{"id":"https://openalex.org/W848698283","doi":null,"title":"Dieescting the effects of sweet tastants in the human gut-brain axis","display_name":"Dieescting the effects of sweet tastants in the human gut-brain axis","publication_year":2014,"publication_date":"2014-02-10","ids":{"openalex":"https://openalex.org/W848698283","mag":"848698283"},"language":"en","primary_location":{"id":"pmh:oai:pure.atira.dk:studenttheses/9d71c67b-36c1-4cec-8df0-bf7d41b24476","doi":null,"is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/studentTheses/9d71c67b-36c1-4cec-8df0-bf7d41b24476","pdf_url":"https://pure.manchester.ac.uk/ws/files/54549425/FULL_TEXT.PDF","source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"synchronisedUnifiedStudentThesis","raw_type":"Phd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.manchester.ac.uk/ws/files/54549425/FULL_TEXT.PDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054326199","display_name":"Charlotte E. Bryant","orcid":"https://orcid.org/0000-0002-4364-9315","observed_orcids":["https://orcid.org/0000-0002-4364-9315"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Charlotte E. Bryant","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4364-9315","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5054326199"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.03180000185966492,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/sweet-taste-receptor","display_name":"sweet taste receptor","score":0.8259999752044678},{"id":"https://openalex.org/keywords/artificial-sweeteners","display_name":"artificial sweeteners","score":0.8389999866485596},{"id":"https://openalex.org/keywords/natural-sugars","display_name":"natural sugars","score":0.6430000066757202},{"id":"https://openalex.org/keywords/lactisole","display_name":"lactisole","score":0.8479999899864197},{"id":"https://openalex.org/keywords/gastric-emptying","display_name":"gastric emptying","score":0.9020000100135803},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.4620000123977661},{"id":"https://openalex.org/keywords/appetite","display_name":"appetite","score":0.703000009059906},{"id":"https://openalex.org/keywords/satiety","display_name":"satiety","score":0.9330000281333923},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.7940000295639038},{"id":"https://openalex.org/keywords/gastrointestinal-hormones","display_name":"gastrointestinal hormones","score":0.675000011920929},{"id":"https://openalex.org/keywords/blood-glucose","display_name":"blood glucose","score":0.6899999976158142},{"id":"https://openalex.org/keywords/brain-activation","display_name":"brain activation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6100000143051147},{"id":"https://openalex.org/keywords/aspartame","display_name":"aspartame","score":0.6930000185966492},{"id":"https://openalex.org/keywords/saccharin","display_name":"saccharin","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C8868529","wikidata":"https://www.wikidata.org/wiki/Q124794","display_name":"Taste","level":2,"score":0.7354058623313904},{"id":"https://openalex.org/C177857423","wikidata":"https://www.wikidata.org/wiki/Q17077315","display_name":"Gut\u2013brain axis","level":3,"score":0.5884180068969727},{"id":"https://openalex.org/C178006227","wikidata":"https://www.wikidata.org/wiki/Q3454532","display_name":"Taste receptor","level":3,"score":0.5155148506164551},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.48144906759262085},{"id":"https://openalex.org/C75908981","wikidata":"https://www.wikidata.org/wiki/Q28578","display_name":"Appetite","level":2,"score":0.4602893590927124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3682619333267212},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3646343946456909},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3611392080783844},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.35923904180526733},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3294774889945984},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26964065432548523},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.17948320508003235},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1323358416557312}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pure.atira.dk:studenttheses/9d71c67b-36c1-4cec-8df0-bf7d41b24476","doi":null,"is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/studentTheses/9d71c67b-36c1-4cec-8df0-bf7d41b24476","pdf_url":"https://pure.manchester.ac.uk/ws/files/54549425/FULL_TEXT.PDF","source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"synchronisedUnifiedStudentThesis","raw_type":"Phd"},{"id":"mag:848698283","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603200","pdf_url":null,"source":{"id":"https://openalex.org/S4306532719","display_name":"[Thesis]. Manchester, UK: