{"id":"https://openalex.org/W848857674","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.620.8","title":"Application of a platform nanotechnology for anti\u2010NF\u2010kB siRNA delivery to metastatic melanoma","display_name":"Application of a platform nanotechnology for anti\u2010NF\u2010kB siRNA delivery to metastatic melanoma","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W848857674","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.620.8","mag":"848857674"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.29.1_supplement.620.8","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.620.8","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.620.8","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102716787","display_name":"Hua Pan","orcid":"https://orcid.org/0009-0009-3161-0665","observed_orcids":["https://orcid.org/0009-0009-3161-0665","https://orcid.org/0009-0001-1526-7205"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Pan","raw_affiliation_strings":["Department of Medicine Washington University in St. Louis United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Washington University in St. Louis United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113465300","display_name":"Kirk K. Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirk Hou","raw_affiliation_strings":["Department of Medicine Washington University in St. Louis United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Washington University in St. Louis United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Stacy Allen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacy Allen","raw_affiliation_strings":["Department of Medicine Washington University in St. Louis United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Washington University in St. Louis United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112619697","display_name":"Mike J. Scott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mike Scott","raw_affiliation_strings":["Department of Medicine Washington University in St. Louis United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Washington University in St. Louis United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046404222","display_name":"Samuel A. Wickline","orcid":"https://orcid.org/0000-0002-8949-3192","observed_orcids":["https://orcid.org/0000-0002-8949-3192"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel Wickline","raw_affiliation_strings":["Department of Medicine Washington University in St. Louis United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Washington University in St. Louis United States","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00960628,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nf-kappab-p65","display_name":"NF-\u03baB p65","score":0.8109999895095825},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.9269999861717224},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/b16f10-melanoma-cells","display_name":"B16F10 melanoma cells","score":0.9620000123977661},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.5669999718666077},{"id":"https://openalex.org/keywords/intravenous-delivery","display_name":"intravenous delivery","score":0.44699999690055847},{"id":"https://openalex.org/keywords/nanoparticle-cytotoxicity","display_name":"nanoparticle cytotoxicity","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6958392262458801},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6957061886787415},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.6946592330932617},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5849052667617798},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5454720258712769},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5292149186134338},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.50046706199646},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4762811064720154},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4744076430797577},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4062131345272064},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30230921506881714},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2882804274559021},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26117318868637085},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.24260497093200684},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.20254483819007874},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08290809392929077},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07511338591575623},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06207969784736633},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.29.1_supplement.620.8","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.620.8","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.620.8","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3048083890","https://openalex.org/W2999898600","https://openalex.org/W2014304644","https://openalex.org/W2030182917","https://openalex.org/W2135334810","https://openalex.org/W4394692425","https://openalex.org/W2892007550","https://openalex.org/W3101858969","https://openalex.org/W2091395844","https://openalex.org/W4399128052"],"abstract_inverted_index":{"A":[0],"cationic":[1],"peptide-based":[2],"nanotechnology":[3],"system":[4],"for":[5,164],"siRNA":[6,73,94,119,144,171],"delivery":[7,92,227],"recently":[8],"developed":[9],"in":[10,58,76,98,123,196,207,234,237,242,254],"our":[11],"lab":[12],"not":[13],"only":[14],"overcomes":[15],"limitations":[16],"of":[17,29,48,56,93,130,143,179,228,247],"serum":[18],"instability,":[19],"endosomal":[20],"entrapment":[21],"and":[22,43,84,101,113,157,182,191,236],"vascular":[23],"constraint":[24],"at":[25,110],"the":[26,54,62,117,177,244],"disease":[27],"sites":[28],"interest,":[30],"but":[31],"also":[32],"exhibits":[33],"an":[34],"exceptional":[35],"safety":[36],"profile":[37],"(Hou":[38],"et":[39],"al,":[40],"ACS":[41],"Nano":[42],"Biomaterials;":[44],"2014).":[45],"The":[46],"objective":[47],"this":[49,221,255],"study":[50],"was":[51],"to":[52,89,95,106,135],"address":[53],"role":[55],"NF-kB":[57],"melanoma":[59,202,248],"by":[60],"inhibiting":[61],"canonical":[63],"pathway":[64],"component,":[65],"p65,":[66],"with":[67,78,214],"55nm":[68],"diameter":[69],"nanoparticles":[70],"carrying":[71],"anti-p65":[72,118],"(p65":[74],"NP)":[75],"mice":[77,127,158],"pulmonary":[79],"metastatic":[80],"melanoma.":[81],"Flow":[82],"cytometry":[83],"fluorescence":[85],"microscopy":[86],"were":[87,104,146,159,193,209],"used":[88,105],"confirm":[90,107],"cytoplasmic":[91],"B16F10":[96,133,154,180,197],"cells":[97,134,181,198],"vitro.":[99],"RT2-PCR":[100],"western":[102],"blot":[103],"p65":[108,187,232],"knockdown":[109],"both":[111,233],"mRNA":[112,188],"protein":[114,192],"levels":[115],"after":[116,153],"NP":[120,145,172],"treatment.":[121],"For":[122],"vivo":[124],"studies,":[125],"C57BL/6J":[126],"received":[128],"injections":[129],"1/2":[131],"million":[132],"create":[136],"lung":[137,203,249],"metastasis.":[138],"Three":[139],"consecutive":[140],"i.v.":[141],"treatments":[142],"administered":[147],"on":[148,161],"day":[149,162],"4,":[150],"5,":[151],"6":[152],"cell":[155],"injections,":[156],"sacrificed":[160],"7":[163,252],"metastasis":[165,204,250],"evaluation.":[166],"Our":[167],"results":[168],"indicate":[169],"that":[170],"are":[173],"readily":[174],"delivered":[175],"into":[176,183],"cytoplasm":[178],"lungs":[184],"parenchyma.":[185],"Both":[186],"(88%":[189],"less)":[190],"substantially":[194],"depleted":[195],"(n=6).":[199],"After":[200],"treatment,":[201],"(black":[205],"spots":[206],"lung)":[208],"dramatically":[210],"reduced":[211],"as":[212],"compared":[213],"controls":[215],"(n=10":[216],"per":[217],"group).":[218],"In":[219],"conclusion,":[220],"platform":[222],"technology":[223],"enables":[224],"effective":[225,241],"cellular":[226],"specific":[229],"siRNAs":[230],"against":[231],"vitro":[235],"vivo,":[238],"which":[239],"appears":[240],"altering":[243],"natural":[245],"history":[246],"within":[251],"days":[253],"model.":[256]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}