160,241],"innate":[11],"defences":[12,28,77,98,283],"including":[13],"mild":[14,63,123,263],"acidity":[15,52,128,264],"and":[16,53,78,82,117,141,149,163,168,187,203,223,230,243,270],"cationic":[17],"antimicrobial":[18,294],"peptides":[19],"(CAMPs).":[20],"Reduced":[21],"sensitivity":[22],"S.":[24,100,130,145,259],"to":[26,32,51,58,75,95,122,196,233,247,262,280],"these":[27],"appears":[29],"partly":[30],"due":[31,57],"increased":[34],"biosynthesis":[35,108,289],"lysyl-phosphatidylglycerol":[37],"(L-PG)":[38],"in":[39,62,73,92,99,114,120,155,258],"its":[40],"plasma":[41,267],"membrane.":[42,251],"The":[43,103,125,171,206],"precise":[44],"mechanisms":[45],"by":[46,111,137,265],"which":[47],"L-PG":[48,72,87,107,191,207,253,288],"facilitates":[49],"tolerance":[50,261,279],"CAMPs":[54,164,242],"remain":[55],"under-investigated,":[56],"lipid\u2019s":[60],"lability":[61],"aqueous":[64],"conditions.":[65],"This":[66],"study":[67],"examines":[68],"role":[70,257],"responses":[74],"epithelial":[76,282],"describes":[79],"synthesis":[81,192],"characterisation":[83],"a":[85,213,290],"stable":[86],"analogue":[88],"designed":[89],"for":[90,293],"use":[91],"biophysical":[93],"experiments":[94],"investigate":[96],"membrane":[97,132,166,219,236,268,275],"aureus.":[101],"Methods:":[102],"genetic":[104],"regulation":[105],"was":[109,135],"studied":[110],"assessing":[112],"changes":[113,237],"graXRS,":[115],"vraFG":[116],"mprF":[118,202],"expression":[119],"response":[121],"acidity.":[124],"effect":[126,215],"on":[129,165,216],"lipid":[133,147,151,271],"composition":[134],"quantified":[136],"31P":[138],"NMR.":[139],"Monolayers":[140],"bilayers":[142],"formed":[143],"from":[144],"extracts":[148],"synthetic":[150,224],"models":[152],"were":[153],"employed":[154],"investigations":[156],"into":[157,249],"effects":[159],"low":[161],"pH":[162,194,210],"structure":[167],"physicochemical":[169],"properties.":[170,273],"experimental":[172],"techniques":[173],"included":[174],"neutron":[175,178,180],"diffraction,":[176],"small-angle":[177],"scattering,":[179],"reflectivity,":[181],"pressure\u2013area":[182],"isotherms,":[183],"zeta":[184],"potential":[185],"measurements":[186],"2H-NMR.":[188],"Results:":[189],"Increased":[190],"at":[193,209],"5.5,":[195],"~50%":[197],"total":[198],"phospholipid,":[199],"correlated":[200],"with":[201],"graRS":[204],"expression.":[205],"concentrations":[208],"5.5":[211],"produced":[212],"condensing":[214],"bacterial":[218],"(with":[220],"both":[221],"natural":[222],"lipids),":[225],"making":[226,287],"it":[227],"cationically":[228],"charged":[229],"less":[231],"permeable":[232],"solvent.":[234],"These":[235,274],"reduced":[238],"electrostatic":[239],"attraction":[240],"retarded":[244],"their":[245],"ability":[246],"partition":[248],"Conclusions:":[252],"plays":[254],"an":[255],"important":[256],"altering":[266],"charge":[269],"packing":[272],"alterations":[276],"also":[277],"facilitate":[278],"other":[281],"such":[284],"as":[285],"CAMPs,":[286],"putative":[291],"target":[292],"therapeutics.":[295]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-09-01T08:31:24.195828","created_date":"2016-06-24T00:00:00"}