The University of                    Manchester; 2014.","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"[Thesis]. Manchester, UK: The University of Manchester; 2014.","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pure.atira.dk:studenttheses/9d71c67b-36c1-4cec-8df0-bf7d41b24476","doi":null,"is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/studentTheses/9d71c67b-36c1-4cec-8df0-bf7d41b24476","pdf_url":"https://pure.manchester.ac.uk/ws/files/54549425/FULL_TEXT.PDF","source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"synchronisedUnifiedStudentThesis","raw_type":"Phd"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W848698283.pdf","grobid_xml":"https://content.openalex.org/works/W848698283.grobid-xml"},"referenced_works_count":207,"referenced_works":["https://openalex.org/W61265102","https://openalex.org/W1508612022","https://openalex.org/W1569037784","https://openalex.org/W1594379317","https://openalex.org/W1614085367","https://openalex.org/W1616790409","https://openalex.org/W1752174928","https://openalex.org/W1786158486","https://openalex.org/W1789139980","https://openalex.org/W1808647690","https://openalex.org/W1842623328","https://openalex.org/W1858943160","https://openalex.org/W1952062595","https://openalex.org/W1952249607","https://openalex.org/W1952505253","https://openalex.org/W1968022266","https://openalex.org/W1969104991","https://openalex.org/W1969385890","https://openalex.org/W1970250202","https://openalex.org/W1971280724","https://openalex.org/W1972224209","https://openalex.org/W1972534040","https://openalex.org/W1975775502","https://openalex.org/W1978089427","https://openalex.org/W1978167872","https://openalex.org/W1980436365","https://openalex.org/W1980693983","https://openalex.org/W1980992098","https://openalex.org/W1982227541","https://openalex.org/W1984085793","https://openalex.org/W1986043247","https://openalex.org/W1987242122","https://openalex.org/W1989952505","https://openalex.org/W1990651463","https://openalex.org/W1990784939","https://openalex.org/W1991133912","https://openalex.org/W1993623582","https://openalex.org/W1994802618","https://openalex.org/W1998712051","https://openalex.org/W1998996187","https://openalex.org/W1999661399","https://openalex.org/W1999708091","https://openalex.org/W1999925806","https://openalex.org/W2001323377","https://openalex.org/W2002297978","https://openalex.org/W2003662371","https://openalex.org/W2008351004","https://openalex.org/W2008582388","https://openalex.org/W2009646834","https://openalex.org/W2009762469","https://openalex.org/W2010255580","https://openalex.org/W2010671489","https://openalex.org/W2011790043","https://openalex.org/W2012242464","https://openalex.org/W2012256652","https://openalex.org/W2013073744","https://openalex.org/W2013883904","https://openalex.org/W2014389426","https://openalex.org/W2015639995","https://openalex.org/W2016443228","https://openalex.org/W2016453788","https://openalex.org/W2016798380","https://openalex.org/W2017533053","https://openalex.org/W2021568996","https://openalex.org/W2026133107","https://openalex.org/W2029978047","https://openalex.org/W2030322836","https://openalex.org/W2033002758","https://openalex.org/W2035456909","https://openalex.org/W2040160899","https://openalex.org/W2042011044","https://openalex.org/W2042312271","https://openalex.org/W2043351054","https://openalex.org/W2043552025","https://openalex.org/W2044015990","https://openalex.org/W2044174105","https://openalex.org/W2045279454","https://openalex.org/W2045798561","https://openalex.org/W2046325265","https://openalex.org/W2046686669","https://openalex.org/W2048369021","https://openalex.org/W2048455036","https://openalex.org/W2048809940","https://openalex.org/W2049881191","https://openalex.org/W2050663954","https://openalex.org/W2050917227","https://openalex.org/W2053575156","https://openalex.org/W2055005535","https://openalex.org/W2055186717","https://openalex.org/W2056867246","https://openalex.org/W2056908956","https://openalex.org/W2058239117","https://openalex.org/W2058677931","https://openalex.org/W2059117845","https://openalex.org/W2059428929","https://openalex.org