{"id":"https://openalex.org/W85018998","doi":null,"title":"Development of biomarkers for the identification of pathogenic Candida species","display_name":"Development of biomarkers for the identification of pathogenic Candida species","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W85018998","mag":"85018998"},"language":"en","primary_location":{"id":"pmh:oai:repositorium.sdum.uminho.pt:1822/22836","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1822/22836","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1822/22836","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084274682","display_name":"Joana Carvalho-Pereira","orcid":"https://orcid.org/0000-0001-7813-8382","observed_orcids":["https://orcid.org/0000-0001-7813-8382"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joana Carvalho-Pereira","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7813-8382","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5084274682"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12668","display_name":"Yeasts and Rust Fungi Studies","score":0.11540000140666962,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10825","display_name":"Plant Pathogens and Fungal Diseases","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-species-identification","display_name":"Candida species identification","score":0.906000018119812},{"id":"https://openalex.org/keywords/microsatellite-markers","display_name":"microsatellite markers","score":0.9549999833106995},{"id":"https://openalex.org/keywords/multiplex-pcr","display_name":"multiplex PCR","score":0.7070000171661377},{"id":"https://openalex.org/keywords/species-specific-markers","display_name":"species-specific markers","score":0.39500001072883606},{"id":"https://openalex.org/keywords/fungal-infection","display_name":"fungal infection","score":0.38100001215934753},{"id":"https://openalex.org/keywords/antifungal-susceptibility","display_name":"antifungal susceptibility","score":0.6520000100135803},{"id":"https://openalex.org/keywords/bacterial-typing","display_name":"strain typing","score":0.40400001406669617},{"id":"https://openalex.org/keywords/candida-tropicalis","display_name":"Candida tropicalis","score":0.5740000009536743},{"id":"https://openalex.org/keywords/candida-parapsilosis","display_name":"Candida parapsilosis","score":0.9179999828338623},{"id":"https://openalex.org/keywords/candida-glabrata","display_name":"Candida glabrata","score":0.9509999752044678},{"id":"https://openalex.org/keywords/candida-krusei","display_name":"Candida krusei","score":0.9990000128746033},{"id":"https://openalex.org/keywords/opportunistic-fungal-infection","display_name":"opportunistic fungal infection","score":0.6460000276565552},{"id":"https://openalex.org/keywords/immunocompromised-patients","display_name":"immunocompromised patients","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.628639817237854},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5370299816131592},{"id":"https://openalex.org/C2909938017","wikidata":"https://www.wikidata.org/wiki/Q2712836","display_name":"Candida infections","level":3,"score":0.4528234899044037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4406298100948334},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.36487656831741333},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.2672566771507263},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.16858407855033875}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:repositorium.sdum.uminho.pt:1822/22836","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1822/22836","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"master thesis"},{"id":"pmh:oai:repositorium.uminho.pt:1822/22836","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1822/22836","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"mag:85018998","doi":null,"is_oa":false,"landing_page_url":"https://repositorium.sdum.uminho.pt/bitstream/1822/22836/1/Joana%20Isabel%20Carvalho%20Pereira.