{"id":"https://openalex.org/W849609062","doi":"https://doi.org/10.3233/rnn-139012","title":"Pathological anxiety and function/dysfunction in the brain's fear/defense circuitry","display_name":"Pathological anxiety and function/dysfunction in the brain's fear/defense circuitry","publication_year":2014,"publication_date":"2014-02-01","ids":{"openalex":"https://openalex.org/W849609062","doi":"https://doi.org/10.3233/rnn-139012","mag":"849609062","pmid":"https://pubmed.ncbi.nlm.nih.gov/23777635"},"language":"en","primary_location":{"id":"doi:10.3233/rnn-139012","doi":"https://doi.org/10.3233/rnn-139012","is_oa":false,"landing_page_url":"https://doi.org/10.3233/rnn-139012","pdf_url":null,"source":{"id":"https://openalex.org/S6182497","display_name":"Restorative Neurology and Neuroscience","issn_l":"0922-6028","issn":["0922-6028","1878-3627"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Restorative Neurology and Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103091769","display_name":"Peter J. Lang","orcid":"https://orcid.org/0000-0001-5914-7478","observed_orcids":["https://orcid.org/0000-0001-5914-7478"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Lang","raw_affiliation_strings":["Center for the Study of Emotion & Attention, University of Florida, FL, USA","Center for the Study of Emotion & Attention, University of Florida, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for the Study of Emotion & Attention, University of Florida, FL, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Center for the Study of Emotion & Attention, University of Florida, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013373039","display_name":"Lisa M. McTeague","orcid":"https://orcid.org/0000-0003-4475-9425","observed_orcids":["https://orcid.org/0000-0003-4475-9425"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa M. McTeague","raw_affiliation_strings":["Center for the Study of Emotion & Attention, University of Florida, FL, USA","Center for the Study of Emotion & Attention, University of Florida, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for the Study of Emotion & Attention, University of Florida, FL, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Center for the Study of Emotion & Attention, University of Florida, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102755882","display_name":"Margaret M. Bradley","orcid":"https://orcid.org/0000-0003-0293-4571","observed_orcids":["https://orcid.org/0000-0003-0293-4571"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret M. Bradley","raw_affiliation_strings":["Center for the Study of Emotion & Attention, University of Florida, FL, USA","Center for the Study of Emotion & Attention, University of Florida, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for the Study of Emotion & Attention, University of Florida, FL, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Center for the Study of Emotion & Attention, University of Florida, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":5.5202,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.94620913,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"32","issue":"1","first_page":"63","last_page":"77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.03099999949336052,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pathological-anxiety","display_name":"pathological anxiety","score":0.9309999942779541},{"id":"https://openalex.org/keywords/anxiety-disorders","display_name":"anxiety disorders","score":0.7319999933242798},{"id":"https://openalex.org/keywords/fear-memory","display_name":"fear memory","score":0.8579999804496765},{"id":"https://openalex.org/keywords/maladaptive-plasticity","display_name":"maladaptive plasticity","score":0.75},{"id":"https://openalex.org/keywords/generalized-anxiety-disorder","display_name":"generalized anxiety disorder","score":0.8130000233650208},{"id":"https://openalex.org/keywords/comorbid-mood-disorders","display_name":"comorbid mood disorders","score":0.9049999713897705},{"id":"https://openalex.org/keywords/blunted-affect","display_name":"blunted affect","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.721760630607605},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.7215834259986877},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6100664734840393},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5616973638534546},{"id":"https://openalex.org/C123273963","wikidata":"https://www.wikidata.org/wiki/Q624758","display_name":"Psychopathology","level":2,"score":0.5498511791229248},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.5112428665161133},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.4498358368873596},{"id":"https://openalex.org/C2777134132","wikidata":"https://www.wikidata.org/wiki/Q188638","display_name":"Mood disorders","level":3,"score":0.446207195520401},{"id":"https://openalex.org/C2776317618","wikidata":"https://www.wikidata.org/wiki/Q544006","display_name":"Anxiety disorder","level":3,"score":0.43812257051467896},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.41515541076660156},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.32466432452201843},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.21860060095787048},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1602349877357483},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000223","descriptor_name":"Adaptation, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005239","descriptor_name":"Fear","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3233/rnn-139012","doi":"https://doi.org/10.3233/rnn-139012","is_oa":false,"landing_page_url":"https://doi.org/10.3233/rnn-139012","pdf_url":null,"source":{"id":"https://openalex.org/S6182497","display_name":"Restorative Neurology and Neuroscience","issn_l":"0922-6028","issn":["0922-6028","1878-3627"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Restorative Neurology and Neuroscience","raw_type":"journal-article"},{"id":"pmid:23777635","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23777635","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Restorative neurology and neuroscience","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4161414332","display_name":null,"funder_award_id":"R01-MH094386","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4489148646","display_name":"Attention