/W2060044054","https://openalex.org/W2061377780","https://openalex.org/W2063783584","https://openalex.org/W2064492226","https://openalex.org/W2065786925","https://openalex.org/W2067059133","https://openalex.org/W2067355591","https://openalex.org/W2069404752","https://openalex.org/W2070634735","https://openalex.org/W2072522618","https://openalex.org/W2073327313","https://openalex.org/W2074933180","https://openalex.org/W2075464348","https://openalex.org/W2077185686","https://openalex.org/W2077971193","https://openalex.org/W2078060668","https://openalex.org/W2078341047","https://openalex.org/W2078967110","https://openalex.org/W2079539251","https://openalex.org/W2079737026","https://openalex.org/W2081709860","https://openalex.org/W2082113374","https://openalex.org/W2082156702","https://openalex.org/W2082286447","https://openalex.org/W2083215956","https://openalex.org/W2083763054","https://openalex.org/W2084948079","https://openalex.org/W2084965262","https://openalex.org/W2085993091","https://openalex.org/W2086177834","https://openalex.org/W2087617885","https://openalex.org/W2088347796","https://openalex.org/W2088723911","https://openalex.org/W2089699203","https://openalex.org/W2089933763","https://openalex.org/W2091685843","https://openalex.org/W2092622920","https://openalex.org/W2095386072","https://openalex.org/W2095708332","https://openalex.org/W2096436906","https://openalex.org/W2097334615","https://openalex.org/W2098267014","https://openalex.org/W2099688918","https://openalex.org/W2100090810","https://openalex.org/W2101900774","https://openalex.org/W2102237655","https://openalex.org/W2102392334","https://openalex.org/W2102899573","https://openalex.org/W2107636466","https://openalex.org/W2108078135","https://openalex.org/W2109132990","https://openalex.org/W2109762839","https://openalex.org/W2112781973","https://openalex.org/W2116592293","https://openalex.org/W2118772291","https://openalex.org/W2119511015","https://openalex.org/W2120476264","https://openalex.org/W2121499324","https://openalex.org/W2125459062","https://openalex.org/W2127820755","https://openalex.org/W2128333388","https://openalex.org/W2128413154","https://openalex.org/W2129362735","https://openalex.org/W2129796845","https://openalex.org/W2134247737","https://openalex.org/W2138724749","https://openalex.org/W2139026758","https://openalex.org/W2140893502","https://openalex.org/W2141256458","https://openalex.org/W2141331973","https://openalex.org/W2141452234","https://openalex.org/W2143952061","https://openalex.org/W2147267528","https://openalex.org/W2147288185","https://openalex.org/W2147496400","https://openalex.org/W2147842920","https://openalex.org/W2149023087","https://openalex.org/W2149933158","https://openalex.org/W2150899357","https://openalex.org/W2152084611","https://openalex.org/W2153042980","https://openalex.org/W2154044488","https://openalex.org/W2154497567","https://openalex.org/W2155159177","https://openalex.org/W2155286130","https://openalex.org/W2156316935","https://openalex.org/W2156689802","https://openalex.org/W2157456431","https://openalex.org/W2158597227","https://openalex.org/W2159308559","https://openalex.org/W2161555995","https://openalex.org/W2163647683","https://openalex.org/W2164121465","https://openalex.org/W2164440959","https://openalex.org/W2164578066","https://openalex.org/W2165940444","https://openalex.org/W2167525293","https://openalex.org/W2168093058","https://openalex.org/W2168568879","https://openalex.org/W2168672668","https://openalex.org/W2170277935","https://openalex.org/W2170419237","https://openalex.org/W2172260641","https://openalex.org/W2241897892","https://openalex.org/W2269039163","https://openalex.org/W2273336745","https://openalex.org/W2277104672","https://openalex.org/W2283802849","https://openalex.org/W2289378992","https://openalex.org/W2396115787","https://openalex.org/W2895186996","https://openalex.org/W3012569365"],"related_works":["https://openalex.org/W2613355956","https://openalex.org/W2343242356","https://openalex.org/W2887266233","https://openalex.org/W4253051157","https://openalex.org/W3020890641","https://openalex.org/W4385542977","https://openalex.org/W6958654491","https://openalex.org/W2902604961","https://openalex.org/W2058677931","https://openalex.org/W2056930108"],"abstract_inverted_index":{"The":[0,56,98,129,266,325],"importance":[1],"of":[2,10,24,45,59,95,147,232,254,307,310,349,395,416,434],"nutrient":[3],"induced":[4],"gut-brain":[5,50,127,153,165,255