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repositorium.sdum.uminho.pt:1822/22836","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1822/22836","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"master thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7097011484","https://openalex.org/W2058666279","https://openalex.org/W2126805513","https://openalex.org/W2765981304","https://openalex.org/W7128385854","https://openalex.org/W2124589927","https://openalex.org/W1966229896","https://openalex.org/W2087348828","https://openalex.org/W7095718510","https://openalex.org/W3124206326"],"abstract_inverted_index":{"In":[0],"the":[1,4,14,23,35,54,83,93,131,138,141,166,219,234,249,279,287,303,344,406,415],"last":[2],"decades":[3],"incidence":[5],"of":[6,16,25,98,134,140,143,152,233,281,289,324,347,364,383,434,448],"fungal":[7,43],"infections":[8,44,60,353,393],"has":[9,294],"increased":[10,368],"exponentially,":[11],"due":[12],"to":[13,52,85,90,112,227,253,311,369,403,413,445],"development":[15],"more":[17],"aggressive":[18],"therapeutic":[19],"techniques,":[20],"which":[21],"increase":[22],"number":[24,363],"immunocompromised":[26],"and":[27,48,73,95,114,149,183,194,214,243,265,284,298,319,354,359,371,389,391,397,441],"in":[28,45,200,212,229,271,278,286,306,332,375,423],"risk":[29],"individuals.":[30],"The":[31,326,362,399],"Candida":[32,49,127,168,418],"species":[33,57,100,128,147],"are":[34,76,101,269],"most":[36,55,416],"common":[37,56,417],"etiological":[38],"agents":[39],"isolated":[40,338,385],"from":[41,203,339,349,355,386],"opportunistic":[42],"these":[46],"patients":[47],"albicans":[50,155,257,317,336],"appears":[51],"be":[53,312,411],"isolated.":[58],"However,":[59,117],"caused":[61],"by":[62],"nonalbicans":[63],"species,":[64,91,169,419],"such":[65,438],"as":[66,109,439],"C.":[67,69,71,74,154,175,179,181,184,220,235,256,316,335,449],"parapsilosis,":[68,180],"glabrata,":[70,178],"tropicalis":[72,182,221,236],"krusei,":[75],"increasing":[77],"alarmingly.":[78],"It":[79],"is":[80,276,443],"thought":[81],"that":[82,224,405,432],"susceptibility":[84],"antifungal":[86],"drugs":[87],"varies":[88],"according":[89],"thus,":[92],"rapid":[94],"correct":[96],"identification":[97,151],"infecting":[99],"crucial.":[102],"Microsatellite":[103],"sequences":[104],"have":[105,120],"been":[106,121,295],"largely":[107],"used":[108,412],"molecular":[110],"targets":[111],"differentiate":[113,414,446],"characterize":[115],"strains.":[116],"no":[118],"studies":[119],"performed":[122],"using":[123],"microsatellite":[124,144,163,260,293,328,407],"DNA":[125],"for":[126,146,150,161,165,174,218,302,315],"identification.":[129],"Therefore,":[130],"main":[132,167],"objectives":[133],"this":[135,195,238,307],"work":[136],"were":[137,172,188,251,262,330],"evaluation":[139],"potential":[142],"markers":[145,164,171,187,261,268,329],"differentiation":[148,346],"specific":[153,255,314],"lineages.":[156],"After":[157,231],"an":[158,421],"intensive":[159],"search":[160],"described":[162,297,301],"several":[170],"selected":[173,222],"albicans,":[176],"C,":[177],"krusei.":[185],"These":[186,267],"combined":[189],"into":[190],"a":[191,321],"multiplex":[192,215],"strategy":[193],"new":[196],"developed":[197],"system":[198,239],"tested":[199,208,331],"81":[201],"strains":[202,318,337,348,366,384],"10":[204],"different":[205,340],"species.":[206],"All":[207],"loci":[209,408],"amplified":[210],"correctly":[211],"single":[213],"conditions,":[216],"except":[217],"locus":[223],"was":[225,300,367,428],"unable":[226],"amplify":[228],"multiplex.":[230],"removal":[232],"primers,":[237],"showed":[240],"100%":[241,244],"specificity":[242],"sensibility.":[245],"To":[246],"test":[247],"if":[248],"microsatellites":[250],"able":[252,444],"identify":[254],"lineages":[258,447],"two":[259,272,327],"used,":[263],"CAI":[264,275,292,376],"CAVIII.":[266],"located":[270,277],"repeat-containing":[273],"ORFs,":[274,437],"terminal-3\u2019":[280,288],"RLM1":[282,440],"gene":[283],"CAVIII":[285,299,309],"SAP8":[290,442],"gene.":[291],"previously":[296],"first":[304],"time":[305],"study.":[308],"demonstrated":[310,378],"highly":[313],"presented":[320],"discriminatory":[322],"power":[323],"0.72.":[325],"144":[333],"unrelated":[334],"body":[341],"locations,":[342],"allowing":[343],"statistical":[345,372],"oral":[350],"cavity,":[351],"vulvovaginal":[352],"extra-mucosal":[356,365],"(respiratory":[357,394],"tract":[358],"urine)":[360],"infections.":[361],"224":[370],"analysis":[373,409,433],"based":[374],"genotypes,":[377],"significant":[379],"differences":[380],"between":[381],"genotypes":[382],"superficial":[387],"(oral":[388],"vagina)":[390],"invasive":[392],"tract,":[395],"urine":[396],"blood).":[398],"results":[400],"obtained":[401],"allowed":[402],"conclude":[404],"can":[410],"being":[420],"alternative":[422],"clinical":[424],"diagnosis.":[425],"Moreover,":[426],"it":[427],"also":[429],"possible":[430],"observe":[431],"repeat":[435],"containing":[436],"albicans.":[450]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
