{"id":"https://openalex.org/W85055323","doi":null,"title":"The human metabolism of caffeine to theophylline.","display_name":"The human metabolism of caffeine to theophylline.","publication_year":1976,"publication_date":"1976-02-01","ids":{"openalex":"https://openalex.org/W85055323","mag":"85055323","pmid":"https://pubmed.ncbi.nlm.nih.gov/1257607"},"language":"en","primary_location":{"id":"pmid:1257607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1257607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research communications in chemical pathology and pharmacology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001007354","display_name":"Stephen Sved","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Sved","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036880599","display_name":"R. D. Hossie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R D Hossie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111471427","display_name":"I.J. McGilveray","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I J McGilveray","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3333,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.78115747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"13","issue":"2","first_page":"185","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11264","display_name":"Coffee research and impacts","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11264","display_name":"Coffee research and impacts","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.030700000002980232,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":0.7839999794960022},{"id":"https://openalex.org/keywords/theophylline","display_name":"theophylline","score":0.9990000128746033},{"id":"https://openalex.org/keywords/caffeine-metabolism","display_name":"caffeine metabolism","score":0.9089999794960022},{"id":"https://openalex.org/keywords/aminophylline","display_name":"aminophylline","score":0.796999990940094},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.6669999957084656},{"id":"https://openalex.org/keywords/plasma-concentration","display_name":"plasma concentration","score":0.7279999852180481},{"id":"https://openalex.org/keywords/coffee-consumption","display_name":"coffee consumption","score":0.7879999876022339},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.3149999976158142}],"concepts":[{"id":"https://openalex.org/C2778095195","wikidata":"https://www.wikidata.org/wiki/Q407308","display_name":"Theophylline","level":2,"score":0.9873834252357483},{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.9829534888267517},{"id":"https://openalex.org/C2776202631","wikidata":"https://www.wikidata.org/wiki/Q471763","display_name":"Aminophylline","level":2,"score":0.9281260967254639},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.6632692813873291},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5756576657295227},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4985363483428955},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48827099800109863},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4803415536880493},{"id":"https://openalex.org/C2781018748","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator","level":3,"score":0.42840760946273804},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3149414360523224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30396097898483276},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16709133982658386},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.10130894184112549}],"mesh":[{"descriptor_ui":"D000493","descriptor_name":"Allopurinol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000628","descriptor_name":"Aminophylline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1257607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1257607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research communications in chemical pathology and pharmacology","raw_type":"Journal Article"},{"id":"mag:85055323","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1257607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1965482506","https://openalex.org/W2044681042","https://openalex.org/W2404682289","https://openalex.org/W1994143503","https://openalex.org/W207344400","https://openalex.org/W2056979568","https://openalex.org/W4387724049","https://openalex.org/W4206391171","https://openalex.org/W1968221669","https://openalex.org/W2416661590"],"abstract_inverted_index":{"Theophylline":[0],"peak":[1,27],"plasma":[2],"concentration":[3],"of":[4,14,20,40,54,82],"over":[5],"170":[6],"ng/ml":[7],"average":[8,52],"was":[9,22,29],"observed":[10,31],"when":[11],"300":[12],"mg":[13],"caffeine,":[15,41],"equivalent":[16],"to":[17,24,46,58],"2-3":[18],"cups":[19],"coffee,":[21],"administered":[23],"humans.":[25],"This":[26],"level":[28],"not":[30],"until":[32],"at":[33],"least":[34],"7":[35],"hr":[36],"post":[37],"administration.":[38,90],"Accumulation":[39],"with":[42,67,88],"its":[43],"subsequent":[44],"metabolism":[45],"theophylline,":[47],"in":[48,70],"patients,":[49],"who":[50,61],"consume":[51],"quantities":[53],"caffeine-containing":[55],"beverages":[56],"relative":[57],"those":[59],"patients":[60],"avoid":[62],"such":[63],"drinks":[64],"could":[65],"interfere":[66],"bioavailability":[68],"studies":[69],"normal":[71],"volunteers.":[72],"However,":[73],"it":[74],"may":[75],"account":[76],"for":[77],"only":[78],"a":[79],"small":[80],"portion":[81],"the":[83],"variable":[84],"clinical":[85],"effects":[86],"associated":[87],"aminophylline":[89]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}