{"id":"https://openalex.org/W849946536","doi":"https://doi.org/10.1016/j.joca.2015.06.007","title":"Huo-Luo-Xiao-Ling (HLXL)-Dan, a Traditional Chinese Medicine, for patients with osteoarthritis of the knee: a multi-site, randomized, double-blind, placebo-controlled phase II clinical trial","display_name":"Huo-Luo-Xiao-Ling (HLXL)-Dan, a Traditional Chinese Medicine, for patients with osteoarthritis of the knee: a multi-site, randomized, double-blind, placebo-controlled phase II clinical trial","publication_year":2015,"publication_date":"2015-06-20","ids":{"openalex":"https://openalex.org/W849946536","doi":"https://doi.org/10.1016/j.joca.2015.06.007","mag":"849946536","pmid":"https://pubmed.ncbi.nlm.nih.gov/26099553","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4663117"},"language":"en","primary_location":{"id":"doi:10.1016/j.joca.2015.06.007","doi":"https://doi.org/10.1016/j.joca.2015.06.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.joca.2015.06.007","pdf_url":"http://www.oarsijournal.com/article/S1063458415012157/pdf","source":{"id":"https://openalex.org/S13054843","display_name":"Osteoarthritis and Cartilage","issn_l":"1063-4584","issn":["1063-4584","1522-9653"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and Cartilage","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.oarsijournal.com/article/S1063458415012157/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015198590","display_name":"Lixing Lao","orcid":"https://orcid.org/0000-0003-0198-9714","observed_orcids":["https://orcid.org/0000-0003-0198-9714"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK","US"],"is_corresponding":true,"raw_author_name":"L. Lao","raw_affiliation_strings":["Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, USA; School of Chinese Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. Electronic address: lxlao1@hku.hk","Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, USA","School of Chinese Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, USA; School of Chinese Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. Electronic address: lxlao1@hku.hk","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"School of Chinese Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026165132","display_name":"Marc C. Hochberg","orcid":"https://orcid.org/0000-0001-7705-5593","observed_orcids":["https://orcid.org/0000-0001-7705-5593"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M. Hochberg","raw_affiliation_strings":["Division of Rheumatology & Clinical Immunology, Department of Medicine, School of Medicine, University of Maryland, Baltimore, USA. Electronic address: mhochber@medicine.umaryland.edu","Division of Rheumatology & Clinical Immunology, Department of Medicine, School of Medicine, University of Maryland, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology & Clinical Immunology, Department of Medicine, School of Medicine, University of Maryland, Baltimore, USA. Electronic address: mhochber@medicine.umaryland.edu","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Division of Rheumatology & Clinical Immunology, Department of Medicine, School of Medicine, University of Maryland, Baltimore, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061850330","display_name":"David Y.W. Lee","orcid":"https://orcid.org/0000-0002-8045-4656","observed_orcids":["https://orcid.org/0000-0002-8045-4656"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D.Y.W. Lee","raw_affiliation_strings":["Mailman Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA. Electronic address: dlee@mclean.harvard.edu","Mailman Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA"],"raw_orcid":"https://orcid.org/0000-0002-8045-4656","affiliations":[{"raw_affiliation_string":"Mailman Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA. Electronic address: dlee@mclean.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]},{"raw_affiliation_string":"Mailman Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114257614","display_name":"Adele M. Kaplan Gilpin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A.M.K. Gilpin","raw_affiliation_strings":["Department of Epidemiology and Public Health, School of Medicine, University of Maryland, Baltimore, USA. Electronic address: adele.gilpin@gmail.com","Department of Epidemiology and Public Health, School of Medicine, University of Maryland, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Public Health, School of Medicine, University of Maryland, Baltimore, USA. Electronic address: adele.gilpin@gmail.com","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Department of Epidemiology and Public Health, School of Medicine, University of Maryland, Baltimore, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111945161","display_name":"Harry H. S. Fong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"H.H.S. Fong","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: hfong@uic.edu","Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: hfong@uic.edu","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA;","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064989322","display_name":"PATRICIA W. LANGENBERG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"P. Langenberg","raw_affiliation_strings":["Department of Epidemiology and Public Health, School of Medicine, University of Maryland, Baltimore, USA. Electronic address: PLANGENB@epi.umaryland.edu","Department of Epidemiology and Public Health, School of Medicine, University of Maryland, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Public Health, School of Medicine, University of Maryland, Baltimore, USA. Electronic address: PLANGENB@epi.umaryland.edu","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Department of Epidemiology and Public Health, School of Medicine, University of Maryland, Baltimore, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051567284","display_name":"Kelly Chen","orcid":"https://orcid.org/0009-0000-2429-1525","observed_orcids":["https://orcid.org/0009-0000-2429-1525"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"K. Chen","raw_affiliation_strings":["Department of Family and Community Medicine, School of Medicine, University of Maryland, Baltimore, USA. Electronic address: KChen@som.umaryland.edu","Department of Family and Community Medicine, School of Medicine, University of Maryland, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family and Community Medicine, School of Medicine, University of Maryland, Baltimore, USA. Electronic address: KChen@som.umaryland.edu","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Department of Family and Community Medicine, School of Medicine, University of Maryland, Baltimore, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114236877","display_name":"E.K. Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":true,"raw_author_name":"E.K. Li","raw_affiliation_strings":["Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China. Electronic address: edmundli@cuhk.edu.hk","Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China. Electronic address: edmundli@cuhk.edu.hk","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]},{"raw_affiliation_string":"Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065412132","display_name":"Lai\u2010Shan Tam","orcid":"https://orcid.org/0000-0001-6410-8852","observed_orcids":["https://orcid.org/0000-0001-6410-8852"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":true,"raw_author_name":"L.S. Tam","raw_affiliation_strings":["Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China. Electronic address: lstam@cuhk.edu.hk","Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China. Electronic address: lstam@cuhk.edu.hk","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]},{"raw_affiliation_string":"Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049567539","display_name":"Brian Berman","orcid":"https://orcid.org/0000-0001-6610-4863","observed_orcids":["https://orcid.org/0000-0001-6610-4863"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"B. Berman","raw_affiliation_strings":["Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, USA. Electronic address: BBerman@som.umaryland.edu","Center For Integrative Medicine, School of Medicine, University of Maryland, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, USA. Electronic address: BBerman@som.umaryland.edu","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Center For Integrative Medicine, School of Medicine, University of Maryland, Baltimore, USA","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5015198590","https://openalex.org/A5026165132","https://openalex.org/A5049567539","https://openalex.org/A5051567284","https://openalex.org/A5061850330","https://openalex.org/A5064989322","https://openalex.org/A5065412132","https://openalex.org/A5111945161","https://openalex.org/A5114236877","https://openalex.org/A5114257614"],"corresponding_institution_ids":["https://openalex.org/I126744593","https://openalex.org/I136199984","https://openalex.org/I177725633","https://openalex.org/I2801148111","https://openalex.org/I39422238","https://openalex.org/I4210114914","https://openalex.org/I889458895"],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":null,"fwci":1.3964,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.79393758,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"23","issue":"12","first_page":"2102","last_page":"2108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13444","display_name":"Medical Research and Treatments","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10902","display_name":"Complementary and Alternative Medicine Studies","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.8550000190734863},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.8960000276565552},{"id":"https://openalex.org/keywords/knee-pain","display_name":"knee pain","score":0.8920000195503235},{"id":"https://openalex.org/keywords/knee-function","display_name":"knee function","score":0.8970000147819519},{"id":"https://openalex.org/keywords/womac","display_name":"WOMAC","score":0.8629999756813049},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9089298844337463},{"id":"https://openalex.org/C2779286237","wikidata":"https://www.wikidata.org/wiki/Q3569749","display_name":"WOMAC","level":4,"score":0.8716845512390137},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.8434106707572937},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7930725812911987},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6015700101852417},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.593065083026886},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5524840354919434},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.5306597948074341},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.46459388732910156},{"id":"https://openalex.org/C2779279471","wikidata":"https://www.wikidata.org/wiki/Q6421876","display_name":"Knee pain","level":4,"score":0.41685181856155396},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4117385745048523},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.4114096760749817},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.1069803237915039},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008516","descriptor_name":"Medicine, Chinese Traditional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.joca.2015.06.007","doi":"https://doi.org/10.1016/j.joca.2015.06.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.joca.2015.06.007","pdf_url":"http://www.oarsijournal.com/article/S1063458415012157/pdf","source":{"id":"https://openalex.org/S13054843","display_name":"Osteoarthritis and Cartilage","issn_l":"1063-4584","issn":["1063-4584","1522-9653"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and Cartilage","raw_type":"journal-article"},{"id":"pmid:26099553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26099553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and cartilage","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:pubmedcentral.nih.gov:4663117","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4663117","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Osteoarthritis Cartilage","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.joca.2015.06.007","doi":"https://doi.org/10.1016/j.joca.2015.06.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.joca.2015.06.007","pdf_url":"http://www.oarsijournal.com/article/S1063458415012157/pdf","source":{"id":"https://openalex.org/S13054843","display_name":"Osteoarthritis and Cartilage","issn_l":"1063-4584","issn":["1063-4584","1522-9653"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and Cartilage","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G8442804234","display_name":"Arthritis and Traditional Chinese Medicine","funder_award_id":"P01AT002605","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"}],"funders":[{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W849946536.pdf","grobid_xml":"https://content.openalex.org/works/W849946536.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W198987307","https://openalex.org/W1573647268","https://openalex.org/W1609869336","https://openalex.org/W1885747990","https://openalex.org/W1967463990","https://openalex.org/W2015469289","https://openalex.org/W2024240141","https://openalex.org/W2026123588","https://openalex.org/W2027473538","https://openalex.org/W2030289766","https://openalex.org/W2031572026","https://openalex.org/W2032541700","https://openalex.org/W2043449872","https://openalex.org/W2080451219","https://openalex.org/W2085788584","https://openalex.org/W2112870271","https://openalex.org/W2120902529","https://openalex.org/W2127087386","https://openalex.org/W2140513563","https://openalex.org/W2152586066","https://openalex.org/W2152985277","https://openalex.org/W2156220503","https://openalex.org/W2203103645"],"related_works":["https://openalex.org/W2087734242","https://openalex.org/W2792098893","https://openalex.org/W3173929934","https://openalex.org/W1978652873","https://openalex.org/W4210949294","https://openalex.org/W2949481829","https://openalex.org/W2406526524","https://openalex.org/W4409102045","https://openalex.org/W2105420299","https://openalex.org/W4411940909"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}