{"id":"https://openalex.org/W84909961","doi":null,"title":"Alzheimer's neurofibrillary tangles contain unique epitopes and epitopes in common with the heat-stable microtubule associated proteins tau and MAP2.","display_name":"Alzheimer's neurofibrillary tangles contain unique epitopes and epitopes in common with the heat-stable microtubule associated proteins tau and MAP2.","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W84909961","mag":"84909961","pmid":"https://pubmed.ncbi.nlm.nih.gov/2433949","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1899538"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1899538","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1899538","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1899538","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111940095","display_name":"S. -H. Yen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S H Yen","raw_affiliation_strings":["Neuroscience"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009533777","display_name":"Dennis W. Dickson","orcid":"https://orcid.org/0000-0001-7189-7917","observed_orcids":["https://orcid.org/0000-0001-7189-7917"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D W Dickson","raw_affiliation_strings":["Neuroscience"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111590905","display_name":"Alex Crowe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Crowe","raw_affiliation_strings":["Yeshiva University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yeshiva University","institution_ids":["https://openalex.org/I19772626"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Butler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Butler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110138549","display_name":"Michael L. Shelanski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M L Shelanski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.1807,"has_fulltext":false,"cited_by_count":146,"citation_normalized_percentile":{"value":0.98763979,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"126","issue":"1","first_page":"81","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9309999942779541},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.8859999775886536},{"id":"https://openalex.org/keywords/map2","display_name":"MAP2","score":0.9649999737739563},{"id":"https://openalex.org/keywords/microtubule-associated-proteins","display_name":"microtubule-associated proteins","score":0.949999988079071},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9169999957084656},{"id":"https://openalex.org/keywords/epitopes","display_name":"antigenic determinants","score":0.7450000047683716},{"id":"https://openalex.org/keywords/antibody-cross-reactivity","display_name":"antibody cross-reactivity","score":0.6290000081062317},{"id":"https://openalex.org/keywords/soma","display_name":"soma","score":0.5080000162124634},{"id":"https://openalex.org/keywords/immunostaining","display_name":"immunostaining","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.9036895036697388},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.6673373579978943},{"id":"https://openalex.org/C61081601","wikidata":"https://www.wikidata.org/wiki/Q1102066","display_name":"Microtubule-associated protein","level":3,"score":0.6499829292297363},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6050162315368652},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5848872065544128},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.571629524230957},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.5493941307067871},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5186885595321655},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49199315905570984},{"id":"https://openalex.org/C2781241564","wikidata":"https://www.wikidata.org/wiki/Q1347450","display_name":"Epitope mapping","level":4,"score":0.4346614181995392},{"id":"https://openalex.org/C78598654","wikidata":"https://www.wikidata.org/wiki/Q17140316","display_name":"Linear epitope","level":4,"score":0.433645099401474},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37534260749816895},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.3393312096595764},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.2660229206085205},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.241062730550766},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2124740183353424},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15601381659507751},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13763362169265747},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08849257230758667},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007158","descriptor_name":"Immunologic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009454","descriptor_name":"Neurofibrils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009454","descriptor_name":"Neurofibrils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1899538","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1899538","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