,398],"signalling":[6,399],"in":[7,48,71,81,92,101,124,140,150,237,269,281,298,367,383,427,438],"the":[8,19,25,37,40,49,82,85,93,112,125,141,145,151,230,239,295,303,393],"regulation":[9],"human":[11,126,152,418],"food":[12,204,264],"intake":[13],"has":[14,76,409],"become":[15],"increasingly":[16],"apparent":[17],"as":[18,225],"obesity":[20],"epidemic":[21],"progresses.":[22],"Much":[23],"caloric":[26],"excess":[27],"consumed":[28],"comes":[29],"from":[30,54],"dietary":[31],"sugars,":[32],"but":[33],"our":[34],"knowledge":[35],"about":[36],"mechanisms":[38,94],"mediating":[39,238],"physiological":[41],"and":[42,73,155,170,187,201,208,211,279,305,329,343,369,436,440],"appetitive":[43],"effects":[44,58,146,394],"sweet":[46,86,116,137,148,159,218,234,331,378,405],"tastants":[47,149,437],"axis":[51],"is":[52,400],"far":[53],"complete.":[55],"comparative":[57],"natural":[60],"sugars":[61],"vs.":[62],"artificial":[63],"non-nutritive":[64,275],"sweeteners":[65],"are":[66,381],"also":[67,119],"poorly":[68],"understood.":[69],"Research":[70],"animal":[72],"cellular":[74],"models":[75],"suggested":[77],"a":[78,121,217,226,352,385,413,431],"key":[79,107,122,130],"role":[80,123,231],"gut":[83,115,142,162,233,259,377],"for":[84,412],"taste":[87,117,138,160,219,235,379,406],"receptors":[88,118,139,236,380],"previously":[89],"well":[90],"described":[91],"oral":[96,158,328,347,404],"taste.":[97],"work":[99],"presented":[100,297],"this":[102],"thesis":[103],"sought":[104],"to":[105,133,144,228,241,359,391,423],"answer":[106],"questions":[108],"initially":[109],"based":[110],"on":[111,248,316,333,355],"hypothesis":[113],"that":[114,273,302,345,376],"play":[120],"axis.":[128],"aims":[131],"were":[132,179,185,365],"elucidate":[134],"i)":[135],"whether":[136,157,317],"contribute":[143],"axis,":[154],"ii)":[156],"modulates":[161],"physiology":[163],"and/or":[164],"signalling.":[166],"Fifty-eight":[167],"(36":[168],"males":[169],"22":[171],"females)":[172],"young":[173],"(23.3":[174],"+":[175,192],"3.4":[176],"years)":[177],"participants":[178],"recruited":[180],"into":[181],"four":[182,271],"studies.":[183],"All":[184],"healthy":[186,417],"generally":[188],"lean":[189],"(BMI":[190],"22.3":[191],"1.9).":[193],"Key":[194],"methodologies":[195],"used":[196,224],"included":[197],"gastric":[198,249,308],"emptying,":[199],"appetite":[200,261,292],"satiety":[202],"scores,":[203],"intake,":[205],"blood":[206,257],"hormone":[207],"glycaemic":[209,288],"responses,":[210],"functional":[212,340],"brain":[213,334,341,357],"imaging.In":[214],"chapter":[215,270,299],"3,":[216],"receptor":[220],"antagonist,":[221],"lactisole,":[222],"was":[223,319,336],"tool":[227],"investigate":[229,424],"responses":[240,289,358],"glucose.":[242,396],"However,":[243,294],"lactisole":[244],"had":[245,351],"no":[246],"impact":[247,354],"emptying":[250,309],"(a":[251],"proxy":[252],"measure":[253],"signalling),":[256],"glucose,":[258],"hormones,":[260],"ratings":[262],"or":[263,290,322],"intake.":[265],"data":[267,372],"outlined":[268],"revealed":[272],"ingesting":[274],"sweeteners,":[276],"(aspartame,":[277],"saccharin,":[278],"acesulfame-k)":[280],"combination":[282],"with":[283],"glucose":[284,311,350,362],"did":[285],"not":[286],"enhance":[287],"affect":[291],"ratings.":[293],"studies":[296,421],"five":[300],"demonstrated":[301,344],"pattern":[304],"rate":[306],"very":[312],"clearly":[313],"differed":[314],"depending":[315],"it":[318],"given":[320],"orally":[321],"administered":[323],"intragastrically.":[324],"interaction":[326],"between":[327],"gastrointestinal":[330],"stimuli":[332],"activation":[335],"therefore":[337],"investigated":[338],"using":[339,430],"imaging,":[342],"an":[346,360],"pre-taste":[348],"marked":[353],"subsequent":[356],"intragastric":[361],"load.":[363],"Effects":[364],"observed":[366],"homeostatic":[368],"non-homeostatic":[370],"regions.These":[371],"offer":[373],"little":[374],"evidence":[375],"important":[382],"humans:":[384],"non-taste":[386],"pathway":[387],"appears":[388],"more":[389,428],"likely":[390],"mediate":[392],"However":[397],"markedly":[401],"affected":[402],"by":[403],"receptors.":[407],"This":[408],"direct":[410],"relevance":[411],"better":[414],"understanding":[415],"nutrition.":[419],"Future":[420],"need":[422],"these":[425],"interactions":[426],"detail,":[429],"wider":[432],"panel":[433],"nutrients":[435],"health":[439],"disease.":[441]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}