{"id":"https://openalex.org/W84924379","doi":null,"title":"CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2'deoxycytidine.","display_name":"CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2'deoxycytidine.","publication_year":1995,"publication_date":"1995-09-21","ids":{"openalex":"https://openalex.org/W84924379","mag":"84924379","pmid":"https://pubmed.ncbi.nlm.nih.gov/7566983"},"language":"en","primary_location":{"id":"pmid:7566983","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7566983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004712121","display_name":"Gregory A. Otterson","orcid":"https://orcid.org/0000-0001-9877-8512","observed_orcids":["https://orcid.org/0000-0001-9877-8512"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G A Otterson","raw_affiliation_strings":["NCI-Navy Oncology Branch, National Cancer Institute, Bethesda, MD 20889, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NCI-Navy Oncology Branch, National Cancer Institute, Bethesda, MD 20889, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026861780","display_name":"Samir N. Khleif","orcid":"https://orcid.org/0000-0003-2707-5224","observed_orcids":["https://orcid.org/0000-0003-2707-5224"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S N Khleif","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100780046","display_name":"Wei Chen","orcid":"https://orcid.org/0000-0002-9934-4000","observed_orcids":["https://orcid.org/0000-0002-9934-4000"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052315651","display_name":"Amy B. Coxon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A B Coxon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110240441","display_name":"F. J. Kaye","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F J Kaye","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.6688,"has_fulltext":false,"cited_by_count":212,"citation_normalized_percentile":{"value":0.96117255,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"6","first_page":"1211","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdkn2","display_name":"CDKN2","score":0.8840000033378601},{"id":"https://openalex.org/keywords/p16ink4","display_name":"p16INK4","score":0.9890000224113464},{"id":"https://openalex.org/keywords/dna-hypermethylation","display_name":"DNA hypermethylation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.7710000276565552},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9380000233650208},{"id":"https://openalex.org/keywords/decitabine","display_name":"decitabine","score":0.9819999933242798},{"id":"https://openalex.org/keywords/demethylation","display_name":"demethylation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/tumor-suppressor-pathways","display_name":"tumor suppressor pathways","score":0.7689999938011169},{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.9459999799728394},{"id":"https://openalex.org/keywords/exon-1","display_name":"exon 1","score":0.5619999766349792},{"id":"https://openalex.org/keywords/hypomethylation","display_name":"hypomethylation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.6660000085830688},{"id":"https://openalex.org/keywords/lag-phase","display_name":"lag phase","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8694812059402466},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7249436378479004},{"id":"https://openalex.org/C2779277951","wikidata":"https://www.wikidata.org/wiki/Q5255196","display_name":"Demethylating agent","level":5,"score":0.6619081497192383},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.6258970499038696},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.596027672290802},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.5916497111320496},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.5899136066436768},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5766397714614868},{"id":"https://openalex.org/C2776750431","wikidata":"https://www.wikidata.org/wiki/Q7117832","display_name":"p14arf","level":5,"score":0.532105565071106},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5071189403533936},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4908605217933655},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4778982400894165},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4141228199005127},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.39197948575019836},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3775070905685425},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26436764001846313}],"mesh":[{"descriptor_ui":"D000077209","descriptor_name":"Decitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015254","descriptor_name":"DNA Modification Methylases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:7566983","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7566983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},{"id":"mag:84924379","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7566983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1995382565","https://openalex.org/W2090032248","https://openalex.org/W2335765354","https://openalex.org/W2138394146","https://openalex.org/W2090442799","https://openalex.org/W2377291145","https://openalex.org/W2136390455","https://openalex.org/W2361361359","https://openalex.org/W2122580718","https://openalex.org/W7095549132"],"abstract_inverted_index":{"Absent":[0],"expression":[1,76,102],"of":[2,14,30,56,63,71,103,108,124],"the":[3,33,64,89,100,120,125,139,158,172],"cyclin":[4],"dependent":[5],"kinase-inhibitor,":[6],"p16INK4,":[7],"is":[8,42,128],"observed":[9,136],"in":[10,27,39,69,106,144],"a":[11,28,57,112,129,166],"wide":[12],"range":[13],"primary":[15],"human":[16],"cancers.":[17],"Although":[18],"homozygous":[19],"deletions":[20],"and":[21,51,77,171],"point":[22,155],"mutations":[23,156],"have":[24,45,52],"been":[25],"reported":[26],"subset":[29],"these":[31,109],"tumors,":[32],"molecular":[34],"basis":[35],"for":[36,83,132],"absent":[37],"p16INK4":[38,104,149],"other":[40],"samples":[41,72,110],"unknown.":[43],"We":[44],"examined":[46],"33":[47],"tumor":[48,145,174],"cell":[49],"lines":[50,146],"shown":[53],"that":[54,122,147,151],"hypermethylation":[55,123],"G:C-rich":[58],"region":[59],"within":[60,157],"exon":[61,140],"1":[62,141],"CDKN2":[65,80,126,159],"gene":[66,127,133],"was":[67],"present":[68],"100%":[70],"with":[73,88,119],"wildtype":[74],"RB":[75],"no":[78],"detectable":[79],"mutations.":[81],"Treatment":[82],"at":[84,138],"least":[85],"4":[86],"hours":[87],"demethylating":[90],"agent":[91],"5-aza":[92],"2'deoxycytidine,":[93],"but":[94],"not":[95],"5-azacytidine":[96],"or":[97,150],"6-azacytidine,":[98],"induces":[99],"prolonged":[101],"protein":[105],"each":[107],"following":[111],"discrete":[113],"24-48":[114],"hour":[115],"lag":[116],"period.":[117],"Consistent":[118],"hypothesis":[121],"tumor-specific":[130],"mechanism":[131],"inactivation,":[134],"we":[135],"hypomethylation":[137],"site":[142],"exclusively":[143],"expressed":[148],"had":[152],"sustained":[153],"inactivating":[154],"open":[160],"reading":[161],"frame.":[162],"These":[163],"findings":[164],"demonstrate":[165],"link":[167],"between":[168],"DNA":[169],"methylation":[170],"p16INK4:RB":[173],"suppressor":[175],"pathway.":[176]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