:2433949","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2433949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:84909961","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2433949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1899538","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1899538","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W2205754","https://openalex.org/W41942748","https://openalex.org/W1484194388","https://openalex.org/W1587065131","https://openalex.org/W1604814851","https://openalex.org/W1611407165","https://openalex.org/W1616748355","https://openalex.org/W1775749144","https://openalex.org/W1970040471","https://openalex.org/W1975536870","https://openalex.org/W1981050556","https://openalex.org/W1994030229","https://openalex.org/W1994852663","https://openalex.org/W1995562130","https://openalex.org/W1999008576","https://openalex.org/W2009162588","https://openalex.org/W2012116143","https://openalex.org/W2014636427","https://openalex.org/W2018289835","https://openalex.org/W2030804101","https://openalex.org/W2036745486","https://openalex.org/W2042118644","https://openalex.org/W2045360507","https://openalex.org/W2052086914","https://openalex.org/W2053121988","https://openalex.org/W2060458492","https://openalex.org/W2062098298","https://openalex.org/W2075199998","https://openalex.org/W2093256659","https://openalex.org/W2094885700","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2134277673","https://openalex.org/W2159232487","https://openalex.org/W2226321147"],"related_works":["https://openalex.org/W129024722","https://openalex.org/W1983988051","https://openalex.org/W2134206623","https://openalex.org/W1981050556","https://openalex.org/W2096171722","https://openalex.org/W2077951173","https://openalex.org/W2053377573","https://openalex.org/W1967641379","https://openalex.org/W2205754","https://openalex.org/W1995674720"],"abstract_inverted_index":{"Ten":[0],"monoclonal":[1,280],"antibodies":[2,25,47,82,176,193,210,281],"raised":[3,83],"against":[4,89],"Alzheimer's":[5],"neurofibrillary":[6],"tangles":[7],"(ANTs)":[8],"were":[9],"characterized":[10],"for":[11],"reactivity":[12],"with":[13,36,81,100,127,143,166,211,241],"heat-stable":[14,37,57,144],"microtubule":[15,38],"fractions":[16,165,179],"from":[17,137,215],"bovine":[18,90,216],"and":[19,62,72,86,93,107,115,119,198,284,286],"human":[20],"brain.":[21,217],"Five":[22],"of":[23,55,78,125,149,153,163,170,208,248,258,262,271,295],"the":[24,31,67,171,287,293],"showed":[26],"very":[27],"little":[28],"reaction,":[29],"but":[30],"other":[32],"five":[33],"reacted":[34],"strongly":[35,104],"associated":[39],"proteins":[40,43,68,80,214],"(MAPs).":[41],"The":[42,151,201,269],"recognized":[44,173,278],"by":[45,76,161,174,186,206,234,279],"these":[46],"have":[48,245,291],"estimated":[49],"molecular":[50],"weights":[51],"similar":[52],"to":[53,105,109,255,274],"those":[54],"known":[56],"MAPs,":[58],"tau":[59,71,92,106,114,133,154,213,283],"(52-68":[60],"kd)":[61],"MAP2":[63,73,116,135],"(200-250":[64],"kd).":[65],"That":[66],"are":[69,146,232,239],"indeed":[70],"is":[74,158,180,253,267],"demonstrated":[75,160,246],"reaction":[77],"electroblotted":[79],"in":[84,156,177,182,196,221,264,282],"mouse":[85],"guinea":[87],"pig":[88],"brain":[91],"MAP2.":[94,123],"One":[95],"anti-ANT":[96],"antibody":[97],"reacts":[98],"only":[99],"tau,":[101],"two":[102],"bind":[103],"weakly":[108],"MAP2,":[110,285],"one":[111,120],"recognizes":[112],"both":[113],"equally":[117],"well,":[118],"primarily":[121],"stains":[122],"Extraction":[124],"ANT":[126,157,195,296],"2%":[128],"SDS":[129],"does":[130],"not":[131],"remove":[132],"or":[134,226,260],"epitopes":[136,141,155,277],"ANT,":[138],"indicating":[139],"that":[140,244],"shared":[142,276],"MAPs":[145,259,263],"integral":[147],"components":[148],"ANT.":[150],"existence":[152],"also":[159],"immunoblotting":[162],"ANT-enriched":[164,178],"anti-tau":[167,175,209,235],"antibodies.":[168,236],"Most":[169],"material":[172],"present":[181],"large":[183],"molecules":[184],"excluded":[185],"3%":[187],"polyacrylamide":[188],"gel":[189],"upon":[190],"electrophoresis.":[191],"Anti-tau":[192],"immunostain":[194],"immunofluorescence":[197],"immunoperoxidase":[199],"studies.":[200],"immunostaining":[202],"can":[203],"be":[204,275],"blocked":[205],"absorption":[207],"purified":[212],"Not":[218],"all":[219],"ANTs":[220,266],"any":[222],"given":[223],"tissue":[224],"section":[225],"isolated":[227],"Alzheimer":[228],"perikarial":[229],"preparations,":[230],"however,":[231],"stained":[233],"These":[237],"results":[238],"consistent":[240],"previous":[242],"studies":[243],"heterogeneity":[247,252],"ANTs.":[249],"Whether":[250],"this":[251,289],"due":[254],"biochemical":[256],"modification":[257],"absence":[261],"some":[265],"unknown.":[268],"significance":[270],"what":[272],"appear":[273],"implications":[288],"may":[290],"on":[292],"pathogenesis":[294],"formation,":[297],"requires":[298],"further":[299],"investigation.":[300]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