Capture in Fear, Anxiety, and Depression","funder_award_id":"R21MH082702","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G5401526555","display_name":"Center for the Study of Emotion and Attention","funder_award_id":"P50MH072850","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6619255883","display_name":"Traumatic Exposure, PTSD and Physiological Reactivity","funder_award_id":"F31MH069048","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G7586699898","display_name":"Anxiety, comorbidity, negative affect, and fear circuit activation","funder_award_id":"4r01mh094386-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320310009","display_name":"University of Florida","ror":"https://ror.org/02y3ad647"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W14300483","https://openalex.org/W1001071950","https://openalex.org/W1495502407","https://openalex.org/W1496028880","https://openalex.org/W1527550792","https://openalex.org/W1553506120","https://openalex.org/W1607171655","https://openalex.org/W1964711918","https://openalex.org/W1965412569","https://openalex.org/W1967087306","https://openalex.org/W1967231325","https://openalex.org/W1967823058","https://openalex.org/W1977465442","https://openalex.org/W1977500242","https://openalex.org/W1981590577","https://openalex.org/W1981879624","https://openalex.org/W1982844998","https://openalex.org/W1984783862","https://openalex.org/W1986066265","https://openalex.org/W1986711940","https://openalex.org/W1986779034","https://openalex.org/W1987900652","https://openalex.org/W1989486988","https://openalex.org/W1994097311","https://openalex.org/W1999807232","https://openalex.org/W2003360731","https://openalex.org/W2006091191","https://openalex.org/W2008245053","https://openalex.org/W2015312708","https://openalex.org/W2018342377","https://openalex.org/W2019871806","https://openalex.org/W2020902468","https://openalex.org/W2021085650","https://openalex.org/W2021502766","https://openalex.org/W2024686567","https://openalex.org/W2025887442","https://openalex.org/W2038068277","https://openalex.org/W2046523960","https://openalex.org/W2054630277","https://openalex.org/W2054863711","https://openalex.org/W2059403298","https://openalex.org/W2060555434","https://openalex.org/W2060926272","https://openalex.org/W2061068571","https://openalex.org/W2061734625","https://openalex.org/W2063437472","https://openalex.org/W2067201491","https://openalex.org/W2070583390","https://openalex.org/W2072522618","https://openalex.org/W2078447042","https://openalex.org/W2078560091","https://openalex.org/W2080212176","https://openalex.org/W2085971650","https://openalex.org/W2090332743","https://openalex.org/W2094542138","https://openalex.org/W2095330158","https://openalex.org/W2100991928","https://openalex.org/W2102748276","https://openalex.org/W2108337682","https://openalex.org/W2110747672","https://openalex.org/W2122384242","https://openalex.org/W2125197016","https://openalex.org/W2126907906","https://openalex.org/W2129071550","https://openalex.org/W2132020717","https://openalex.org/W2133466515","https://openalex.org/W2140404090","https://openalex.org/W2141187875","https://openalex.org/W2147784213","https://openalex.org/W2147807532","https://openalex.org/W2147810841","https://openalex.org/W2154058918","https://openalex.org/W2157217643","https://openalex.org/W2159232688","https://openalex.org/W2160683465","https://openalex.org/W2167123432","https://openalex.org/W2480062921","https://openalex.org/W2765169362","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1547865271","https://openalex.org/W173399038","https://openalex.org/W4404761397","https://openalex.org/W2479937479","https://openalex.org/W2738938674","https://openalex.org/W2132020717","https://openalex.org/W2124211275","https://openalex.org/W3198087387","https://openalex.org/W2075986471","https://openalex.org/W1527084800"],"abstract_inverted_index":{"Research":[0],"from":[1,44,106],"the":[2,8,50,75,135,156,165,169,180,198],"University":[3],"of":[4,10,77,88,100,146,155,167,171,182,200],"Florida":[5],"Center":[6],"for":[7,151],"Study":[9],"Emotion":[11],"and":[12,34,46,56,85,103,122,189],"Attention":[13],"aims":[14],"to":[15,39,111,193],"develop":[16],"neurobiological":[17],"measures":[18],"that":[19,53,68,137],"objectively":[20],"discriminate":[21],"among":[22],"symptom":[23],"patterns":[24],"in":[25,49,94,116,160,174,186,197],"patients":[26,117],"with":[27,118,128,142,164],"anxiety":[28,33,101,121,161],"disorders.":[29,125,176],"From":[30],"this":[31,143],"perspective,":[32],"mood":[35,124],"pathologies":[36],"are":[37,149],"considered":[38],"be":[40],"brain":[41,90],"disorders,":[42],"resulting":[43],"dysfunction":[45,140,173],"maladaptive":[47],"plasticity":[48],"neural":[51],"circuits":[52],"determine":[54],"fearful/defensive":[55],"appetitive/reward":[57],"behavior":[58],"(Insel":[59],"et":[60],"al.,":[61],"2010).":[62],"We":[63],"review":[64],"recent":[65],"studies":[66,127],"indicating":[67],"an":[69,152],"enhanced":[70],"probe":[71],"startle":[72],"reflex":[73],"during":[74],"processing":[76],"fear":[78,109],"memory":[79],"cues":[80],"(mediated":[81],"by":[82],"cortico-limbic":[83],"circuitry":[84,159],"thus":[86],"indicative":[87],"plastic":[89],"changes),":[91],"varies":[92],"systematically":[93],"strength":[95],"over":[96],"a":[97,112,191],"spectrum-wide":[98],"dimension":[99,145],"pathology-across":[102],"within":[104],"diagnoses-extending":[105],"strong":[107],"focal":[108],"reactions":[110],"consistently":[113],"blunted":[114,201],"reaction":[115],"more":[119],"generalized":[120],"comorbid":[123],"Preliminary":[126],"functional":[129],"magnetic":[130],"resonance":[131],"imaging":[132],"(fMRI)":[133],"encourage":[134],"hypothesis":[136],"fear/defense":[138],"circuit":[139,172,187,195],"covaries":[141],"same":[144],"psychopathology.":[147],"Plans":[148],"described":[150],"extended":[153],"study":[154],"brain's":[157],"motivation":[158],"spectrum":[162],"patients,":[163],"aim":[166],"defining":[168],"specifics":[170],"severe":[175],"A":[177],"sub-project":[178],"explores":[179],"use":[181],"real-time":[183],"fMRI":[184],"feedback":[185],"analysis":[188],"as":[190],"modality":[192],"up-regulate":[194],"function":[196],"context":[199],"affect.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}